Overview
Background
Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research Institute - the University of Queensland, Brisbane, Australia.
A/Prof Winkler’s research focuse is understanding how micro-environments in the body protect and control normal and/or malignant stem Cells. Her innovative stem cell niche research has been recognised as among ten of the best research projects in Australia (by National Health and Medical Research Council) with patents and clinical translation.
A/Prof Winker's current research explores how stem cell niches change with ageing, inflammation, cancer therapy or radiation damage, with view to identify key detrimental niche components involved. This knowledge may be used to develop novel treatment strategies to improve cancer therapy outcomes, alleviate adverse cancer therapy side-effects that currently affect up tp 80% of Australian cancer therapy patientts plus facilitate healthier old age.
Availability
- Dr Ingrid Winkler is:
- Available for supervision
Research impacts
A/Prof's research on how normal and malignant cells alter their local environment (niches) was at the forefront of this new field. The identification of mechanisms by which normal and malignant cells change their niche, enabled these components to be therapeutically targeted leading to high impact manuscripts, industry partnerships and clinical translation with large Phase 2/3 clinical trials ongoing.
Works
Search Professor Ingrid Winkler’s works on UQ eSpace
2019
Conference Publication
Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells
Patel, Jatin, Lukowski, Samuel L., Winkler, Ingrid, Tay, Joshua and Khosrotehrani, Kiarash (2019). Single Cell Profiling of Aortic Endothelium Identifies Hierarchy From Endovascular Progenitors to Differentiated Cells. Annual Scientific Meeting and Scientific Sessions of the American-Heart-Association on Vascular Discovery - From Genes to Medicine, Boston, MA United States, 14-16 May 2019. Philadelphia, PA United States: Lippincott Williams & Wilkins.
2019
Journal Article
HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR
Bisht, Kavita, Brunck, Marion E., Matsumoto, Taichi, McGirr, Crystal, Nowlan, Bianca, Fleming, Whitney, Keech, Thomas, Magor, Graham, Perkins, Andrew C., Davies, Julie, Walkinshaw, Gail, Flippin, Lee, Winkler, Ingrid G. and Levesque, Jean-Pierre (2019). HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR. Blood Advances, 3 (3), 406-418. doi: 10.1182/bloodadvances.2018017566
2018
Journal Article
Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment
Kaur, Simranpreet, Raggatt, Liza J., Millard, Susan M., Wu, Andy C., Batoon, Lena, Jacobsen, Rebecca N., Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean-Pierre and Pettit, Allison R. (2018). Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. Blood, 132 (7), 735-749. doi: 10.1182/blood-2018-01-829663
2018
Conference Publication
Prostaglandin I-2 in the endosteal bone marrow niche as a novel regulator of hematopoietic stem cells
Tay, Joshua, Levesque, Jean-Pierre, Helwani, Falak, Price, Gareth, Nowlan, Bianca, Barbier, Valerie and Winkler, Ingrid G. (2018). Prostaglandin I-2 in the endosteal bone marrow niche as a novel regulator of hematopoietic stem cells. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA United States, 1-4 December 2018. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2018-99-115869
2018
Conference Publication
Self-repopulating recipient bone marrow recipient macrophages promote hematopoietic stem cell engraftment post autologous transplantation
Pettit, Allison, Kaur, Simranpreet, Raggatt, Liza, Millard, Susan, Wu, Andy, Batoon, Lena, Jacobsen, Rebecca, Winkler, Ingrid, MacDonald, Kelli, Perkins, Andrew, Hume, David and Levesque, Jean-Pierre (2018). Self-repopulating recipient bone marrow recipient macrophages promote hematopoietic stem cell engraftment post autologous transplantation. 47th Annual Scientific Meeting of the International Society for Experimental Hematology, Los Angeles, CA, United States, 23-26 August 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2018.06.117
2018
Conference Publication
Vascular E-selectin acts as a gatekeeper inducing commitment and loss of self-renewal in HSC transmigrating through the marrow vasculture
Winkler, Ingrid G., Barbier, Valerie, Lowe, Jessica, Tay, Joshua, Magnani, John L., Marlton, Paula, Mills, Anthony K., Perkins, Andrew, Fiveash, Corrine E., Erbani, Johanna M. and Levesque, Jean-Pierre (2018). Vascular E-selectin acts as a gatekeeper inducing commitment and loss of self-renewal in HSC transmigrating through the marrow vasculture. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA United States, 1-4 December 2018. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2018-99-120376
2017
Conference Publication
Macrophage involvement in the response of acute myeloid leukaemia to chemotherapy
Keech, Thomas, McGirr, Crystal, Winkler, Ingrid G. and Levesque, Jean-Pierre (2017). Macrophage involvement in the response of acute myeloid leukaemia to chemotherapy. 59th Annual Meeting of the American Society of Hematology (ASH), Atlanta, GA USA, 9-12 December 2017. Washington, DC USA: American Society of Hematology.
2017
Conference Publication
Vascular E-Selectin Mediates Chemo-Resistance in Acute Myeloid Leukemia Initiating Cells Via Canonical Receptors PSGL-1 (CD162) and Hcell (CD44) and AKT Signaling
Winkler, Ingrid G., Erbani, Johanna M., Barbier, Valerie, Davies, Julie M., Tay, Joshua, Fiveash, Corrine E., Lowe, Jessica, Tallack, Michael, Magnani, John L. and Levesque, Jean-Pierre (2017). Vascular E-Selectin Mediates Chemo-Resistance in Acute Myeloid Leukemia Initiating Cells Via Canonical Receptors PSGL-1 (CD162) and Hcell (CD44) and AKT Signaling. 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA, United States, 9-12 December 2017. Washington, DC, United States: American Society of Hematology.
2017
Journal Article
Cellular players of hematopoietic stem cell mobilization in the bone marrow niche
Tay, Joshua, Levesque, Jean‑Pierre and Winkler, Ingrid G. (2017). Cellular players of hematopoietic stem cell mobilization in the bone marrow niche. International Journal of Hematology, 105 (2), 129-140. doi: 10.1007/s12185-016-2162-4
2017
Book Chapter
The role of mesenchymal stem cells in hematopoiesis
Levesque, Jean-Pierre, Jacobsen, Rebecca N. and Winkler, Ingrid G. (2017). The role of mesenchymal stem cells in hematopoiesis. The biology and therapeutic application of mesenchymal cells. (pp. 467-480) edited by Kerry Atkinson. Hoboken, NJ, United States: John Wiley and Sons. doi: 10.1002/9781118907474.ch32
2016
Conference Publication
Therapeutic Blockade of Macrophage Colony Stimulating Factor (CSF-1) Delays AML Progression in Mice In Vivo
Goh, Sal Lee, Levesque, Jean-Pierre, Petitt, Allison R., Barbier, Valarie and Winkler, Ingrid G. (2016). Therapeutic Blockade of Macrophage Colony Stimulating Factor (CSF-1) Delays AML Progression in Mice In Vivo. 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego Ca, Dec 03-06, 2016. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V128.22.2835.2835
2016
Journal Article
Cell adhesion molecules in normal and malignant hematopoiesis: from bench to bedside
Levesque, Jean-Pierre and Winkler, Ingrid G. (2016). Cell adhesion molecules in normal and malignant hematopoiesis: from bench to bedside. Current Stem Cell Reports, 2 (4), 356-367. doi: 10.1007/s40778-016-0066-0
2016
Conference Publication
Prostaglandin I2 is produced in the endosteal region of the bone marrow and protects haematopoietic stem cell from irradiation stress
Tay, Joshua, Levesque, Jean-Pierre, Helwani, Falak, Price, Gareth, Barbier, Valerie, Nowlan, Bianca and Winkler, Ingrid (2016). Prostaglandin I2 is produced in the endosteal region of the bone marrow and protects haematopoietic stem cell from irradiation stress. 45th Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), San Diego, CA, United States, 25-28 August 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.224
2016
Conference Publication
Therapeutic blockade of macrophage colony stimulating factor (CSF-1) delays leukaemia progression of AMLin mice in vivo
Goh, Sal Lee, Levesque, Jean-Pierre, Pettit, Allison, Barbier, Valerie, Jeanclos, Cecile and Winkler, Ingrid (2016). Therapeutic blockade of macrophage colony stimulating factor (CSF-1) delays leukaemia progression of AMLin mice in vivo. 45th Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), San Diego, CA, United States, 25-28 August 2016. Philadelphia, PA, United States: Elsevier.
2016
Journal Article
CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer
Wu, Andy C., He, Yaowu, Broomfield, Amy, Paatan, Nicoll J., Harrington, Brittney S., Tseng, Hsu-Wen, Beaven, Elizabeth A., Kiernan, Deirdre M., Swindle, Peter, Clubb, Adrian B., Levesque, Jean-Pierre, Winkler, Ingrid G., Ling, Ming-Tat, Srinivasan, Bhuvana, Hooper, John D. and Pettit, Allison R. (2016). CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer. Journal of Pathology, 239 (2), 218-230. doi: 10.1002/path.4718
2016
Journal Article
Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak
Winkler, Ingrid G., Wiercinska, Eliza, Barbier, Valerie, Nowlan, Bianca, Bonig, Halvard and Levesque, Jean-Pierre (2016). Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak. Experimental Hematology, 44 (4), 303-314.e1. doi: 10.1016/j.exphem.2016.01.001
2016
Journal Article
Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouse
Jacobsen, Rebecca N., Nowlan, Bianca, Brunck, Marion E., Barbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Pierre (2016). Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouse. Experimental Hematology, 44 (3), 207-212.e4. doi: 10.1016/j.exphem.2015.11.004
2016
Conference Publication
Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation
Levesque, Jean-Pierre, Kaur, Simranpreet, Jacobsen, Rebecca, Millard, Susan, Batoon, Lena, Winkler, Ingrid, Macdonald, Kelli, Perkins, Andrew, Hume, David, Raggatt, Liza and Pettit, Allison (2016). Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation. 45th Annual Scientific Meeting of the ISEH – International Society for Experimental Hematology, San Diego, CA, United States, 25-28 August, 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.049
2016
Conference Publication
Hematopoietic Stem Cell Mobilization and Erythropoiesis Suppression in Response to Lipopolysaccharides Involve Two Distinct Tlr4-Depedent Mechanisms with Different Requirement for G-Csf Receptors
Bisht, Kavita, Jacobsen, Rebecca, Brunck, Marion, Keech, Thomas, McGirr, Crystal, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid and Levesque, Jean-Pierre (2016). Hematopoietic Stem Cell Mobilization and Erythropoiesis Suppression in Response to Lipopolysaccharides Involve Two Distinct Tlr4-Depedent Mechanisms with Different Requirement for G-Csf Receptors. 45th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), San Diego, CA, United States, 25-28 August 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.096
2016
Conference Publication
Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation
Winkler, Ingrid G., Barbier, Valerie, Ward, Micheal, Tallack, Michael, Lowe, Jessica, Davies, Julie, Erbani, Johanna, Magnani, John L. and Levesque, Jean-Pierre (2016). Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation. 58th Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego, CA, United States, 3-6 December 2016. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.v128.22.2823.2823
Funding
Supervision
Availability
- Dr Ingrid Winkler is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Reducing long-term side-effects of chemotherapy in cancer survivors
Associate Advisor
Other advisors: Dr Hana Starobova, Professor Irina Vetter
-
Doctor Philosophy
Understanding pain mechanisms in the path towards target-specific analgesic agent design
Associate Advisor
Other advisors: Dr Hana Starobova, Professor Irina Vetter
Completed supervision
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2024
Doctor Philosophy
Immune cell regulation by the microenvironment
Principal Advisor
Other advisors: Honorary Professor Kristen Radford, Dr Hana Starobova
-
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2019
Doctor Philosophy
The role of bone marrow niches in the regulation of normal and malignant haematopoietic stem cells
Principal Advisor
Other advisors: Professor Jean-Pierre Levesque
-
2017
Doctor Philosophy
The role of prostaglandin I2 in haematopoietic stem cell in the bone marrow niche
Principal Advisor
Other advisors: Professor Jean-Pierre Levesque
-
2015
Doctor Philosophy
Understanding heterotopic ossification after spinal cord injury
Principal Advisor
Other advisors: Professor Jean-Pierre Levesque
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2023
Doctor Philosophy
Unravelling the response and functional role of microglia in different inflammatory conditions
Associate Advisor
Other advisors: Professor Marc Ruitenberg, Professor Jana Vukovic
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2022
Doctor Philosophy
Establishing Humanized Mouse Models to Evaluate Immunotherapy
Associate Advisor
Other advisors: Honorary Professor Kristen Radford
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2021
Doctor Philosophy
The Role of Macrophages in Acute Myeloid Leukaemia Progression and Sensitivity to Chemotherapy
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
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2015
Doctor Philosophy
Role of Bone Marrow Macrophages in Regulating Haematopoiesis
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
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2011
Doctor Philosophy
The Role of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in Haematopoiesis
Associate Advisor
Other advisors: Professor Jean-Pierre Levesque
Media
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