Defining the membrane protein cargo transported by Retromer (2016-2020)
Abstract
Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signaling and development. Endosomal transport occurs within membrane domains and membrane vesicular carriers formed by Retromer. This project aims to define the transmembrane proteins sorted by the distinct retromer complexes that form within the cell and the sorting signals essential for their correct trafficking and localisation.
