Dr Patrick Harris
Dr

Patrick Harris

Email: 
Phone: 
+61 7 334 65476

Background

Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).

Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria

Availability

Dr Patrick Harris is:
Available for supervision

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, University of London
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Clinical trials

    Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections

  • Antibiotic resistance

    Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter

  • Clinical application of genomics

    Use of whole genome sequencing in clinical microbiology

Research impacts

He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics

Search Professor Patrick Harris’s works on UQ eSpace

252 works between 2009 and 2025
All (252) Journal Article (224) Book Chapter (2) Conference Publication (23) Other Outputs (3)

181 - 200 of 252 works

2019

Journal Article

Evaluation of the SpeeDx Carba (beta) multiplex real-time PCR assay for detection of NDM, KPC, OXA-48-like, IMP-4-like and VIM carbapenemase genes

Bordin, Amanda, Trembizki, Ella, Windsor, Madeline, Wee, Rachel, Tan, Lit Yeen, Buckley, Cameron, Syrmis, Melanie, Bergh, Haakon, Cottrell, Kyra, Zowawi, Hosam M., Sidjabat, Hanna E, Harris, Patrick N. A., Nimmo, Graeme R., Paterson, David L. and Whiley, David M. (2019). Evaluation of the SpeeDx Carba (beta) multiplex real-time PCR assay for detection of NDM, KPC, OXA-48-like, IMP-4-like and VIM carbapenemase genes. BMC Infectious Diseases, 19 (1) 571, 571. doi: 10.1186/s12879-019-4176-z

Evaluation of the SpeeDx Carba (beta) multiplex real-time PCR assay for detection of NDM, KPC, OXA-48-like, IMP-4-like and VIM carbapenemase genes

2019

Journal Article

Beta-lactam/beta-lactamase inhibitor therapy for potential AmpC-producing organisms: a systematic review and meta-analysis

Cheng, Matthew P., Lee, Robyn S., Cheng, Alexandre P., De L'étoile-Morel, Samuel, Demir, Koray, Yansouni, Cedric P., Harris, Patrick, Mcdonald, Emily G. and Lee, Todd C. (2019). Beta-lactam/beta-lactamase inhibitor therapy for potential AmpC-producing organisms: a systematic review and meta-analysis. Open Forum Infectious Diseases, 6 (7) ofz248. doi: 10.1093/ofid/ofz248

Beta-lactam/beta-lactamase inhibitor therapy for potential AmpC-producing organisms: a systematic review and meta-analysis

2019

Journal Article

By ZEUS!: can we use intravenous fosfomycin for complicated urinary tract infections?

Harris, Patrick N. A. (2019). By ZEUS!: can we use intravenous fosfomycin for complicated urinary tract infections?. Clinical Infectious Diseases, 69 (12), 2057-2058. doi: 10.1093/cid/ciz185

By ZEUS!: can we use intravenous fosfomycin for complicated urinary tract infections?

2019

Journal Article

Association between higher ambient temperature and orthopaedic infection rates: a systematic review and meta-analysis

Vickers, Mark L., Pelecanos, Anita, Tran, Marie, Eriksson, Lars, Assoum, Mohamad, Harris, Patrick N., Jaiprakash, Anjali, Parkinson, Benjamin, Dulhunty, Joel and Crawford, Ross W. (2019). Association between higher ambient temperature and orthopaedic infection rates: a systematic review and meta-analysis. ANZ Journal of Surgery, 89 (9) ans.15089, 1028-1034. doi: 10.1111/ans.15089

Association between higher ambient temperature and orthopaedic infection rates: a systematic review and meta-analysis

2019

Journal Article

Antibiotics for ceftriaxone resistant gram-negative bacterial bloodstream infections-reply

Harris, Patrick N. A., Tambyah, Paul and Paterson, David L. (2019). Antibiotics for ceftriaxone resistant gram-negative bacterial bloodstream infections-reply. The Journal of the American Medical Association, 321 (6), 613-614. doi: 10.1001/jama.2018.19353

Antibiotics for ceftriaxone resistant gram-negative bacterial bloodstream infections-reply

2019

Conference Publication

SRA down under: cache and analysis platform for infectious disease

Cuddihy, Thom, Forde, Brian, Rhodes, Nicholas, Paterson, David, Gorse, Dominique, Beatson, Scott and Harris, Patrick (2019). SRA down under: cache and analysis platform for infectious disease. Australian national conference for Health Informatics (HIC 2019), Melbourne, Australia, 12-14 August 2019. Amsterdam, Netherlands: IOS Press. doi: 10.3233/SHTI190776

SRA down under: cache and analysis platform for infectious disease

2019

Journal Article

Infections by multidrug-resistant gram-negative bacteria: what's new in our arsenal and what's in the pipeline?

Koulenti, Despoina, Song, Andrew, Ellingboe, Aaron, Abdul-Aziz, Mohd Hafiz, Harris, Patrick, Gavey, Emile and Lipman, Jeffrey (2019). Infections by multidrug-resistant gram-negative bacteria: what's new in our arsenal and what's in the pipeline?. International Journal of Antimicrobial Agents, 53 (3), 211-224. doi: 10.1016/j.ijantimicag.2018.10.011

Infections by multidrug-resistant gram-negative bacteria: what's new in our arsenal and what's in the pipeline?

2019

Journal Article

Re: Comparison of Fosfomycin against Fluoroquinolones for Transrectal Prostate Biopsy Prophylaxis: An Individual Patient-Data Meta-Analysis

Roberts, M. J., Scott, S., Harris, P. N., Naber, K., Wagenlehner, F. M.E. and Doi, S. A.R. (2019). Re: Comparison of Fosfomycin against Fluoroquinolones for Transrectal Prostate Biopsy Prophylaxis: An Individual Patient-Data Meta-Analysis. Journal of Urology, 201 (5), 839-840. doi: 10.1016/j.juro.2018.05.090

Re: Comparison of Fosfomycin against Fluoroquinolones for Transrectal Prostate Biopsy Prophylaxis: An Individual Patient-Data Meta-Analysis

2019

Conference Publication

Molecular Characterization of Multidrug-Resistant Gram-negative Bacilli in Egypt: A Snapshot Study

Zowawi, H., Thomas, M., Abdelrahman, S., Shabban, M., Harris, P. and Paterson, D. (2019). Molecular Characterization of Multidrug-Resistant Gram-negative Bacilli in Egypt: A Snapshot Study. GCCMID 2018, Dubai, United Arab Emirates, 7-10 November 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jiph.2018.10.081

Molecular Characterization of Multidrug-Resistant Gram-negative Bacilli in Egypt: A Snapshot Study

2019

Journal Article

Antimicrobial treatment challenges in the era of carbapenem resistance

Peri, Anna Maria, Doi, Yohei, Potoski, Brian A., Harris, Patrick N.A., Paterson, David L. and Righi, Elda (2019). Antimicrobial treatment challenges in the era of carbapenem resistance. Diagnostic Microbiology and Infectious Disease, 94 (4), 413-425. doi: 10.1016/j.diagmicrobio.2019.01.020

Antimicrobial treatment challenges in the era of carbapenem resistance

2018

Journal Article

Fosfomycin: what was old is new again

Avent, Minyon L., Rogers, Benjamin A., Cheng, Allen C., Athan, Eugene, Francis, Joshua R., Roberts, Matthew J., Paterson, David L. and Harris, Patrick N. A. (2018). Fosfomycin: what was old is new again. Internal Medicine Journal, 48 (12), 1425-1429. doi: 10.1111/imj.14122

Fosfomycin: what was old is new again

2018

Other Outputs

Defining an evidence-based approach for the optimal management of gram-negative infections in the era of emerging antimicrobial resistance

Harris, Patrick Noel Angier (2018). Defining an evidence-based approach for the optimal management of gram-negative infections in the era of emerging antimicrobial resistance. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/dca09ed

Defining an evidence-based approach for the optimal management of gram-negative infections in the era of emerging antimicrobial resistance

2018

Journal Article

Health risks of flood disasters

Paterson, David L., Wright, Hugh and Harris, Patrick N.A. (2018). Health risks of flood disasters. Clinical Infectious Diseases, 67 (9), 1450-1454. doi: 10.1093/cid/ciy227

Health risks of flood disasters

2018

Journal Article

Infectious complications following transrectal ultrasound-guided prostate biopsy: what additional diagnostic value do blood cultures provide?

Sukumaran, Vichitra, Roberts, Matthew J. and Harris, Patrick N. A. (2018). Infectious complications following transrectal ultrasound-guided prostate biopsy: what additional diagnostic value do blood cultures provide?. Infectious Diseases, 50 (11-12), 1-3. doi: 10.1080/23744235.2018.1508886

Infectious complications following transrectal ultrasound-guided prostate biopsy: what additional diagnostic value do blood cultures provide?

2018

Journal Article

Discovery of mcr-1-mediated colistin resistance in a highly virulent Escherichia coli lineage

Forde, Brian M., Zowawi, Hosam M., Harris, Patrick N. A., Roberts, Leah, Ibrahim, Emad, Shaikh, Nissar, Deshmukh, Anand, Sid Ahmed, Mazen A., Al Maslamani, Muna, Cottrell, Kyra, Trembizki, Ella, Sundac, Lana, Yu, Heidi H., Li, Jian, Schembri, Mark A., Whiley, David M., Paterson, David L. and Beatson, Scott A. (2018). Discovery of mcr-1-mediated colistin resistance in a highly virulent Escherichia coli lineage. mSphere, 3 (5) e00486-18. doi: 10.1128/msphere.00486-18

Discovery of mcr-1-mediated colistin resistance in a highly virulent Escherichia coli lineage

2018

Journal Article

Effect of piperacillin-tazobactam vs meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance: a randomized clinical trial

Harris, Patrick N. A., Tambyah, Paul A., Lye, David C., Mo, Yin, Lee, Tau H., Yilmaz, Mesut, Alenazi, Thamer H., Arabi, Yaseen, Falcone, Marco, Bassetti, Matteo, Righi, Elda, Rogers, Benjamin A., Kanj, Souha, Bhally, Hasan, Iredell, Jon, Mendelson, Marc, Boyles, Tom H., Looke, David, Miyakis, Spiros, Walls, Genevieve, Al Khamis, Mohammed, Zikri, Ahmed, Crowe, Amy, Ingram, Paul, Daneman, Nick, Griffin, Paul, Athan, Eugene, Lorenc, Penelope, Baker, Peter ... MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN) (2018). Effect of piperacillin-tazobactam vs meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance: a randomized clinical trial. JAMA, 320 (10), 984-994. doi: 10.1001/jama.2018.12163

Effect of piperacillin-tazobactam vs meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance: a randomized clinical trial

2018

Journal Article

Treatment of infections with OXA-48 producing Enterobacteriaceae

Stewart, Adam, Harris, Patrick, Henderson, Andrew and Paterson, David (2018). Treatment of infections with OXA-48 producing Enterobacteriaceae. Antimicrobial Agents and Chemotherapy, 62 (11) e01195-18, AAC.01195-18. doi: 10.1128/aac.01195-18

Treatment of infections with OXA-48 producing Enterobacteriaceae

2018

Journal Article

Long-term morbidity and mortality following bloodstream infection: a systematic literature review

McNamara, John F., Righi, Elda, Wright, Hugh, Hartel, Gunter F., Harris, Patrick N. A. and Paterson, David L. (2018). Long-term morbidity and mortality following bloodstream infection: a systematic literature review. The Journal of Infection, 77 (1), 1-8. doi: 10.1016/j.jinf.2018.03.005

Long-term morbidity and mortality following bloodstream infection: a systematic literature review

2018

Journal Article

The effectiveness of targeted relative to empiric prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy: a meta-analysis

Scott, Susan, Harris, Patrick N., Williamson, Deborah A., Liss, Michael A., Doi, Suhail A. R. and Roberts, Matthew J. (2018). The effectiveness of targeted relative to empiric prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy: a meta-analysis. World Journal of Urology, 36 (7), 1007-1017. doi: 10.1007/s00345-018-2217-7

The effectiveness of targeted relative to empiric prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy: a meta-analysis

2018

Journal Article

Copper ions and coordination complexes as novel carbapenem adjuvants

Djoko, Karrera Y., Achard, Maud E. S., Phan, Minh-Duy, Lo, Alvin W., Miraula, Manfredi, Prombhul, Sasiprapa, Hancock, Steven J., Peters, Kate M., Sidjabat, Hanna E., Harris, Patrick N., Mitić, Nataša, Walsh, Timothy R., Anderson, Gregory J., Shafer, William M., Paterson, David L., Schenk, Gerhard, McEwan, Alastair G. and Schembri, Mark A. (2018). Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy, 62 (2) e02280-17. doi: 10.1128/AAC.02280-17

Copper ions and coordination complexes as novel carbapenem adjuvants

Current funding

  • 2025 - 2030
    Comparative effectiveness of Class II/III medical devices to prevent bloodstream infections in central venous catheters: The IVCare adaptive platform RCT
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2025 - 2029
    ROAD RCT: Resistance Optimised Antibiotic Dosing in critically ill patients - a Randomised Controlled Trial
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2025 - 2029
    New diagnostic strategies for antibiotic-resistant infections
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2025
    Testing EBL-1463 (a novel non-beta-lactam PBP inhibitor) against metallo-betalactamase producing Enterobacterales
    Mutabilis SAS
    Open grant
  • 2024 - 2026
    Reducing blood culture contamination with the use of a needle-less blood draw device (PIVO Pro): An adaptive group sequential randomized controlled trial (The PIVO Trial)
    Becton, Dickinson and Company
    Open grant
  • 2024 - 2028
    Unlocking the gut microbiome to track the spread of AMR genes and pathogens
    MRFF - Global Health Initiative
    Open grant
  • 2024 - 2025
    A Rapid, Routine Genomics Service for Clinical Haematology (QLD Health Targeted CRF led by RBWH Metro North Health)
    Metro North Hospital and Health Service
    Open grant
  • 2023 - 2026
    New diagnostic strategies for antibiotic-resistant infections
    Queensland Health Clinical Research Fellowships
    Open grant
  • 2023 - 2025
    Performance of emerging diagnostic techniques for the diagnosis of severe infections in neutropenic patients with haematological malignancies
    Microbio Ltd
    Open grant
  • 2023 - 2027
    Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis
    The Children's Hospital Foundation
    Open grant
  • 2018 - 2030
    Investigator Driven Randomized Controlled Trial of Cefiderocol versus Standard Therapy for Healthcare Associated and Hospital Acquired Gram-negative Blood Stream Infection (the GAME CHANGER trial)
    Shionogi & Company, Limited
    Open grant

Past funding

  • 2023 - 2025
    Development of Wastewater-based epidemiology as a complementary approach for antimicrobial resistance surveillance
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2023 - 2024
    Improving management of fungal infections during blood cancer treatment
    Gilead Australia Fellowship
    Open grant
  • 2022 - 2024
    The 3,000 Genomes project: using machine learning and artificial intelligence for robust culture-independent susceptibility testing
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2022 - 2023
    Non-inferiority of low-level (LLD) versus high-level disinfection (HLD) for elimination of bacteria on contaminated ultrasound transducers: A randomised controlled trial (ASUM grant via MNHHS)
    Metro North Hospital and Health Service
    Open grant
  • 2022 - 2024
    Prediction of catheter associated bloodstream infection and hospital-onset sepsis events in critically ill adults
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2021 - 2022
    Improving Diagnosis, Management and Prevention of Invasive Meningococcal Disease
    Metro North Hospital and Health Service
    Open grant
  • 2021 - 2022
    Peripherally inserted central catheter Innovation to reduce Infections and Clots: the PICNIC trial
    NHMRC Project Grant
    Open grant
  • 2020 - 2021
    Assessing the epidemiology and variation of the variable virulence factor BimABM of Burkholderia pseudomallei in Queensland
    European Society of Clinical Microbiology and Infectious Diseases Study Group Research Grant
    Open grant
  • 2020 - 2021
    Assessing the effects of new and old antibiotics on gut microbiota of hospitalized patients
    Avant Mutual Group Limited
    Open grant
  • 2020
    Rapid detection of resistance genes from Gram-negative bacteria isolated from blood in ICU-admitted patients
    Pathology Queensland - Study, Education & Research Trust Fund
    Open grant
  • 2020 - 2021
    Assessing the effects of new and old antibiotics on the gut microbiome of hospitalized patients
    Metro North Hospital and Health Service
    Open grant
  • 2019 - 2022
    A Multicentre, Parallel Group Open-label Randomised Controlled Non-Inferiority Phase 3 Trial, of ceftolozane-tazobactam versus meropenem for definitive treatment [...] MERINO-3
    Merck Sharp & Dohme Australia
    Open grant
  • 2019 - 2021
    Virulence and detection of Escherichia coli that cause neonatal meningitis
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2021
    Rapid point-of-care tests for multidrug resistant bacteria tailored for QLD paediatrics
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2022
    A multifaceted approach to the treatment and prevention of antibiotic-resistant bacterial infections
    NHMRC Early Career Fellowships
    Open grant
  • 2019 - 2023
    Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2019 - 2021
    Peripherally inserted central catheter Innovation to reduCe Infections and Clots: the PICNIC trial (NHMRC Project Grant led by Griffith University)
    Griffith University
    Open grant
  • 2019 - 2020
    Rapid detection of resistance genes from gram-negative bacteria isolated from blood in ICU-admitted patients to enable timely and effective treatment
    Metro North Hospital and Health Service
    Open grant
  • 2018 - 2023
    Cluster randomised trial of a multimodal intervention to reduce antimicrobial use in residential aged care facilities
    NHMRC MRFF - Antimicrobial Resistance Targeted Call for Research
    Open grant
  • 2018 - 2019
    Evaluation of cefiderocol (S-649266) against Burkholderia pseudomallei isolates from Queensland, Australia
    Shionogi & Company, Limited
    Open grant
  • 2018
    Rapid characterisation of pathogens for personalised antimicrobial selection in critically ill patients
    Metro North Hospital and Health Service
    Open grant
  • 2017 - 2018
    Pilot Randomised Controlled Trial of Penicillin versus Flucloxacillin for Definitive Treatment of Invasive Penicillin susceptible Staphylococcus aureas
    Metro North Hospital and Health Service
    Open grant
  • 2015
    Pilot randomised controlled trial of meropenem versus piperacillin-tazobactam for the definitive treatment of bloodstream infections caused by AmpC beta-lactamase producing Enterobacter spp, ...
    Royal Brisbane and Women's Hospital
    Open grant

Availability

Dr Patrick Harris is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    New diagnostic strategies for antibiotic-resistant infections

    Principal Advisor

    Other advisors: Associate Professor Adam Irwin

  • Doctor Philosophy

    Novel technologies for the diagnosis of bloodstream infection: performance and clinical application

    Principal Advisor

  • Doctor Philosophy

    Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.

    Associate Advisor

    Other advisors: Dr Brian Forde

  • Doctor Philosophy

    Novel trial design in evaluation of antibiotics.

    Associate Advisor

    Other advisors: Mr Mark Chatfield

  • Doctor Philosophy

    Clinical and laboratory applications of new and emerging methods of diagnosis of infection

    Associate Advisor

  • Doctor Philosophy

    Clinical epidemiology and treatment of central nervous system infections in Asia

    Associate Advisor

  • Doctor Philosophy

    Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics

    Associate Advisor

  • Doctor Philosophy

    Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales

    Associate Advisor

    Other advisors: Dr Brian Forde, Mr Mark Chatfield

  • Doctor Philosophy

    Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.

    Associate Advisor

    Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin

Completed supervision

Enquiries

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