Dr Ingrid Winkler
Dr

Ingrid Winkler

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Background

Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research Institute - the University of Queensland, Brisbane, Australia.

A/Prof Winkler’s research focuse is understanding how micro-environments in the body protect and control normal and/or malignant stem Cells. Her innovative stem cell niche research has been recognised as among ten of the best research projects in Australia (by National Health and Medical Research Council) with patents and clinical translation.

A/Prof Winker's current research explores how stem cell niches change with ageing, inflammation, cancer therapy or radiation damage, with view to identify key detrimental niche components involved. This knowledge may be used to develop novel treatment strategies to improve cancer therapy outcomes, alleviate adverse cancer therapy side-effects that currently affect up tp 80% of Australian cancer therapy patientts plus facilitate healthier old age.

Availability

Dr Ingrid Winkler is:
Available for supervision

Research impacts

A/Prof's research on how normal and malignant cells alter their local environment (niches) was at the forefront of this new field. The identification of mechanisms by which normal and malignant cells change their niche, enabled these components to be therapeutically targeted leading to high impact manuscripts, industry partnerships and clinical translation with large Phase 2/3 clinical trials ongoing.

Search Professor Ingrid Winkler’s works on UQ eSpace

124 works between 1976 and 2025
All (124) Journal Article (60) Conference Publication (58) Book Chapter (6)

101 - 120 of 124 works

2006

Conference Publication

Increased hypoxia, HIF-1 alpha protein and VEGF transcripts in bone marrow mobilized with G-CSF or cyclophosphamide (CY)

Levesque, Jean-Pierre, Winkler, Ingrid G., Hendy, Jean and Nilsson, Susan K. (2006). Increased hypoxia, HIF-1 alpha protein and VEGF transcripts in bone marrow mobilized with G-CSF or cyclophosphamide (CY). 48th Annual Meeting of the American Society of Hematology, Orlando, FL United States, 9-12 December 2006. Washington, DC United States: American Society of Hematology.

Increased hypoxia, HIF-1 alpha protein and VEGF transcripts in bone marrow mobilized with G-CSF or cyclophosphamide (CY)

2005

Conference Publication

G-CSF potently suppresses osteoblast activity in the bone marrow

Christopher, M. J., Liu, F., Short, B., Simmons, P. J., Winkler, I., Levesque, J. P. and Link, D. C. (2005). G-CSF potently suppresses osteoblast activity in the bone marrow. 47th Annual Meeting of the American-Society-of-Hematology, Atlanta, GA, United States, 10-13 December 2005. Washington, DC, United States: American Society of Hematology.

G-CSF potently suppresses osteoblast activity in the bone marrow

2005

Conference Publication

The inhibition of the osteoblast niche during hematopoietic stem cell mobilization is an indirect effect involving mature bone marrow leukocytes, IL6 and soluble IL6 receptor

Levesque, JP, Winkler, IG, Sims, N, Morris, H, Simmons, PJ and Takamatsu, Y (2005). The inhibition of the osteoblast niche during hematopoietic stem cell mobilization is an indirect effect involving mature bone marrow leukocytes, IL6 and soluble IL6 receptor. 47th Annual Meeting of the American-Society-of-Hematology, Atlanta Ga, Dec 10-13, 2005. WASHINGTON: AMER SOC HEMATOLOGY. doi: 10.1182/blood.V106.11.1966.1966

The inhibition of the osteoblast niche during hematopoietic stem cell mobilization is an indirect effect involving mature bone marrow leukocytes, IL6 and soluble IL6 receptor

2005

Journal Article

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization

Winkler, IG, Hendy, J, Coughlin, P, Horvath, A and Levesque, JP (2005). Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. Journal of Experimental Medicine, 201 (7), 1077-1088. doi: 10.1084/jem.20042299

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization

2005

Journal Article

Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells

Eto, Tetsuya, Winkler, Ingrid, Purton, Louise E. and Levesque, Jean-Pierre (2005). Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells. Experimental Hematology, 33 (2), 232-242. doi: 10.1016/j.exphem.2004.10.018

Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells

2005

Journal Article

G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow

Semerad, CL, Christopher, MJ, Liu, FL, Short, B, Simmons, PJ, Winkler, I, Levesque, JP, Chappel, J, Ross, FP and Link, DC (2005). G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood, 106 (9), 3020-3027. doi: 10.1182/blood-2004-01-0272

G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow

2004

Conference Publication

Protease-dependent and protease-independent mechanisms of hematopoietic progenitor cell (HPC) mobilization

Levesque, JP, Liu, F, Winkler, IG, Simmons, PJ, Betsuyaku, T, Senior, R, Pham, C and Link, DC (2004). Protease-dependent and protease-independent mechanisms of hematopoietic progenitor cell (HPC) mobilization. 33rd Annual Meeting of the International Society for Experimental Hematology, New Orleans, LA, United States, 17-20 July 2004. Philadelphia, PA, United States: Elsevier.

Protease-dependent and protease-independent mechanisms of hematopoietic progenitor cell (HPC) mobilization

2004

Journal Article

Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1

Winkler, IG, Snapp, KR, Simmons, PJ and Levesque, JP (2004). Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1. Blood, 103 (5), 1685-1692. doi: 10.1182/blood-2003-06-1921

Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1

2003

Conference Publication

P-selectin delays the in vitro differentiation of murine lin- Sca-1+c-KIT+ cells whereas E-selectin accelerates their differentiation

Eto, T, Winkler, , Purton, L, Simmons, P and Levesque, JP (2003). P-selectin delays the in vitro differentiation of murine lin- Sca-1+c-KIT+ cells whereas E-selectin accelerates their differentiation. 32nd Annual Scientific Meeting of the International Society for Experimental Hematology, Paris, France, 5-8 July 2003. Philadelphia, PA, United States: Elsevier.

P-selectin delays the in vitro differentiation of murine lin- Sca-1+c-KIT+ cells whereas E-selectin accelerates their differentiation

2003

Journal Article

Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells

Levesque, JP, Hendy, J, Winkler, IG, Takamatsu, Y and Simmons, PJ (2003). Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells. Experimental Hematology, 31 (2), 109-117. doi: 10.1016/S0301-472X(02)01028-7

Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells

2002

Conference Publication

Proteases that cleave c-KIT receptor (CD117) from the surface of hemopoietic progenitor cells are released in the bone marrow during G-CSF-induced mobilization

Levesque, J. P., Hendy, J., Winkler, I. G., Takamatsu, Y. and Simmons, P. J. (2002). Proteases that cleave c-KIT receptor (CD117) from the surface of hemopoietic progenitor cells are released in the bone marrow during G-CSF-induced mobilization. 44th Annual Meeting of the American-Society-of-Hematology, Philadelphia, PA, United States, 6-10 December 2002. Washington, DC, United States: American Society of Hematology.

Proteases that cleave c-KIT receptor (CD117) from the surface of hemopoietic progenitor cells are released in the bone marrow during G-CSF-induced mobilization

2002

Journal Article

Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment

Levesque, JP, Hendy, J, Takamatsu, Y, Williams, B, Winkler, IG and Simmons, PJ (2002). Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Experimental Hematology, 30 (5), 440-449. doi: 10.1016/S0301-472X(02)00788-9

Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment

2001

Conference Publication

Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells

Winkler, IG, Eto, T, Purton, LE, Haylock, DN, Snapp, KR, Kansas, GS, Simmons, PJ and Levesque, JP (2001). Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells. Unknown, Unknown, Unknown. Washington, DC United States: American Society of Hematology.

Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells

2001

Conference Publication

VCAM-1 cleavage and release of neutrophil serine proteases elastase and cathepsin G in the bone marrow are common features of hemopoietic progenitor cell mobilization induced by G-CSF or chemotherapy

Levesque, J. P., Hendy, J., Takamatsu, Y., Williams, B., Winkler, I. G. and Simmons, P. J. (2001). VCAM-1 cleavage and release of neutrophil serine proteases elastase and cathepsin G in the bone marrow are common features of hemopoietic progenitor cell mobilization induced by G-CSF or chemotherapy. *, *, *. Washington, DC, United States: American Society of Hematology.

VCAM-1 cleavage and release of neutrophil serine proteases elastase and cathepsin G in the bone marrow are common features of hemopoietic progenitor cell mobilization induced by G-CSF or chemotherapy

2000

Journal Article

Construction of infectious feline foamy virus genomes: Cat antisera do not cross-neutralize feline foamy virus chimera with serotype-specific env sequences

Zemba, M, Alke, A, Bodem, J, Winkler, IG, Flower, RLP, Pfrepper, KI, Delius, H, Flugel, RM and Lochelt, M (2000). Construction of infectious feline foamy virus genomes: Cat antisera do not cross-neutralize feline foamy virus chimera with serotype-specific env sequences. Virology, 266 (1), 150-156. doi: 10.1006/viro.1999.0037

Construction of infectious feline foamy virus genomes: Cat antisera do not cross-neutralize feline foamy virus chimera with serotype-specific env sequences

2000

Journal Article

Antibody to human foamy virus not detected in individuals treated with blood products or in blood donors

Winkler, IG, Flugel, RM, Asikainen, K and Flower, RLP (2000). Antibody to human foamy virus not detected in individuals treated with blood products or in blood donors. Vox Sanguinis, 79 (2), 118-119. doi: 10.1046/j.1423-0410.2000.79201182.x

Antibody to human foamy virus not detected in individuals treated with blood products or in blood donors

1999

Conference Publication

Detection of gene conversion associated with Miltenberger blood group polymorphisms

Woodland, NB, Flower, RL and Winkler, IG (1999). Detection of gene conversion associated with Miltenberger blood group polymorphisms. BETHESDA: AMER ASSOC BLOOD BANKS.

Detection of gene conversion associated with Miltenberger blood group polymorphisms

1999

Journal Article

Epidemiology of feline foamy virus and feline immunodeficiency virus infections in domestic and feral cats: a seroepidemiological study

Winkler, IG, Lochelt, M and Flower, RLP (1999). Epidemiology of feline foamy virus and feline immunodeficiency virus infections in domestic and feral cats: a seroepidemiological study. Journal of Clinical Microbiology, 37 (9), 2848-2851. doi: 10.1128/JCM.37.9.2848-2851.1999

Epidemiology of feline foamy virus and feline immunodeficiency virus infections in domestic and feral cats: a seroepidemiological study

1998

Journal Article

Detection and molecular characterisation of feline foamy virus serotypes in naturally infected cats

Winkler, IG, Flugel, RM, Lochelt, M and Flower, RLP (1998). Detection and molecular characterisation of feline foamy virus serotypes in naturally infected cats. Virology, 247 (2), 144-151. doi: 10.1006/viro.1998.9232

Detection and molecular characterisation of feline foamy virus serotypes in naturally infected cats

1997

Journal Article

Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses (vol 70, pg 9027, 1996)

Bodem, J, Lochelt, M, Winkler, , Flower, RP, Delius, H and Flugel, RM (1997). Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses (vol 70, pg 9027, 1996). Journal of Virology, 71 (11), 8952-8952.

Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses (vol 70, pg 9027, 1996)

Past funding

  • 2022 - 2024
    Reducing long-term side-effects of chemotherapy in cancer survivors
    The Kid's Cancer Project
    Open grant
  • 2021 - 2022
    New immunotherapeutics for Acute Myeloid Leukemia
    TdC Senior Research Grant
    Open grant
  • 2020 - 2022
    Unleashing natural killer cell activity against childhood leukemia
    The Children's Hospital Foundation
    Open grant
  • 2020 - 2022
    New strategies to alleviate the effects of chemotherapy in children with leukemia
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2021
    Helping damaged brains recover
    Mater Misericordiae Ltd
    Open grant
  • 2018 - 2020
    Colony-stimulating factor 1 receptor tyrosine kinase, a new target to treat acute myeloid leukemia
    Cancer Council Queensland
    Open grant
  • 2018 - 2020
    Increasing haematopoietic stem cell mobilisation by targeting a novel niche factor
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Mechanisms by which Endothelial Selectins regulate Normal and Malignant Stem Cell fate
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Niche regulation of normal and malignant stem cells
    NHMRC Research Fellowship
    Open grant
  • 2015 - 2018
    Haematopoietic Stem Cell glycome regulates outcome of niche interactions
    NHMRC Project Grant
    Open grant
  • 2014 - 2015
    A new approach to tackling chemotherapy-induced mucositis
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    NHMRC Career Development Fellowship (CDF Level 2): Manipulation of haematopoietic stem cell niches to improve therapeutic outcomes
    NHMRC Career Development Fellowship
    Open grant
  • 2013 - 2016
    Role of bone marrow cells in leukemia progression and resistance to chemotherapy
    NHMRC Project Grant
    Open grant
  • 2013
    Characterisation and manipulation of bone marrow niche factors regulating acute myeloid leukaemia stem cell fate
    Cancer Council Queensland
    Open grant

Availability

Dr Ingrid Winkler is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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