
Overview
Background
Brian Forde is a fellow in microbial bioinformatics and Advance Queensland Industry Research Fellow at the University of Queensland (UQ) Centre for Clinical Research (CCR). Brian was awarded a PhD from University College Cork, Ireland, in 2013 and developed his interest in bacterial genomics as a postdoctoral fellow at the UQ School of Chemistry and Molecular Biosciences (SCMB). Currently, his work is primarily focused on clinical microbial genomics, including: the evolution of antibiotic resistance, genomic epidemiology, genomic surveillance of Infectious Diseases and translating genomic research into clinical practice. Since 2017 he has been part of a multidisciplinary team, including researchers, infectious diseases clinicians and infection control professionals, leading the introduction of WGS to investigate hospital-acquired infection in Queensland (https://www.queenslandgenomics.org). In 2020, Brian was awarded Advance Queensland Industry Research Fellowship to explore the application of Artificial Intelligence to genomic surveillance and transmission dynamics.
Availability
- Dr Brian Forde is:
- Available for supervision
Qualifications
- Bachelor (Honours) of Science (Advanced), University College Cork
- Doctor of Philosophy, National University of Ireland
Research impacts
Since 2010 Brian has co-authored 52 journal articles, with 13 as first, co-first or senior author. His has been cited 1430 times, resulting in a h-index of 19 and an i10-index of 25 (Google Scholar 28/10/2020). Brians work is regularly published in leading specialist microbiology or infectious disease journals including MBio, AAC and JAC and have also featured in high impact journals such as Nat Comm, Nat Micro, PNAS, CID and CMR. Recent work include a longitudinal study describing a unique comprehensive genomic analysis of a clonal lineage within a single individual over a 5-year period (Forde et al. Nat Comm, 2019). This work provided the framework for the utilization of genomics to help manage and treat patients suffering from debilitating chronic infections.
As part of Queensland Genomics Brian has led and assisted in projects that apply genomics to characterise and resolve infectious outbreaks in clinical settings (Chapman & Forde et al. JCM, 2020; Roberts et al. Nat Comm, 2020; Roberts et al. bioRxiv, 2018). In his current role as lead Bioinformatician for the Queensland Genomics (QG) infectious diseases (ID) project, Brian has developed pipelines for surveillance of priority bacterial pathogens. These tools, which included the development of an outbreak detection and visualisation tool, CATHAI (https:cathai.beatsonlab.com), are used by infection control professional in large Brisbane metropolitan hospitals.
Works
Search Professor Brian Forde’s works on UQ eSpace
2015
Journal Article
Molecular analysis of asymptomatic bacteriuria Escherichia coli strain VR50 reveals adaptation to the urinary tract by gene acquisition
Beatson, Scott A., Ben Zakour, Nouri L., Totsika, Makrina, Forde, Brian M., Watts, Rebecca E., Mabbett, Amanda N., Szubert, Jan M., Sarkar, Sohinee, Phan, Minh-Duy, Peters, Kate M., Petty, Nicola K., Alikhan, Nabil-Fareed, Sullivan, Mitchell J., Gawthorne, Jayde A., Stanton-Cook, Mitchell, Nguyen Thi Khanh Nhu, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, Hancock, Viktoria, Ussery, David W., Ulett, Glen C. and Schembri, Mark A. (2015). Molecular analysis of asymptomatic bacteriuria Escherichia coli strain VR50 reveals adaptation to the urinary tract by gene acquisition. Infection and Immunity, 83 (5), 1749-1764. doi: 10.1128/IAI.02810-14
2015
Journal Article
Molecular Characterization of a Multidrug Resistance IncF Plasmid from the Globally Disseminated Escherichia coli ST131 Clone.
Phan, Minh Duy, Forde, Brian M., Peters, Kate M., Sarkar, Sohinee, Hancock, Steven, Stanton-Cook, Mitchell, Zakour, Nouri L. Ben, Upton, Mathew, Beatson, Scott A. and Schembri, Mark A. (2015). Molecular Characterization of a Multidrug Resistance IncF Plasmid from the Globally Disseminated Escherichia coli ST131 Clone.. PLoS One, 10 (4) e0122369, e0122369-e0122369. doi: 10.1371/journal.pone.0122369
2015
Journal Article
Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958
Phan, Minh-Duy, Peters, Kate M., Sarkar, Sohinee, Forde, Brian M., Lo, Alvin W., Stanton-Cook, Mitchell, Roberts, Leah W., Upton, Mathew, Beatson, Scott A. and Schembri, Mark A. (2015). Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958. Journal of Antimicrobial Chemotherapy, 70 (7) dkv066, 1969-1972. doi: 10.1093/jac/dkv066
2014
Journal Article
Unusual genome complexity in Lactobacillus salivarius JCM1046
Raftis, Emma J., Forde, Brian M., Claesson, Marcus J. and O'Toole, Paul W. (2014). Unusual genome complexity in Lactobacillus salivarius JCM1046. BMC Genomics, 15 (1) 771, 771. doi: 10.1186/1471-2164-15-771
2014
Journal Article
The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone
Forde, Brian M., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Phan, Minh-Duy, Totsika, Makrina, Peters, Kate M., Chan, Kok Gan, Schembri, Mark A., Upton, Mathew and Beatson, Scott A. (2014). The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone. PLoS One, 9 (8) e104400, e104400.1-e104400.13. doi: 10.1371/journal.pone.0104400
2014
Journal Article
Global dissemination of a multidrug resistant Escherichia coli clone
Petty, Nicola K., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Skippington, Elizabeth, Totsika, Makrina, Forde, Brian M., Phan, Minh-Duy, Gomes Moriel, Danilo, Peters, Kate M., Davies, Mark, Rogers, Benjamin A., Dougan, Gordon, Rodriguez-Baño, Jesús, Pascual, Alvaro, Pitout, Johann D., Upton, Mathew, Paterson, David L., Walsh, Timothy R., Schembri, Mark A. and Beatson, Scott A. (2014). Global dissemination of a multidrug resistant Escherichia coli clone. Proceedings of the National Academy of Sciences, 111 (15), 5694-5699. doi: 10.1073/pnas.1322678111
2013
Journal Article
Next-generation sequencing technologies and their impact on microbial genomics
Forde, Brian M. and O'Toole, Paul W. (2013). Next-generation sequencing technologies and their impact on microbial genomics. Briefings in Functional Genomics, 12 (5), 440-453. doi: 10.1093/bfgp/els062
2012
Journal Article
Characterization of pro-inflammatory flagellin proteins produced by Lactobacillus ruminis and related motile Lactobacilli
Neville, B. Anne, Forde, Brian M., Claesson, Marcus J., Darby, Trevor, Coghlan, Avril, Nally, Kenneth, Ross, R. Paul and O'Toole, Paul W. (2012). Characterization of pro-inflammatory flagellin proteins produced by Lactobacillus ruminis and related motile Lactobacilli. PLoS One, 7 (7) e40592, e40592. doi: 10.1371/journal.pone.0040592
2012
Journal Article
Draft Genome Sequences of Helicobacter pylori Strains 17874 and P79
Clancy, Ceara D., Forde, Brian M., Moore, Stanley A. and O'Toole, Paul W. (2012). Draft Genome Sequences of Helicobacter pylori Strains 17874 and P79. Journal of Bacteriology, 194 (9), 2402-2402. doi: 10.1128/JB.00230-12
2012
Journal Article
Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota
Riboulet-Bisson, Eliette, Sturme, Mark H. J., Jeffery, Ian B., O'Donnell, Michelle M., Neville, B. Anne, Forde, Brian M., Claesson, Marcus J., Harris, Hugh, Gardiner, Gillian E., Casey, Patrick G., Lawlor, Peadar G., O'Toole, Paul W. and Ross, R. Paul (2012). Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota. PLoS One, 7 (2) e31113, e31113. doi: 10.1371/journal.pone.0031113
2011
Conference Publication
Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts
Forde, Brian M., Neville, B. Anne, O'Donnell, Michelle M. , Riboulet-Bisson, E., Claesson, M. J., Coghlan, Avril, Ross, R. Paul and O'Toole, Paul W. (2011). Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts. 10th Symposium on Lactic Acid Bacterium (LAB), Egmond aan Zee, Netherlands, 28 August-1 September 2011. London, United Kingdom: BioMed Central. doi: 10.1186/1475-2859-10-S1-S13
2011
Conference Publication
Carbohydrate catabolic flexibility in the mammalian intestinal commensal Lactobacillus ruminis revealed by fermentation studies aligned to genome annotations
Donnell, Michelle M. O', Forde, Brian M., Neville, B., Ross, Paul R. and Toole, Paul W. O' (2011). Carbohydrate catabolic flexibility in the mammalian intestinal commensal Lactobacillus ruminis revealed by fermentation studies aligned to genome annotations. 10th Symposium on Lactic Acid Bacterium, The Netherlands, 28 August - 1 September 2011. London, United Kingdom: BioMed Central. doi: 10.1186/1475-2859-10-S1-S12
2010
Journal Article
Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen
O'Toole, Paul W., Snelling, William J., Canchaya, Carlos, Forde, Brian M., Hardie, Kim R., Josenhans, Christine, Graham, Robert L. J., McMullan, Geoff, Parkhill, Julian, Belda, Eugenio and Bentley, Stephen D. (2010). Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen. BMC Genomics, 11 (1) 164, 164. doi: 10.1186/1471-2164-11-164
Funding
Current funding
Past funding
Supervision
Availability
- Dr Brian Forde is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Genomic and molecular characterisation of antibiotic resistance mechanisms
Principal Advisor
Other advisors: Professor Mark Schembri
-
Doctor Philosophy
Malaria and Infections Diseases in military personnel in the Asia Pacific Region
Principal Advisor
-
Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Principal Advisor
Other advisors: Dr Patrick Harris
-
Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Patrick Harris, Mr Mark Chatfield
-
Doctor Philosophy
A Multidisciplinary Approach to Identifying Novel Vaccine and Drug Targets of Non-Tuberculous Mycobacteria
Associate Advisor
Other advisors: Professor Nick West
-
Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Patrick Harris, Mr Mark Chatfield
Completed supervision
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2022
Doctor Philosophy
Comparative Genomics of Extraintestinal Pathogenic Escherichia coli
Associate Advisor
Other advisors: Associate Professor Scott Beatson
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2022
Doctor Philosophy
New approaches in visualising genomic data for surveillance and control of drug-resistant bacteria in healthcare settings
Associate Advisor
Other advisors: Associate Professor Scott Beatson
-
2019
Doctor Philosophy
Factors that influence Neisseria gonorrhoeae antimicrobial resistance and transmission in Australia
Associate Advisor
Other advisors: Associate Professor Scott Beatson, Associate Professor David Whiley
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2019
Doctor Philosophy
Evolution and function of mobile genetic elements and DNA methyltransferases in extraintestinal pathogenic Escherichia coli
Associate Advisor
Other advisors: Associate Professor Scott Beatson
Media
Enquiries
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