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Molecules and mechanisms regulating axonal degeneration and regeneration in C. elegans neurons (2012-2015)

Abstract

Axonal degeneration is a characteristic hallmark of neuronal injury, and of several neurodegenerative conditions. Axonal regeneration, which is the regrowth of the proximal axonal fragment still attached to the cell body, is a complementary event observed following nerve injury in a number of vertebrate and invertebrate neurons. Understanding the cellular and molecular mechanisms regulating axonal degeneration and regeneration is essential to identify key targets for the treatment of neurodegenerative conditions and nerve injuries. The overall aim of this Future Fellowship is to use the powerful genetic tools available for the nematode C. elegans to discover the basic molecular elements and mechanisms regulating these processes.

Experts

Professor Massimo Hilliard

Affiliate of Clem Jones Centre for Ageing and Dementia Research
Clem Jones Centre for Ageing Dementia Research
Faculty of Health, Medicine and Behavioural Sciences
NHMRC Leadership Fellow - GL
Queensland Brain Institute
Faculty of Health, Medicine and Behavioural Sciences
Massimo Hilliard
Massimo Hilliard