
Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
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Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
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Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2016
Journal Article
Prostate biopsy-related infection: a systematic review of risk factors, prevention strategies, and management approaches
Roberts, Matthew J., Bennett, Harrison Y., Harris, Patrick N., Holmes, Michael, Grummet, Jeremy, Naber, Kurt and Wagenlehner, Florian M. E. (2016). Prostate biopsy-related infection: a systematic review of risk factors, prevention strategies, and management approaches. Urology, 104, 11-21. doi: 10.1016/j.urology.2016.12.011
2016
Journal Article
Detection of carbapenemase activity in Enterobacteriaceae using LC-MS/MS in comparison with the neo-rapid CARB kit using direct visual assessment and colorimetry
Huber, Charlotte A., Sidjabat, Hanna E., Zowawi, Hosam M., Kvaskoff, David, Reed, Sarah, McNamara, John F., McCarthy, Kate L., Harris, Patrick, Toh, Benjamin, Wailan, Alexander M. and Paterson, David L. (2016). Detection of carbapenemase activity in Enterobacteriaceae using LC-MS/MS in comparison with the neo-rapid CARB kit using direct visual assessment and colorimetry. Journal of Microbiological Methods, 131, 68-72. doi: 10.1016/j.mimet.2016.10.005
2016
Journal Article
Central nervous system nocardiosis in Queensland: a report of 20 cases and review of the literature
Rafiei, Nastaran, Peri, Anna Maria, Righi, Elda, Harris, Patrick and Paterson, David L. (2016). Central nervous system nocardiosis in Queensland: a report of 20 cases and review of the literature. Medicine, 95 (46) e5255, e5255. doi: 10.1097/MD.0000000000005255
2016
Journal Article
An outbreak of scrub typhus in military personnel despite protocols for antibiotic prophylaxis: doxycycline resistance excluded by a quantitative PCR-based susceptibility assay
Harris, Patrick N. A., Oltvolgyi, Csongor, Islam, Aminul, Hussain-Yusuf, Hazizul, Loewenthal, Mark R., Vincent, Gemma, Stenos, John and Graves, Stephen (2016). An outbreak of scrub typhus in military personnel despite protocols for antibiotic prophylaxis: doxycycline resistance excluded by a quantitative PCR-based susceptibility assay. Microbes and Infection, 18 (6), 406-411. doi: 10.1016/j.micinf.2016.03.006
2016
Journal Article
Empiric piperacillin-tazobactam versus carbapenems in the treatment of bacteraemia due to extended-spectrum beta-lactamase-producing enterobacteriaceae
Ng, Tat Ming, Khong, Wendy X., Harris, Patrick N. A., De, Partha P., Chow, Angela, Tambyah, Paul A. and Lye, David C. (2016). Empiric piperacillin-tazobactam versus carbapenems in the treatment of bacteraemia due to extended-spectrum beta-lactamase-producing enterobacteriaceae. Plos One, 11 (4) e0153696, e0153696. doi: 10.1371/journal.pone.0153696
2016
Journal Article
Colistin resistance: a major breach in our last line of defence
Paterson, David L. and Harris, Patrick N. A. (2016). Colistin resistance: a major breach in our last line of defence. The Lancet Infectious Diseases, 16 (2), 132-133. doi: 10.1016/S1473-3099(15)00463-6
2016
Journal Article
Carbapenems versus alternative antibiotics for the treatment of bloodstream infections caused by Enterobacter, Citrobacter or Serratia species: a systematic review with meta-analysis
Harris, Patrick N. A., Wei, Jane Y., Shen, Andrew W., Abdile, Ahmed A., Paynter, Stuart, Huxley, Rachel R., Pandeya, Nirmala, Doi, Yohei, Huh, Kyungmin, O'Neal, Catherine S., Talbot, Thomas R. and Paterson, David L. (2016). Carbapenems versus alternative antibiotics for the treatment of bloodstream infections caused by Enterobacter, Citrobacter or Serratia species: a systematic review with meta-analysis. Journal of Antimicrobial Chemotherapy, 71 (2) dkv346, 296-306. doi: 10.1093/jac/dkv346
2016
Conference Publication
Multi-drug Resistant Enterobacteriaceae from Bhutan: Whole Genome Sequencing of ESBL and Carbapenemase-producing Strains
Harris, Patrick N. A., Wailan, Alexander, Buckley, Cameron, Catchpoole, Elizabeth, Zowawi, Hosam M., Whiley, David, Tshokey, Tshokey, Sharma, Ragunath, Chong, Smathi and Paterson, David L. (2016). Multi-drug Resistant Enterobacteriaceae from Bhutan: Whole Genome Sequencing of ESBL and Carbapenemase-producing Strains. International Congress for Tropical Medicine and Malaria (ICTMM 2016), Brisbane Australia, 18-22 September 2016.
2016
Conference Publication
Mapping the global prevalence of resistance to antimicrobials in gram-negative urinary pathogens: a meta-analysis of contemporary studies
Harris, Patrick N. A., Zowawi, Hosam M., Banu, Shahera and Paterson, David L. (2016). Mapping the global prevalence of resistance to antimicrobials in gram-negative urinary pathogens: a meta-analysis of contemporary studies. The 55th Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) / International Society of Chemotherapy (ISC)’s International Congress of Chemotherapy and Infection (ICC) - ICAAC/ICC, San Diego, CA, United States, 18-22 September 2016.
2015
Journal Article
The emerging threat of multidrug-resistant Gram-negative bacteria in urology
Zowawi, Hosam M., Harris, Patrick N. A., Roberts, Matthew J., Tambyah, Paul A., Schembri, Mark A., Pezzani, M. Diletta, Williamson, Deborah A. and Paterson, David L. (2015). The emerging threat of multidrug-resistant Gram-negative bacteria in urology. Nature Reviews Urology, 12 (10), 570-584. doi: 10.1038/nrurol.2015.199
2015
Journal Article
Community-acquired pyelonephritis in pregnancy caused by KPC-producing Klebsiella pneumoniae
Khatri, Asma, Murphy, Nina Naeger, Wiest, Peter, Osborn, Melissa, Garber, Kathleen, Hecker, Michelle, Hurless, Kelly, Rudin, Susan D., Jacobs, Michael R., Kalayjian, Robert C., Salata, Robert A., Van Duin, David, Perez, Federico, Bonomob, Robert A., Paterson, David L. and Harris, Patrick N. A. (2015). Community-acquired pyelonephritis in pregnancy caused by KPC-producing Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 59 (8), 4375-4378. doi: 10.1128/AAC.00553-15
2015
Journal Article
Editorial commentary: the new acinetobacter equation: hypervirulence plus antibiotic resistance equals big trouble
Paterson, David L. and Harris, Patrick N. A. (2015). Editorial commentary: the new acinetobacter equation: hypervirulence plus antibiotic resistance equals big trouble. Clinical Infectious Diseases, 61 (2), 155-156. doi: 10.1093/cid/civ227
2015
Journal Article
Antimicrobial susceptibility reporting and treatment selection for AmpC-producing Enterobacteriaceae: what do microbiologists and infectious disease practitioners actually practice?
Harris, P. N. A., Alder, L. and Paterson, D. L. (2015). Antimicrobial susceptibility reporting and treatment selection for AmpC-producing Enterobacteriaceae: what do microbiologists and infectious disease practitioners actually practice?. Pathology, 47 (4), 386-388. doi: 10.1097/PAT.0000000000000255
2015
Journal Article
Comparable outcomes for β-lactam/β-lactamase inhibitor combinations and carbapenems in definitive treatment of bloodstream infections caused by cefotaxime-resistant Escherichia coli or Klebsiella pneumoniae
Harris, Patrick N. A., Yin, Mo, Jureen, Roland, Chew, Jonathan, Ali, Jaminah, Paynter, Stuart, Paterson, David L. and Tambyah, Paul A. (2015). Comparable outcomes for β-lactam/β-lactamase inhibitor combinations and carbapenems in definitive treatment of bloodstream infections caused by cefotaxime-resistant Escherichia coli or Klebsiella pneumoniae. Antimicrobial Resistance and Infection Control, 4 (1) 14, 14.1-14.10. doi: 10.1186/s13756-015-0055-6
2015
Journal Article
Facing the challenge of multidrug-resistant gram-negative bacilli in Australia
Harris, Patrick, Paterson, David and Rogers, Benjamin (2015). Facing the challenge of multidrug-resistant gram-negative bacilli in Australia. Medical Journal of Australia, 202 (5), 243-246. doi: 10.5694/mja14.01257
2015
Journal Article
Antiseptic body washes for reducing the transmission of methicillin-resistant Staphylococcus aureus: A cluster crossover study
Harris, Patrick N. A., Le, Bich Diep, Tambyah, Paul, Hsu, Li Yang, Pada, Surinder, Archuleta, Sophia, Salmon, Sharon, Mukhopadhyay, Amartya, Dillon, Jasmine, Ware, Robert and Fisher, Dale A. (2015). Antiseptic body washes for reducing the transmission of methicillin-resistant Staphylococcus aureus: A cluster crossover study. Open Forum Infectious Diseases, 2 (2) ofv051, ofv051. doi: 10.1093/ofid/ofv051
2015
Journal Article
Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial
Harris, Patrick N. A., Peleg, Anton Y., Iredell, Jon, Ingram, Paul R., Miyakis, Spiros, Stewardson, Andrew J., Rogers, Benjamin A., McBryde, Emma S., Roberts, Jason A., Lipman, Jeff, Athan, Eugene, Paul, Sanjoy K., Baker, Peter, Harris-Brown, Tiffany and Paterson, David L. (2015). Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial. Trials, 16 (1) 24, 24.1-24.8. doi: 10.1186/s13063-014-0541-9
2015
Journal Article
Clinical management of infections caused by enterobacteriaceae that express extended-spectrum β-Lactamase and AmpC enzymes
Harris, Patrick N. A. (2015). Clinical management of infections caused by enterobacteriaceae that express extended-spectrum β-Lactamase and AmpC enzymes. Seminars in Respiratory and Critical Care Medicine, 36 (1), 56-73. doi: 10.1055/s-0034-1398387
2015
Journal Article
β-lactam and β-lactamase inhibitor combinations in the treatment of extended-spectrum β-lactamase producing Enterobacteriaceae: Time for a reappraisal in the era of few antibiotic options?
Harris, Patrick N. A., Tambyah, Paul A. and Paterson, David L. (2015). β-lactam and β-lactamase inhibitor combinations in the treatment of extended-spectrum β-lactamase producing Enterobacteriaceae: Time for a reappraisal in the era of few antibiotic options?. The Lancet Infectious Diseases, 15 (4), 475-485. doi: 10.1016/S1473-3099(14)70950-8
2014
Journal Article
Atypical hand, foot, and mouth disease: eczema coxsackium can also occur in adults
Harris, Patrick N. A., Wang, Alvin D., Yin, Mo, Lee, Chun Kiat and Archuleta, Sophia (2014). Atypical hand, foot, and mouth disease: eczema coxsackium can also occur in adults. Lancet Infectious Diseases, 14 (11), 1043-1043. doi: 10.1016/S1473-3099(14)70976-4
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
New diagnostic strategies for antibiotic-resistant infections
Principal Advisor
Other advisors: Associate Professor Adam Irwin
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Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis
Principal Advisor
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Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
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Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Associate Advisor
Other advisors: Dr Brian Forde
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Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
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Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
Completed supervision
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2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
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2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
Enquiries
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