How autotransporter proteins mediate bacterial interactions (ARC Discovery Project administered by La Trobe University) (2018-2021)
Abstract
Autotransporter proteins are an extremely common group of surface proteins that play a central role in controlling bacterial interactions with their environment. These proteins possess diverse functions often linked to increased bacterial fitness and augmented pathogenic potential. To date detailed molecular analysis of the mechanisms that control autotransporter function are unknown. This project aims to investigate the structure-function relationships that underpin key autotransporter roles in bacterial cell adhesion, aggregation and biofilm formation. The outcomes of this work will provide an intellectual framework for understanding and inhibiting this key group of virulence proteins.
