
Overview
Background
Brian Forde is a fellow in microbial bioinformatics and Advance Queensland Industry Research Fellow at the University of Queensland (UQ) Centre for Clinical Research (CCR). Brian was awarded a PhD from University College Cork, Ireland, in 2013 and developed his interest in bacterial genomics as a postdoctoral fellow at the UQ School of Chemistry and Molecular Biosciences (SCMB). Currently, his work is primarily focused on clinical microbial genomics, including: the evolution of antibiotic resistance, genomic epidemiology, genomic surveillance of Infectious Diseases and translating genomic research into clinical practice. Since 2017 he has been part of a multidisciplinary team, including researchers, infectious diseases clinicians and infection control professionals, leading the introduction of WGS to investigate hospital-acquired infection in Queensland (https://www.queenslandgenomics.org). In 2020, Brian was awarded Advance Queensland Industry Research Fellowship to explore the application of Artificial Intelligence to genomic surveillance and transmission dynamics.
Availability
- Dr Brian Forde is:
- Available for supervision
Qualifications
- Bachelor (Honours) of Science (Advanced), University College Cork
- Doctor of Philosophy, National University of Ireland
Research impacts
Since 2010 Brian has co-authored 52 journal articles, with 13 as first, co-first or senior author. His has been cited 1430 times, resulting in a h-index of 19 and an i10-index of 25 (Google Scholar 28/10/2020). Brians work is regularly published in leading specialist microbiology or infectious disease journals including MBio, AAC and JAC and have also featured in high impact journals such as Nat Comm, Nat Micro, PNAS, CID and CMR. Recent work include a longitudinal study describing a unique comprehensive genomic analysis of a clonal lineage within a single individual over a 5-year period (Forde et al. Nat Comm, 2019). This work provided the framework for the utilization of genomics to help manage and treat patients suffering from debilitating chronic infections.
As part of Queensland Genomics Brian has led and assisted in projects that apply genomics to characterise and resolve infectious outbreaks in clinical settings (Chapman & Forde et al. JCM, 2020; Roberts et al. Nat Comm, 2020; Roberts et al. bioRxiv, 2018). In his current role as lead Bioinformatician for the Queensland Genomics (QG) infectious diseases (ID) project, Brian has developed pipelines for surveillance of priority bacterial pathogens. These tools, which included the development of an outbreak detection and visualisation tool, CATHAI (https:cathai.beatsonlab.com), are used by infection control professional in large Brisbane metropolitan hospitals.
Works
Search Professor Brian Forde’s works on UQ eSpace
2019
Other Outputs
The evolution of nitroimidazole antibiotic resistance in Mycobacterium tuberculosis
Lee, Brendon M., Almeida, Deepak V., Afriat-Jurnou, Livnat, Aung, Htin Lin, Forde, Brian M., Hards, Kiel, Pidot, Sacha J., Ahmed, F. Hafna, Mohamed, A. Elaaf, Taylor, Matthew C., West, Nicholas P., Stinear, Timothy P., Greening, Chris, Beatson, Scott A., Cook, Gregory M., Nuermberger, Eric L. and Jackson, Colin J. (2019). The evolution of nitroimidazole antibiotic resistance in Mycobacterium tuberculosis. doi: 10.1101/631127
2019
Journal Article
Novel insights into pasteurellosis in captive pinnipeds
Crawford, Rebecca L., Blyde, David, Blackall, Patrick J., Forde, Brian M., Beatson, Scott A., Harris, Louise M., Turni, Conny and Omaleki, Lida (2019). Novel insights into pasteurellosis in captive pinnipeds. Veterinary Microbiology, 231, 232-237. doi: 10.1016/j.vetmic.2019.03.017
2019
Other Outputs
Genomic investigation reveals contaminated detergent as the source of an ESBL-producing Klebsiella michiganensis outbreak in a neonatal unit
Chapman, Paul, Forde, Brian M., Roberts, Leah W., Bergh, Haakon, Vesey, Debra, Jennison, Amy V., Moss, Susan, Paterson, David L., Beatson, Scott A. and Harris, Patrick N. A. (2019). Genomic investigation reveals contaminated detergent as the source of an ESBL-producing Klebsiella michiganensis outbreak in a neonatal unit. doi: 10.1101/568154
2019
Journal Article
Detection of epidemic scarlet fever group A Streptococcus in Australia
Walker, Mark J., Brouwer, Stephan, Forde, Brian M., Worthing, Kate A., McIntyre, Liam, Sundac, Lana, Maloney, Sam, Roberts, Leah W., Barnett, Timothy C., Richter, Johanna, Cork, Amanda J., Irwin, Adam D., You, Yuanhai, Zhang, Jianzhong, Dougan, Gordon, Yuen, K. Y., Nizet, Victor, Beatson, Scott A., Grimwood, Keith and Davies, Mark R. (2019). Detection of epidemic scarlet fever group A Streptococcus in Australia. Clinical Infectious Diseases, 69 (7), 1232-1234. doi: 10.1093/cid/ciz099
2019
Conference Publication
SRA down under: cache and analysis platform for infectious disease
Cuddihy, Thom, Forde, Brian, Rhodes, Nicholas, Paterson, David, Gorse, Dominique, Beatson, Scott and Harris, Patrick (2019). SRA down under: cache and analysis platform for infectious disease. Australian national conference for Health Informatics (HIC 2019), Melbourne, Australia, 12-14 August 2019. Amsterdam, Netherlands: IOS Press. doi: 10.3233/SHTI190776
2018
Journal Article
Discovery of mcr-1-mediated colistin resistance in a highly virulent Escherichia coli lineage
Forde, Brian M., Zowawi, Hosam M., Harris, Patrick N. A., Roberts, Leah, Ibrahim, Emad, Shaikh, Nissar, Deshmukh, Anand, Sid Ahmed, Mazen A., Al Maslamani, Muna, Cottrell, Kyra, Trembizki, Ella, Sundac, Lana, Yu, Heidi H., Li, Jian, Schembri, Mark A., Whiley, David M., Paterson, David L. and Beatson, Scott A. (2018). Discovery of mcr-1-mediated colistin resistance in a highly virulent Escherichia coli lineage. mSphere, 3 (5) e00486-18. doi: 10.1128/msphere.00486-18
2018
Journal Article
Discovery of new genes involved in curli production by a uropathogenic Escherichia coli strain from the highly virulent O45:K1:H7 lineage
Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Peters, Kate M., Lo, Alvin W., Forde, Brian M., Min Chong, Teik, Yin, Wai-Fong, Chan, Kok-Gan, Chromek, Milan, Brauner, Annelie, Chapman, Matthew R., Beatson, Scott A. and Schembri, Mark A. (2018). Discovery of new genes involved in curli production by a uropathogenic Escherichia coli strain from the highly virulent O45:K1:H7 lineage. mBio, 9 (4) e01462-18. doi: 10.1128/mbio.01462-18
2018
Journal Article
Use of whole genome sequencing to investigate an increase in Neisseria gonorrhoeae infection among women in urban areas of Australia
Buckley, Cameron, Forde, Brian M., Trembizki, Ella, Lahra, Monica M., Beatson, Scott A. and Whiley, David M. (2018). Use of whole genome sequencing to investigate an increase in Neisseria gonorrhoeae infection among women in urban areas of Australia. Scientific Reports, 8 (1) 1503, 1-7. doi: 10.1038/s41598-018-20015-x
2017
Journal Article
Genome-wide discovery of genes required for capsule production by uropathogenic Escherichia coli
Goh, Kelvin G. K., Phan, Minh-Duy, Forde, Brian M., Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, Ulett, Glen C., Sweet, Matthew J., Beatson, Scott A. and Schembri, Mark A. (2017). Genome-wide discovery of genes required for capsule production by uropathogenic Escherichia coli. MBio, 8 (5) e01558-17. doi: 10.1128/mBio.01558-17
2017
Journal Article
Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391
Sullivan, Matthew J, Forde, Brian M, Prince, Darren W, Ipe, Deepak S, Ben Zakour, Nouri L, Davies, Mark R, Dougan, Gordon, Beatson, Scott A and Ulett, Glen C (2017). Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391. Genome Announcements, 5 (42) e01107-17. doi: 10.1128/genomeA.01107-17
2017
Journal Article
Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli
Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Achard, Maud E. S., Forde, Brian M., Hong, Kar Wai, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, West, Nicholas P., Walker, Mark J., Paterson, David L., Beatson, Scott A. and Schembri, Mark A. (2017). Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli. Journal of Antimicrobial Chemotherapy, 72 (10), 2729-2736. doi: 10.1093/jac/dkx204
2017
Other Outputs
SMRT sequencing reveals differential patterns of methylation in two O111:H- Shiga toxigenic Escherichia coli isolates from a historic hemolytic uremic syndrome outbreak in Australia
Forde, Brian M., McAllister, Lauren J., Paton, James C., Paton, Adrienne W. and Beatson, Scott A. (2017). SMRT sequencing reveals differential patterns of methylation in two O111:H- Shiga toxigenic Escherichia coli isolates from a historic hemolytic uremic syndrome outbreak in Australia. doi: 10.1101/173336
2017
Journal Article
Identification of IncA/C plasmid replication and maintenance genes and development of a plasmid multi-locus sequence-typing scheme
Hancock, Steven J., Phan, Minh-Duy, Peters, Kate M., Forde, Brian M., Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, Paterson, David L., Walsh, Timothy R., Beatson, Scott A. and Schembri, Mark A. (2017). Identification of IncA/C plasmid replication and maintenance genes and development of a plasmid multi-locus sequence-typing scheme. Antimicrobial Agents and Chemotherapy, 61 (2) e01740. doi: 10.1128/AAC.01740-16
2016
Journal Article
Draft genome sequences of Helicobacter pylori strains 17874 and P79
Clancy, Ceara D., Forde, Brian M., Moore, Stanley A. and O'Toole, Paul W. (2016). Draft genome sequences of Helicobacter pylori strains 17874 and P79. Journal of Bacteriology, 198 (13), 1902-1902. doi: 10.1128/JB.00307-16
2016
Journal Article
Mechanisms involved in acquisition of blaNDM genes by IncA/C2 and IncFIIY plasmids
Wailan, Alexander M., Sidjabat, Hanna E., Yam, Wan Keat, Alikhan, Nabil-Fareed, Petty, Nicola K., Sartor, Anna L., Williamson, Deborah A., Forde, Brian M., Schembri, Mark A., Beatson, Scott A., Paterson, David L., Walsh, Timothy R. and Partridge, Sally R. (2016). Mechanisms involved in acquisition of blaNDM genes by IncA/C2 and IncFIIY plasmids. Antimicrobial Agents and Chemotherapy, 60 (7), 4082-4088. doi: 10.1128/AAC.00368-16
2016
Conference Publication
Multi-hospital spread of a pan-resistant Klebsiella pneumoniae clone with an ISEcp1-directed blaOXA-181 insertion into the mgrB gene in the AE
Pal, Tibor , Sonnevend, Agnes Maria , Ghazawi, Akela , Haidermota, Aliashgher , Girgis, Safinaz , Alfaresi, Mubarak , Omar, Mohammed , Paterson, David L. , Beatson, Scott , Forde, Brian and Zowawi, Hosam M. (2016). Multi-hospital spread of a pan-resistant Klebsiella pneumoniae clone with an ISEcp1-directed blaOXA-181 insertion into the mgrB gene in the AE. The 26th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID), Amsterdam, Netherlands, 9-12 April 2016.
2015
Journal Article
Lineage-specific methyltransferases define the methylome of the globally disseminated Escherichia coli ST131 clone
Forde, Brian M., Phan, Minh-Duy, Gawthorne, Jayde A., Ashcroft, Melinda M., Stanton-Cook, Mitchell, Sarkar, Sohinee, Peters, Kate M., Chan, Kok-Gan, Chong, Teik Min, Yin, Wai-Fong, Upton, Mathew, Schembri, Mark A. and Beatson, Scott A. (2015). Lineage-specific methyltransferases define the methylome of the globally disseminated Escherichia coli ST131 clone. MBio, 6 (6) e01602-15, e01602-15. doi: 10.1128/mBio.01602-15
2015
Journal Article
Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone
Ben Zakour, Nouri L., Davies, Mark R., You, Yuanhai, Chen, Jonathan H. K., Forde, Brian M., Stanton-Cook, Mitchell, Yang, Ruifu, Cui, Yujun, Barnett, Timothy C., Venturini, Carola, Ong, Cheryl-lynn Y., Tse, Herman, Dougan, Gordon, Zhang, Jianzhong, Yuen, Kwok-Yung, Beatson, Scott A. and Walker MJ (2015). Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone. Scientific Reports, 5 (1) 15877, 15877.1-15877.7. doi: 10.1038/srep15877
2015
Journal Article
Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae.
Zowawi, Hosam M., Forde, Brian M., Alfaresi, Mubarak, Alzarouni, Abdulqadir, Farahat, Yasser, Chong, Teik-Min, Yin, Wai-Fong, Chan, Kok-Gan, Li, Jian, Schembri, Mark A., Beatson, Scott A. and Paterson, David L. (2015). Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae.. Scientific Reports, 5 (Art No.: 15082) 15082, 15082. doi: 10.1038/srep15082
2015
Journal Article
Molecular characterization of the multidrug resistant escherichia coli ST131 clone
Schembri, Mark A., Ben Zakour, Nouri L., Minh-Duy Phan, Forde, Brian M., Stanton-Cook, Mitchell and Beatson, Scott A. (2015). Molecular characterization of the multidrug resistant escherichia coli ST131 clone. Pathogens, 4 (3), 422-430. doi: 10.3390/pathogens4030422
Funding
Current funding
Past funding
Supervision
Availability
- Dr Brian Forde is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Malaria and Infections Diseases in military personnel in the Asia Pacific Region
Principal Advisor
-
Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Principal Advisor
Other advisors: Dr Patrick Harris
-
Doctor Philosophy
Genomic and molecular characterisation of antibiotic resistance mechanisms
Principal Advisor
Other advisors: Professor Mark Schembri
-
Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Patrick Harris, Mr Mark Chatfield
-
Doctor Philosophy
A Multidisciplinary Approach to Identifying Novel Vaccine and Drug Targets of Non-Tuberculous Mycobacteria
Associate Advisor
Other advisors: Professor Nick West
-
Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Patrick Harris, Mr Mark Chatfield
Completed supervision
-
2022
Doctor Philosophy
Comparative Genomics of Extraintestinal Pathogenic Escherichia coli
Associate Advisor
Other advisors: Associate Professor Scott Beatson
-
2022
Doctor Philosophy
New approaches in visualising genomic data for surveillance and control of drug-resistant bacteria in healthcare settings
Associate Advisor
Other advisors: Associate Professor Scott Beatson
-
2019
Doctor Philosophy
Factors that influence Neisseria gonorrhoeae antimicrobial resistance and transmission in Australia
Associate Advisor
Other advisors: Associate Professor Scott Beatson, Associate Professor David Whiley
-
2019
Doctor Philosophy
Evolution and function of mobile genetic elements and DNA methyltransferases in extraintestinal pathogenic Escherichia coli
Associate Advisor
Other advisors: Associate Professor Scott Beatson
Media
Enquiries
For media enquiries about Dr Brian Forde's areas of expertise, story ideas and help finding experts, contact our Media team: