Australian marine biodiversity as a source of new drugs to control neurodegenerative disease (2007-2010)
Abstract
This project aims to explore Australian marine biodiversity to discover natural products capable of inhibiting biochemical processes critical to a range of neurodegenerative diseases - including Alzheimer's, Parkinson's, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Epilepsy and Neuropathic Pain. In collaboration with the industry partner, NeuroPharma, we will detect, isolate and identify novel bioactive metabolites from marine samples, prepare semi-synthetic and synthetic analogues, define pharmacophores, and assess the potential of these compounds as drug lead candidates for the treatment of neurodegenerative disease. Promising leads will be advanced to pre-clinical development.'',
