Dr Patrick Harris
Dr

Patrick Harris

Email: 
Phone: 
+61 7 334 65476

Background

Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).

Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria

Availability

Dr Patrick Harris is:
Available for supervision

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, University of London
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Clinical trials

    Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections

  • Antibiotic resistance

    Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter

  • Clinical application of genomics

    Use of whole genome sequencing in clinical microbiology

Research impacts

He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics

Search Professor Patrick Harris’s works on UQ eSpace

237 works between 2009 and 2024
All (237) Journal Article (213) Book Chapter (2) Conference Publication (20) Other Outputs (2)

221 - 237 of 237 works

2014

Journal Article

What do infectious diseases physicians do? A 2-week snapshot of inpatient consultative activities across Australia, New Zealand and Singapore

Ingram, P. R., Murray, Ronan J., Cheng, Allen C., Blyth, C. C., Walls, Tony, Fisher, D. A., Davis, Josh S., Abbott, Iain, Kanapathipillai, Rupa, Madigan, Victoria, McLellan, Duncan, Briggs, Simon, King, Claire, Hurley, James, Lim, Lyn-Li, Kennedy, Karina, Wilson, Heather, Evans, Thomas, Maze, Michael, Pithie, Alan, Chong, Lauren, Leung, Grace, McCann, Sarah, Lee, Lai-yang, Wolfgang, Jill, Day, Thomas, Silva, Gustinna De, Martinello, Marianne, Gliddon, Thomas ... on behalf of the Australasian Society for Infectious Diseases Clinical Research Network (2014). What do infectious diseases physicians do? A 2-week snapshot of inpatient consultative activities across Australia, New Zealand and Singapore. Clinical Microbiology and Infection, 20 (10), O737-O744. doi: 10.1111/1469-0691.12581

What do infectious diseases physicians do? A 2-week snapshot of inpatient consultative activities across Australia, New Zealand and Singapore

2014

Journal Article

Melioidosis: refining management of a tropical time bomb

Fisher, Dale A. and Harris, Patrick N. A. (2014). Melioidosis: refining management of a tropical time bomb. The Lancet, 383 (9919), 762-764. doi: 10.1016/S0140-6736(13)62143-1

Melioidosis: refining management of a tropical time bomb

2013

Journal Article

Acute Q fever in northern Queensland: variation in incidence related to rainfall and geographical location

Harris, P., Eales, K. M., Squires, R., Govan, B. and Norton, R. (2013). Acute Q fever in northern Queensland: variation in incidence related to rainfall and geographical location. Epidemiology and Infection, 141 (5), 1034-1038. doi: 10.1017/S0950268812001495

Acute Q fever in northern Queensland: variation in incidence related to rainfall and geographical location

2012

Journal Article

Antibiotic therapy for inducible AmpC β-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides?

Harris, P. N. A. and Ferguson, J. K. (2012). Antibiotic therapy for inducible AmpC β-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides?. International Journal of Antimicrobial Agents, 40 (4), 297-305. doi: 10.1016/j.ijantimicag.2012.06.004

Antibiotic therapy for inducible AmpC β-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides?

2012

Journal Article

Adhesive tape in the health care setting: another high-risk fomite?

Harris, Patrick N. A., Ashhurst-Smith, Chris, Berenger, Sandy J. and Ferguson, John K. (2012). Adhesive tape in the health care setting: another high-risk fomite?. Medical Journal of Australia, 196 (1), 34-34. doi: 10.5694/mja11.11211

Adhesive tape in the health care setting: another high-risk fomite?

2012

Journal Article

Comparison of Vitek MS (MALDI-TOF) to standard routine identification methods: an advance but no panacea

Harris, Patrick, Winney, Ian, Ashhurst-Smith, Chris, O'Brien, Mark and Graves, Stephen (2012). Comparison of Vitek MS (MALDI-TOF) to standard routine identification methods: an advance but no panacea. Pathology, 44 (6), 583-585. doi: 10.1097/PAT.0b013e328358343c

Comparison of Vitek MS (MALDI-TOF) to standard routine identification methods: an advance but no panacea

2011

Journal Article

Coxiella burnetii causing haemophagocytic syndrome: a rare complication of an unusual pathogen

Harris, P., Dixit, R. and Norton, R. (2011). Coxiella burnetii causing haemophagocytic syndrome: a rare complication of an unusual pathogen. Infection, 39 (6), 579-582. doi: 10.1007/s15010-011-0142-4

Coxiella burnetii causing haemophagocytic syndrome: a rare complication of an unusual pathogen

2011

Journal Article

Reply

Norton, R., Harris, P. and Senthuran, S. (2011). Reply. Internal Medicine Journal, 41 (9), 710-710. doi: 10.1111/j.1445-5994.2011.02558.x

Reply

2011

Journal Article

Bacteraemia caused by beta-haemolytic streptococci in North Queensland: changing trends over a 14-year period

Harris, P., Siew, D-A., Proud, M., Buettner, P. and Norton, R. (2011). Bacteraemia caused by beta-haemolytic streptococci in North Queensland: changing trends over a 14-year period. Clinical Microbiology and Infection, 17 (8), 1216-1222. doi: 10.1111/j.1469-0691.2010.03427.x

Bacteraemia caused by beta-haemolytic streptococci in North Queensland: changing trends over a 14-year period

2011

Journal Article

Evidence of Burkholderia pseudomallei-specific immunity in patient sera persistently nonreactive by the indirect hemagglutination assay

Harris, Patrick N. A., Williams, Natasha L., Morris, Jodie L., Ketheesan, Natkunam and Norton, Robert E. (2011). Evidence of Burkholderia pseudomallei-specific immunity in patient sera persistently nonreactive by the indirect hemagglutination assay. Clinical and Vaccine Immunology, 18 (8), 1288-1291. doi: 10.1128/CVI.00077-11

Evidence of Burkholderia pseudomallei-specific immunity in patient sera persistently nonreactive by the indirect hemagglutination assay

2011

Journal Article

Challenges in the microbiological diagnosis and management of hVISA infections

Cheong, Jenny Wan Sai, Harris, Patrick, Oman, Kimberly and Norton, Robert (2011). Challenges in the microbiological diagnosis and management of hVISA infections. Pathology, 43 (4), 357-361. doi: 10.1097/PAT.0b013e3283464ca3

Challenges in the microbiological diagnosis and management of hVISA infections

2011

Journal Article

Comparative in vitro susceptibility of Burkholderia pseudomallei to doripenem, ertapenem, tigecycline and moxifloxacin

Harris, Patrick, Engler, Cathy and Norton, Robert (2011). Comparative in vitro susceptibility of Burkholderia pseudomallei to doripenem, ertapenem, tigecycline and moxifloxacin. International Journal of Antimicrobial Agents, 37 (6), 547-549. doi: 10.1016/j.ijantimicag.2011.02.001

Comparative in vitro susceptibility of Burkholderia pseudomallei to doripenem, ertapenem, tigecycline and moxifloxacin

2011

Journal Article

Automated erythrocytapheresis for severe falciparum malaria

Harris, P., Price, S., Senthuran, S., Cochupanachimootil, J. and Norton, R. (2011). Automated erythrocytapheresis for severe falciparum malaria. Internal Medicine Journal, 41 (1A), 60-63. doi: 10.1111/j.1445-5994.2010.02362.x

Automated erythrocytapheresis for severe falciparum malaria

2010

Journal Article

Another killer of the Australian Bush: a rapidly fatal meningoencephalitis in a child

Norton, Robert, Harris, Patrick, Ryan, Pat and Simpson, Scott (2010). Another killer of the Australian Bush: a rapidly fatal meningoencephalitis in a child. Clinical Infectious Diseases, 50 (10), 1375-1376. doi: 10.1086/652146

Another killer of the Australian Bush: a rapidly fatal meningoencephalitis in a child

2010

Journal Article

Herpes zoster meningoencephalitis: Not only a disease of the immunocompromised?

Douglas, A., Harris, P., Francis, F. and Norton, R. (2010). Herpes zoster meningoencephalitis: Not only a disease of the immunocompromised?. Infection, 38 (1), 73-75. doi: 10.1007/s15010-009-9092-5

Herpes zoster meningoencephalitis: Not only a disease of the immunocompromised?

2010

Journal Article

Pandemic influenza H1N1 2009 in north Queensland – risk factors for admission in a region with a large indigenous population.

Harris, Patrick N., Dixit, Rashmi, Francis, Fleur, Buettner, Petra G., Leahy, Clinton, Burgher, Bjorn, Egan, Angela, Proud, Michelle, Jayalath, Ruvinka, Grewal, Amrit and Norton, Robert E. (2010). Pandemic influenza H1N1 2009 in north Queensland – risk factors for admission in a region with a large indigenous population.. Communicable Diseases Intelligence Quarterly Report, 34 (2), 102-109.

Pandemic influenza H1N1 2009 in north Queensland – risk factors for admission in a region with a large indigenous population.

2009

Journal Article

Clinical features that affect indirect-hemagglutination-assay responses to Burkholderia pseudomallei

Harris, Patrick N. A., Ketheesan, Natkunam, Owens, Leigh and Norton, Robert E. (2009). Clinical features that affect indirect-hemagglutination-assay responses to Burkholderia pseudomallei. Clinical and Vaccine Immunology, 16 (6), 924-930. doi: 10.1128/CVI.00026-09

Clinical features that affect indirect-hemagglutination-assay responses to Burkholderia pseudomallei

Current funding

  • 2025 - 2029
    New diagnostic strategies for antibiotic-resistant infections
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2026
    Reducing blood culture contamination with the use of a needle-less blood draw device (PIVO Pro): An adaptive group sequential randomized controlled trial (The PIVO Trial)
    Becton, Dickinson and Company
    Open grant
  • 2024 - 2028
    Unlocking the gut microbiome to track the spread of AMR genes and pathogens
    NHMRC MRFF - Global Health Initiative
    Open grant
  • 2023 - 2026
    New diagnostic strategies for antibiotic-resistant infections
    Queensland Health Clinical Research Fellowships
    Open grant
  • 2023 - 2026
    Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis
    The Children's Hospital Foundation
    Open grant
  • 2023 - 2025
    Development of Wastewater-based epidemiology as a complementary approach for antimicrobial resistance surveillance
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2023 - 2024
    Improving management of fungal infections during blood cancer treatment
    Gilead Australia Fellowship
    Open grant
  • 2018 - 2025
    Investigator Driven Randomized Controlled Trial of Cefiderocol versus Standard Therapy for Healthcare Associated and Hospital Acquired Gram-negative Blood Stream Infection (the GAME CHANGER trial)
    Shionogi & Company, Limited
    Open grant

Past funding

  • 2022 - 2024
    The 3,000 Genomes project: using machine learning and artificial intelligence for robust culture-independent susceptibility testing
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2022 - 2023
    Non-inferiority of low-level (LLD) versus high-level disinfection (HLD) for elimination of bacteria on contaminated ultrasound transducers: A randomised controlled trial (ASUM grant via MNHHS)
    Metro North Hospital and Health Service
    Open grant
  • 2022 - 2024
    Prediction of catheter associated bloodstream infection and hospital-onset sepsis events in critically ill adults
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2021 - 2022
    Improving Diagnosis, Management and Prevention of Invasive Meningococcal Disease
    Metro North Hospital and Health Service
    Open grant
  • 2021 - 2022
    Peripherally inserted central catheter Innovation to reduce Infections and Clots: the PICNIC trial
    NHMRC Project Grant
    Open grant
  • 2020 - 2021
    Assessing the epidemiology and variation of the variable virulence factor BimABM of Burkholderia pseudomallei in Queensland
    European Society of Clinical Microbiology and Infectious Diseases Study Group Research Grant
    Open grant
  • 2020 - 2021
    Assessing the effects of new and old antibiotics on gut microbiota of hospitalized patients
    Avant Mutual Group Limited
    Open grant
  • 2020
    Rapid detection of resistance genes from Gram-negative bacteria isolated from blood in ICU-admitted patients
    Pathology Queensland - Study, Education & Research Trust Fund
    Open grant
  • 2020 - 2021
    Assessing the effects of new and old antibiotics on the gut microbiome of hospitalized patients
    Metro North Hospital and Health Service
    Open grant
  • 2019 - 2022
    A Multicentre, Parallel Group Open-label Randomised Controlled Non-Inferiority Phase 3 Trial, of ceftolozane-tazobactam versus meropenem for definitive treatment [...] MERINO-3
    Merck Sharp & Dohme Australia
    Open grant
  • 2019 - 2021
    Virulence and detection of Escherichia coli that cause neonatal meningitis
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2021
    Rapid point-of-care tests for multidrug resistant bacteria tailored for QLD paediatrics
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2022
    A multifaceted approach to the treatment and prevention of antibiotic-resistant bacterial infections
    NHMRC Early Career Fellowships
    Open grant
  • 2019 - 2023
    Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2019 - 2021
    Peripherally inserted central catheter Innovation to reduCe Infections and Clots: the PICNIC trial (NHMRC Project Grant led by Griffith University)
    Griffith University
    Open grant
  • 2019 - 2020
    Rapid detection of resistance genes from gram-negative bacteria isolated from blood in ICU-admitted patients to enable timely and effective treatment
    Metro North Hospital and Health Service
    Open grant
  • 2018 - 2023
    Cluster randomised trial of a multimodal intervention to reduce antimicrobial use in residential aged care facilities
    NHMRC MRFF - Antimicrobial Resistance Targeted Call for Research
    Open grant
  • 2018 - 2019
    Evaluation of cefiderocol (S-649266) against Burkholderia pseudomallei isolates from Queensland, Australia
    Shionogi & Company, Limited
    Open grant
  • 2018
    Rapid characterisation of pathogens for personalised antimicrobial selection in critically ill patients
    Metro North Hospital and Health Service
    Open grant
  • 2017 - 2018
    Pilot Randomised Controlled Trial of Penicillin versus Flucloxacillin for Definitive Treatment of Invasive Penicillin susceptible Staphylococcus aureas
    Metro North Hospital and Health Service
    Open grant
  • 2015
    Pilot randomised controlled trial of meropenem versus piperacillin-tazobactam for the definitive treatment of bloodstream infections caused by AmpC beta-lactamase producing Enterobacter spp, ...
    Royal Brisbane and Women's Hospital
    Open grant

Availability

Dr Patrick Harris is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Burkholderia pseudomallei: towards rapid diagnosis and management

    Principal Advisor

    Other advisors: Mr Mark Chatfield

  • Doctor Philosophy

    Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis

    Principal Advisor

  • Doctor Philosophy

    Novel trial design in evaluation of antibiotics.

    Associate Advisor

    Other advisors: Mr Mark Chatfield

  • Doctor Philosophy

    Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections

    Associate Advisor

    Other advisors: Dr Brian Forde, Mr Mark Chatfield

  • Doctor Philosophy

    Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.

    Associate Advisor

    Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin

  • Doctor Philosophy

    Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics

    Associate Advisor

  • Doctor Philosophy

    Clinical and laboratory applications of new and emerging methods of diagnosis of infection

    Associate Advisor

Completed supervision

Enquiries

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