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Dr Brian Forde
Dr

Brian Forde

Email: 
Phone: 
+61 7 344 36245

Overview

Background

Brian Forde is a fellow in microbial bioinformatics and Advance Queensland Industry Research Fellow at the University of Queensland (UQ) Centre for Clinical Research (CCR). Brian was awarded a PhD from University College Cork, Ireland, in 2013 and developed his interest in bacterial genomics as a postdoctoral fellow at the UQ School of Chemistry and Molecular Biosciences (SCMB). Currently, his work is primarily focused on clinical microbial genomics, including: the evolution of antibiotic resistance, genomic epidemiology, genomic surveillance of Infectious Diseases and translating genomic research into clinical practice. Since 2017 he has been part of a multidisciplinary team, including researchers, infectious diseases clinicians and infection control professionals, leading the introduction of WGS to investigate hospital-acquired infection in Queensland (https://www.queenslandgenomics.org). In 2020, Brian was awarded Advance Queensland Industry Research Fellowship to explore the application of Artificial Intelligence to genomic surveillance and transmission dynamics.

Availability

Dr Brian Forde is:
Available for supervision

Qualifications

  • Bachelor (Honours) of Science (Advanced), University College Cork
  • Doctor of Philosophy, National University of Ireland

Research impacts

Since 2010 Brian has co-authored 52 journal articles, with 13 as first, co-first or senior author. His has been cited 1430 times, resulting in a h-index of 19 and an i10-index of 25 (Google Scholar 28/10/2020). Brians work is regularly published in leading specialist microbiology or infectious disease journals including MBio, AAC and JAC and have also featured in high impact journals such as Nat Comm, Nat Micro, PNAS, CID and CMR. Recent work include a longitudinal study describing a unique comprehensive genomic analysis of a clonal lineage within a single individual over a 5-year period (Forde et al. Nat Comm, 2019). This work provided the framework for the utilization of genomics to help manage and treat patients suffering from debilitating chronic infections.

As part of Queensland Genomics Brian has led and assisted in projects that apply genomics to characterise and resolve infectious outbreaks in clinical settings (Chapman & Forde et al. JCM, 2020; Roberts et al. Nat Comm, 2020; Roberts et al. bioRxiv, 2018). In his current role as lead Bioinformatician for the Queensland Genomics (QG) infectious diseases (ID) project, Brian has developed pipelines for surveillance of priority bacterial pathogens. These tools, which included the development of an outbreak detection and visualisation tool, CATHAI (https:cathai.beatsonlab.com), are used by infection control professional in large Brisbane metropolitan hospitals.

Works

Search Professor Brian Forde’s works on UQ eSpace

100 works between 2010 and 2024

21 - 40 of 100 works

2023

Journal Article

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

2023

Journal Article

Treatment Failure Due to Adaptive Resistance Mechanisms in a Severe and Complicated Bloodstream Infection Due to

Stewart, Adam G., Roberts, Jason A., Forde, Brian M., Bergh, Haakon, Kidd, Timothy J., Wright, Hugh and Harris, Patrick N. A. (2023). Treatment Failure Due to Adaptive Resistance Mechanisms in a Severe and Complicated Bloodstream Infection Due to . Microbial Drug Resistance, 29 (4), 145-149. doi: 10.1089/mdr.2022.0179

Treatment Failure Due to Adaptive Resistance Mechanisms in a Severe and Complicated Bloodstream Infection Due to

2022

Journal Article

High prevalence of ArmA-16S rRNA methyltransferase among aminoglycoside-resistant Klebsiella pneumoniae bloodstream isolates

Isler, Burcu, Falconer, Caitlin, Vatansever, Cansel, Özer, Berna, Çınar, Güle, Aslan, Abdullah Tarık, Forde, Brian, Harris, Patrick, Şimşek, Funda, Tülek, Necla, Demirkaya, Hamiyet, Menekşe, Şirin, Akalin, Halis, Balkan, İlker İnanç, Aydın, Mehtap, Tigen, Elif Tükenmez, Demir, Safiye Koçulu, Kapmaz, Mahir, Keske, Şiran, Doğan, Özlem, Arabacı, Çiğdem, Yağcı, Serap, Hazırolan, Gülşen, Bakır, Veli Oğuzalp, Gönen, Mehmet, Saltoğlu, Neşe, Azap, Alpay, Azap, Özlem, Akova, Murat ... Paterson, David L. (2022). High prevalence of ArmA-16S rRNA methyltransferase among aminoglycoside-resistant Klebsiella pneumoniae bloodstream isolates. Journal of Medical Microbiology, 71 (12) 001629, 1-8. doi: 10.1099/jmm.0.001629

High prevalence of ArmA-16S rRNA methyltransferase among aminoglycoside-resistant Klebsiella pneumoniae bloodstream isolates

2022

Journal Article

Immunomodulation by foods and microbes: unravelling the molecular tango

Forde, Brian, Yao, Lu, Shaha, Rupin, Murphy, Sally, Lunjani, Nonhlanhla and O'Mahony, Liam (2022). Immunomodulation by foods and microbes: unravelling the molecular tango. Allergy: European Journal of Allergy and Clinical Immunology, 77 (12), 3513-3526. doi: 10.1111/all.15455

Immunomodulation by foods and microbes: unravelling the molecular tango

2022

Conference Publication

Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bloodstream infections in Central Australia

Langham, Freya, Tsai, Danny, Camilleri, Shayne, Forde, Brian, Harris, Patrick, Roberts, Jason A. and Chiong, Fabian (2022). Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bloodstream infections in Central Australia. 32nd International Congress of Antimicrobial Chemotherapy (ICC), Perth, WA Australia, 27-30 November 2022. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s2213-7165(22)00286-7

Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bloodstream infections in Central Australia

2022

Journal Article

Case report: a fatal case of Aspergillus felis infection in an immunocompetent host

Parkes-Smith, Jill, Bauer, Michelle J., Bergh, Haakon, Eidan, Anthony, Forde, Brian M., Hilton, John, Kidd, Timothy J., Schmidt, Campbell, Stewart, Adam G. and Harris, Patrick N. A. (2022). Case report: a fatal case of Aspergillus felis infection in an immunocompetent host. Access Microbiology, 4 (11) acmi000453, 1-4. doi: 10.1099/acmi.0.000453

Case report: a fatal case of Aspergillus felis infection in an immunocompetent host

2022

Journal Article

Optimized method for bacterial nucleic acid extraction from positive blood culture broth for whole-genome sequencing, resistance phenotype prediction, and downstream molecular applications

Bauer, Michelle J., Peri, Anna Maria, Lüftinger, Lukas, Beisken, Stephan, Bergh, Haakon, Forde, Brian M., Buckley, Cameron, Cuddihy, Thom, Tan, Patrice, Paterson, David L., Whiley, David M. and Harris, Patrick N. A. (2022). Optimized method for bacterial nucleic acid extraction from positive blood culture broth for whole-genome sequencing, resistance phenotype prediction, and downstream molecular applications. Journal of Clinical Microbiology, 60 (11) e01012-22, 1-11. doi: 10.1128/jcm.01012-22

Optimized method for bacterial nucleic acid extraction from positive blood culture broth for whole-genome sequencing, resistance phenotype prediction, and downstream molecular applications

2022

Conference Publication

Lonepinella - the devil in the oral cavity (of the koala)

Omaleki, Lida, Blyde, David, McKay, Philippa, Lobo, Edina T., Zhang, Ge, Harris, Louise M., Sinclair, Holly A., Bergh, Haakon, White, Rhys T., Forde, Brian M., Beatson, Scott A., Turni, Conny and Blackall, Patrick J. (2022). Lonepinella - the devil in the oral cavity (of the koala). One Health Downunder Symposium 2022, Brisbane, QLD Australia, 12-13 September 2022.

Lonepinella - the devil in the oral cavity (of the koala)

2022

Journal Article

Clinical implementation of routine whole-genome sequencing for hospital infection control of multi-drug resistant pathogens

Forde, Brian M., Bergh, Haakon, Cuddihy, Thom, Hajkowicz, Krispin, Hurst, Trish, Playford, E Geoffrey, Henderson, Belinda C., Runnegar, Naomi, Clark, Julia, Jennison, Amy V., Moss, Susan, Hume, Anna, Leroux, Hugo, Beatson, Scott A., Paterson, David L. and Harris, Patrick N. A. (2022). Clinical implementation of routine whole-genome sequencing for hospital infection control of multi-drug resistant pathogens. Clinical Infectious Diseases, 76 (3), e1277-e1284. doi: 10.1093/cid/ciac726

Clinical implementation of routine whole-genome sequencing for hospital infection control of multi-drug resistant pathogens

2022

Journal Article

Comparison of ceftazidime-avibactam susceptibility testing methods against OXA-48-like carrying Klebsiella blood stream isolates

Isler, Burcu, Vatansever, Cansel, Özer, Berna, Çınar, Güle, Aslan, Abdullah Tarık, Stewart, Adam, Simos, Peter, Falconer, Caitlin, Bauer, Michelle J., Forde, Brian, Harris, Patrick, Şimşek, Funda, Tülek, Necla, Demirkaya, Hamiyet, Menekşe, Şirin, Akalin, Halis, Balkan, İlker İnanç, Aydın, Mehtap, Tigen, Elif Tükenmez, Demir, Safiye Koçulu, Kapmaz, Mahir, Keske, Şiran, Doğan, Özlem, Arabacı, Çiğdem, Yağcı, Serap, Hazırolan, Gülşen, Bakır, Veli Oğuzalp, Gönen, Mehmet, Saltoğlu, Neşe ... Can, Füsun (2022). Comparison of ceftazidime-avibactam susceptibility testing methods against OXA-48-like carrying Klebsiella blood stream isolates. Diagnostic Microbiology and Infectious Disease, 104 (1) 115745, 1-4. doi: 10.1016/j.diagmicrobio.2022.115745

Comparison of ceftazidime-avibactam susceptibility testing methods against OXA-48-like carrying Klebsiella blood stream isolates

2022

Journal Article

Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase-producing versus non-producing Escherichia coli in a hollow-fibre infection model

Islam, Kamrul, Sime, Fekade B., Bauer, Michelle J., Forde, Brian M., Wallis, Steven C., Harris, Patrick, Naicker, Saiyuri, Shirin, Tahmina, Habib, Zakir H., Flora, Meerjady S. and Roberts, Jason A. (2022). Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase-producing versus non-producing Escherichia coli in a hollow-fibre infection model. International Journal of Antimicrobial Agents, 60 (2) 106623, 1-7. doi: 10.1016/j.ijantimicag.2022.106623

Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase-producing versus non-producing Escherichia coli in a hollow-fibre infection model

2022

Journal Article

Proof-of-concept, rapid, instrument-free molecular detection of Neisseria gonorrhoeae and ciprofloxacin susceptibility

Ayfan, Abdulrahman K. S., Macdonald, Joanne, Irwin, Adam D., Zowawi, Hosam M., Forde, Brian M., Paterson, David L., Lahra, Monica M. and Whiley, David M. (2022). Proof-of-concept, rapid, instrument-free molecular detection of Neisseria gonorrhoeae and ciprofloxacin susceptibility. Journal of Antimicrobial Chemotherapy, 77 (11), 2933-2936. doi: 10.1093/jac/dkac242

Proof-of-concept, rapid, instrument-free molecular detection of Neisseria gonorrhoeae and ciprofloxacin susceptibility

2022

Journal Article

Pharmacodynamic evaluation of piperacillin/tazobactam versus meropenem against extended-spectrum β-lactamase-producing and non-producing Escherichia coli clinical isolates in a hollow-fibre infection model

Islam, Kamrul, Sime, Fekade B., Wallis, Steven C., Bauer, Michelle J., Forde, Brian M., Harris, Patrick, Shirin, Tahmina, Habib, Zakir H., Flora, Meerjady S. and Roberts, Jason A. (2022). Pharmacodynamic evaluation of piperacillin/tazobactam versus meropenem against extended-spectrum β-lactamase-producing and non-producing Escherichia coli clinical isolates in a hollow-fibre infection model. Journal of Antimicrobial Chemotherapy, 77 (9), 2448-2455. doi: 10.1093/jac/dkac186

Pharmacodynamic evaluation of piperacillin/tazobactam versus meropenem against extended-spectrum β-lactamase-producing and non-producing Escherichia coli clinical isolates in a hollow-fibre infection model

2022

Journal Article

Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli

Hancock, Steven J., Lo, Alvin W., Ve, Thomas, Day, Christopher J., Tan, Lendl, Mendez, Alejandra A., Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Peters, Kate M., Richards, Amanda C., Fleming, Brittany A., Chang, Chyden, Ngu, Dalton H. Y., Forde, Brian M., Haselhorst, Thomas, Goh, Kelvin G. K., Beatson, Scott A., Jennings, Michael P., Mulvey, Matthew A., Kobe, Bostjan and Schembri, Mark A. (2022). Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli. PLoS Pathogens , 18 (6) e1010582, e1010582. doi: 10.1371/journal.ppat.1010582

Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli

2022

Journal Article

A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2

Albrich, Werner C., Ghosh, Tarini Shankar, Ahearn-Ford, Sinead, Mikaeloff, Flora, Lunjani, Nonhlanhla, Forde, Brian, Suh, Noémie, Kleger, Gian-Reto, Pietsch, Urs, Frischknecht, Manuel, Garzoni, Christian, Forlenza, Rossella, Horgan, Mary, Sadlier, Corinna, Negro, Tommaso Rochat, Pugin, Jérôme, Wozniak, Hannah, Cerny, Andreas, Neogi, Ujjwal, O’Toole, Paul W. and O’Mahony, Liam (2022). A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2. Gut Microbes, 14 (1) 2073131, 1-16. doi: 10.1080/19490976.2022.2073131

A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2

2022

Journal Article

Impact of Long COVID on health and quality of life

O’ Mahony, Liam, Buwalda, Tanja, Blair, Matthew, Forde, Brian, Lunjani, Nonhlanhla, Ambikan, Anoop, Neogi, Ujjwal, Barrett, Peter, Geary, Eoin, O'Connor, Nuala, Dineen, Jennifer, Clarke, Gerard, Kelleher, Eric, Horgan, Mary, Jackson, Arthur and Sadlier, Corinna (2022). Impact of Long COVID on health and quality of life. HRB Open Research, 5 31, 1-19. doi: 10.12688/hrbopenres.13516.1

Impact of Long COVID on health and quality of life

2022

Journal Article

Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

Isler, Burcu, Özer, Berna, Çınar, Güle, Aslan, Abdullah Tarık, Vatansever, Cansel, Falconer, Caitlin, Dolapçı, İştar, Şimşek, Funda, Tülek, Necla, Demirkaya, Hamiyet, Menekşe, Şirin, Akalin, Halis, Balkan, İlker İnanç, Aydın, Mehtap, Tigen, Elif Tükenmez, Demir, Safiye Koçulu, Kapmaz, Mahir, Keske, Şiran, Doğan, Özlem, Arabacı, Çiğdem, Yağcı, Serap, Hazırolan, Gülşen, Bakır, Veli Oğuzalp, Gönen, Mehmet, Chatfield, Mark D., Forde, Brian, Saltoğlu, Neşe, Azap, Alpay, Azap, Özlem ... Ergönül, Önder (2022). Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting. European Journal of Clinical Microbiology and Infectious Diseases, 41 (5), 841-847. doi: 10.1007/s10096-022-04425-4

Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

2022

Journal Article

Phase variation in the glycosyltransferase genes of Pasteurella multocida associated with outbreaks of fowl cholera on free-range layer farms

Omaleki, Lida, Blackall, Patrick J., Cuddihy, Thom, White, Rhys T., Courtice, Jodi M., Turni, Conny, Forde, Brian M. and Beatson, Scott A. (2022). Phase variation in the glycosyltransferase genes of Pasteurella multocida associated with outbreaks of fowl cholera on free-range layer farms. Microbial Genomics, 8 (3) 000772. doi: 10.1099/mgen.0.000772

Phase variation in the glycosyltransferase genes of Pasteurella multocida associated with outbreaks of fowl cholera on free-range layer farms

2022

Journal Article

Successful treatment of a chronic oroantral fistula infected with extensively drug resistant bacteria using long‐term oesophageal tube feeding and several non‐conventional treatments in a horse

Fletcher, J.R., Yuen, K.Y., Stewart, A.J., Young, A.C., Gibson, J.S., James, O.A., Medina‐Torres, C.E., Forde, B.M. and Sole‐Guitart, A. (2022). Successful treatment of a chronic oroantral fistula infected with extensively drug resistant bacteria using long‐term oesophageal tube feeding and several non‐conventional treatments in a horse. Australian Veterinary Journal, 100 (3), 107-113. doi: 10.1111/avj.13136

Successful treatment of a chronic oroantral fistula infected with extensively drug resistant bacteria using long‐term oesophageal tube feeding and several non‐conventional treatments in a horse

2022

Journal Article

A high-quality reference genome for the fish pathogen Streptococcus iniae

Alsheikh-Hussain, Areej S., Ben Zakour, Nouri L., Forde, Brian M., Rudenko, Oleksandra, Barnes, Andrew C. and Beatson, Scott A. (2022). A high-quality reference genome for the fish pathogen Streptococcus iniae. Microbial Genomics, 8 (3) 000777. doi: 10.1099/mgen.0.000777

A high-quality reference genome for the fish pathogen Streptococcus iniae

Funding

Current funding

  • 2024 - 2028
    Unlocking the gut microbiome to track the spread of AMR genes and pathogens
    NHMRC MRFF - Global Health Initiative
    Open grant
  • 2023 - 2026
    Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis
    The Children's Hospital Foundation
    Open grant
  • 2023 - 2025
    Development of Wastewater-based epidemiology as a complementary approach for antimicrobial resistance surveillance
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2023 - 2027
    A Faster Cure for Tuberculosis: Revealing Adjunctive Antimicrobial Solutions
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022 - 2024
    The 3,000 Genomes project: using machine learning and artificial intelligence for robust culture-independent susceptibility testing
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2021 - 2023
    Automating Infectious Disease Surveillance with Artificial Intelligence
    Advance Queensland Industry Research Fellowships
    Open grant

Supervision

Availability

Dr Brian Forde is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Malaria and Infections Diseases in military personnel in the Asia Pacific Region

    Principal Advisor

  • Doctor Philosophy

    A Multidisciplinary Approach to Identifying Novel Vaccine and Drug Targets of Non-Tuberculous Mycobacteria

    Associate Advisor

    Other advisors: Associate Professor Nick West

  • Doctor Philosophy

    Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections

    Associate Advisor

    Other advisors: Dr Patrick Harris, Mr Mark Chatfield

Completed supervision

Media

Enquiries

For media enquiries about Dr Brian Forde's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au