Bioactive Polymers for Wound Healing Applications (2005-2008)
Abstract
VitroGro is a growth factor complex which enhances cell growth and migration, and hence has great potential for treating wounds. Tissue Therapies, which holds the rights to commercialization of VitroGro , is seeking to develop methods of delivering VitroGro in its active form to the wound environment. Two solutions to this problem will be developed in this project; a bioactive bandage containing a novel combination of microspheres and a hydrogel matrix, and secondly an in-situ polymerisable matrix for treatment of deep wounds. The growth factor complex will be protected from aggressive proteases through encapsulation within microspheres, and the use of MMP-inhibiting comonomers.
