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2024 Journal Article Dynamin1 long- and short-tail isoforms exploit distinct recruitment and spatial patterns to form endocytic nanoclustersJiang, Anmin, Kudo, Kye, Gormal, Rachel S., Ellis, Sevannah, Guo, Sikao, Wallis, Tristan P., Longfield, Shanley F., Robinson, Phillip J., Johnson, Margaret E., Joensuu, Merja and Meunier, Frédéric A. (2024). Dynamin1 long- and short-tail isoforms exploit distinct recruitment and spatial patterns to form endocytic nanoclusters. Nature Communications, 15 (1) 4060, 1-21. doi: 10.1038/s41467-024-47677-8 |
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2024 Journal Article The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acidsAkefe, Isaac O, Saber, Saber H., Matthews, Benjamin, Venkatesh, Bharat G., Gormal, Rachel S., Blackmore, Daniel G., Alexander, Suzy, Sieriecki, Emma, Gambin, Yann, Bertran-Gonzalez, Jesus, Vitale, Nicolas, Humeau, Yann, Gaudin, Arnaud, Ellis, Sevannah A., Michaels, Alysee A., Xue, Mingshan, Cravatt, Benjamin, Joensuu, Merja, Wallis, Tristan P. and Meunier, Frédéric A. (2024). The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids. The EMBO Journal, 43 (4), 533-567. doi: 10.1038/s44318-024-00030-7 |
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2023 Journal Article Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma membrane nanocluster for synaptic vesicle entryJoensuu, Merja, Syed, Parnayan, Saber, Saber H., Lanoue, Vanessa, Wallis, Tristan P., Rae, James, Blum, Ailisa, Gormal, Rachel S., Small, Christopher, Sanders, Shanley, Jiang, Anmin, Mahrhold, Stefan, Krez, Nadja, Cousin, Michael A., Cooper‐White, Ruby, Cooper‐White, Justin J., Collins, Brett M., Parton, Robert G., Balistreri, Giuseppe, Rummel, Andreas and Meunier, Frédéric A. (2023). Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma membrane nanocluster for synaptic vesicle entry. The EMBO Journal, 42 (13) e112095, e112095. doi: 10.15252/embj.2022112095 |
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2020 Journal Article Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivityCantuti-Castelvetri, Ludovico, Ojha, Ravi, Pedro, Liliana D., Djannatian, Minou, Franz, Jonas, Kuivanen, Suvi, van der Meer, Franziska, Kallio, Katri, Kaya, Tuğberk, Anastasina, Maria, Smura, Teemu, Levanov, Lev, Szirovicza, Leonora, Tobi, Allan, Kallio-Kokko, Hannimari, Österlund, Pamela, Joensuu, Merja, Meunier, Frédéric A., Butcher, Sarah J., Winkler, Martin Sebastian, Mollenhauer, Brit, Helenius, Ari, Gokce, Ozgun, Teesalu, Tambet, Hepojoki, Jussi, Vapalahti, Olli, Stadelmann, Christine, Balistreri, Giuseppe and Simons, Mikael (2020). Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science, 370 (6518) abd2985, 856-860. doi: 10.1126/science.abd2985 |
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2017 Journal Article Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized moleculesJoensuu, Merja, Martinez-Marmol, Ramon, Padmanabhan, Pranesh, Glass, Nick R., Durisic, Nela, Pelekanos, Matthew, Mollazade, Mahdie, Balistreri, Giuseppe, Amor, Rumelo, Cooper-White, Justin J., Goodhill, Geoffrey J. and Meunier, Frederic A. (2017). Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules. Nature Protocols, 12 (12), 2590-2622. doi: 10.1038/nprot.2017.116 |
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2016 Journal Article Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesiclesJoensuu, Merja, Padmanabhan, Pranesh, Durisic, Nela, Bademosi, Adekunle T. D., Cooper-Williams, Elizabeth, Morrow, Isabel C., Harper, Callista B., Jung, WooRam, Parton, Robert G., Goodhill, Geoffrey J., Papadopulos, Andreas and Meunier, Frederic A. (2016). Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles. Journal of Cell Biology, 215 (2), 277-292. doi: 10.1083/jcb.201604001 |
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2024 Journal Article Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal virusesOjha, Ravi, Jiang, Anmin, Mantylae, Elina, Quirin, Tania, Modhira, Naphak, Witte, Robert, Gaudin, Arnaud, De Zanetti, Lisa, Gormal, Rachel Sarah, Vihinen-Ranta, Maija, Mercer, Jason, Suomalainen, Maarit, Greber, Urs F., Yamauchi, Yohei, Lozach, Pierre-Yves, Helenius, Ari, Vapalahti, Olli, Young, Paul, Watterson, Daniel, Meunier, Frederic A., Joensuu, Merja and Balistreri, Giuseppe (2024). Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses. Plos Pathogens, 20 (11) e1012690, e1012690. doi: 10.1371/journal.ppat.1012690 |
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2024 Journal Article SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recyclingSmall, Christopher, Harper, Callista, Jiang, Anmin, Kontaxi, Christiana, Pronot, Marie, Yak, Nyakuoy, Malapaka, Anusha, Davenport, Elizabeth C., Wallis, Tristan P., Gormal, Rachel S., Joensuu, Merja, Martínez‐Mármol, Ramón, Cousin, Michael A. and Meunier, Frédéric A. (2024). SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling. Journal of Neurochemistry, 168 (9), 3188-3208. doi: 10.1111/jnc.16186 |
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2024 Journal Article Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesiclesLongfield, Shanley F., Gormal, Rachel S., Feller, Matis, Parutto, Pierre, Reingruber, Jürgen, Wallis, Tristan P., Joensuu, Merja, Augustine, George J., Martínez-Mármol, Ramón, Holcman, David and Meunier, Frédéric A. (2024). Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles. Nature Communications, 15 (1) 2217, 1-18. doi: 10.1038/s41467-024-46256-1 |
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2023 Journal Article Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesiclesLongfield, Shanley F., Mollazade, Mahdie, Wallis, Tristan P., Gormal, Rachel S., Joensuu, Merja, Wark, Jesse R., van Waardenberg, Ashley J., Small, Christopher, Graham, Mark E., Meunier, Frédéric A. and Martínez-Mármol, Ramón (2023). Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles. Nature Communications, 14 (1) 7277, 1-20. doi: 10.1038/s41467-023-43130-4 |
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2023 Journal Article Super-resolved trajectory-derived nanoclustering analysis using spatiotemporal indexingWallis, Tristan P., Jiang, Anmin, Young, Kyle, Hou, Huiyi, Kudo, Kye, McCann, Alex J., Durisic, Nela, Joensuu, Merja, Oelz, Dietmar, Nguyen, Hien, Gormal, Rachel S. and Meunier, Frédéric A. (2023). Super-resolved trajectory-derived nanoclustering analysis using spatiotemporal indexing. Nature Communications, 14 (1) 3353, 1-16. doi: 10.1038/s41467-023-38866-y |
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2023 Journal Article SARS-CoV-2 infection of human neurons is TMPRSS2 independent, requires endosomal cell entry, and can be blocked by inhibitors of host phosphoinositol-5 kinaseKettunen, Pinja, Lesnikova, Angelina, Räsänen, Noora, Ojha, Ravi, Palmunen, Leena, Laakso, Markku, Lehtonen, Šárka, Kuusisto, Johanna, Pietiläinen, Olli, Saber, Saber H., Joensuu, Merja, Vapalahti, Olli P., Koistinaho, Jari, Rolova, Taisia and Balistreri, Giuseppe (2023). SARS-CoV-2 infection of human neurons is TMPRSS2 independent, requires endosomal cell entry, and can be blocked by inhibitors of host phosphoinositol-5 kinase. Journal of Virology, 97 (4), e0014423. doi: 10.1128/jvi.00144-23 |
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2022 Journal Article Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cellsZhu, Yanshan, Chew, Keng Yih, Wu, Melanie, Karawita, Anjana C., McCallum, Georgina, Steele, Lauren E., Yamamoto, Ayaho, Labzin, Larisa I., Yarlagadda, Tejasri, Khromykh, Alexander A., Wang, Xiaohui, Sng, Julian D. J., Stocks, Claudia J., Xia, Yao, Kollmann, Tobias R., Martino, David, Joensuu, Merja, Meunier, Frédéric A., Balistreri, Giuseppe, Bielefeldt-Ohmann, Helle, Bowen, Asha C., Kicic, Anthony, Sly, Peter D., Spann, Kirsten M. and Short, Kirsty R. (2022). Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells. PLoS Biology, 20 (8) e3001728, 1-19. doi: 10.1371/journal.pbio.3001728 |
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2020 Journal Article Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodiesGormal, Rachel S., Padmanabhan, Pranesh, Kasula, Ravikiran, Bademosi, Adekunle T., Coakley, Sean, Giacomotto, Jean, Blum, Ailisa, Joensuu, Merja, Wallis, Tristan P., Lo, Harriet P., Budnar, Srikanth, Rae, James, Ferguson, Charles, Bastiani, Michele, Thomas, Walter G., Pardon, Els, Steyaert, Jan, Yap, Alpha S., Goodhill, Geoffrey J., Hilliard, Massimo A., Parton, Robert G. and Meunier, Frédéric A. (2020). Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies. Proceedings of the National Academy of Sciences of the United States of America, 117 (48), 30476-30487. doi: 10.1073/pnas.2007443117 |
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2020 Journal Article Radial contractility of actomyosin rings facilitates axonal trafficking and structural stabilityWang, Tong, Li, Wei, Martin, Sally, Papadopulos, Andreas, Joensuu, Merja, Liu, Chunxia, Jiang, Anmin, Shamsollahi, Golnoosh, Amor, Rumelo, Lanoue, Vanessa, Padmanabhan, Pranesh and Meunier, Frédéric A. (2020). Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability. Journal of Cell Biology, 219 (5) e201902001, 1-S7. doi: 10.1083/jcb.201902001 |
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2019 Journal Article Phospholipases in neuronal function: a role in learning and memory?Joensuu, Merja, Wallis, Tristan P., Saber, Saber H. and Meunier, Frédéric A. (2019). Phospholipases in neuronal function: a role in learning and memory?. Journal of Neurochemistry, 153 (3) jnc.14918, e14918-333. doi: 10.1111/jnc.14918 |
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2019 Journal Article GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylationWitkos, Tomasz M., Chan, Wing Lee, Joensuu, Merja, Rhiel, Manuel, Pallister, Ed, Thomas-Oates, Jane, Mould, A. Paul, Mironov, Alex A., Biot, Christophe, Guerardel, Yann, Morelle, Willy, Ungar, Daniel, Wieland, Felix T., Jokitalo, Eija, Tassabehji, May, Kornak, Uwe and Lowe, Martin (2019). GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation. Nature Communications, 10 (1) 127, 127. doi: 10.1038/s41467-018-08044-6 |
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2019 Journal Article VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular PrimingKasula, Ravikiran, Blum, Ailisa, Salla-Martret, Merce, Chai, Ye Jin, Jiang, Anmin, Wallis, Tristan P., Gormal, Rachel S., Brouillet, Julie Z., Padmanabhan, Pranesh, Weeratunga, Saroja K., Livingstone, Emma K., Mollazade, Mahdie, Joensuu, Merja, Martínez-Mármol, Ramón, Collins, Brett M. and Meunier, Frederic (2019). VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming. SSRN Electronic Journal. doi: 10.2139/ssrn.3362260 |
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2018 Journal Article Dendritic spine actin cytoskeleton in autism spectrum disorderJoensuu, Merja, Lanoue, Vanessa and Hotulainen, Pirta (2018). Dendritic spine actin cytoskeleton in autism spectrum disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 84 (Pt B), 362-381. doi: 10.1016/j.pnpbp.2017.08.023 |
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2016 Journal Article NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphologyRamo, Olli, Kumar, Darshan, Gucciardo, Erika, Joensuu, Merja, Saarekas, Maiju, Vihinen, Helena, Belevich, Ilya, Smolander, Olli-Pekka, Qian, Kui, Auvinen, Petri and Jokitalo, Eija (2016). NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology. Scientific Reports, 6 (1) 35969. doi: 10.1038/srep35969 |
