Overview
Background
Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research Institute - the University of Queensland, Brisbane, Australia.
A/Prof Winkler’s research focuse is understanding how micro-environments in the body protect and control normal and/or malignant stem Cells. Her innovative stem cell niche research has been recognised as among ten of the best research projects in Australia (by National Health and Medical Research Council) with patents and clinical translation.
A/Prof Winker's current research explores how stem cell niches change with ageing, inflammation, cancer therapy or radiation damage, with view to identify key detrimental niche components involved. This knowledge may be used to develop novel treatment strategies to improve cancer therapy outcomes, alleviate adverse cancer therapy side-effects that currently affect up tp 80% of Australian cancer therapy patientts plus facilitate healthier old age.
Availability
- Dr Ingrid Winkler is:
- Available for supervision
Research impacts
A/Prof's research on how normal and malignant cells alter their local environment (niches) was at the forefront of this new field. The identification of mechanisms by which normal and malignant cells change their niche, enabled these components to be therapeutically targeted leading to high impact manuscripts, industry partnerships and clinical translation with large Phase 2/3 clinical trials ongoing.
Works
Search Professor Ingrid Winkler’s works on UQ eSpace
2013
Conference Publication
Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/8o+VCAM1+ER-HR3+CD169+Erythroid-Island Macrophages
Jacobsen, Rebecca, Pettit, Allison R., Raggatt, Liza J., Nowlan, Bianca, Barbier, Valerie, Forristal, Catherine E., Winkler, Ingrid G. and Levesque, Jean-Pierre (2013). Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/8o+VCAM1+ER-HR3+CD169+Erythroid-Island Macrophages. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, United States, 7-10 December 2013. WASHINGTON: AMER SOC HEMATOLOGY.
2012
Conference Publication
FG-4497, a Pharmacological Stabilizer of HIF-1 alpha Protein, Synergistically Enhances Hematopoietic Stem Cells (HSC) Mobilization in Response to G-CSF and Plerixafor
Forristal, Catherine E., Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid G., Walkinshaw, Gail and Levesque, Jean-Pierre (2012). FG-4497, a Pharmacological Stabilizer of HIF-1 alpha Protein, Synergistically Enhances Hematopoietic Stem Cells (HSC) Mobilization in Response to G-CSF and Plerixafor. 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, United States, 8-11 December 2012. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V120.21.216.216
2012
Journal Article
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
Winkler, Ingrid G., Barbier, Valerie, Nowlan, Bianca, Jacobsen, Rebecca N., Forristal, Catherine E., Patton, John T., Magnani, John L. and Levesque, Jean-Pierre (2012). Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nature Medicine, 18 (11), 1651-1657. doi: 10.1038/nm.2969
2012
Journal Article
Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation
Winkler, I. G., Pettit, A. R., Raggatt, L. J., Jacobsen, R. N., Forristal, C. E., Barbier, V., Nowlan, B., Cisterne, A., Bendall, L. J., Sims, N. A. and Levesque, J-P. (2012). Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia, 26 (7), 1594-1601. doi: 10.1038/leu.2012.17
2012
Book Chapter
Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells
Barbier, Valérie, Nowlan, Bianca, Lévesque, Jean-Pierre and Winkler, Ingrid G. (2012). Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells. Leucocytes: methods and protocols. (pp. 31-43) edited by Ashman, RB. New York, United States: Humana Press. doi: 10.1007/978-1-61779-527-5_3
2012
Book Chapter
Mobilization of hematopoietic stem cells by depleting bone marrow macrophages
Barbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Paul (2012). Mobilization of hematopoietic stem cells by depleting bone marrow macrophages. In Stem cell mobilization: methods and protocols (pp. 117-137) New York, United States: Humana Press. doi:10.1007/978-1-61779-943-3_11
2012
Conference Publication
Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia by human AML oncogenes, and represents a potential therapeutic target
Pattabiraman, Diwakar R., Shakhbazov, Konstantin, Barbier, Valerie, McGirr, Crystal, Krishnan, Keerthana, Mukhopadhyay, Pamela, Hawthorne, Paula, Trezise, Ann, Grimmond, Sean, Papathanasiou, Peter, Perkins, Andrew C., Levesque, Jean-Pierre, Alexander, Warren S., Winkler, Ingrid G. and Gonda, Thomas J. (2012). Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia by human AML oncogenes, and represents a potential therapeutic target. 54th Annual Meeting and Exposition of the American Society of Hematology (ASH), Atlanta, GA, United States, 8-11 Deceember, 2012. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V120.21.2402.2402
2012
Book Chapter
Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo
Barbier, Valérie, Winkler, Ingrid G., Wadley, Robert and Lévesque, Jean-Pierre (2012). Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo. Leucocytes: methods and protocols. (pp. 45-63) edited by Ashman, RB. New York, United States: Humana Press. doi: 10.1007/978-1-61779-527-5_4
2012
Conference Publication
Hypoxia and E-selectin are opposite regulators of hematopoietic stem cell quiescence in the niche
Levesque, Jean-Pierre, Forristal, Catherine and Winkler, Ingrid (2012). Hypoxia and E-selectin are opposite regulators of hematopoietic stem cell quiescence in the niche. 41st Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Amsterdam Netherlands, 23-26 August 2012. Philadelphia, PA United States: Elsevier.
2011
Conference Publication
Impairment of Hematopoietic Stem Cell (HSC) Niche by G-CSF Is Associated with Rapid Mobilization of Serially Reconstituting HSC and Reduced Competitive Repopulation of Mobilized Bone Marrow
Levesque, Jean-Pierre, Barbier, Valerie, Nowlan, Bianca, McCarhty, Domenica and Winkler, Ingrid G. (2011). Impairment of Hematopoietic Stem Cell (HSC) Niche by G-CSF Is Associated with Rapid Mobilization of Serially Reconstituting HSC and Reduced Competitive Repopulation of Mobilized Bone Marrow. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology.
2011
Conference Publication
Oxygen-Independent Stabilization of the Oxygen-Labile Transcription Factor HIF-1 alpha with Dimethyloxalyl Glycine or FG-4497 Increases Hematopoietic Stem Cell Quiescence In Vivo and Mobilization in Response to G-CSF
Forristal, Catherine, Nowlan, Bianca, Barbier, Valerie, McCarthy, Domenica, Walkinshaw, Gail, Winkler, Ingrid G. and Levesque, Jean-Pierre (2011). Oxygen-Independent Stabilization of the Oxygen-Labile Transcription Factor HIF-1 alpha with Dimethyloxalyl Glycine or FG-4497 Increases Hematopoietic Stem Cell Quiescence In Vivo and Mobilization in Response to G-CSF. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology.
2011
Journal Article
Mobilisation strategies for normal and malignant cells
To, L. Bik, Levesque, Jean-Pierre, Herbert, Kirsten E., Winkler, Ingrid G., Bendall, Linda J., Hiwase, Devendra K., Antonenas, Vicki, Rice, Alison M., Gottlieb, David, Mills, Anthony K., Rasko, John E. J., Larsen, Stephen, Beligaswatte, Ashanka, Nilsson, Susan K., Cooney, Julian P., Cambareri, Antony C. and Lewis, Ian D. (2011). Mobilisation strategies for normal and malignant cells. Pathology, 43 (6), 547-565. doi: 10.1097/PAT.0b013e32834a9eb8
2011
Journal Article
Hierarchy of immature hematopoietic cells related to blood flow and niche
Levesque, Jean-Pierre and Winkler, Ingrid G. (2011). Hierarchy of immature hematopoietic cells related to blood flow and niche. Current Opinion in Hematology, 18 (4), 220-225. doi: 10.1097/MOH.0b013e3283475fe7
2011
Conference Publication
Mobilizing agents G-CSF, cyclophosphamide or AMD3100 (Plerixafor) Have distinct effects on osteoblasts, hematopoietic stem cell niches, and B-Lymphopoiesis
Levesque, Jean-Pierre, Bendall, Linda J., Pettit, Allison R., Raggatt, Liza, Jacobsen, Rebecca, Barbier, Valarie, Nowlan, Bianca, Shen, Yi Shen, Sims, Natalie A. and Winkler, Ingrid G. (2011). Mobilizing agents G-CSF, cyclophosphamide or AMD3100 (Plerixafor) Have distinct effects on osteoblasts, hematopoietic stem cell niches, and B-Lymphopoiesis. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology.
2010
Journal Article
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
Winkler, Ingrid G., Sims, Natalie A., Pettit, Allison R., Barbier, Valérie, Nowlan, Bianca, Helwani, Falak, Poulton, Ingrid J., van Rooijen, Nico van, Alexander, Kylie A., Raggatt, Liza J. and Levesque, Jean-Pierre (2010). Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood, 116 (23), 4815-4828. doi: 10.1182/blood-2009-11-253534
2010
Journal Article
Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo
Shen, Yi, Winkler, Ingrid G., Barbier, Valerie, Sims, Natalie A., Hendy, Jean and Lévesque, Jean-Pierre (2010). Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo. PLoS One, 5 (9) e13086, e13086-1-e13086-13. doi: 10.1371/journal.pone.0013086
2010
Conference Publication
A molecular profile of the hematopoietic stem cell niche at the endosteum
Helwani, F., Winkler, I., Price, G. and Levesque, J. P. (2010). A molecular profile of the hematopoietic stem cell niche at the endosteum. 39th Annual Scientific Meeting of the ISEH - Society for Hematology and Stem Cells, Melbourne, VIC, Australia, 15-18 September 2010. Philadelphia, PA, United States: Elsevier.
2010
Conference Publication
The role of tissue inhibitor of metalloproteinase-3 (TIMP-3) in hematopoiesis
Shen, Y., Barbier, V., Winkler, I., Sims, N., Hendy, J. and Levesque, J. P. (2010). The role of tissue inhibitor of metalloproteinase-3 (TIMP-3) in hematopoiesis. 39th Annual Scientific Meeting of the ISEH - Society for Hematology and Stem Cells, Melbourne, VIC, Australia, 15-18 September 2010. Philadelphia, PA, United States: Elsevier.
2010
Journal Article
Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: Serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches
Winkler, Ingrid G., Barbier, Valérie, Wadley, Robert, Zannettino, Andrew C. W., Williams, Sharon and Lévesque, Jean-Pierre (2010). Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: Serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood, 116 (3), 375-385. doi: 10.1182/blood-2009-07-233437
2010
Conference Publication
Co-culture maintenance of functional haematopoietic stem cells and expansion of their progeny
Cook, M., Brooke, G., Doran, M., Winkler, I., Levesque, J. P. and Atkinson, K. (2010). Co-culture maintenance of functional haematopoietic stem cells and expansion of their progeny. 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, Vienna Austria, Mar 21-24, 2010. LONDON: NATURE PUBLISHING GROUP.
Funding
Current funding
Supervision
Availability
- Dr Ingrid Winkler is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Reducing long-term side-effects of chemotherapy in cancer survivors
Associate Advisor
Other advisors: Dr Hana Starobova, Professor Irina Vetter
-
Doctor Philosophy
Understanding pain mechanisms in the path towards target-specific analgesic agent design
Associate Advisor
Other advisors: Dr Hana Starobova, Professor Irina Vetter
Completed supervision
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2024
Doctor Philosophy
Immune cell regulation by the microenvironment
Principal Advisor
Other advisors: Honorary Professor Kristen Radford, Dr Hana Starobova
-
-
2019
Doctor Philosophy
The role of bone marrow niches in the regulation of normal and malignant haematopoietic stem cells
Principal Advisor
Other advisors: Professor Jean-Pierre Levesque
-
2017
Doctor Philosophy
The role of prostaglandin I2 in haematopoietic stem cell in the bone marrow niche
Principal Advisor
Other advisors: Professor Jean-Pierre Levesque
-
2015
Doctor Philosophy
Understanding heterotopic ossification after spinal cord injury
Principal Advisor
Other advisors: Professor Jean-Pierre Levesque
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2023
Doctor Philosophy
Unravelling the response and functional role of microglia in different inflammatory conditions
Associate Advisor
Other advisors: Professor Marc Ruitenberg, Associate Professor Jana Vukovic
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2022
Doctor Philosophy
Establishing Humanized Mouse Models to Evaluate Immunotherapy
Associate Advisor
Other advisors: Dr Camille Guillerey, Honorary Professor Kristen Radford
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2021
Doctor Philosophy
The Role of Macrophages in Acute Myeloid Leukaemia Progression and Sensitivity to Chemotherapy
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
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2015
Doctor Philosophy
Role of Bone Marrow Macrophages in Regulating Haematopoiesis
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
-
2011
Doctor Philosophy
The Role of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in Haematopoiesis
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
Media
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