Electrochemically Driven Molybdoenzyme Catalysis (2008-2010)

Oxidoreductases perform essential tasks in nature by catalysing often synthetically difficult redox transformations. Such enzymes may be integrated with an electrical circuit to produce an enzyme electrode if native activity is preserved. We will conduct parallel electrochemical experiments on the enzymes xanthine dehydrogenase and sulfite dehydrogenase in solution and adsorbed on an electrode. Our study will resolve whether some unusual direct electrochemical behaviour seen recently in these and related molybdenum enzymes is physiologically important