Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
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Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
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Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2021
Journal Article
Discrepancy between VITEK2 and Etest aminoglycoside susceptibility testing for multidrug-resistant Acinetobacter baumannii
Vardanega, John, Maggacis, Raquel, Runnegar, Naomi, Harris, Patrick N.A. and Sehu, Marjoree M. (2021). Discrepancy between VITEK2 and Etest aminoglycoside susceptibility testing for multidrug-resistant Acinetobacter baumannii. Pathology, 53 (6), 1-3. doi: 10.1016/j.pathol.2020.10.021
2021
Journal Article
PRO: Carbapenems should be used for ALL infections caused by ceftriaxone-resistant Enterobacterales
Paterson, David L., Isler, Burcu and Harris, Patrick N. A. (2021). PRO: Carbapenems should be used for ALL infections caused by ceftriaxone-resistant Enterobacterales. JAC-Antimicrobial Resistance, 3 (1). doi: 10.1093/jacamr/dlab013
2021
Journal Article
Escherichia coli sequence type 457 is an emerging extended-spectrum-β-lactam-resistant lineage with reservoirs in wildlife and food-producing animals
Nesporova, Kristina, Wyrsch, Ethan R., Valcek, Adam, Bitar, Ibrahim, Chaw, Khin, Harris, Patrick, Hrabak, Jaroslav, Literak, Ivan, Djordjevic, Steven P. and Dolejska, Monika (2021). Escherichia coli sequence type 457 is an emerging extended-spectrum-β-lactam-resistant lineage with reservoirs in wildlife and food-producing animals. Antimicrobial Agents and Chemotherapy, 65 (1) e01118-20, 1-18. doi: 10.1128/AAC.01118-20
2021
Journal Article
Clinical management of severe infections caused by carbapenem-resistant gram-negative bacteria: a worldwide cross-sectional survey addressing the use of antibiotic combinations
Carrara, Elena, Savoldi, Alessia, Piddock, Laura J. V., Franceschi, Francois, Ellis, Sally, Sharland, Mike, Brink, Adrian John, Harris, Patrick N. A., Levy-Hara, Gabriel, Rohit, Anusha, Tsioutis, Constantinos, Zayyad, Hiba, Giske, Christian, Chiamenti, Margherita, Bragantini, Damiano, Righi, Elda, Gorska, Anna and Tacconelli, Evelina (2021). Clinical management of severe infections caused by carbapenem-resistant gram-negative bacteria: a worldwide cross-sectional survey addressing the use of antibiotic combinations. Clinical Microbiology and Infection, 28 (1), 66-72. doi: 10.1016/j.cmi.2021.05.002
2021
Journal Article
Cost-effectiveness analysis of whole-genome sequencing during an outbreak of carbapenem-resistant Acinetobacter baumannii
Elliott, Thomas M., Harris, Patrick N., Roberts, Leah W., Doidge, Michelle, Hurst, Trish, Hajkowicz, Krispin, Forde, Brian, Paterson, David L. and Gordon, Louisa G. (2021). Cost-effectiveness analysis of whole-genome sequencing during an outbreak of carbapenem-resistant Acinetobacter baumannii. Antimicrobial Stewardship and Healthcare Epidemiology, 1 (1) e62, e62. doi: 10.1017/ash.2021.233
2021
Journal Article
Detecting antimicrobial resistance in Escherichia coli using benchtop attenuated total reflectance-Fourier transform infrared spectroscopy and machine learning
Wijesinghe, Hewa G. S., Hare, Dominic J., Mohamed, Ahmed, Shah, Alok K., Harris, Patrick N. A. and Hill, Michelle M. (2021). Detecting antimicrobial resistance in Escherichia coli using benchtop attenuated total reflectance-Fourier transform infrared spectroscopy and machine learning. The Analyst, 146 (20), 6211-6219. doi: 10.1039/d1an00546d
2021
Journal Article
Strengths and caveats of identifying resistance genes from whole genome sequencing data
Forde, Brian M., De Oliveira, David M. P., Falconer, Caitlin, Graves, Bianca and Harris, Patrick N. A. (2021). Strengths and caveats of identifying resistance genes from whole genome sequencing data. Expert Review of Anti-Infective Therapy, 20 (4), 1-15. doi: 10.1080/14787210.2022.2013806
2020
Journal Article
An update on cefepime and its future role in combination with novel β-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa
Isler, Burcu, Harris, Patrick, Stewart, Adam G. and Paterson, David L. (2020). An update on cefepime and its future role in combination with novel β-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa. The Journal of Antimicrobial Chemotherapy, 76 (3), 550-560. doi: 10.1093/jac/dkaa511
2020
Journal Article
Budget impact analysis of routinely using whole-genomic sequencing of six multidrug-resistant bacterial pathogens in Queensland, Australia
Gordon, Louisa G., Elliott, Thomas M., Forde, Brian, Mitchell, Brett, Russo, Philip L., Paterson, David L. and Harris, Patrick N. A. (2020). Budget impact analysis of routinely using whole-genomic sequencing of six multidrug-resistant bacterial pathogens in Queensland, Australia. BMJ Open, 11 (2) e041968, e041968. doi: 10.1136/bmjopen-2020-041968
2020
Journal Article
Achromobacter infections and treatment options
Isler, Burcu, Kidd, Timothy J., Stewart, Adam G., Harris, Patrick and Paterson, David L. (2020). Achromobacter infections and treatment options. Antimicrobial Agents and Chemotherapy, 64 (11) e01025, 1-16. doi: 10.1128/aac.01025-20
2020
Journal Article
Association between minimum inhibitory concentration, beta-lactamase genes and mortality for patients treated with piperacillin/tazobactam or meropenem from the MERINO study
Henderson, A., Paterson, D. L., Chatfield, M. D., Tambyah, P. A., Lye, D. C., De, P. P., Lin, R. T. P., Chew, K. L., Yin, M., Lee, T. H., Yilmaz, M., Cakmak, R., Alenazi, T. H., Arabi, Y. M., Falcone, M., Bassetti, M., Righi, E., Rogers, B.A., Kanj, S. S., Bhally, H., Iredell, J., Mendelson, M., Boyles, T. H., Looke, D. F. M., Runnegar, N. J., Miyakis, S., Walls, G., AI Khamis, M., Zikri, A. ... For the MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN) (2020). Association between minimum inhibitory concentration, beta-lactamase genes and mortality for patients treated with piperacillin/tazobactam or meropenem from the MERINO study. Clinical Infectious Diseases, 73 (11), e3842-e3850. doi: 10.1093/cid/ciaa1479
2020
Journal Article
SECUREment bundles to prevent peripheral intravenous catheter failure-the SECURE-PIVC trial: Study protocol for a pilot randomized controlled trial
Corley, Amanda, Ullman, Amanda J., Marsh, Nicole, Larsen, Emily N., Mihala, Gabor, Harris, Patrick N.A. and Rickard, Claire M. (2020). SECUREment bundles to prevent peripheral intravenous catheter failure-the SECURE-PIVC trial: Study protocol for a pilot randomized controlled trial. British Journal of Nursing, 29 (19), S40-S46. doi: 10.12968/bjon.2020.29.19.S40
2020
Journal Article
Is ceftazidime/avibactam an option for serious infections due to ESBL and AmpC producing Enterobacterales?: a systematic review and meta-analysis
Isler, Burcu, Ezure, Yukiko, García-Fogeda Romero, Jose Luis, Harris, Patrick, Stewart, Adam G. and Paterson, David L. (2020). Is ceftazidime/avibactam an option for serious infections due to ESBL and AmpC producing Enterobacterales?: a systematic review and meta-analysis. Antimicrobial Agents and Chemotherapy, 65 (1) e01052-20. doi: 10.1128/AAC.01052-20
2020
Journal Article
Reply to Rezahosseini and Nielsen
McNamara, John F., Harris, Patrick N. A., Chatfield, Mark D. and Paterson, David L. (2020). Reply to Rezahosseini and Nielsen. Clinical Infectious Diseases, 72 (11), e916-e916. doi: 10.1093/cid/ciaa1449
2020
Journal Article
Comparative genomics and antimicrobial resistance profiling of Elizabethkingia isolates reveals nosocomial transmission and in vitro susceptibility to fluoroquinolones, tetracyclines and trimethoprim-sulfamethoxazole
Burnard, Delaney, Gore, Letitia, Henderson, Andrew, Ranasinghe, Ama, Bergh, Haakon, Cottrell, Kyra, Sarovich, Derek S., Price, Erin P., Paterson, David L. and Harris, Patrick N. A. (2020). Comparative genomics and antimicrobial resistance profiling of Elizabethkingia isolates reveals nosocomial transmission and in vitro susceptibility to fluoroquinolones, tetracyclines and trimethoprim-sulfamethoxazole. Journal of Clinical Microbiology, 58 (9) e00730-20. doi: 10.1128/jcm.00730-20
2020
Journal Article
Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae
Sumi, Chandra Datta, Heffernan, Aaron J., Naicker, Saiyuri, Islam, Kamrul, Cottrell, Kyra, Wallis, Steven C., Lipman, Jeffrey, Harris, Patrick N. A., Sime, Fekade B. and Roberts, Jason A. (2020). Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy, 75 (9), 2633-2640. doi: 10.1093/jac/dkaa211
2020
Journal Article
Acute myocardial infarction and community-acquired Staphylococcus aureus bloodstream infection: an observational cohort study
McNamara, John F., Harris, Patrick N. A., Chatfield, Mark D. and Paterson, David L. (2020). Acute myocardial infarction and community-acquired Staphylococcus aureus bloodstream infection: an observational cohort study. Clinical Infectious Diseases, 73 (9), e2647-e2655. doi: 10.1093/cid/ciaa1197
2020
Other Outputs
Genomic surveillance, characterisation and intervention of a carbapenem-resistant Acinetobacter baumannii outbreak in critical care
Roberts, Leah W., Forde, Brian M., Hurst, Trish, Ling, Weiping, Nimmo, Graeme R., Bergh, Haakon, George, Narelle, Hajkowicz, Krispin, McNamara, John F, Lipman, Jeffrey, Permana, Budi, Schembri, Mark A., Paterson, David, Beatson, Scott A. and Harris, Patrick N. A. (2020). Genomic surveillance, characterisation and intervention of a carbapenem-resistant Acinetobacter baumannii outbreak in critical care. doi: 10.1101/2020.08.10.20166652
2020
Journal Article
Transrectal versus transperineal prostate biopsy under intravenous anaesthesia: a clinical, microbiological and cost analysis of 2048 cases over 11 years at a tertiary institution
Roberts, Matthew J., Macdonald, Alastair, Ranasinghe, Sachinka, Bennett, Harrison, Teloken, Patrick E., Harris, Patrick, Paterson, David, Coughlin, Geoff, Dunglison, Nigel, Esler, Rachel, Gardiner, Robert A., Elliott, Thomas, Gordon, Louisa and Yaxley, John (2020). Transrectal versus transperineal prostate biopsy under intravenous anaesthesia: a clinical, microbiological and cost analysis of 2048 cases over 11 years at a tertiary institution. Prostate Cancer and Prostatic Diseases, 24 (1), 169-176. doi: 10.1038/s41391-020-0263-x
2020
Journal Article
Contamination of SARS-CoV-2 RT-PCR probes at the oligonucleotide manufacturer
Wang, Claire Y.T., Buckley, Cameron, Bletchly, Cheryl, Harris, Patrick and Whiley, David (2020). Contamination of SARS-CoV-2 RT-PCR probes at the oligonucleotide manufacturer. Pathology, 52 (7), 814-816. doi: 10.1016/j.pathol.2020.08.002
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
New diagnostic strategies for antibiotic-resistant infections
Principal Advisor
Other advisors: Associate Professor Adam Irwin
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Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis
Principal Advisor
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Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
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Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Associate Advisor
Other advisors: Dr Brian Forde
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Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
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Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
Completed supervision
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2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
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2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
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