
Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
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Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
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Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2018
Journal Article
Melioidosis, Singapore, 2003–2014
Pang, Long, Harris, Patrick N. A., Seiler, Rachel L., Ooi, Peng Lim, Cutter, Jeffrey, Goh, Kee Tai, Cook, Alex R., Fisher, Dale and Chai, Louis Yi Ann (2018). Melioidosis, Singapore, 2003–2014. Emerging Infectious Diseases, 24 (1), 140-143. doi: 10.3201/eid2401.161449
2018
Book Chapter
Prostate biopsy related infection – risk factors, prevention strategies and management approaches
Bennett, Harrison Y., Harris, Patrick N., Holmes, Michael, Grummet, Jeremy and Roberts, Matthew (2018). Prostate biopsy related infection – risk factors, prevention strategies and management approaches. Urogenital infections and inflammations. (pp. 1-30) edited by T.E. Bjerklund Johansen, F. M.E. Wagenlehner, Y.-H. Cho, T. Matsumoto, J. N. Krieger, D. Shoskes and K. Naber. Berlin, Germany: GMS Publishing House. doi: 10.5680/lhuii000040
2017
Journal Article
Comparison of fosfomycin against fluoroquinolones for transrectal prostate biopsy prophylaxis: an individual patient-data meta-analysis
Roberts, Matthew J, Scott, Susan, Harris, Patrick N, Naber, Kurt, Wagenlehner, Florian M E and Doi, Suhail A R (2017). Comparison of fosfomycin against fluoroquinolones for transrectal prostate biopsy prophylaxis: an individual patient-data meta-analysis. World journal of urology, 36 (3), 323-330. doi: 10.1007/s00345-017-2163-9
2017
Journal Article
Whole genome analysis of cephalosporin-resistant Escherichia coli from bloodstream infections in Australia, New Zealand and Singapore: high prevalence of CMY-2 producers and ST131 carrying blaCTX-M-15 and blaCTX-M-27
Harris, Patrick N. A., Ben Zakour, Nouri L., Roberts, Leah W., Wailan, Alexander M., Zowawi, Hosam M., Tambyah, Paul A., Lye, David C., Jureen, Roland, Lee, Tau H., Yin, Mo, Izharuddin, Ezlyn, Looke, David, Runnegar, Naomi, Rogers, Benjamin, Bhally, Hasan, Crowe, Amy, Schembri, Mark A., Beatson, Scott A. and Paterson, David L. (2017). Whole genome analysis of cephalosporin-resistant Escherichia coli from bloodstream infections in Australia, New Zealand and Singapore: high prevalence of CMY-2 producers and ST131 carrying blaCTX-M-15 and blaCTX-M-27. The Journal of Antimicrobial Chemotherapy, 73 (3), 634-642. doi: 10.1093/jac/dkx466
2017
Journal Article
Geographical variation in therapy for bloodstream infections due to multidrug-resistant Enterobacteriaceae: a post-hoc analysis of the INCREMENT study
Harris, Patrick N. A., Pezzani, M. Diletta, Gutierrez-Gutierrez, Belen, Viale, Pierluigi, Hsueh, Po-Ren, Ruiz-Garbajosa, Patricia, Venditti, Mario, Tumbarello, Mario, Navarro-Francisco, Carolina, Calbo, Esther, Akova, Murat, Giamarellou, Helen, Oliver, Antonio, Almirante, Benito, Gasch, Oriol, Martinez-Martinez, Luis, Schwaber, Mitchell J., Daikos, George, Pitout, Johann, Pena, Carmen, Hernandez-Torres, Alicia, Doi, Yohei, Perez, Federico, Tuon, Felipe Francisco, Tacconelli, Evelina, Carmeli, Yehuda, Bonomo, Robert A., Pascual, Alvaro, Paterson, David L. and Rodriguez-Bano, Jesus (2017). Geographical variation in therapy for bloodstream infections due to multidrug-resistant Enterobacteriaceae: a post-hoc analysis of the INCREMENT study. International Journal of Antimicrobial Agents, 50 (5), 664-672. doi: 10.1016/j.ijantimicag.2017.08.005
2017
Journal Article
Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: a consensus definition
Harris, P.N.A., McNamara, J.F., Lye, D.C., Davis, J.S., Bernard, L., Cheng, A.C., Doi, Y., Fowler, V.G., Kaye, K.S., Leibovici, L., Lipman, J., Llewelyn, M.J., Munoz-Price, S., Paul, M., Peleg, A.Y., Rodriguez-Bano, J., Rogers, B.A., Seifert, H., Thamlikitkul, V., Thwaites, G., Tong, S.Y.C., Turnidge, J., Utili, R., Webb, S.A.R. and Paterson, D.L. (2017). Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: a consensus definition. Clinical Microbiology and Infection, 23 (8), 533-541. doi: 10.1016/j.cmi.2016.10.023
2017
Journal Article
Chlorhexidine gluconate or polyhexamethylene biguanide disc dressing to reduce the incidence of central-line-associated bloodstream infection: a feasibility randomized controlled trial (the CLABSI trial)
Webster, J., Larsen, E., Marsh, N., Choudhury, A., Harris, P. and Rickard, C. M. (2017). Chlorhexidine gluconate or polyhexamethylene biguanide disc dressing to reduce the incidence of central-line-associated bloodstream infection: a feasibility randomized controlled trial (the CLABSI trial). Journal of Hospital Infection, 96 (3), 223-228. doi: 10.1016/j.jhin.2017.04.009
2017
Conference Publication
FOSFOMYCIN PROPHYLAXIS FOR TRANSRECTAL PROSTATE BIOPSY REDUCES INFECTIOUS COMPLICATIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Roberts, Matthew, Scott, Susan, Harris, Patrick, Naber, Kurt, Wagenlehner, Florian and Doi, Suhail (2017). FOSFOMYCIN PROPHYLAXIS FOR TRANSRECTAL PROSTATE BIOPSY REDUCES INFECTIOUS COMPLICATIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS. HOBOKEN: WILEY.
2017
Journal Article
Global prevalence of carbapenem resistance in neutropenic patients and association with mortality and carbapenem use: systematic review and meta-analysis
Righi, Elda, Peri, Anna Maria, Harris, Patrick N. A., Wailan, Alexander M., Liborio, Mariana, Lane, Steven W. and Paterson, David L. (2017). Global prevalence of carbapenem resistance in neutropenic patients and association with mortality and carbapenem use: systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy, 72 (3), 668-677. doi: 10.1093/jac/dkw459
2017
Journal Article
Risk factors for relapse or persistence of bacteraemia caused by Enterobacter spp.: a case-control study
Harris, Patrick N. A., Peri, Anna M., Pelecanos, Anita M., Hughes, Carly M., Paterson, David L. and Ferguson, John K. (2017). Risk factors for relapse or persistence of bacteraemia caused by Enterobacter spp.: a case-control study. Antimicrobial Resistance and Infection Control, 6 (1) 14, 14. doi: 10.1186/s13756-017-0177-0
2017
Other Outputs
Clinical meta-data from patients with bloodstream infections caused by 3GC-resistant E. coli
Harris, Patrick N.A. (2017). Clinical meta-data from patients with bloodstream infections caused by 3GC-resistant E. coli. Harvard Dataverse. (Dataset)
2017
Conference Publication
Ability of blaNDM to disseminate worldwide into extensively drug-resistant bacterial hosts poses a major challenge to infection control and treatment: a global multi-centred whole-genome sequencing analysis
Ng, Oon Tek , Lee, Jia Jun , Harris, Patrick , Sidjabat, Hanna Evelina , Zowawi, Hosam , Shan Rajahram, Giri , Abdul Hameed, Ahneez Bt , Menon, Jayaram , Fong, Fennie Kah Ling , Hopkins, Katie , Wareham, David , Ho, Pak-Leung , Lo, Stephanie , Lau, Andes , Isozumi, Rie , Patel, Robin , Cunningham, Scott A. , Vasoo, Shawn , Kojic, Milan and Khong, Wei Xin (2017). Ability of blaNDM to disseminate worldwide into extensively drug-resistant bacterial hosts poses a major challenge to infection control and treatment: a global multi-centred whole-genome sequencing analysis. The 27th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID), Vienna Austria, 22-25 April 2017.
2017
Other Outputs
Risk factors for relapse or persistence of bacteraemia caused by Enterobacter spp.: a case-control study
Harris, Patrick N.A. (2017). Risk factors for relapse or persistence of bacteraemia caused by Enterobacter spp.: a case-control study. Harvard Dataverse. (Dataset)
2017
Book Chapter
Meropenem / Meropenem-vaborbactam
Peleg, A. Y. and Harris, P. (2017). Meropenem / Meropenem-vaborbactam. Kucers' the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs. (pp. 697-722) edited by Lindsay Grayson. Boca Raton, FL United States: Taylor & Francis. doi: 10.1201/9781315152110
2016
Journal Article
Prostate biopsy-related infection: a systematic review of risk factors, prevention strategies, and management approaches
Roberts, Matthew J., Bennett, Harrison Y., Harris, Patrick N., Holmes, Michael, Grummet, Jeremy, Naber, Kurt and Wagenlehner, Florian M. E. (2016). Prostate biopsy-related infection: a systematic review of risk factors, prevention strategies, and management approaches. Urology, 104, 11-21. doi: 10.1016/j.urology.2016.12.011
2016
Journal Article
Detection of carbapenemase activity in Enterobacteriaceae using LC-MS/MS in comparison with the neo-rapid CARB kit using direct visual assessment and colorimetry
Huber, Charlotte A., Sidjabat, Hanna E., Zowawi, Hosam M., Kvaskoff, David, Reed, Sarah, McNamara, John F., McCarthy, Kate L., Harris, Patrick, Toh, Benjamin, Wailan, Alexander M. and Paterson, David L. (2016). Detection of carbapenemase activity in Enterobacteriaceae using LC-MS/MS in comparison with the neo-rapid CARB kit using direct visual assessment and colorimetry. Journal of Microbiological Methods, 131, 68-72. doi: 10.1016/j.mimet.2016.10.005
2016
Journal Article
Central nervous system nocardiosis in Queensland: a report of 20 cases and review of the literature
Rafiei, Nastaran, Peri, Anna Maria, Righi, Elda, Harris, Patrick and Paterson, David L. (2016). Central nervous system nocardiosis in Queensland: a report of 20 cases and review of the literature. Medicine, 95 (46) e5255, e5255. doi: 10.1097/MD.0000000000005255
2016
Journal Article
An outbreak of scrub typhus in military personnel despite protocols for antibiotic prophylaxis: doxycycline resistance excluded by a quantitative PCR-based susceptibility assay
Harris, Patrick N. A., Oltvolgyi, Csongor, Islam, Aminul, Hussain-Yusuf, Hazizul, Loewenthal, Mark R., Vincent, Gemma, Stenos, John and Graves, Stephen (2016). An outbreak of scrub typhus in military personnel despite protocols for antibiotic prophylaxis: doxycycline resistance excluded by a quantitative PCR-based susceptibility assay. Microbes and Infection, 18 (6), 406-411. doi: 10.1016/j.micinf.2016.03.006
2016
Journal Article
Empiric piperacillin-tazobactam versus carbapenems in the treatment of bacteraemia due to extended-spectrum beta-lactamase-producing enterobacteriaceae
Ng, Tat Ming, Khong, Wendy X., Harris, Patrick N. A., De, Partha P., Chow, Angela, Tambyah, Paul A. and Lye, David C. (2016). Empiric piperacillin-tazobactam versus carbapenems in the treatment of bacteraemia due to extended-spectrum beta-lactamase-producing enterobacteriaceae. Plos One, 11 (4) e0153696, e0153696. doi: 10.1371/journal.pone.0153696
2016
Journal Article
Colistin resistance: a major breach in our last line of defence
Paterson, David L. and Harris, Patrick N. A. (2016). Colistin resistance: a major breach in our last line of defence. The Lancet Infectious Diseases, 16 (2), 132-133. doi: 10.1016/S1473-3099(15)00463-6
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
New diagnostic strategies for antibiotic-resistant infections
Principal Advisor
Other advisors: Associate Professor Adam Irwin
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Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
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Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Associate Advisor
Other advisors: Dr Brian Forde
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Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
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Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
Completed supervision
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2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
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2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
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