Unravelling the mechanism of vesicular docking in neurosecretory cells (2015-2018)
Abstract
The fusion of secretory vesicles (SVs) by exocytosis underpins neuronal and hormonal communication. The goal of this project is to unravel all the steps bringing these vesicles to the plasma membrane where they dock. Specifically, we will unravel the role for the cytoskeleton in creating an interface where SV confinement leads to the appropriate pairing of molecules mediating the fusion between the vesicles and the plasma membrane. Unravelling these novel molecular mechanisms is essential for our understanding of neuronal function in the healthy nervous and hormonal systems.
