Dr Ingrid Winkler
Dr

Ingrid Winkler

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Background

Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research Institute - the University of Queensland, Brisbane, Australia.

A/Prof Winkler’s research focuse is understanding how micro-environments in the body protect and control normal and/or malignant stem Cells. Her innovative stem cell niche research has been recognised as among ten of the best research projects in Australia (by National Health and Medical Research Council) with patents and clinical translation.

A/Prof Winker's current research explores how stem cell niches change with ageing, inflammation, cancer therapy or radiation damage, with view to identify key detrimental niche components involved. This knowledge may be used to develop novel treatment strategies to improve cancer therapy outcomes, alleviate adverse cancer therapy side-effects that currently affect up tp 80% of Australian cancer therapy patientts plus facilitate healthier old age.

Availability

Dr Ingrid Winkler is:
Available for supervision

Research impacts

A/Prof's research on how normal and malignant cells alter their local environment (niches) was at the forefront of this new field. The identification of mechanisms by which normal and malignant cells change their niche, enabled these components to be therapeutically targeted leading to high impact manuscripts, industry partnerships and clinical translation with large Phase 2/3 clinical trials ongoing.

Search Professor Ingrid Winkler’s works on UQ eSpace

117 works between 1976 and 2024
All (117) Journal Article (59) Book Chapter (6) Conference Publication (52)

41 - 60 of 117 works

2016

Conference Publication

Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation

Kaur, S., Raggatt, L. J., Jacobsen, R. N., Millard, S., Batoon, L., Winkler, I. G., Macdonald, K. P. A., Perkins, A. C., Hume, D. A., Levesque, J. P. and Pettit, A. R. (2016). Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation

2015

Journal Article

Tissue engineered humanized bone supports human hematopoiesis in vivo

Holzapfel, Boris M., Hutmacher, Dietmar W., Nowlan, Bianca, Barbier, Valerie, Thibaudeau, Laure, Theodoropoulos, Christina, Hooper, John D., Loessner, Daniela, Clements, Judith A., Russell, Pamela J., Pettit, Allison R., Winkler, Ingrid G. and Levesque, Jean-Pierre (2015). Tissue engineered humanized bone supports human hematopoiesis in vivo. Biomaterials, 61, 103-114. doi: 10.1016/j.biomaterials.2015.04.057

Tissue engineered humanized bone supports human hematopoiesis in vivo

2015

Journal Article

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle

Genet, Francois, Kulina, Irina, Vaquette, Cedryck, Torossian, Frederic, Millard, Susan, Pettit, Allison R., Sims, Natalie A., Anginot, Adrienne, Guerton, Bernadette, Winkler, Ingrid G., Barbier, Valerie, Lataillade, Jean-Jacques, Le Bousse-Kerdiles, Marie-Caroline, Hutmacher, Dietmar W. and Levesque, Jean-Pierre (2015). Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle. Journal of Pathology, 236 (2), 229-240. doi: 10.1002/path.4519

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle

2015

Journal Article

Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML

Forristal, C. E., Brown, A. L., Helwani, F. M., Winkler, I. G., Nowlan, B., Barbier, V., Powell, R. J., Engler, G. A., Diakiw, S. M., Zannettino, A. C. W., Martin, S., Pattabiraman, D., D'Andrea, R. J., Lewis, I. D. and Levesque, J. P. (2015). Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia, 29 (10), 2075-2085. doi: 10.1038/leu.2015.102

Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML

2015

Journal Article

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α

Forristal, C. E., Nowlan, B., Jacobsen, R. N., Barbier, V., Walkinshaw, G., Walkley, C. R., Winkler, I. G. and Levesque, J. P. (2015). HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α. Leukemia, 29 (6), 1366-1378. doi: 10.1038/leu.2015.8

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α

2015

Conference Publication

Mobilization of CD8(+) Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade

Winkler, Ingrid G., Barbier, Valerie, Radford, Kristen J., Davies, Julie M., Levesque, Jean-Pierre, Smith, Theodore A. G., Fogler, William E. and Magnani, John L. (2015). Mobilization of CD8(+) Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade. 57th Annual Meeting of the American Society of Hematology, Orlando, FL United States, 5-8 December 2015. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V126.23.512.512

Mobilization of CD8(+) Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade

2015

Conference Publication

Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages

Kaur, Simranpreet, Raggatt, Liza J., Jacobsen, Rebecca, Millard, Susan, Barbier, Valerie, Nowlan, Bianca, Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean P. and Pettit, Allison R. (2015). Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages. 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto, Japan, 17-19 September 2015. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2015.06.157

Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages

2014

Conference Publication

Bacterial liposaccharides block medullary erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+LY-6G+ Erythroid island macrophages in the bone marrow

Jacobsen, Rebecca, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid and Levesque, Jean-Pierre (2014). Bacterial liposaccharides block medullary erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+LY-6G+ Erythroid island macrophages in the bone marrow. 43rd Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), Montreal, Canada, 21-24 August 2014. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2014.07.147

Bacterial liposaccharides block medullary erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+LY-6G+ Erythroid island macrophages in the bone marrow

2014

Journal Article

Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse

Jacobsen, Rebecca N., Forristal, Catherine E., Raggatt, Liza J., Nowlan, Bianca, Barbier, Valerie, Kaur, Simranpreet, van Rooijen, Nico, Winkler, Ingrid G., Pettit, Allison R. and Levesque, Jean-Pierre (2014). Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse. Experimental Hematology, 42 (7), 547-561. doi: 10.1016/j.exphem.2014.03.009

Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse

2014

Journal Article

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

Pattabiraman, Diwakar R., McGirr, Crystal, Shakhbazov, Konstantin, Barbier, Valerie, Krishnan, Keerthana, Mukhopadhyay, Pamela, Hawthorne, Paula, Trezise, Ann, Ding, Jianmin, Grimmond, Sean M., Papathanasiou, Peter, Alexander, Warren S., Perkins, Andrew C., Levesque, Jean-Pierre, Winkler, Ingrid G. and Gonda, Thomas J. (2014). Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes. Blood, 123 (17), 2682-2690. doi: 10.1182/blood-2012-02-413187

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

2014

Conference Publication

Vascular Niche E-Selectin Protects Acute Myeloid Leukaemia Stem Cells from Chemotherapy

Winkler, Ingrid G., Barbier, Valerie, Pattabiraman, Diwakar R., Gonda, Thomas J., Magnani, John L. and Levesque, Jean-Pierre (2014). Vascular Niche E-Selectin Protects Acute Myeloid Leukaemia Stem Cells from Chemotherapy. 56th Annual Meeting of the American Society of Hematology, San Francisco CA, United States, 6-9 December 2014. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V124.21.620.620

Vascular Niche E-Selectin Protects Acute Myeloid Leukaemia Stem Cells from Chemotherapy

2014

Conference Publication

Mobilisation of Reconstituting HSC Is Boosted By Synergy Between G-CSF and E-Selectin Antagonist GMI-1271

Winkler, Ingrid G., Barbier, Valerie, Perkins, Andrew C., Magnani, John L. and Levesque, Jean-Pierre (2014). Mobilisation of Reconstituting HSC Is Boosted By Synergy Between G-CSF and E-Selectin Antagonist GMI-1271. 56th Annual Meeting of the American Society of Hematology, San Francisco, CA United States, 6-9 December 2014. Washington, DC United States: American Society of Hematology.

Mobilisation of Reconstituting HSC Is Boosted By Synergy Between G-CSF and E-Selectin Antagonist GMI-1271

2013

Conference Publication

Hypoxia Inducible Factor (HIF)-2 alpha Enhances Proliferation Of Malignant Hematopoietic Cells In The Hypoxic Malignant Bone Marrow

Forristal, Catherine E., Helwani, Falak, Martin, Sally, Nowlan, Bianca, Winkler, Ingrid G., Zannettino, Andrew and Levesque, Jean-Pierre (2013). Hypoxia Inducible Factor (HIF)-2 alpha Enhances Proliferation Of Malignant Hematopoietic Cells In The Hypoxic Malignant Bone Marrow. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, United States, 7-10 December 2013. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V122.21.2895.2895

Hypoxia Inducible Factor (HIF)-2 alpha Enhances Proliferation Of Malignant Hematopoietic Cells In The Hypoxic Malignant Bone Marrow

2013

Conference Publication

Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery

Winkler, Ingrid G., Barbier, Valerie, Nutt, Heather L., Hasnain, Sumaira Z., Levesque, Jean-Pierre, Magnani, John L. and McGuckin, Michael A. (2013). Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans La, Dec 07-10, 2013. WASHINGTON: AMER SOC HEMATOLOGY.

Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery

2013

Conference Publication

Pharmacological stabilization of hypoxia-inducible factor-1α (HIF-1α) enhances hematopoietic stem cell mobilization in response to G-CSF and plerixafor

Forristal, Catherine, Nowlan, B., Barbier, Valerie, Winkler, Ingrid, Walkinshaw, Gail and Levesque, Jean-Pierre (2013). Pharmacological stabilization of hypoxia-inducible factor-1α (HIF-1α) enhances hematopoietic stem cell mobilization in response to G-CSF and plerixafor. 42nd Annual Scientific Meeting of the International Society for Experimental Hematology and Stem Cells (ISEH), Vienna, Austria, 22-25 August 2013. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2013.05.284

Pharmacological stabilization of hypoxia-inducible factor-1α (HIF-1α) enhances hematopoietic stem cell mobilization in response to G-CSF and plerixafor

2013

Journal Article

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

Oancea, Iulia, Png, Chin Wen, Das, Indrajit, Lourie, Rohan, Winkler, Ingrid G., Eri, Rajaraman, Subramaniam, Nathan, Jinnah, H. A., McWhinney, Brett C., Levesque, Jean-Pierre, McGuckin, Michael A., Duley, John A. and Florin, Timothy H. J. (2013). A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity. Gut, 62 (4), 594-605. doi: 10.1136/gutjnl-2012-302274

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

2013

Journal Article

B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2

Winkler, Ingrid G., Bendall, Linda J., Forristal, Catherine E., Helwani, Falak, Nowlan, Bianca, Barbier, Valerie, Shen, Yi, Cisterne, Adam, Sedger, Lisa M. and Levesque, Jean-Pierre (2013). B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2. Haematologica, 98 (3), 325-333. doi: 10.3324/haematol.2012.069260

B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2

2013

Journal Article

Nichotherapy for stem cells: there goes the neighborhood

Levesque, Jean-Pierre, Winkler, Ingrid G. and Rasko, John E. J. (2013). Nichotherapy for stem cells: there goes the neighborhood. BioEssays, 35 (3), 183-190. doi: 10.1002/bies.201200111

Nichotherapy for stem cells: there goes the neighborhood

2013

Journal Article

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

Forristal, Catherine E., Winkler, Ingrid G., Nowlan, Bianca, Barbier, Valerie, Walkinshaw, Gail and Levesque, Jean-Pierre (2013). Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Blood, 121 (5), 759-769. doi: 10.1182/blood-2012-02-408419

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

2013

Conference Publication

Mobilising Doses of G-Csf Stop Medullary Erythropoiesis by Depleting Cd169+Macrophages

Jacobsen, Rebecca, Pettit, Allison, Barbier, Valerie, Nowlan, Bianca, Raggatt, Liza, Winkler, Ingrid and Levesque, Jean-Pierre (2013). Mobilising Doses of G-Csf Stop Medullary Erythropoiesis by Depleting Cd169+Macrophages. 42nd Annual Scientific Meeting of ISEH - Society for Hematology and Stem Cells, Vienna, Austria, 22-25 August 2013. Philadelphia, PA United States: Elsevier Inc. doi: 10.1016/j.exphem.2013.05.230

Mobilising Doses of G-Csf Stop Medullary Erythropoiesis by Depleting Cd169+Macrophages

Current funding

  • 2022 - 2024
    Reducing long-term side-effects of chemotherapy in cancer survivors
    The Kid's Cancer Project
    Open grant

Past funding

  • 2021 - 2022
    New immunotherapeutics for Acute Myeloid Leukemia
    TdC Senior Research Grant
    Open grant
  • 2020 - 2022
    Unleashing natural killer cell activity against childhood leukemia
    The Children's Hospital Foundation
    Open grant
  • 2020 - 2022
    New strategies to alleviate the effects of chemotherapy in children with leukemia
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2021
    Helping damaged brains recover
    Mater Misericordiae Ltd
    Open grant
  • 2018 - 2020
    Colony-stimulating factor 1 receptor tyrosine kinase, a new target to treat acute myeloid leukemia
    Cancer Council Queensland
    Open grant
  • 2018 - 2020
    Increasing haematopoietic stem cell mobilisation by targeting a novel niche factor
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Mechanisms by which Endothelial Selectins regulate Normal and Malignant Stem Cell fate
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Niche regulation of normal and malignant stem cells
    NHMRC Research Fellowship
    Open grant
  • 2015 - 2018
    Haematopoietic Stem Cell glycome regulates outcome of niche interactions
    NHMRC Project Grant
    Open grant
  • 2014 - 2015
    A new approach to tackling chemotherapy-induced mucositis
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    NHMRC Career Development Fellowship (CDF Level 2): Manipulation of haematopoietic stem cell niches to improve therapeutic outcomes
    NHMRC Career Development Fellowship
    Open grant
  • 2013 - 2016
    Role of bone marrow cells in leukemia progression and resistance to chemotherapy
    NHMRC Project Grant
    Open grant
  • 2013
    Characterisation and manipulation of bone marrow niche factors regulating acute myeloid leukaemia stem cell fate
    Cancer Council Queensland
    Open grant

Availability

Dr Ingrid Winkler is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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