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Dr Brian Forde
Dr

Brian Forde

Email: 
Phone: 
+61 7 344 36245

Overview

Background

Brian Forde is a fellow in microbial bioinformatics and Advance Queensland Industry Research Fellow at the University of Queensland (UQ) Centre for Clinical Research (CCR). Brian was awarded a PhD from University College Cork, Ireland, in 2013 and developed his interest in bacterial genomics as a postdoctoral fellow at the UQ School of Chemistry and Molecular Biosciences (SCMB). Currently, his work is primarily focused on clinical microbial genomics, including: the evolution of antibiotic resistance, genomic epidemiology, genomic surveillance of Infectious Diseases and translating genomic research into clinical practice. Since 2017 he has been part of a multidisciplinary team, including researchers, infectious diseases clinicians and infection control professionals, leading the introduction of WGS to investigate hospital-acquired infection in Queensland (https://www.queenslandgenomics.org). In 2020, Brian was awarded Advance Queensland Industry Research Fellowship to explore the application of Artificial Intelligence to genomic surveillance and transmission dynamics.

Availability

Dr Brian Forde is:
Available for supervision

Qualifications

  • Bachelor (Honours) of Science (Advanced), University College Cork
  • Doctor of Philosophy, National University of Ireland

Research impacts

Since 2010 Brian has co-authored 52 journal articles, with 13 as first, co-first or senior author. His has been cited 1430 times, resulting in a h-index of 19 and an i10-index of 25 (Google Scholar 28/10/2020). Brians work is regularly published in leading specialist microbiology or infectious disease journals including MBio, AAC and JAC and have also featured in high impact journals such as Nat Comm, Nat Micro, PNAS, CID and CMR. Recent work include a longitudinal study describing a unique comprehensive genomic analysis of a clonal lineage within a single individual over a 5-year period (Forde et al. Nat Comm, 2019). This work provided the framework for the utilization of genomics to help manage and treat patients suffering from debilitating chronic infections.

As part of Queensland Genomics Brian has led and assisted in projects that apply genomics to characterise and resolve infectious outbreaks in clinical settings (Chapman & Forde et al. JCM, 2020; Roberts et al. Nat Comm, 2020; Roberts et al. bioRxiv, 2018). In his current role as lead Bioinformatician for the Queensland Genomics (QG) infectious diseases (ID) project, Brian has developed pipelines for surveillance of priority bacterial pathogens. These tools, which included the development of an outbreak detection and visualisation tool, CATHAI (https:cathai.beatsonlab.com), are used by infection control professional in large Brisbane metropolitan hospitals.

Works

Search Professor Brian Forde’s works on UQ eSpace

113 works between 2010 and 2024

101 - 113 of 113 works

2015

Journal Article

Molecular analysis of asymptomatic bacteriuria Escherichia coli strain VR50 reveals adaptation to the urinary tract by gene acquisition

Beatson, Scott A., Ben Zakour, Nouri L., Totsika, Makrina, Forde, Brian M., Watts, Rebecca E., Mabbett, Amanda N., Szubert, Jan M., Sarkar, Sohinee, Phan, Minh-Duy, Peters, Kate M., Petty, Nicola K., Alikhan, Nabil-Fareed, Sullivan, Mitchell J., Gawthorne, Jayde A., Stanton-Cook, Mitchell, Nguyen Thi Khanh Nhu, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, Hancock, Viktoria, Ussery, David W., Ulett, Glen C. and Schembri, Mark A. (2015). Molecular analysis of asymptomatic bacteriuria Escherichia coli strain VR50 reveals adaptation to the urinary tract by gene acquisition. Infection and Immunity, 83 (5), 1749-1764. doi: 10.1128/IAI.02810-14

Molecular analysis of asymptomatic bacteriuria Escherichia coli strain VR50 reveals adaptation to the urinary tract by gene acquisition

2015

Journal Article

Molecular Characterization of a Multidrug Resistance IncF Plasmid from the Globally Disseminated Escherichia coli ST131 Clone.

Phan, Minh Duy, Forde, Brian M., Peters, Kate M., Sarkar, Sohinee, Hancock, Steven, Stanton-Cook, Mitchell, Zakour, Nouri L. Ben, Upton, Mathew, Beatson, Scott A. and Schembri, Mark A. (2015). Molecular Characterization of a Multidrug Resistance IncF Plasmid from the Globally Disseminated Escherichia coli ST131 Clone.. PLoS One, 10 (4) e0122369, e0122369-e0122369. doi: 10.1371/journal.pone.0122369

Molecular Characterization of a Multidrug Resistance IncF Plasmid from the Globally Disseminated Escherichia coli ST131 Clone.

2015

Journal Article

Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958

Phan, Minh-Duy, Peters, Kate M., Sarkar, Sohinee, Forde, Brian M., Lo, Alvin W., Stanton-Cook, Mitchell, Roberts, Leah W., Upton, Mathew, Beatson, Scott A. and Schembri, Mark A. (2015). Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958. Journal of Antimicrobial Chemotherapy, 70 (7) dkv066, 1969-1972. doi: 10.1093/jac/dkv066

Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958

2014

Journal Article

Unusual genome complexity in Lactobacillus salivarius JCM1046

Raftis, Emma J., Forde, Brian M., Claesson, Marcus J. and O'Toole, Paul W. (2014). Unusual genome complexity in Lactobacillus salivarius JCM1046. BMC Genomics, 15 (1) 771, 771. doi: 10.1186/1471-2164-15-771

Unusual genome complexity in Lactobacillus salivarius JCM1046

2014

Journal Article

The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone

Forde, Brian M., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Phan, Minh-Duy, Totsika, Makrina, Peters, Kate M., Chan, Kok Gan, Schembri, Mark A., Upton, Mathew and Beatson, Scott A. (2014). The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone. PLoS One, 9 (8) e104400, e104400.1-e104400.13. doi: 10.1371/journal.pone.0104400

The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone

2014

Journal Article

Global dissemination of a multidrug resistant Escherichia coli clone

Petty, Nicola K., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Skippington, Elizabeth, Totsika, Makrina, Forde, Brian M., Phan, Minh-Duy, Gomes Moriel, Danilo, Peters, Kate M., Davies, Mark, Rogers, Benjamin A., Dougan, Gordon, Rodriguez-Baño, Jesús, Pascual, Alvaro, Pitout, Johann D., Upton, Mathew, Paterson, David L., Walsh, Timothy R., Schembri, Mark A. and Beatson, Scott A. (2014). Global dissemination of a multidrug resistant Escherichia coli clone. Proceedings of the National Academy of Sciences, 111 (15), 5694-5699. doi: 10.1073/pnas.1322678111

Global dissemination of a multidrug resistant Escherichia coli clone

2013

Journal Article

Next-generation sequencing technologies and their impact on microbial genomics

Forde, Brian M. and O'Toole, Paul W. (2013). Next-generation sequencing technologies and their impact on microbial genomics. Briefings in Functional Genomics, 12 (5), 440-453. doi: 10.1093/bfgp/els062

Next-generation sequencing technologies and their impact on microbial genomics

2012

Journal Article

Characterization of pro-inflammatory flagellin proteins produced by Lactobacillus ruminis and related motile Lactobacilli

Neville, B. Anne, Forde, Brian M., Claesson, Marcus J., Darby, Trevor, Coghlan, Avril, Nally, Kenneth, Ross, R. Paul and O'Toole, Paul W. (2012). Characterization of pro-inflammatory flagellin proteins produced by Lactobacillus ruminis and related motile Lactobacilli. PLoS One, 7 (7) e40592, e40592. doi: 10.1371/journal.pone.0040592

Characterization of pro-inflammatory flagellin proteins produced by Lactobacillus ruminis and related motile Lactobacilli

2012

Journal Article

Draft Genome Sequences of Helicobacter pylori Strains 17874 and P79

Clancy, Ceara D., Forde, Brian M., Moore, Stanley A. and O'Toole, Paul W. (2012). Draft Genome Sequences of Helicobacter pylori Strains 17874 and P79. Journal of Bacteriology, 194 (9), 2402-2402. doi: 10.1128/JB.00230-12

Draft Genome Sequences of Helicobacter pylori Strains 17874 and P79

2012

Journal Article

Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota

Riboulet-Bisson, Eliette, Sturme, Mark H. J., Jeffery, Ian B., O'Donnell, Michelle M., Neville, B. Anne, Forde, Brian M., Claesson, Marcus J., Harris, Hugh, Gardiner, Gillian E., Casey, Patrick G., Lawlor, Peadar G., O'Toole, Paul W. and Ross, R. Paul (2012). Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota. PLoS One, 7 (2) e31113, e31113. doi: 10.1371/journal.pone.0031113

Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota

2011

Conference Publication

Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts

Forde, Brian M., Neville, B. Anne, O'Donnell, Michelle M. , Riboulet-Bisson, E., Claesson, M. J., Coghlan, Avril, Ross, R. Paul and O'Toole, Paul W. (2011). Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts. 10th Symposium on Lactic Acid Bacterium (LAB), Egmond aan Zee, Netherlands, 28 August-1 September 2011. London, United Kingdom: BioMed Central. doi: 10.1186/1475-2859-10-S1-S13

Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts

2011

Conference Publication

Carbohydrate catabolic flexibility in the mammalian intestinal commensal Lactobacillus ruminis revealed by fermentation studies aligned to genome annotations

Donnell, Michelle M. O', Forde, Brian M., Neville, B., Ross, Paul R. and Toole, Paul W. O' (2011). Carbohydrate catabolic flexibility in the mammalian intestinal commensal Lactobacillus ruminis revealed by fermentation studies aligned to genome annotations. 10th Symposium on Lactic Acid Bacterium, The Netherlands, 28 August - 1 September 2011. London, United Kingdom: BioMed Central. doi: 10.1186/1475-2859-10-S1-S12

Carbohydrate catabolic flexibility in the mammalian intestinal commensal Lactobacillus ruminis revealed by fermentation studies aligned to genome annotations

2010

Journal Article

Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen

O'Toole, Paul W., Snelling, William J., Canchaya, Carlos, Forde, Brian M., Hardie, Kim R., Josenhans, Christine, Graham, Robert L. J., McMullan, Geoff, Parkhill, Julian, Belda, Eugenio and Bentley, Stephen D. (2010). Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen. BMC Genomics, 11 (1) 164, 164. doi: 10.1186/1471-2164-11-164

Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen

Funding

Current funding

  • 2025 - 2029
    ROAD RCT: Resistance Optimised Antibiotic Dosing in critically ill patients - a Randomised Controlled Trial
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2025 - 2029
    ROAD RCT: Resistance Optimised Antibiotic Dosing in critically ill patients - a Randomised Controlled Trial
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2024 - 2028
    Unlocking the gut microbiome to track the spread of AMR genes and pathogens
    MRFF - Global Health Initiative
    Open grant
  • 2024 - 2025
    A Rapid, Routine Genomics Service for Clinical Haematology (QLD Health Targeted CRF led by RBWH Metro North Health)
    Metro North Hospital and Health Service
    Open grant
  • 2023 - 2027
    Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis
    The Children's Hospital Foundation
    Open grant
  • 2023 - 2027
    A Faster Cure for Tuberculosis: Revealing Adjunctive Antimicrobial Solutions
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2023 - 2025
    Development of Wastewater-based epidemiology as a complementary approach for antimicrobial resistance surveillance
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2022 - 2024
    The 3,000 Genomes project: using machine learning and artificial intelligence for robust culture-independent susceptibility testing
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2021 - 2023
    Automating Infectious Disease Surveillance with Artificial Intelligence
    Advance Queensland Industry Research Fellowships
    Open grant

Supervision

Availability

Dr Brian Forde is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Genomic and molecular characterisation of antibiotic resistance mechanisms

    Principal Advisor

    Other advisors: Professor Mark Schembri

  • Doctor Philosophy

    Malaria and Infections Diseases in military personnel in the Asia Pacific Region

    Principal Advisor

  • Doctor Philosophy

    Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.

    Principal Advisor

    Other advisors: Dr Patrick Harris

  • Doctor Philosophy

    Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales

    Associate Advisor

    Other advisors: Dr Patrick Harris, Mr Mark Chatfield

  • Doctor Philosophy

    A Multidisciplinary Approach to Identifying Novel Vaccine and Drug Targets of Non-Tuberculous Mycobacteria

    Associate Advisor

    Other advisors: Professor Nick West

  • Doctor Philosophy

    Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections

    Associate Advisor

    Other advisors: Dr Patrick Harris, Mr Mark Chatfield

Completed supervision

Media

Enquiries

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