Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
-
Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
-
Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
-
Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2019
Journal Article
Benzylpenicillin versus flucloxacillin for penicillin susceptible Staphylococcus aureus bloodstream infections from a large retrospective cohort study
Henderson, A., Harris, P., Hartel, G., Paterson, D., Turnidge, J., Davis, J. S. and Tong, S. Y. C. (2019). Benzylpenicillin versus flucloxacillin for penicillin susceptible Staphylococcus aureus bloodstream infections from a large retrospective cohort study. International Journal of Antimicrobial Agents, 54 (4), 491-495. doi: 10.1016/j.ijantimicag.2019.05.020
2019
Journal Article
Quantitative real-time PCR assay for the rapid identification of the intrinsically multidrug-resistant bacterial pathogen Stenotrophomonas maltophilia
Fraser, Tamieka A., Bell, Mikaela G., Harris, Patrick N. A., Bell, Scott C., Bergh, Haakon, Thuy-Khanh Nguyen,, Kidd, Timothy J., Nimmo, Graeme R., Sarovich, Derek S. and Price, Erin P. (2019). Quantitative real-time PCR assay for the rapid identification of the intrinsically multidrug-resistant bacterial pathogen Stenotrophomonas maltophilia. Microbial Genomics, 5 (10) 000307. doi: 10.1099/mgen.0.000307
2019
Journal Article
Modifiable risk factors for multidrug-resistant Gram-negative infection in critically ill burn patients: a systematic review and meta-analysis
Vickers, Mark L., Malacova, Eva, Milinovich, Gabriel J., Harris, Patrick, Eriksson, Lars, Dulhunty, Joel M. and Cotta, Menino O. (2019). Modifiable risk factors for multidrug-resistant Gram-negative infection in critically ill burn patients: a systematic review and meta-analysis. ANZ Journal of Surgery, 89 (10) ans.15393, 1256-1260. doi: 10.1111/ans.15393
2019
Journal Article
Bacterial identification using an Absciex 5800 TOF/TOF MALDI research instrument and an external database
Huber, Charlotte A, Pflüger, Valentin, Reed, Sarah, Cottrell, Kyra, Sidjabat, Hanna E, Ranasinghe, Ama, Zowawi, Hosam, Harris, Patrick and Paterson, David L (2019). Bacterial identification using an Absciex 5800 TOF/TOF MALDI research instrument and an external database. Journal of Microbiological Methods, 164 105685, 105685. doi: 10.1016/j.mimet.2019.105685
2019
Other Outputs
Quantitative real-time PCR assay for the rapid identification of the multidrug-resistant bacterial pathogen Stenotrophomonas maltophilia
Fraser, Tamieka A., Bell, Mikaela G., Harris, Patrick N.A., Bell, Scott C., Bergh, Haakon, Nguyen, Thuy-Khanh, Kidd, Timothy J., Nimmo, Graeme R., Sarovich, Derek S. and Price, Erin P. (2019). Quantitative real-time PCR assay for the rapid identification of the multidrug-resistant bacterial pathogen Stenotrophomonas maltophilia. doi: 10.1101/702985
2019
Journal Article
Evaluation of the SpeeDx Carba (beta) multiplex real-time PCR assay for detection of NDM, KPC, OXA-48-like, IMP-4-like and VIM carbapenemase genes
Bordin, Amanda, Trembizki, Ella, Windsor, Madeline, Wee, Rachel, Tan, Lit Yeen, Buckley, Cameron, Syrmis, Melanie, Bergh, Haakon, Cottrell, Kyra, Zowawi, Hosam M., Sidjabat, Hanna E, Harris, Patrick N. A., Nimmo, Graeme R., Paterson, David L. and Whiley, David M. (2019). Evaluation of the SpeeDx Carba (beta) multiplex real-time PCR assay for detection of NDM, KPC, OXA-48-like, IMP-4-like and VIM carbapenemase genes. BMC Infectious Diseases, 19 (1) 571, 571. doi: 10.1186/s12879-019-4176-z
2019
Journal Article
Beta-lactam/beta-lactamase inhibitor therapy for potential AmpC-producing organisms: a systematic review and meta-analysis
Cheng, Matthew P., Lee, Robyn S., Cheng, Alexandre P., De L'étoile-Morel, Samuel, Demir, Koray, Yansouni, Cedric P., Harris, Patrick, Mcdonald, Emily G. and Lee, Todd C. (2019). Beta-lactam/beta-lactamase inhibitor therapy for potential AmpC-producing organisms: a systematic review and meta-analysis. Open Forum Infectious Diseases, 6 (7) ofz248. doi: 10.1093/ofid/ofz248
2019
Journal Article
By ZEUS!: can we use intravenous fosfomycin for complicated urinary tract infections?
Harris, Patrick N. A. (2019). By ZEUS!: can we use intravenous fosfomycin for complicated urinary tract infections?. Clinical Infectious Diseases, 69 (12), 2057-2058. doi: 10.1093/cid/ciz185
2019
Journal Article
Association between higher ambient temperature and orthopaedic infection rates: a systematic review and meta-analysis
Vickers, Mark L., Pelecanos, Anita, Tran, Marie, Eriksson, Lars, Assoum, Mohamad, Harris, Patrick N., Jaiprakash, Anjali, Parkinson, Benjamin, Dulhunty, Joel and Crawford, Ross W. (2019). Association between higher ambient temperature and orthopaedic infection rates: a systematic review and meta-analysis. ANZ Journal of Surgery, 89 (9) ans.15089, 1028-1034. doi: 10.1111/ans.15089
2019
Other Outputs
Genomic investigation reveals contaminated detergent as the source of an ESBL-producing Klebsiella michiganensis outbreak in a neonatal unit
Chapman, Paul, Forde, Brian M., Roberts, Leah W., Bergh, Haakon, Vesey, Debra, Jennison, Amy V., Moss, Susan, Paterson, David L., Beatson, Scott A. and Harris, Patrick N. A. (2019). Genomic investigation reveals contaminated detergent as the source of an ESBL-producing Klebsiella michiganensis outbreak in a neonatal unit. doi: 10.1101/568154
2019
Journal Article
Antibiotics for ceftriaxone resistant gram-negative bacterial bloodstream infections-reply
Harris, Patrick N. A., Tambyah, Paul and Paterson, David L. (2019). Antibiotics for ceftriaxone resistant gram-negative bacterial bloodstream infections-reply. The Journal of the American Medical Association, 321 (6), 613-614. doi: 10.1001/jama.2018.19353
2019
Conference Publication
SRA down under: cache and analysis platform for infectious disease
Cuddihy, Thom, Forde, Brian, Rhodes, Nicholas, Paterson, David, Gorse, Dominique, Beatson, Scott and Harris, Patrick (2019). SRA down under: cache and analysis platform for infectious disease. Australian national conference for Health Informatics (HIC 2019), Melbourne, Australia, 12-14 August 2019. Amsterdam, Netherlands: IOS Press. doi: 10.3233/SHTI190776
2019
Journal Article
Infections by multidrug-resistant gram-negative bacteria: what's new in our arsenal and what's in the pipeline?
Koulenti, Despoina, Song, Andrew, Ellingboe, Aaron, Abdul-Aziz, Mohd Hafiz, Harris, Patrick, Gavey, Emile and Lipman, Jeffrey (2019). Infections by multidrug-resistant gram-negative bacteria: what's new in our arsenal and what's in the pipeline?. International Journal of Antimicrobial Agents, 53 (3), 211-224. doi: 10.1016/j.ijantimicag.2018.10.011
2019
Journal Article
Re: Comparison of Fosfomycin against Fluoroquinolones for Transrectal Prostate Biopsy Prophylaxis: An Individual Patient-Data Meta-Analysis
Roberts, M. J., Scott, S., Harris, P. N., Naber, K., Wagenlehner, F. M.E. and Doi, S. A.R. (2019). Re: Comparison of Fosfomycin against Fluoroquinolones for Transrectal Prostate Biopsy Prophylaxis: An Individual Patient-Data Meta-Analysis. Journal of Urology, 201 (5), 839-840. doi: 10.1016/j.juro.2018.05.090
2019
Conference Publication
Molecular Characterization of Multidrug-Resistant Gram-negative Bacilli in Egypt: A Snapshot Study
Zowawi, H., Thomas, M., Abdelrahman, S., Shabban, M., Harris, P. and Paterson, D. (2019). Molecular Characterization of Multidrug-Resistant Gram-negative Bacilli in Egypt: A Snapshot Study. GCCMID 2018, Dubai, United Arab Emirates, 7-10 November 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jiph.2018.10.081
2019
Journal Article
Antimicrobial treatment challenges in the era of carbapenem resistance
Peri, Anna Maria, Doi, Yohei, Potoski, Brian A., Harris, Patrick N.A., Paterson, David L. and Righi, Elda (2019). Antimicrobial treatment challenges in the era of carbapenem resistance. Diagnostic Microbiology and Infectious Disease, 94 (4), 413-425. doi: 10.1016/j.diagmicrobio.2019.01.020
2018
Journal Article
Fosfomycin: what was old is new again
Avent, Minyon L., Rogers, Benjamin A., Cheng, Allen C., Athan, Eugene, Francis, Joshua R., Roberts, Matthew J., Paterson, David L. and Harris, Patrick N. A. (2018). Fosfomycin: what was old is new again. Internal Medicine Journal, 48 (12), 1425-1429. doi: 10.1111/imj.14122
2018
Other Outputs
Defining an evidence-based approach for the optimal management of gram-negative infections in the era of emerging antimicrobial resistance
Harris, Patrick Noel Angier (2018). Defining an evidence-based approach for the optimal management of gram-negative infections in the era of emerging antimicrobial resistance. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/dca09ed
2018
Journal Article
Health risks of flood disasters
Paterson, David L., Wright, Hugh and Harris, Patrick N.A. (2018). Health risks of flood disasters. Clinical Infectious Diseases, 67 (9), 1450-1454. doi: 10.1093/cid/ciy227
2018
Journal Article
Infectious complications following transrectal ultrasound-guided prostate biopsy: what additional diagnostic value do blood cultures provide?
Sukumaran, Vichitra, Roberts, Matthew J. and Harris, Patrick N. A. (2018). Infectious complications following transrectal ultrasound-guided prostate biopsy: what additional diagnostic value do blood cultures provide?. Infectious Diseases, 50 (11-12), 1-3. doi: 10.1080/23744235.2018.1508886
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
-
Doctor Philosophy
Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis
Principal Advisor
-
Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
-
Doctor Philosophy
New diagnostic strategies for antibiotic-resistant infections
Principal Advisor
Other advisors: Associate Professor Adam Irwin
-
Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
-
Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
-
Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Associate Advisor
Other advisors: Dr Brian Forde
-
Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
-
Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
-
Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
-
Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
-
Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
-
Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
-
Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
Completed supervision
-
2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
-
2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
-
2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
Enquiries
For media enquiries about Dr Patrick Harris's areas of expertise, story ideas and help finding experts, contact our Media team: