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A novel click chemistry approach to identify learning and memory molecules (2016-2019)

Abstract

Long-term memories do not form immediately after learning. Initially fragile, they become resistant to disruption through a process known as memory consolidation. In a second process, termed reconsolidation, pre-established memories are updated and re-stored. Both processes depend on protein synthesis, but little is known about the particular sets of proteins that are involved. The project applies a novel biochemical protocol to a newly established transgenic mouse model, that allows the visualisation and identification of newly synthesised proteins in the hippocampus, a brain area that is critical in memory formation. Together this project will contribute to a deeper understanding at a molecular level of how memory is stored in neurons.

Experts

Professor Jurgen Götz

NHMRC Leadership Fellow
Queensland Brain Institute
Faculty of Health, Medicine and Behavioural Sciences
Affiliate of Centre for Extracellular Vesicle Nanomedicine
Centre for Extracellular Vesicle Nanomedicine
Faculty of Health, Medicine and Behavioural Sciences
Centre Director of Clem Jones Centre for Ageing and Dementia Research
Clem Jones Centre for Ageing Dementia Research
Faculty of Health, Medicine and Behavioural Sciences
Jurgen Götz
Jurgen Götz