Overview
Background
Dr Nyoman Kurniawan is a Senior Research Fellow in the Centre for Advanced Imaging and the Facility Manager for Preclincal 16.4T Microimaging 9.4T MRI scanners.
Dr Kurniawan’s research areas are:
- Diffusion magnetic resonance imaging of mouse neuroanatomy, with view to study neurological disease model, including:
- developmental abnormalities
- spinal cord diseases
- Development of 3D mouse brain, human spinal cord and cephalopod brain atlases using high resolution structural and diffusion MRI
- Development of MR methods for nephron imaging
- Application of MRI for agriculture imaging
Availability
- Dr Nyoman Kurniawan is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Spinal cord MRI
Using MRI to study degeneration and recovery in animal models of MS (EAE) and translation to clinical settings.
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Kidney imaging
Development of new MRI methods to image nephrons
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Development of structural connectome for animal model
Using diffusion MRI and fibre tracking to analyse brain wiring in animal models (rodents, fish, chepalopods)
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Development of MRI methods for agriculture imaging
Using MRI to characterise fruit maturation/ripening and root responses in crops.
Research impacts
Dr Kurniawan research focus is development of new MRI approaches for characterising animal models and ex vivo tissue specimens with the aim of relating the MRI signal to underlying tissue microstructures and processes. Insights gained with this approach have the potential to translate into improved use of MRI in humans. For example, he is working with clinicians at the Jamieson Trauma Institute to develop diffusion methods to measure brachial plexus injury.
Dr Kurniawan has a number of national and international collaborations, in the area of tumour microimaging (University of Sydney); multimodal MR imaging of Alzheimer brain (University of Southern California, USA), developing human spinal cord atlas (Polytechnique Montreal, Canada), and nephron imaging (Monash and University of Nottingham, UK).
Dr Kurniawan also works tangentialy in the applications of MRI to characterise agricultural products. He has been working with Uniquely Australian Foods at QAFFI, using MRI to characterise native fruit maturation and ripening process for commercialisation. Recently, he has obtained research infrastructure funding to establish Agriculture MRI facility at the Gatton Campus.
Works
Search Professor Nyoman Kurniawan’s works on UQ eSpace
2011
Journal Article
Segmentation of the mouse hippocampal formation in magnetic resonance images
Richards, Kay, Watson, Charles, Buckley, Rachel F., Kurniawan, Nyoman D., Yang, Zhengyi, Keller, Marianne D., Bearem, Richard, Bartlett, Perry F., Egan, Gary F., Galloway, Graham J., Paxinos, George, Petrou, Steven and Reutens, David C. (2011). Segmentation of the mouse hippocampal formation in magnetic resonance images. NeuroImage, 58 (3), 732-740. doi: 10.1016/j.neuroimage.2011.06.025
2011
Journal Article
Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration
Cowin, Gary J., Butler, Tim J., Kurniawan, Nyoman D., Watson, Charles and Wallace, Robyn H. (2011). Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration. Neuroimage, 58 (1), 69-74. doi: 10.1016/j.neuroimage.2011.06.003
2011
Journal Article
16 T Diffusion microimaging of fixed prostate tissue: Preliminary findings
Bourne, Roger, Kurniawan, Nyoman, Cowin, Gary, Syed, Paul and Watson, Geoff (2011). 16 T Diffusion microimaging of fixed prostate tissue: Preliminary findings. Magnetic Resonance in Medicine, 66 (1), 244-247. doi: 10.1002/mrm.22778
2011
Journal Article
Fgfr3 regulates development of the caudal telencephalon
Moldrich, Randal X., Mezzera, Cecilia, Holmes, William M., Goda, Sailaja, Brookfield, Sam J., Rankin, Alastair J., Barr, Emily, Kurniawan, Nyoman, Dewar, Deborah, Richards, Linda J., López-Bendito, Guillermina and Iwata, Tomoko (2011). Fgfr3 regulates development of the caudal telencephalon. Developmental Dynamics, 240 (6), 1586-1599. doi: 10.1002/dvdy.22636
2011
Journal Article
Non-invasive diffusion tensor imaging detects white matter degeneration in the spinal cord of a mouse model of amyotrophic lateral sclerosis
Underwood, Clare K., Kurniawan, Nyoman D., Butler, Tim J., Cowin, Gary J. and Wallace, Robyn H. (2011). Non-invasive diffusion tensor imaging detects white matter degeneration in the spinal cord of a mouse model of amyotrophic lateral sclerosis. NeuroImage, 55 (2), 455-461. doi: 10.1016/j.neuroimage.2010.12.044
2011
Conference Publication
High-resolution zebrafish white matter fibertracks
Kurniawan, N. D., Cowin, G., Collin, S. P. and Ullmann, J. F. (2011). High-resolution zebrafish white matter fibertracks. 19th Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Montréal, Québec, Canada, 7-13 May 2011.
2011
Book Chapter
Effect of molecular architecture on the performance of (19)F NMR imaging agents
Peng, Hui, Thurecht, Kristofer, Hsu, Steven, Blakey, Idriss, Squires, Oliver, Kurniawan, Nyoman, Rose, Stephen and Whittaker, Andrew (2011). Effect of molecular architecture on the performance of (19)F NMR imaging agents. NMR Spectroscopy of Polymers: Innovative Strategies for Complex Macromolecules. (pp. 459-472) edited by H. N. Cheng, Tetsuo Asakur and Alan D. English. Washington, DC, United States: American Chemical Society. doi: 10.1021/bk-2011-1077.ch028
2011
Conference Publication
Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography
Kerbler, Georg, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2011). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. 10th International Conference on Alzheimer's and Parkinson Diseases, Barcelona, Spain, 9-13 March 2011.
2011
Book Chapter
Calcium-Binding EGF-Like Domains
Boswell, Emma J., Kurniawan, Nyoman D. and Downing, A. Kristina (2011). Calcium-Binding EGF-Like Domains. Encyclopedia of Inorganic and Bioinorganic Chemistry. (pp. 1-19) Chichester, United Kingdom: John Wiley & Sons. doi: 10.1002/9781119951438.eibc0513
2010
Journal Article
Comparative mouse brain tractography of diffusion magnetic resonance imaging
Moldrich, Randal X., Pannek, Kerstin, Hoch, Renee, Rubenstein, John L., Kurniawan, Nyoman D. and Richards, Linda J. (2010). Comparative mouse brain tractography of diffusion magnetic resonance imaging. NeuroImage, 51 (3), 1027-1036. doi: 10.1016/j.neuroimage.2010.03.035
2010
Journal Article
A three-dimensional digital atlas of the zebrafish brain
Ullmann, Jeremy F. P., Cowin, Gary, Kurniawan, Nyoman D. and Collin, Shaun P. (2010). A three-dimensional digital atlas of the zebrafish brain. NeuroImage, 51 (1), 76-82. doi: 10.1016/j.neuroimage.2010.01.086
2010
Journal Article
Magnetic resonance histology of the adult zebrafish brain: Optimization of fixation and gadolinium contrast enhancement
Ullmann, Jeremy F. P., Cowin, Gary, Kurniawan, Nyoman D. and Collin, Shaun P. (2010). Magnetic resonance histology of the adult zebrafish brain: Optimization of fixation and gadolinium contrast enhancement. NMR in Biomedicine, 23 (4), 341-346. doi: 10.1002/nbm.1465
2010
Journal Article
HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
Da Silva, Leonard, Simpson, Peter T., Smart, Chanek E., Cocciardi, Sibylle, Waddell, Nic, Lane, Annette, Morrison, Brian J., Vargas, Ana Cristina, Healey, Sue, Beesley, Jonathan, Pakkiri, Pria, Parry, Suzanne, Kurniawan, Nyoman, Reid, Lynne, Keith, Patricia, Faria, Paulo, Pereira, Emilio, Skalova, Alena, Bilous, Michael, Balleine, Rosemary L., Do, Hongdo, Dobrovic, Alexander, Fox, Stephen, Franco, Marcello, Reynolds, Brent, Khanna, Kum Kum, Cummings, Margaret, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2010). HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer. Breast Cancer Research, 12 (4) R46, R46-1-R46-11. doi: 10.1186/bcr2603
2010
Conference Publication
Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography
Georg Kerbler, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2010). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. 3rd Brain Plasticity Symposium, Brisbane, Australia, 14-16 September 2010.
2010
Conference Publication
16T diffusion tensor microimaging of prostate tissue ex vivo demonstrates diffusion compartmentation inferred from in vivo measurements
Bourne, Roger, Kurniawan, Nyoman, Cowin, Gary, Sved, Paul and Watson, Geoff (2010). 16T diffusion tensor microimaging of prostate tissue ex vivo demonstrates diffusion compartmentation inferred from in vivo measurements. 96th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2010), Chicago, IL, United States, 28 November – 3 December 2010. Oak Brook, IL, United States: Radiological Society of North America (RSNA).
2010
Conference Publication
A new approach to mouse brain mapping
Bartlett, Perry, Beare, Richard, Buckley, Rachel F., Egan, Gary, Faggian, Nathan, Galloway, Graham, Keller, Marianne Dorothea, Kurniawan, Nyoman D., Paxinos, George, Petrou, Steven, Reutens, David, Richards, Kay, Vukovic, Jana, Wang, Deming, Watson, Charles, Yang, Steven and Zhao, Peter (2010). A new approach to mouse brain mapping. ISMRM, Stockholm, Sweden, 1-7 May, 2010. New York, NY, U.S.A.: International Society of Magnetic Resonance in Medicine.
2010
Conference Publication
In vivo MRI studies of Crim1 mutant mice: a model of abnormal renal vascular disease
Kurniawan, Nyoman D., Wilkinson, Lorine J. and Little, Melissa H. (2010). In vivo MRI studies of Crim1 mutant mice: a model of abnormal renal vascular disease. World Molecular Imaging Conference, Kyoto , Japan, 8-11 September 2010.
2009
Journal Article
Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice
Piper, Michael, Moldrich, Randal, Lindwall, Charlotta, Little, Erica, Barry, Guy, Mason, Sharon, Sunn, Nana, Kurniawan, Nyoman D., Gronostajski, Richard M. and Richards, Linda J. (2009). Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice. Neural Development, 4 (Article # 43) 43, 1-16. doi: 10.1186/1749-8104-4-43
2009
Conference Publication
High-resolution magnetic resonance histology of the zebrafish brain: a 3D atlas and online database
Ullmann, J.F.P., Cowin, G., Kurniawan, N.D. and Collin, S.P. (2009). High-resolution magnetic resonance histology of the zebrafish brain: a 3D atlas and online database. Society for Neuroscience 39th Annual Meeting, Chicago Il, United States, 17-21 October 2009.
2008
Conference Publication
Advanced paternal age alters brain development and behaviour in C57BL/6J mice
Foldi, Claire Jennifer, Cowin G, Kurniawan, Nyoman D., McGrath, John J., Eyles, Darryl and Burne, Thomas H.J. (2008). Advanced paternal age alters brain development and behaviour in C57BL/6J mice. Australian Neuroscience Society, Hobart , Tasmania, 27-30 January, 2008. Bedford Park SA: Australian Neuroscience Society.
Funding
Current funding
Supervision
Availability
- Dr Nyoman Kurniawan is:
- Available for supervision
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Available projects
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Developing novel methods of kidney MRI acquisition and image analysis using artificial intelligence
Nephrons are the basic functional unit of the kidney, an organ with a central role in maintaining homeostasis in the body. The number of nephrons in the kidneys and their microstructure reflect the success of renal development and the trajectory of renal health through life. Low nephron number increases the risk of chronic kidney disease, hypertension and cardiovascular disease.
Current methods for nephron quantitation are limited to ex vivo methods which are labour intensive, affected by shrinkage or use contrast agents. Magnetic Resonance Imaging (MRI) has strong potential to characterise kidney microstructures, but in vivo it suffers from low image resolution and motion artefacts. This PhD project aims to develop novel methods for kidney MR image acquisitions and analyses using artificial intelligence (such as Deep Learning and super resolution methods) to allow characterisation of key components of nephrons, the glomeruli and tubules. It is expected that these new methods will play important roles in future kidney research and contribute to reducing Australia’s epidemic of chronic kidney disease.
This is an opportunity to work with researchers at the Centre for Advanced Imaging, a leading imaging research facility in Australia, and The University of Queensland School of Information Technology and Electrical Engineering.
The project will suit an enthusiastic and highly motivated student with a background in computer science, physics or engineering.
Supervision history
Current supervision
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Doctor Philosophy
Mapping human cervical spinal cord using high resolution structural and diffusion magnetic resonance imaging
Principal Advisor
Other advisors: Dr Gary Cowin
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Doctor Philosophy
Machine learning methods for visualisation and quantification of nephrons with MRI.
Associate Advisor
Other advisors: Dr Shakes Chandra
Completed supervision
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2024
Doctor Philosophy
Development of Diffusion MRI and Tractography Protocols to Characterise Mouse Brain Development
Principal Advisor
Other advisors: Professor Michael Piper
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2023
Doctor Philosophy
Multimodal MRI to monitor disease and treatment in a chronic-progressive EAE mouse model of multiple sclerosis
Principal Advisor
Other advisors: Dr Gary Cowin, Dr Nemat Khan
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2019
Doctor Philosophy
Advanced Diffusion Magnetic Resonance Imaging at Ultrahigh Field to Investigate Neurological Microstructural Changes in an EAE Mouse Model of Multiple Sclerosis
Principal Advisor
Other advisors: Emeritus Professor Maree Smith
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2018
Doctor Philosophy
Anatomical Study of the Human Cervical Spinal Cord and Pathology Assessment of Spinal Cord Injury in Animal Models Using Magnetic Resonance Imaging
Principal Advisor
Other advisors: Dr Gary Cowin, Professor Marc Ruitenberg
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2018
Doctor Philosophy
Neurological study of a mouse model of Fetal Alcohol Spectrum Disorders using advanced imaging techniques
Principal Advisor
Other advisors: Dr Karine Mardon
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2015
Doctor Philosophy
Development of magnetic resonance diffusion weighted imaging at 16.4T to assess neurological degeneration in a mouse model of multiple sclerosis
Principal Advisor
Other advisors: Emeritus Professor Maree Smith
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2020
Doctor Philosophy
The cardioprotective effects of growth hormone secretagogues in mouse models of myocardial ischemia reperfusion and infarction
Associate Advisor
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2017
Doctor Philosophy
Measuring the progression of upper motor neuron disease using diffusion MRI and its correlation with Clinical phenotype
Associate Advisor
Other advisors: Associate Professor Robert Henderson, Professor Pamela McCombe, Dr Kerstin Pannek
Media
Enquiries
Contact Dr Nyoman Kurniawan directly for media enquiries about:
- Imaging - MRI
- Magnetic Resonance Imaging
- MRI
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