![Professor Peter Gray](/sites/default/files/profiles/1295.jpeg)
Overview
Background
Professor Peter Gray is a pioneer of biotechnology research and development in Australia. In 2003 he was appointed AIBN’s inaugural Director and has since overseen the institute’s growth to 450 people and an annual turnover of $40million. Before joining AIBN, he was Professor and Head of Biotechnology at UNSW.
Professor Gray has held academic positions at University College London and the University of California, Berkeley. He has had commercial experience in the US, working for Eli Lilly and Co and the Cetus Corporation. His research collaborations include groups at Stanford University; the University of California, Berkeley; and the University of British Columbia, Vancouver.
He serves on several boards and government committees. He is on the board of Engineering Conferences International, New York, a group that runs global, multi-disciplinary engineering conferences, many of which have played key roles in developing emerging industry sectors. The conferences include cell culture engineering; vaccine technology; and scale-up and manufacturing of cell-based therapies. Professor Gray also serves on the board of Biopharmaceuticals Australia Pty Ltd, the company established to build a GMP grade biopharmaceuticals manufacturing facility in Brisbane, and has been heavily involved in negotiations that led to DSM Biologics becoming the facility’s operator.
Professor Gray is a Fellow and Vice-President of the Australian Academy of Technological Sciences and Engineering and a Fellow of the Australian Institute of Company Directors. He has chaired, served on organising committees for, and given plenary and keynote addresses at many key international conferences. In 2006 he attracted to Sydney and chaired the International Biotechnology Symposium – the first time a conference in the four-yearly series was held in the southern hemisphere. Professor Gray is a founder and past president of the Australian Biotechnology Association (Ausbiotech).
Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses. He has twice been listed by Engineers Australia among the top 100 most influential engineers in Australia, and in 2001 was awarded the Australian Government’s Centenary Medal.
Availability
- Professor Peter Gray is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Australian Academy of Technological Sciences and Engineering, Australian Academy of Technological Sciences and Engineering
- Engineers Australia, Engineers Australia
- International Institute of Biotechnology and Toxicology, International Institute of Biotechnology and Toxicology
Research impacts
Research
Mammalian Cell Lines and Stem Cell Bioprocesses
Professor Peter Gray leads a research group with a focus on bioengineering of mammalian cell protein expression and stem cell systems. The research group is growing a strategic link with DSM Biologics, a contract manufacturer that takes early-stage projects to the next stage of commercial development. AIBN is developing mammalian cell lines, which form the basis of biologics, medicines based on natural proteins, and DSM will produce and commercialise them at a $65 million scale-up facility at Brisbane’s Princess Alexandra Hospital in Brisbane.
Professor Gray's research group is collaborating with Sydney-based Biosceptre International Ltd in a partnership aiming to develop a bio-process for producing monoclonal antibodies to treat cancer. AIBN researchers will characterise candidate therapeutic monoclonal antibodies that bind to Biosceptre's novel cancer target, known as nf-P2X7. Research and development will include antibody and cell line development; bioprocess development; and recombinant protein production in pre-commercial quantities ahead of preclinical trials. The Biosceptre collaboration is a critical step towards preclinical and human clinical trials. The long-term goal is to develop a therapeutic monoclonal antibody capable of specifically detecting nf-P2X7 and inducing cancer cell death without affecting normal healthy cells.
Ongoing research in Professor Gray's research group and Australian Animal Health Laboratory in Victoria with a Hendra virus antibody aims to determine its shelf life, to see how long it can be stored. The AIBN research group has developed a process to produce large amounts of high-quality antibody. The research group has produce batches of the experimental antibody for Queensland Health and collaborators at the CSIRO Australian Animal Health Laboratory in Geelong for testing in animal trials.
Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses.
Works
Search Professor Peter Gray’s works on UQ eSpace
2006
Journal Article
Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology
Catzel, D., Chin, D. Y., Stanton, P. G., Gray, P. P. and Mahler, S. A. (2006). Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology. Journal of Biotechnology, 122 (1), 73-85. doi: 10.1016/j.jbiotec.2005.08.026
2006
Journal Article
Stable suspension of layered double hydroxide nanoparticles in aqueous solution
Xu, Zhi Ping, Stevenson, Gregory S., Lu, Chao-Qing, Lu, Gao Qing (Max), Bartlett, Perry F. and Gray, Peter P. (2006). Stable suspension of layered double hydroxide nanoparticles in aqueous solution. Journal of The American Chemical Society, 128 (1), 36-37. doi: 10.1021/ja056652a
2006
Journal Article
Splitting the difference: When near enough is not close enough
Sleiman, R. J., Gray, P. P. and Sunstrom, N. A. (2006). Splitting the difference: When near enough is not close enough. Cytometry Part A, 69A (5), 426-426.
2005
Conference Publication
A proteome analysis of conditioned media from human neonatal fibroblasts used in the maintenance of human embryonic stem cells
Prowse, Andrew B. J., McQuade, Leon R., Bryant, Katherin J., Van Dyk, Derek D., Tuch, BBernard E. and Gray, Peter P. (2005). A proteome analysis of conditioned media from human neonatal fibroblasts used in the maintenance of human embryonic stem cells. 3rd International Proteomics Conference/1st Taiwan Proteomics Conference/2nd AOHUPO Congress, Taipei, Taiwan, 14-17 May 2004. Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/pmic.200401087
2004
Journal Article
Enhanced productivity of G1 phase Chinese hamster ovary cells using the GADD153 promoter
de Boer, L., Gray, P. P. and Sunstrom, N. A. (2004). Enhanced productivity of G1 phase Chinese hamster ovary cells using the GADD153 promoter. Biotechnology Letters, 26 (1), 61-65. doi: 10.1023/B:BILE.0000009462.10772.a4
2004
Journal Article
Process development for a recombinant Chinese Hamster Ovary (CHO) cell line utilizing a metal induced and amplified metallothionein expression system
Huang, EP, Marquis, CP and Gray, PP (2004). Process development for a recombinant Chinese Hamster Ovary (CHO) cell line utilizing a metal induced and amplified metallothionein expression system. Biotechnology And Bioengineering, 88 (4), 437-450. doi: 10.1002/bit.20194
2003
Other Outputs
Isolation method for recombinant glycoprotein biopharmaceuticals
Catzel, D., Gray, P. P. and Mahler, S. M. (2003). Isolation method for recombinant glycoprotein biopharmaceuticals. Australian Provisional Patent #61759780.
2003
Journal Article
Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line
Van Dyk, Derek D., Misztal, David R., Wilkins, Marc R., Mackintosh, James A., Poljak, Anne, Varnail, Jodie C., Teber, Erdahl, Walsh, Bradley J. and Gray, Peter P. (2003). Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line. Proteomics, 3 (2), 147-156. doi: 10.1002/pmic.200390023
2003
Book
Review of Australian Biotechnology Education
Gray, P., Barnard, R. T., Franco, C., Rifkin, W., Hine, D. C. and Young, F. (2003). Review of Australian Biotechnology Education. Canberra: Commonwealth of Australia.
2003
Other Outputs
Review of Australian Biotechnology Education, Australian Universities Teaching Committee, Department of Education Science and Training
Gray, P., Barnard, R., Franco, C., Rifkin, W., Hine, D. and Young, F. (2003). Review of Australian Biotechnology Education, Australian Universities Teaching Committee, Department of Education Science and Training. Not available:
2003
Other Outputs
AUTC Review of Biotechnology 2003
Gray, P., Barnard, R. T., Franco, C., Rifkin, W., Hine, D. C. and Young, F. (2003). AUTC Review of Biotechnology 2003. Canberra: Department of Employment, Science and Technology and Australian Universities Teaching Committee.
2003
Journal Article
Effect of shear stress on expression of a recombinant protein by Chinese hamster ovary cells
Keane, Julian T., Ryan, David and Gray, Peter P. (2003). Effect of shear stress on expression of a recombinant protein by Chinese hamster ovary cells. Biotechnology and Bioengineering, 81 (2), 211-220. doi: 10.1002/bit.10472
2003
Journal Article
Purification of recombinant human growth hormone from CHO cell culture supernatant by Gradiflow preparative electrophoresis technology
Catzel, D., Lalevski, H., Marquis, C. P., Gray, P. P., Van Dyk, D. and Mahler, S. M. (2003). Purification of recombinant human growth hormone from CHO cell culture supernatant by Gradiflow preparative electrophoresis technology. Protein Expression And Purification, 32 (1), 126-134. doi: 10.1016/j.pep.2003.07.002
2002
Conference Publication
Ultramicroporous membranes for hydrogen separation
M. C. Duke, J. C. Diniz da Costa, G. Q. Lu, M. Petch and P. Gray (2002). Ultramicroporous membranes for hydrogen separation. EERE 2002, Environmental Engineering Research Event, Blackheath, NSW, Australia, 3-6 December, 2002.
2000
Journal Article
Phase I clinical trial of the chimeric monoclonal antibody (c30.6) in patients with metastatic colorectal cancer
Ward, RL, Packham, D, Smythe, AM, Murray, J, Anderson-Stewart, P, Kitchen, N, Muirhead, R, Phillips, P, Gray, P, Bigg-Wither, G, Prabakaran, K, Freund, J, Fullham, M, Rule, M, Dalley, D, Meagher, A, Hawkins, NJ and Smith, GM (2000). Phase I clinical trial of the chimeric monoclonal antibody (c30.6) in patients with metastatic colorectal cancer. Clinical Cancer Research, 6 (12), 4674-4683.
2000
Journal Article
Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells
Sunstrom, NAS, Gay, RD, Wong, DC, Kitchen, NA, DeBoer, L and Gray, PP (2000). Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells. Biotechnology Progress, 16 (5), 698-702. doi: 10.1021/bp000102t
1999
Journal Article
A rapid selection/amplification procedure for high-level expression of recombinant protein in a metal-amplifiable mammalian expression system
Bailey, C. G., Baig, M., Gray, P. P. and Sunstrom, N. A. (1999). A rapid selection/amplification procedure for high-level expression of recombinant protein in a metal-amplifiable mammalian expression system. Biotechnology Techniques, 13 (9), 615-619. doi: 10.1023/A:1008926708028
1997
Journal Article
Chinese hamster ovary cells produce sufficient recombinant insulin-like growth factor I to support growth in serum-free medium - Serum-free growth of IGF-I producing CHO cells
Hunt, S. M. N., Pak, S. C. O., Bridges, M. W., Gray, P. P. and Sleigh, M. J. (1997). Chinese hamster ovary cells produce sufficient recombinant insulin-like growth factor I to support growth in serum-free medium - Serum-free growth of IGF-I producing CHO cells. Cytotechnology, 24 (55), 55-64. doi: 10.1023/A:1007969502256
1997
Journal Article
'Super-CHO' - A cell line capable of regulatable autocrine growth under fully defined, protein free conditions
Gray, P. P. (1997). 'Super-CHO' - A cell line capable of regulatable autocrine growth under fully defined, protein free conditions. Abstracts of Papers of The American Chemical Society, 213, 61-BIOT.
1997
Journal Article
Expression of recombinant human follicle stimulating hormone mRNA in Chinese hamster ovary cells under different promoters
Watanapokasin, Y and Gray, PP (1997). Expression of recombinant human follicle stimulating hormone mRNA in Chinese hamster ovary cells under different promoters. Asia-pacific Journal of Molecular Biology And Biotechnology, 5 (2), 87-93.
Funding
Current funding
Supervision
Availability
- Professor Peter Gray is:
- Available for supervision
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Supervision history
Completed supervision
-
2015
Doctor Philosophy
Development of a Culture Platform for the Expansion of Pluripotent Human Embryonic Stem Cells Cells with the use of Nanopolymers
Principal Advisor
Other advisors: Professor Michael Monteiro
-
2015
Doctor Philosophy
Novel Cell Engineering of the Unfolded Protein Response to Achieve Efficient Therapeutic Protein Production Cell Line
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2012
Doctor Philosophy
Modulating epigenetic and post-transcriptional regulation for increased recombinant protein production in mammalian cells.
Principal Advisor
-
2011
Doctor Philosophy
Process development and characterisation of transient expression technology in CHO cells
Principal Advisor
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Associate Advisor
Other advisors: Dr Verónica Martinez Salazar, Professor Esteban Marcellin
-
2020
Doctor Philosophy
Engineering Chinese Hamster Ovary Cells for Improved Monoclonal Antibody Productivity by Modulating Feedback Regulation of the Secretory Pathway
Associate Advisor
Other advisors: Dr Marianne Gillard, Emeritus Professor Stephen Mahler
-
2016
Doctor Philosophy
Understanding CHO cells biology for enhanced biopharmaceutical production: a comparative transcriptomic and proteomic approach
Associate Advisor
Other advisors: Professor Esteban Marcellin, Professor Lars Nielsen
-
2014
Doctor Philosophy
Engineered Polymer Nanoparticles for Intracellular DNA Delivery
Associate Advisor
Other advisors: Professor Michael Monteiro
-
2014
Doctor Philosophy
Understanding and overcoming monoterpene toxicity in Saccharomyces cerevisia for the production of sustainable jet fuels
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Global metabolic effect of manipulating pyruvate dehydrogenase complex activity in mammalian cells
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Using network thermodynamics and metabolomics for the study of dynamic mammalian cell metabolism
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2012
Doctor Philosophy
Characterisation of mammalian cells during protein production - a systems biology approach
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2009
Doctor Philosophy
Nanoparticles with Application in the Delivery of Nucleic Acids to Mammalian Cells
Associate Advisor
Media
Enquiries
Contact Professor Peter Gray directly for media enquiries about:
- Bioengineering
- Biopharmaceutical production
- Bioprocessing
- Biotechnology
- Biotechnology - economics
- Cell cultures
- Commercialisation and science research
- Economics - biotechnology
- Metabolism
- Metabolites
- Resarch and commercialisation
- Science research innovation
- Stem cells
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