Overview
Background
Dr Nyoman Kurniawan is a Senior Research Fellow in the Centre for Advanced Imaging and the Facility Manager for Preclincal 16.4T Microimaging 9.4T MRI scanners.
Dr Kurniawan’s research areas are:
- Diffusion magnetic resonance imaging of mouse neuroanatomy, with view to study neurological disease model, including:
- developmental abnormalities
- spinal cord diseases
- Development of 3D mouse brain, human spinal cord and cephalopod brain atlases using high resolution structural and diffusion MRI
- Development of MR methods for nephron imaging
- Application of MRI for agriculture imaging
Availability
- Dr Nyoman Kurniawan is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Spinal cord MRI
Using MRI to study degeneration and recovery in animal models of MS (EAE) and translation to clinical settings.
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Kidney imaging
Development of new MRI methods to image nephrons
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Development of structural connectome for animal model
Using diffusion MRI and fibre tracking to analyse brain wiring in animal models (rodents, fish, chepalopods)
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Development of MRI methods for agriculture imaging
Using MRI to characterise fruit maturation/ripening and root responses in crops.
Research impacts
Dr Kurniawan research focus is development of new MRI approaches for characterising animal models and ex vivo tissue specimens with the aim of relating the MRI signal to underlying tissue microstructures and processes. Insights gained with this approach have the potential to translate into improved use of MRI in humans. For example, he is working with clinicians at the Jamieson Trauma Institute to develop diffusion methods to measure brachial plexus injury.
Dr Kurniawan has a number of national and international collaborations, in the area of tumour microimaging (University of Sydney); multimodal MR imaging of Alzheimer brain (University of Southern California, USA), developing human spinal cord atlas (Polytechnique Montreal, Canada), and nephron imaging (Monash and University of Nottingham, UK).
Dr Kurniawan also works tangentialy in the applications of MRI to characterise agricultural products. He has been working with Uniquely Australian Foods at QAFFI, using MRI to characterise native fruit maturation and ripening process for commercialisation. Recently, he has obtained research infrastructure funding to establish Agriculture MRI facility at the Gatton Campus.
Works
Search Professor Nyoman Kurniawan’s works on UQ eSpace
2016
Conference Publication
Toward Better Diagnosis for Cardiovascular Disease: Molecular Imaging via Dual Contrast Iron Oxide Nanoparticles
Ta, Hang , Li, Zhen , Hagemeyer, Christoph , Cowin, Gary , Kurniawan, Nyoman , Karlheinz, Peter and Whittaker, Andrew K. (2016). Toward Better Diagnosis for Cardiovascular Disease: Molecular Imaging via Dual Contrast Iron Oxide Nanoparticles. QCVRN Cardiovascular Research Showcase Event, Brisbane, Australia, 22 November 2016.
2016
Conference Publication
Sensitivity of magnetic resonance imaging to fingolimod dosage in a cuprizone mouse model
Ziser, L., Meyer-Schell, N., Sullivan, R. K., Reutens, D. C., Kurniawan, N. D., Chen, M. and Vegh, V. (2016). Sensitivity of magnetic resonance imaging to fingolimod dosage in a cuprizone mouse model. 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), London, United Kingdom, 14-17 September 2016. London, United Kingdom: SAGE Publications.
2015
Journal Article
In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla
Alomair, Othman I, Brereton, Ian M, Smith, Maree T, Galloway, Graham J and Kurniawan, Nyoman D (2015). In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla. Plos One, 10 (6) e0130133, e0130133. doi: 10.1371/journal.pone.0130133
2015
Journal Article
Brain tissue compartment density estimated using diffusion-weighted MRI yields tissue parameters consistent with histology
Sepehrband, Farshid, Clark, Kristi A., Ullmann, Jeremy F. P., Kurniawan, Nyoman D., Leanage, Gayeshika, Reutens, David C. and Yang, Zhengyi (2015). Brain tissue compartment density estimated using diffusion-weighted MRI yields tissue parameters consistent with histology. Human Brain Mapping, 36 (9), 3687-3702. doi: 10.1002/hbm.22872
2015
Journal Article
Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder
Fenlon, Laura R., Liu, Sha, Gobius, Ilan, Kurniawan, Nyoman D., Murphy, Skyle, Moldrich, Randal X. and Richards, Linda J. (2015). Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder. Neural Development, 10 (10) 10, 1-14. doi: 10.1186/s13064-015-0033-y
2015
Journal Article
Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling
Wilkinson, Lorine J., Neal, Calida S., Singh, Reetu R., Sparrow, Duncan B., Kurniawan, Nyoman D., Ju, Adler, Grieve, Stuart M., Dunwoodie, Sally L., Moritz, Karen M. and Little, Melissa H. (2015). Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling. Kidney International, 87 (5), 975-983. doi: 10.1038/ki.2014.394
2015
Journal Article
Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint
Undheim, Eivind A.B., Hamilton, Brett R., Kurniawan, Nyoman D., Bowlay, Greg, Cribb, Bronwen W., Merritt, David J., Fry,Bryan G., King, Glenn F and Venter, Deon J. (2015). Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 112 (13), 4026-4031. doi: 10.1073/pnas.1424068112
2015
Journal Article
lop-DWI: a novel scheme for pre-processing of diffusion-weighted images in the gradient direction domain
Sepehrband, Farshid, Choupan, Jeiran, Caruyer, Emmanuel, Kurniawan, Nyoman D., Gal, Yaniv, Tieng, Quang M., McMahon, Katie L., Vegh, Viktor, Reutens, David C. and Yang, Zhengyi (2015). lop-DWI: a novel scheme for pre-processing of diffusion-weighted images in the gradient direction domain. Frontiers in Neurology, 5 (JAN) 290, 290.1-290.13. doi: 10.3389/fneur.2014.00290
2015
Other Outputs
Average wild-type C57BL/6J mouse 3D MRI cerebellum labels
Egan, Gary F., Reutens, David, Galloway, Graham J., Watson, Charles, Janke, Andrew , Kurniawan, Nyoman D. and Ullmann, Jeremy F. (2015). Average wild-type C57BL/6J mouse 3D MRI cerebellum labels. The University of Queensand. (Dataset) doi: 10.14264/uql.2015.866
2015
Other Outputs
Average wild-type C57BL/6J mouse 3D MRI non-symmetric brain image
Egan, Gary F., Reutens, David, Bartlett, Perry F., Galloway, Graham J., Petrou, Steven, Watson, Charles, Keller, Marianne D., Janke, Andrew , Kurniawan, Nyoman D. and Ullmann, Jeremy F. (2015). Average wild-type C57BL/6J mouse 3D MRI non-symmetric brain image. Australian Mouse Brain Mapping Consortium. (Dataset) doi: 10.14264/uql.2015.863
2015
Conference Publication
Protective Role of Growth Hormone Secretagogues Against Myocardial Dysfunction in Mouse Models of Myocardial Ischemia Reperfusion and Infarction
McDonald, H., Kurniawan, N. D., Peart, J. and Chen, C. (2015). Protective Role of Growth Hormone Secretagogues Against Myocardial Dysfunction in Mouse Models of Myocardial Ischemia Reperfusion and Infarction. Autumn Meeting of the British-Society-for-Cardiovascular-Research - Translation of Cardiovascular Science to the Clinic, Glasgow, Scotland, 7-8 September 2015. London, United Kingdom: BMJ Group. doi: 10.1136/heartjnl-2015-308734.4
2015
Other Outputs
Average wild-type C57BL/6J mouse 3D MRI cortex labels
Egan, Gary F., Reutens, David, Galloway, Graham J., Watson, Charles, Janke, Andrew , Kurniawan, Nyoman D. and Ullmann, Jeremy F. (2015). Average wild-type C57BL/6J mouse 3D MRI cortex labels. The University of Queensand. (Dataset) doi: 10.14264/uql.2015.865
2015
Book Chapter
Research methods
Fry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D. ... Sunagar, K. (2015). Research methods. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. (pp. 153-214) New York, NY, United States: Oxford University Press.
2015
Conference Publication
Differential short- and long-term behavioural effects of chronic antipsychotic treatment in adolescent and adult rats
Moe, A. A. K., Cui, X., Kurniawan, N. D., Alexander, S., Burne, T. H. J. and Eyles, D. W. (2015). Differential short- and long-term behavioural effects of chronic antipsychotic treatment in adolescent and adult rats. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.13188
2015
Other Outputs
Average wild-type C57BL/6J mouse 3D MRI Basal Ganglia labels
Egan, Gary F., Reutens, David, Galloway, Graham J., Watson, Charles, Janke, Andrew , Kurniawan, Nyoman D. and Ullmann, Jeremy F. (2015). Average wild-type C57BL/6J mouse 3D MRI Basal Ganglia labels. The University of Queensland. (Dataset) doi: 10.14264/uql.2015.867
2015
Other Outputs
Average wild-type C57BL/6J mouse 3D MRI brain image
Egan, Gary F., Reutens, David, Bartlett, Perry F., Galloway, Graham J., Paxinos, George, Petrou, Steven, Watson, Charles, Keller, Marianne D., Janke, Andrew and Kurniawan, Nyoman D. (2015). Average wild-type C57BL/6J mouse 3D MRI brain image. The University of Queensand. (Dataset) doi: 10.14264/uql.2015.864
2014
Journal Article
MRI changes and complement activation correlate with epileptogenicity in a mouse model of temporal lobe epilepsy
Kharatishvili, Irina, Shan, Zuyao Y., She, David T., Foong, Samuel, Kurniawan, Nyoman D. and Reutens, David C. (2014). MRI changes and complement activation correlate with epileptogenicity in a mouse model of temporal lobe epilepsy. Brain Structure and Function, 219 (2), 683-706. doi: 10.1007/s00429-013-0528-4
2014
Journal Article
Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model
Guidi, Sandra, Stagni, Fiorenza, Bianchi, Patrizia, Ciani, Elisabetta, Giacomini, Andrea, De Franceschi, Marianna, Moldrich, Randal, Kurniawan, Nyoman, Mardon, Karine, Giuliani, Alessandro, Calzà, Laura and Bartesaghi, Renata (2014). Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model. Brain, 137 (2), 380-401. doi: 10.1093/brain/awt340
2014
Journal Article
Microscopic diffusion properties of fixed breast tissue: Preliminary findings
Norddin, Narina, Power, Carl, Watson, Geoffrey, Cowin, Gary, Kurniawan, Nyoman D., Gluch, Laurence and Bourne, Roger M. (2014). Microscopic diffusion properties of fixed breast tissue: Preliminary findings. Magnetic Resonance in Medicine, 74 (6), 1733-1739. doi: 10.1002/mrm.25555
2014
Conference Publication
A segmentation guide and probabilistic atlas of the C57BL/6J mouse brain from magnetic resonance imaging
Ullmann, Jeremy , Watson, Charles , Janke, Andrew , Keller, Marianne, Kurniawan, Nyoman , Yang, Zhengyi , Richards, Kay, Paxinos, George, Egan, Gary, Petrou, Steven, Bartlett, Perry, Galloway, Graham and Reutens, David (2014). A segmentation guide and probabilistic atlas of the C57BL/6J mouse brain from magnetic resonance imaging. 5th INCF Congress of Neuroinformatics, Munich, Germany, 10-12 September 2012. Lausanne, Switzerland: Frontiers Research Foundation. doi: 10.3389/conf.fninf.2014.08.00035
Funding
Current funding
Supervision
Availability
- Dr Nyoman Kurniawan is:
- Available for supervision
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Available projects
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Developing novel methods of kidney MRI acquisition and image analysis using artificial intelligence
Nephrons are the basic functional unit of the kidney, an organ with a central role in maintaining homeostasis in the body. The number of nephrons in the kidneys and their microstructure reflect the success of renal development and the trajectory of renal health through life. Low nephron number increases the risk of chronic kidney disease, hypertension and cardiovascular disease.
Current methods for nephron quantitation are limited to ex vivo methods which are labour intensive, affected by shrinkage or use contrast agents. Magnetic Resonance Imaging (MRI) has strong potential to characterise kidney microstructures, but in vivo it suffers from low image resolution and motion artefacts. This PhD project aims to develop novel methods for kidney MR image acquisitions and analyses using artificial intelligence (such as Deep Learning and super resolution methods) to allow characterisation of key components of nephrons, the glomeruli and tubules. It is expected that these new methods will play important roles in future kidney research and contribute to reducing Australia’s epidemic of chronic kidney disease.
This is an opportunity to work with researchers at the Centre for Advanced Imaging, a leading imaging research facility in Australia, and The University of Queensland School of Information Technology and Electrical Engineering.
The project will suit an enthusiastic and highly motivated student with a background in computer science, physics or engineering.
Supervision history
Current supervision
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Doctor Philosophy
Mapping human cervical spinal cord using high resolution structural and diffusion magnetic resonance imaging
Principal Advisor
Other advisors: Dr Gary Cowin
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Doctor Philosophy
Machine learning methods for visualisation and quantification of nephrons with MRI.
Associate Advisor
Other advisors: Dr Shakes Chandra
Completed supervision
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2024
Doctor Philosophy
Development of Diffusion MRI and Tractography Protocols to Characterise Mouse Brain Development
Principal Advisor
Other advisors: Professor Michael Piper
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2023
Doctor Philosophy
Multimodal MRI to monitor disease and treatment in a chronic-progressive EAE mouse model of multiple sclerosis
Principal Advisor
Other advisors: Dr Gary Cowin, Dr Nemat Khan
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2019
Doctor Philosophy
Advanced Diffusion Magnetic Resonance Imaging at Ultrahigh Field to Investigate Neurological Microstructural Changes in an EAE Mouse Model of Multiple Sclerosis
Principal Advisor
Other advisors: Emeritus Professor Maree Smith
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2018
Doctor Philosophy
Anatomical Study of the Human Cervical Spinal Cord and Pathology Assessment of Spinal Cord Injury in Animal Models Using Magnetic Resonance Imaging
Principal Advisor
Other advisors: Dr Gary Cowin, Professor Marc Ruitenberg
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2018
Doctor Philosophy
Neurological study of a mouse model of Fetal Alcohol Spectrum Disorders using advanced imaging techniques
Principal Advisor
Other advisors: Professor Graham Galloway, Dr Karine Mardon
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2015
Doctor Philosophy
Development of magnetic resonance diffusion weighted imaging at 16.4T to assess neurological degeneration in a mouse model of multiple sclerosis
Principal Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Graham Galloway
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2020
Doctor Philosophy
The cardioprotective effects of growth hormone secretagogues in mouse models of myocardial ischemia reperfusion and infarction
Associate Advisor
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2017
Doctor Philosophy
Measuring the progression of upper motor neuron disease using diffusion MRI and its correlation with Clinical phenotype
Associate Advisor
Other advisors: Associate Professor Robert Henderson, Professor Pamela McCombe, Dr Kerstin Pannek
Media
Enquiries
Contact Dr Nyoman Kurniawan directly for media enquiries about:
- Imaging - MRI
- Magnetic Resonance Imaging
- MRI
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