Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
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Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
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Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2020
Journal Article
Modern clinician-initiated clinical trials to determine optimal therapy for multi-drug resistant Gram-negative infections
Stewart, Adam G., Harris, Patrick N. A., Chatfield, Mark, Evans, Scott R., van Duin, David and Paterson, David L. (2020). Modern clinician-initiated clinical trials to determine optimal therapy for multi-drug resistant Gram-negative infections. Clinical Infectious Diseases, 71 (2), 433-439. doi: 10.1093/cid/ciz1132
2020
Journal Article
Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model
Heffernan, Aaron J., Sime, Fekade B., Sarovich, Derek S., Neely, Michael, Guerra-Valero, Yarmarly, Naicker, Saiyuri, Cottrell, Kyra, Harris, Patrick, Andrews, Katherine T., Ellwood, David, Wallis, Steven C., Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason A. (2020). Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model. Antimicrobial Agents and Chemotherapy, 64 (9) e00879-20. doi: 10.1128/aac.00879-20
2020
Journal Article
Antimicrobial resistance in ESKAPE pathogens
De Oliveira, David M. P., Forde, Brian M., Kidd, Timothy J., Harris, Patrick N. A., Schembri, Mark A., Beatson, Scott A., Paterson, David L. and Walker, Mark J. (2020). Antimicrobial resistance in ESKAPE pathogens. Clinical Microbiology Reviews, 33 (3) e00181-19, e00181-19. doi: 10.1128/cmr.00181-19
2020
Journal Article
Oral cephalosporin and β-lactamase inhibitor combinations for ESBL-producing Enterobacteriaceae urinary tract infections
Stewart, Adam G., Harris, Patrick N. A., Henderson, Andrew, Schembri, Mark A. and Paterson, David L. (2020). Oral cephalosporin and β-lactamase inhibitor combinations for ESBL-producing Enterobacteriaceae urinary tract infections. Journal of Antimicrobial Chemotherapy, 75 (9), 2384-2393. doi: 10.1093/jac/dkaa183
2020
Journal Article
Genomic investigation reveals contaminated detergent as the source of an Extended-Spectrum-β-Lactamase-producing Klebsiella michiganensis outbreak in a neonatal unit
Chapman, Paul, Forde, Brian M., Roberts, Leah W., Bergh, Haakon, Vesey, Debra, Jennison, Amy V., Moss, Susan, Paterson, David L., Beatson, Scott A. and Harris, Patrick N. A. (2020). Genomic investigation reveals contaminated detergent as the source of an Extended-Spectrum-β-Lactamase-producing Klebsiella michiganensis outbreak in a neonatal unit. Journal of Clinical Microbiology, 58 (5) e01980. doi: 10.1128/jcm.01980-19
2020
Journal Article
Beyond the Core Genome: Tracking Plasmids in Outbreaks of Multidrug-resistant Bacteria
Harris, Patrick N. A. and Wailan, Alexander M. (2020). Beyond the Core Genome: Tracking Plasmids in Outbreaks of Multidrug-resistant Bacteria. Clinical Infectious Diseases, 72 (3), 421-422. doi: 10.1093/cid/ciaa052
2020
Other Outputs
Comparative genomics and antimicrobial resistance profiling of Elizabethkingia isolates reveals nosocomial transmission and in vitro susceptibility to fluoroquinolones, tetracyclines and trimethoprim-sulfamethoxazole
Burnard, Delaney, Gore, Letitia, Henderson, Andrew, Ranasinghe, Ama, Bergh, Haakon, Cottrell, Kyra, Sarovich, Derek S., Price, Erin P., Paterson, David L. and Harris, Patrick N. A. (2020). Comparative genomics and antimicrobial resistance profiling of Elizabethkingia isolates reveals nosocomial transmission and in vitro susceptibility to fluoroquinolones, tetracyclines and trimethoprim-sulfamethoxazole. doi: 10.1101/2020.03.12.20032722
2020
Conference Publication
Pharmacodynamic evaluation of intermittent versus prolonged infusion dosing regimens of piperacillin/tazobactam in a hollow-fiber infection model against two susceptible Klebsiella pneumoniae clinical isolates
Sumi, Chandra Datta, B.Sime, Fekade, Heffernan, Aaron J., Naicker, Saiyuri, Islam, Kamrul, Cottrell, Kyra, Harris, Patrick N.A. and Roberts, Jason A. (2020). Pharmacodynamic evaluation of intermittent versus prolonged infusion dosing regimens of piperacillin/tazobactam in a hollow-fiber infection model against two susceptible Klebsiella pneumoniae clinical isolates. Federation of Infection Societies Conference 2019, Edinburgh, United Kingdom, 11-14 November 2019. London, United Kingdom: The Microbiology Society. doi: 10.1099/acmi.fis2019.po0103
2020
Journal Article
Measuring patient-centred long-term outcome following a bloodstream infection: a pilot study
McNamara, J. F., Harris, P. N. A., Chatfield, M. D., Lorenc, P. and Paterson, D. L. (2020). Measuring patient-centred long-term outcome following a bloodstream infection: a pilot study. Clinical Microbiology and Infection, 26 (2), 257.e1-257.e4. doi: 10.1016/j.cmi.2019.10.011
2020
Journal Article
Current evidence for therapy of ceftriaxone-resistant Gram-negative bacteremia
Paterson, David L., Henderson, Andrew and Harris, Patrick N. A. (2020). Current evidence for therapy of ceftriaxone-resistant Gram-negative bacteremia. Current Opinion in Infectious Diseases, 33 (1), 78-85. doi: 10.1097/QCO.0000000000000623
2020
Journal Article
Integrating multiple genomic technologies to investigate an outbreak of carbapenemase-producing Enterobacter hormaechei
Roberts, Leah W., Harris, Patrick N. A., Forde, Brian M., Ben Zakour, Nouri L., Catchpoole, Elizabeth, Stanton-Cook, Mitchell, Phan, Minh-Duy, Sidjabat, Hanna E., Bergh, Haakon, Heney, Claire, Gawthorne, Jayde A., Lipman, Jeffrey, Allworth, Anthony, Chan, Kok-Gan, Chong, Teik Min, Yin, Wai-Fong, Schembri, Mark A., Paterson, David L. and Beatson, Scott A. (2020). Integrating multiple genomic technologies to investigate an outbreak of carbapenemase-producing Enterobacter hormaechei. Nature Communications, 11 (1) 466, 466. doi: 10.1038/s41467-019-14139-5
2020
Journal Article
A hybrid simulation model approach to examine bacterial genome sequencing during a hospital outbreak
Elliott, Thomas M., Lee, Xing J., Foeglein, Anna, Harris, Patrick N. and Gordon, Louisa G. (2020). A hybrid simulation model approach to examine bacterial genome sequencing during a hospital outbreak. BMC Infectious Diseases, 20 (1) 72, 72. doi: 10.1186/s12879-019-4743-3
2020
Journal Article
Erratum to ‘When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit’ [Clin Microbiol Infect 26 (1) (January 2020) 35–40](S1198743X19303969)(10.1016/j.cmi.2019.07.007)
Denny, K. J., De Waele, J., Laupland, K. B., Harris, P. N.A. and Lipman, J. (2020). Erratum to ‘When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit’ [Clin Microbiol Infect 26 (1) (January 2020) 35–40](S1198743X19303969)(10.1016/j.cmi.2019.07.007). Clinical Microbiology and Infection, 26 (6), 801-801. doi: 10.1016/j.cmi.2020.01.016
2020
Journal Article
Bacterial profile, multi-drug resistance and seasonality following lower limb orthopaedic surgery in tropical and subtropical Australian hospitals: an epidemiological cohort study
Vickers, Mark L., Ballard, Emma L., Harris, Patrick N. A., Knibbs, Luke D., Jaiprakash, Anjali, Dulhunty, Joel M., Crawford, Ross W. and Parkinson, Benjamin (2020). Bacterial profile, multi-drug resistance and seasonality following lower limb orthopaedic surgery in tropical and subtropical Australian hospitals: an epidemiological cohort study. International Journal of Environmental Research and Public Health, 17 (2) 657, 1-15. doi: 10.3390/ijerph17020657
2020
Journal Article
When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit
Denny, K. J., De Waele, J., Laupland, K. B., Harris, P. N. A. and Lipman, J. (2020). When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit. Clinical Microbiology and Infection, 26 (1), 35-40. doi: 10.1016/j.cmi.2019.07.007
2020
Journal Article
Clinical and Economic Outcomes of Genome Sequencing Availability on Containing a Hospital Outbreak of Resistant Escherichia coli in Australia
Lee, Xing J., Elliott, Thomas M., Harris, Patrick N. A., Douglas, Joel, Henderson, Belinda, Watson, Catherine, Paterson, David L., Schofield, Deborah S., Graves, Nicholas and Gordon, Louisa G. (2020). Clinical and Economic Outcomes of Genome Sequencing Availability on Containing a Hospital Outbreak of Resistant Escherichia coli in Australia. Value in Health, 23 (8), 994-1002. doi: 10.1016/j.jval.2020.03.006
2020
Journal Article
Evaluating the economic effects of genomic sequencing of pathogens to prioritise hospital patients competing for isolation beds
Elliott, Thomas M., Hare, Nicole, Hajkowicz, Krispin, Hurst, Trish, Doidge, Michelle, Harris, Patrick N. and Gordon, Louisa G. (2020). Evaluating the economic effects of genomic sequencing of pathogens to prioritise hospital patients competing for isolation beds. Australian Health Review, 45 (1), 59-65. doi: 10.1071/AH20071
2020
Conference Publication
Rapid and sensitive molecular detection of antimicrobial resistance (AMR); towards point-of-care testing in low resource settings
Ayfan, A., Ertl, N., Whiley, D., Paterson, D., Heney, C., Harris, P., Macdonald, J., Irwin, A. and Zowawi, H. (2020). Rapid and sensitive molecular detection of antimicrobial resistance (AMR); towards point-of-care testing in low resource settings. GCCMID 2019, Dubai, United Arab Emirates, 6-9 November 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jiph.2020.01.059
2020
Conference Publication
Molecular epidemiology and hospital spread of ceftriaxone non-susceptible enterobacterales in the Sunshine Coast region, Australia
Stewart, Adam, Sarovich, Derek, Price, Erin, Burnard, Delaney, Harris, Patrick, Choong, Keat and Subedi, Shradha (2020). Molecular epidemiology and hospital spread of ceftriaxone non-susceptible enterobacterales in the Sunshine Coast region, Australia. RACP Congress 2020: Balancing medical science with humanity, Online, May 2020. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/imj.4_14846
2019
Journal Article
Genomic analysis of carbapenemase-producing Enterobacteriaceae in Queensland reveals widespread transmission of blaIMP-4 on an IncHI2 plasmid
Roberts, Leah W., Catchpoole, Elizabeth, Jennison, Amy V., Bergh, Haakon, Hume, Anna, Heney, Claire, George, Narelle, Paterson, David L., Schembri, Mark A., Beatson, Scott A. and Harris, Patrick N. A. (2019). Genomic analysis of carbapenemase-producing Enterobacteriaceae in Queensland reveals widespread transmission of blaIMP-4 on an IncHI2 plasmid. Microbial Genomics, 6 (1) 000321. doi: 10.1099/mgen.0.000321
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis
Principal Advisor
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Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
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Doctor Philosophy
New diagnostic strategies for antibiotic-resistant infections
Principal Advisor
Other advisors: Associate Professor Adam Irwin
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Associate Advisor
Other advisors: Dr Brian Forde
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
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Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
Completed supervision
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2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
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2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
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