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Inhibitors of Secretory Phospholipases in Diet Induced Obese Rats (2010-2012)

Abstract

A new drug given to rats fed a high fat/carbohydrate diet shows very promising effects in preventing and treating abdominal obesity, insulin resistance, glucose intolerance, and other risk factors for diabetes and cardiovascular disease. This project will profile biochemical and pharmacological properties of the drug in more detail in order to track down molecular mechanisms of its action and potential therapeutic benefits, guided by studies on rats, biochemical markets, rat and human fat cells.

Experts

Professor David Fairlie

Centre Director of The Centre for Chemistry and Drug Discovery
Centre for Chemistry and Drug Discovery
Institute for Molecular Bioscience
Affiliate of ARC COE for Innovations in Peptide and Protein Science
ARC COE for Innovations in Peptide and Protein Science
Institute for Molecular Bioscience
Centre Director of Institute for Molecular Bioscience
Institute for Molecular Bioscience
NHMRC Leadership Fellow and Group Leader
Institute for Molecular Bioscience
David Fairlie
David Fairlie