Overview
Background
Professor Grant Montgomery FAHMS FSRB Hon FRSNZ
Professor Montgomery was born in New Zealand, completed PhD studies in Animal Science at Massey University and post-doctoral research in France. In 1987, he co-founded the New Zealand Sheep Genomics Program in the Biochemistry Department at the University of Otago and pioneered the introduction of genome mapping methods in farm animals. He moved to Australia in 1999 and joined the Queensland Institute of Medical Research where he ran a successful genome mapping program for human complex disease. In 2016, he moved to the University of Queensland and holds joint appointments at the Institute for Molecular Bioscience (IMB) and the Queensland Brain Institute (QBI). He is a National Health and Medical Research Council Leadership Fellow and Director of the UQ Genome Innovation Hub. He was elected a Fellow the Society for Reproductive Biology in 2012, Fellow of the Australian Academy of Health and Medical Sciences in 2015, and Honorary Fellow of the Royal Society of New Zealand in 2016. His research focusses on discovery of critical genes and pathways increasing risk for common diseases especially reproductive diseases including endometriosis.
Availability
- Professor Grant Montgomery is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Massey University
Research impacts
Professor Montgomery has made substantial contributions to the worldwide effort to map genomic regions contributing to risk for complex traits and diseases, including endometriosis, age at menarche and menopause, cancers of the reproductive tract, melanoma and inflammatory bowel disease. He is conducting systems genetics and functional studies to identify the genes and pathways affected by these genetic risk factors. His work has identified possible target genes and functional consequences of genetic risk factors in genomic regions associated with endometriosis providing novel insights into the causes of this important disease. He lead a consortium of leading endometriosis clinicians and researchers in Australia awarded a MRFF Frontiers in Health and Medical Science to develop earlier diagnosis and personalised treatments for endometriosis. He is co-leader of International Endometriois Genetics Consortium, Patron of the Endometriosis Association (QLD) Inc (QENDO) and has worked closely with QENDO, other patient groups, clinicians and politicians to help develop the National Action Plan for Endometriosis. He is on the Executive Committee of the National Endometriosis Clinical and Scientific Trials (NECST) Network. He is also Director of the UQ Genome Innovation Hub developing novel methods and pipelines for genomics in health and agriculature that can be widely applied in programs across The University of Queensland.
Works
Search Professor Grant Montgomery’s works on UQ eSpace
Featured
2020
Journal Article
Tissue specific regulation of transcription in endometrium and association with disease
Mortlock, Sally, Kendarsari, Raden I., Fung, Jenny N., Gibson, Greg, Yang, Fei, Restuadi, Restuadi, Girling, Jane E., Holdsworth-Carson, Sarah J., Teh, Wan Tinn, Lukowski, Samuel W., Healey, Martin, Qi, Ting, Rogers, Peter A. W., Yang, Jian, McKinnon, Brett and Montgomery, Grant W. (2020). Tissue specific regulation of transcription in endometrium and association with disease. Human Reproduction, 35 (2), 377-393. doi: 10.1093/humrep/dez279
Featured
2019
Journal Article
Genotype-free demultiplexing of pooled single-cell RNA-seq
Xu, Jun, Falconer, Caitlin, Nguyen, Quan, Crawford, Joanna, McKinnon, Brett D., Mortlock, Sally, Senabouth, Anne, Andersen, Stacey, Chiu, Han Sheng, Jiang, Longda, Palpant, Nathan J., Yang, Jian, Mueller, Michael D., Hewitt, Alex W., Pébay, Alice, Montgomery, Grant W., Powell, Joseph E. and Coin, Lachlan J. M. (2019). Genotype-free demultiplexing of pooled single-cell RNA-seq. Genome Biology, 20 (1) 290, 290. doi: 10.1186/s13059-019-1852-7
Featured
2019
Journal Article
Should genetics now be considered the pre-eminent etiologic factor in endometriosis?
Montgomery, Grant W., Mortlock, Sally and Giudice, Linda C. (2019). Should genetics now be considered the pre-eminent etiologic factor in endometriosis?. Journal of Minimally Invasive Gynecology, 27 (2), 280-286. doi: 10.1016/j.jmig.2019.10.020
Featured
2019
Journal Article
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
Gallagher, C. S., Mäkinen, N., Harris, H. R., Rahmioglu, N., Uimari, O., Cook, J. P., Shigesi, N., Ferreira, T., Velez-Edwards, D. R., Edwards, T. L., Mortlock, S., Ruhioglu, Z., Day, F., Becker, C. M., Karhunen, V., Martikainen, H., Järvelin, M.-R., Cantor, R. M., Ridker, P. M., Terry, K. L., Buring, J. E., Gordon, S. D., Medland, S. E., Montgomery, G. W., Nyholt, D. R., Hinds, D. A., Tung, J. Y., Perry, J. R. B., Lind, P. A. ... Morton, C. C. (2019). Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. Nature Communications, 10 (1) 4857, 4857. doi: 10.1038/s41467-019-12536-4
Featured
2019
Journal Article
Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases
Mortlock, Sally, Restuadi, Restuadi, Levien, Rupert, Girling, Jane E., Holdsworth-Carson, Sarah J., Healey, Martin, Zhu, Zhihong, Qi, Ting, Wu, Yang, Lukowski, Samuel W., Rogers, Peter A. W., Yang, Jian, McRae, Allan F., Fung, Jenny N. and Montgomery, Grant W. (2019). Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases. Clinical Epigenetics, 11 (1) 49, 49. doi: 10.1186/s13148-019-0648-7
Featured
2019
Journal Article
Molecular support for heterogonesis resulting in sesquizygotic twinning
Gabbett, Michael T., Laporte, Johanna, Sekar, Renuka, Nandini, Adayapalam, McGrath, Pauline, Sapkota, Yadav, Jiang, Peiyong, Zhang, Haiqiang, Burgess, Trent, Montgomery, Grant W., Chiu, Rossa and Fisk, Nicholas M. (2019). Molecular support for heterogonesis resulting in sesquizygotic twinning. New England Journal of Medicine, 380 (9), 842-849. doi: 10.1056/nejmoa1701313
Featured
2019
Journal Article
Publisher correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
Duffy, David L., Zhu, Gu, Li, Xin, Sanna, Marianna, Iles, Mark M., Jacobs, Leonie C., Evans, David M., Yazar, Seyhan, Beesley, Jonathan, Law, Matthew H., Kraft, Peter, Visconti, Alessia, Taylor, John C., Liu, Fan, Wright, Margaret J., Henders, Anjali K., Bowdler, Lisa, Glass, Dan, Ikram, M. Arfan, Uitterlinden, André G., Madden, Pamela A., Heath, Andrew C., Nelson, Elliot C., Green, Adele C., Chanock, Stephen, Barrett, Jennifer H., Brown, Matthew A., Hayward, Nicholas K., MacGregor, Stuart ... Martin, Nicholas G. (2019). Publisher correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nature Communications, 10 (1) 299, 299. doi: 10.1038/s41467-018-08078-w
Featured
2018
Journal Article
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
Duffy, David L., Zhu, Gu, Li, Xin, Sanna, Marianna, Iles, Mark M., Jacobs, Leonie C., Evans, David M., Yazar, Seyhan, Beesley, Jonathan, Law, Matthew H., Kraft, Peter, Visconti, Alessia, Taylor, John C., Lui, Fan, Wright, Margaret J., Henders, Anjali K., Bowdler, Lisa, Glass, Dan, Ikram, Arfan M., Uitterlinden, André G., Madden, Pamela A., Heath, Andrew C., Nelson, Elliot C., Green, Adele C., Chanock, Stephen, Barrett, Jennifer H., Brown, Matthew A., Hayward, Nicholas K., MacGregor, Stuart ... Martin, Nicholas G. (2018). Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nature Communications, 9 (1) 4774, 4774. doi: 10.1038/s41467-018-06649-5
Featured
2018
Journal Article
Complex genetics of female fertility
Gajbhiye, Rahul, Fung, Jenny N. and Montgomery, Grant W. (2018). Complex genetics of female fertility. npj Genomic Medicine, 3 (1) 29, 29. doi: 10.1038/s41525-018-0068-1
Featured
2018
Journal Article
Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome
Fung, Jenny N., Mortlock, Sally, Girling, Jane E., Holdsworth-Carson, Sarah J., Teh, Wan Tinn, Zhu, Zhihong, Lukowski, Samuel W., McKinnon, Brett D., McRae, Allan, Yang, Jian, Healey, Martin, Powell, Joseph E., Rogers, Peter A. W. and Montgomery, Grant W (2018). Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome. Scientific Reports, 8 (1) 11424, 11424. doi: 10.1038/s41598-018-29462-y
Featured
2018
Journal Article
Genetics of endometriosis: state of the art on genetic risk factors for endometriosis
Fung, Jenny N. and Montgomery, Grant W. (2018). Genetics of endometriosis: state of the art on genetic risk factors for endometriosis. Best Practice & Research: Clinical Obstetrics & Gynaecology, 50, 61-71. doi: 10.1016/j.bpobgyn.2018.01.012
Featured
2017
Journal Article
The genetic regulation of transcription in human endometrial tissue
Fung, Jenny N., Girling, Jane E., Lukowski, Samuel W., Sapkota, Yadav, Wallace, Leanne, Holdsworth-Carson, Sarah J., Henders, Anjali K., Healey, Martin, Rogers, Peter A. W., Powell, Joseph E. and Montgomery, Grant W. (2017). The genetic regulation of transcription in human endometrial tissue. Human Reproduction, 32 (4), 893-904. doi: 10.1093/humrep/dex006
Featured
2017
Journal Article
The genetic architecture of gene expression in peripheral blood
Lloyd-Jones, Luke R., Holloway, Alexander, McRae, Allan, Yang, Jian, Small, Kerrin, Zeng, Biao, Bakshi, Andrew, Metspalu, Andres, Dermitzakis, Manolis, Gibson, Greg, Spector, Tim, Montgomery, Grant, Esko, Tonu, Visscher, Peter M. and Powell, Joseph E. (2017). The genetic architecture of gene expression in peripheral blood. American Journal of Human Genetics, 100 (2), 228-237. doi: 10.1016/j.ajhg.2016.12.008
Featured
2016
Journal Article
Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339
Powell, Joseph E., Fung, Jenny N., Shakhbazov, Konstantin, Sapkota, Yadav, Cloonan, Nicole, Hemani, Gibran, Hillman, Kristine M., Kaufmann, Susanne, Luong, Hien T., Bowdler, Lisa, Painter, Jodie N., Holdsworth-Carson, Sarah J., Visscher, Peter M., Dinger, Marcel E., Healey, Martin, Nyholt, Dale R., French, Juliet D., Edwards, Stacey L., Rogers, Peter A. W. and Montgomery, Grant W. (2016). Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339. Human Molecular Genetics, 25 (22), 5046-5058. doi: 10.1093/hmg/ddw320
Featured
2016
Journal Article
Five endometrial cancer risk loci identified through genome-wide association analysis
Cheng, Timothy H. T., Thompson, Deborah J., O'Mara, Tracy A., Painter, Jodie N., Glubb, Dylan M., Flach, Susanne, Lewis, Annabelle, French, Juliet D., Freeman-Mills, Luke, Church, David, Gorman, Maggie, Martin, Lynn, Hodgson, Shirley, Webb, Penelope M., Attia, John, Holliday, Elizabeth G., McEvoy, Mark, Scott, Rodney J., Henders, Anjali K., Martin, Nicholas G., Montgomery, Grant W., Nyholt, Dale R., Ahmed, Shahana, Healey, Catherine S., Shah, Mitul, Dennis, Joe, Fasching, Peter A., Beckmann, Matthias W., Hein, Alexander ... Spurdle, Amanda B. (2016). Five endometrial cancer risk loci identified through genome-wide association analysis. Nature Genetics, 48 (6), 667-674. doi: 10.1038/ng.3562
Featured
2016
Journal Article
Identification of common genetic variants influencing spontaneous dizygotic twinning and female fertility
Mbarek, Hamdi, Steinberg, Stacy, Nyholt, Dale R., Gordon, Scott D., Miller, Michael B., McRae, Allan F, Hottenga, Jouke Jan, Day, Felix R., Willemsen, Gonneke, de Geus, Eco J., Davies, Gareth E, Martin, Hilary C, Penninx, Brenda W, Jansen, Rick, McAloney, Kerrie, Vink, Jacqueline M., Kaprio, Jaakko, Plomin, Robert, Spector, Tim D., Magnusson, Patrik K., Reversade, Bruno, Harris, R. Alan, Aagaard, Kjersti, Kristjansson, Ragnar P., Olafsson, Isleifur, Eyjolfsson, Gudmundur Ingi, Sigurdardottir, Olof, Iacono, William G., Lambalk, Cornelis B ... Boomsman, Dorret I. (2016). Identification of common genetic variants influencing spontaneous dizygotic twinning and female fertility. American Journal of Human Genetics, 98 (5), 898-908. doi: 10.1016/j.ajhg.2016.03.008
Featured
2016
Journal Article
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
Zhu, Zhihong, Zhang, Futao, Hu, Han, Bakshi, Andrew, Robinson, Matthew R., Powell, Joseph E., Montgomery,Grant W., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2016). Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nature Genetics, 48 (5), 481-487. doi: 10.1038/ng.3538
Featured
2015
Journal Article
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Day, Felix R., Ruth, Katherine S., Thompson, Deborah J., Lunetta, Kathryn L., Pervjakova, Natalia, Chasman, Daniel I., Stolk, Lisette, Finucane, Hilary K., Sulem, Patrick, Bulik-Sullivan, Brendan, Esko, Tonu, Johnson, Andrew D., Elks, Cathy E., Franceschini, Nora, He, Chunyan, Altmaier, Elisabeth, Brody, Jennifer A., Franke, Lude L., Huffman, Jennifer E., Keller, Margaux F., McArdle, Patrick F., Nutile, Teresa, Porcu, Eleonora, Robino, Antonietta, Rose, Lynda M., Schick, Ursula M., Smith, Jennifer A., Teumer, Alexander, Traglia, Michela ... Murray, Anna (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47 (11), 1294-1305. doi: 10.1038/ng.3412
Featured
2015
Journal Article
Functional evaluation of genetic variants associated with endometriosis near GREB1
Fung, Jenny N., Holdsworth-Carson, Sarah J., Sapkota, Yadav, Zhao, Zhen Zhen, Jones, Lincoln, Girling, Jane E., Paiva, Premila, Healey, Martin, Nyholt, Dale R., Rogers, Peter A. W. and Montgomery, Grant W. (2015). Functional evaluation of genetic variants associated with endometriosis near GREB1. Human Reproduction, 30 (5), 1263-1275. doi: 10.1093/humrep/dev051
Featured
2015
Journal Article
Identifying the biological basis of GWAS hits for endometriosis
Fung, Jenny N., Rogers, Peter A. W. and Montgomery, Grant W. (2015). Identifying the biological basis of GWAS hits for endometriosis. Biology of Reproduction, 92 (4) 87. doi: 10.1095/biolreprod.114.126458
Funding
Current funding
Supervision
Availability
- Professor Grant Montgomery is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Investigating the relationship between Endometriosis and Cancer risk.
Associate Advisor
Other advisors: Dr Sally Mortlock
-
Doctor Philosophy
Exploring the role of clinical, lifestyle, environmental and molecular factors in endometriosis risk
Associate Advisor
Other advisors: Dr Allan McRae, Dr Sally Mortlock
-
Doctor Philosophy
Regulation of the endocannabinoid system in the endometrium across menstrual cycle and implications in endometriosis
Associate Advisor
Other advisors: Dr Brett McKinnon, Dr Akwasi Amoako
-
Master Philosophy
Spatial resolved analysis of endometrial tissue
Associate Advisor
Other advisors: Dr Brett McKinnon
Completed supervision
-
2023
Doctor Philosophy
Regulation of transcription in human endometrium and endometriosis
Principal Advisor
Other advisors: Dr Sally Mortlock
-
2023
Doctor Philosophy
Investigation of both epidemiological and genetic risk factors for endometriosis: novel insights and important clinical implications
Principal Advisor
Other advisors: Dr Sally Mortlock
-
-
2016
Doctor Philosophy
Complex trait genetics: mapping, correlation and causation
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
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2012
Doctor Philosophy
Various approaches to identify breast cancer susceptibility genes.
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna
-
2008
Doctor Philosophy
The Aetiology of Obsesity in Australian Families
Associate Advisor
Other advisors: Professor Nick Martin
Media
Enquiries
Contact Professor Grant Montgomery directly for media enquiries about:
- Endometriosis
- Genetics
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