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Professor Peter Gray
Professor

Peter Gray

Email: 
Phone: 
+61 7 334 63888

Overview

Background

Professor Peter Gray is a pioneer of biotechnology research and development in Australia. In 2003 he was appointed AIBN’s inaugural Director and has since overseen the institute’s growth to 450 people and an annual turnover of $40million. Before joining AIBN, he was Professor and Head of Biotechnology at UNSW.

Professor Gray has held academic positions at University College London and the University of California, Berkeley. He has had commercial experience in the US, working for Eli Lilly and Co and the Cetus Corporation. His research collaborations include groups at Stanford University; the University of California, Berkeley; and the University of British Columbia, Vancouver.

He serves on several boards and government committees. He is on the board of Engineering Conferences International, New York, a group that runs global, multi-disciplinary engineering conferences, many of which have played key roles in developing emerging industry sectors. The conferences include cell culture engineering; vaccine technology; and scale-up and manufacturing of cell-based therapies. Professor Gray also serves on the board of Biopharmaceuticals Australia Pty Ltd, the company established to build a GMP grade biopharmaceuticals manufacturing facility in Brisbane, and has been heavily involved in negotiations that led to DSM Biologics becoming the facility’s operator.

Professor Gray is a Fellow and Vice-President of the Australian Academy of Technological Sciences and Engineering and a Fellow of the Australian Institute of Company Directors. He has chaired, served on organising committees for, and given plenary and keynote addresses at many key international conferences. In 2006 he attracted to Sydney and chaired the International Biotechnology Symposium – the first time a conference in the four-yearly series was held in the southern hemisphere. Professor Gray is a founder and past president of the Australian Biotechnology Association (Ausbiotech).

Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses. He has twice been listed by Engineers Australia among the top 100 most influential engineers in Australia, and in 2001 was awarded the Australian Government’s Centenary Medal.

Availability

Professor Peter Gray is:
Available for supervision
Media expert

Qualifications

  • Australian Academy of Technological Sciences and Engineering, Australian Academy of Technological Sciences and Engineering
  • Engineers Australia, Engineers Australia
  • International Institute of Biotechnology and Toxicology, International Institute of Biotechnology and Toxicology

Research impacts

Research

Mammalian Cell Lines and Stem Cell Bioprocesses

Professor Peter Gray leads a research group with a focus on bioengineering of mammalian cell protein expression and stem cell systems. The research group is growing a strategic link with DSM Biologics, a contract manufacturer that takes early-stage projects to the next stage of commercial development. AIBN is developing mammalian cell lines, which form the basis of biologics, medicines based on natural proteins, and DSM will produce and commercialise them at a $65 million scale-up facility at Brisbane’s Princess Alexandra Hospital in Brisbane.

Professor Gray's research group is collaborating with Sydney-based Biosceptre International Ltd in a partnership aiming to develop a bio-process for producing monoclonal antibodies to treat cancer. AIBN researchers will characterise candidate therapeutic monoclonal antibodies that bind to Biosceptre's novel cancer target, known as nf-P2X7. Research and development will include antibody and cell line development; bioprocess development; and recombinant protein production in pre-commercial quantities ahead of preclinical trials. The Biosceptre collaboration is a critical step towards preclinical and human clinical trials. The long-term goal is to develop a therapeutic monoclonal antibody capable of specifically detecting nf-P2X7 and inducing cancer cell death without affecting normal healthy cells.

Ongoing research in Professor Gray's research group and Australian Animal Health Laboratory in Victoria with a Hendra virus antibody aims to determine its shelf life, to see how long it can be stored. The AIBN research group has developed a process to produce large amounts of high-quality antibody. The research group has produce batches of the experimental antibody for Queensland Health and collaborators at the CSIRO Australian Animal Health Laboratory in Geelong for testing in animal trials.

Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses.

Works

Search Professor Peter Gray’s works on UQ eSpace

87 works between 1990 and 2024

61 - 80 of 87 works

2006

Journal Article

Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology

Catzel, D., Chin, D. Y., Stanton, P. G., Gray, P. P. and Mahler, S. A. (2006). Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology. Journal of Biotechnology, 122 (1), 73-85. doi: 10.1016/j.jbiotec.2005.08.026

Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology

2006

Journal Article

Stable suspension of layered double hydroxide nanoparticles in aqueous solution

Xu, Zhi Ping, Stevenson, Gregory S., Lu, Chao-Qing, Lu, Gao Qing (Max), Bartlett, Perry F. and Gray, Peter P. (2006). Stable suspension of layered double hydroxide nanoparticles in aqueous solution. Journal of The American Chemical Society, 128 (1), 36-37. doi: 10.1021/ja056652a

Stable suspension of layered double hydroxide nanoparticles in aqueous solution

2006

Journal Article

Splitting the difference: When near enough is not close enough

Sleiman, R. J., Gray, P. P. and Sunstrom, N. A. (2006). Splitting the difference: When near enough is not close enough. Cytometry Part A, 69A (5), 426-426.

Splitting the difference: When near enough is not close enough

2005

Conference Publication

A proteome analysis of conditioned media from human neonatal fibroblasts used in the maintenance of human embryonic stem cells

Prowse, Andrew B. J., McQuade, Leon R., Bryant, Katherin J., Van Dyk, Derek D., Tuch, BBernard E. and Gray, Peter P. (2005). A proteome analysis of conditioned media from human neonatal fibroblasts used in the maintenance of human embryonic stem cells. 3rd International Proteomics Conference/1st Taiwan Proteomics Conference/2nd AOHUPO Congress, Taipei, Taiwan, 14-17 May 2004. Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/pmic.200401087

A proteome analysis of conditioned media from human neonatal fibroblasts used in the maintenance of human embryonic stem cells

2004

Journal Article

Enhanced productivity of G1 phase Chinese hamster ovary cells using the GADD153 promoter

de Boer, L., Gray, P. P. and Sunstrom, N. A. (2004). Enhanced productivity of G1 phase Chinese hamster ovary cells using the GADD153 promoter. Biotechnology Letters, 26 (1), 61-65. doi: 10.1023/B:BILE.0000009462.10772.a4

Enhanced productivity of G1 phase Chinese hamster ovary cells using the GADD153 promoter

2004

Journal Article

Process development for a recombinant Chinese Hamster Ovary (CHO) cell line utilizing a metal induced and amplified metallothionein expression system

Huang, EP, Marquis, CP and Gray, PP (2004). Process development for a recombinant Chinese Hamster Ovary (CHO) cell line utilizing a metal induced and amplified metallothionein expression system. Biotechnology And Bioengineering, 88 (4), 437-450. doi: 10.1002/bit.20194

Process development for a recombinant Chinese Hamster Ovary (CHO) cell line utilizing a metal induced and amplified metallothionein expression system

2003

Other Outputs

Isolation method for recombinant glycoprotein biopharmaceuticals

Catzel, D., Gray, P. P. and Mahler, S. M. (2003). Isolation method for recombinant glycoprotein biopharmaceuticals. Australian Provisional Patent #61759780.

Isolation method for recombinant glycoprotein biopharmaceuticals

2003

Journal Article

Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line

Van Dyk, Derek D., Misztal, David R., Wilkins, Marc R., Mackintosh, James A., Poljak, Anne, Varnail, Jodie C., Teber, Erdahl, Walsh, Bradley J. and Gray, Peter P. (2003). Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line. Proteomics, 3 (2), 147-156. doi: 10.1002/pmic.200390023

Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line

2003

Book

Review of Australian Biotechnology Education

Gray, P., Barnard, R. T., Franco, C., Rifkin, W., Hine, D. C. and Young, F. (2003). Review of Australian Biotechnology Education. Canberra: Commonwealth of Australia.

Review of Australian Biotechnology Education

2003

Other Outputs

Review of Australian Biotechnology Education, Australian Universities Teaching Committee, Department of Education Science and Training

Gray, P., Barnard, R., Franco, C., Rifkin, W., Hine, D. and Young, F. (2003). Review of Australian Biotechnology Education, Australian Universities Teaching Committee, Department of Education Science and Training. Not available:

Review of Australian Biotechnology Education, Australian Universities Teaching Committee, Department of Education Science and Training

2003

Other Outputs

AUTC Review of Biotechnology 2003

Gray, P., Barnard, R. T., Franco, C., Rifkin, W., Hine, D. C. and Young, F. (2003). AUTC Review of Biotechnology 2003. Canberra: Department of Employment, Science and Technology and Australian Universities Teaching Committee.

AUTC Review of Biotechnology 2003

2003

Journal Article

Effect of shear stress on expression of a recombinant protein by Chinese hamster ovary cells

Keane, Julian T., Ryan, David and Gray, Peter P. (2003). Effect of shear stress on expression of a recombinant protein by Chinese hamster ovary cells. Biotechnology and Bioengineering, 81 (2), 211-220. doi: 10.1002/bit.10472

Effect of shear stress on expression of a recombinant protein by Chinese hamster ovary cells

2003

Journal Article

Purification of recombinant human growth hormone from CHO cell culture supernatant by Gradiflow preparative electrophoresis technology

Catzel, D., Lalevski, H., Marquis, C. P., Gray, P. P., Van Dyk, D. and Mahler, S. M. (2003). Purification of recombinant human growth hormone from CHO cell culture supernatant by Gradiflow preparative electrophoresis technology. Protein Expression And Purification, 32 (1), 126-134. doi: 10.1016/j.pep.2003.07.002

Purification of recombinant human growth hormone from CHO cell culture supernatant by Gradiflow preparative electrophoresis technology

2002

Conference Publication

Ultramicroporous membranes for hydrogen separation

M. C. Duke, J. C. Diniz da Costa, G. Q. Lu, M. Petch and P. Gray (2002). Ultramicroporous membranes for hydrogen separation. EERE 2002, Environmental Engineering Research Event, Blackheath, NSW, Australia, 3-6 December, 2002.

Ultramicroporous membranes for hydrogen separation

2000

Journal Article

Phase I clinical trial of the chimeric monoclonal antibody (c30.6) in patients with metastatic colorectal cancer

Ward, RL, Packham, D, Smythe, AM, Murray, J, Anderson-Stewart, P, Kitchen, N, Muirhead, R, Phillips, P, Gray, P, Bigg-Wither, G, Prabakaran, K, Freund, J, Fullham, M, Rule, M, Dalley, D, Meagher, A, Hawkins, NJ and Smith, GM (2000). Phase I clinical trial of the chimeric monoclonal antibody (c30.6) in patients with metastatic colorectal cancer. Clinical Cancer Research, 6 (12), 4674-4683.

Phase I clinical trial of the chimeric monoclonal antibody (c30.6) in patients with metastatic colorectal cancer

2000

Journal Article

Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells

Sunstrom, NAS, Gay, RD, Wong, DC, Kitchen, NA, DeBoer, L and Gray, PP (2000). Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells. Biotechnology Progress, 16 (5), 698-702. doi: 10.1021/bp000102t

Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells

1999

Journal Article

A rapid selection/amplification procedure for high-level expression of recombinant protein in a metal-amplifiable mammalian expression system

Bailey, C. G., Baig, M., Gray, P. P. and Sunstrom, N. A. (1999). A rapid selection/amplification procedure for high-level expression of recombinant protein in a metal-amplifiable mammalian expression system. Biotechnology Techniques, 13 (9), 615-619. doi: 10.1023/A:1008926708028

A rapid selection/amplification procedure for high-level expression of recombinant protein in a metal-amplifiable mammalian expression system

1997

Journal Article

Chinese hamster ovary cells produce sufficient recombinant insulin-like growth factor I to support growth in serum-free medium - Serum-free growth of IGF-I producing CHO cells

Hunt, S. M. N., Pak, S. C. O., Bridges, M. W., Gray, P. P. and Sleigh, M. J. (1997). Chinese hamster ovary cells produce sufficient recombinant insulin-like growth factor I to support growth in serum-free medium - Serum-free growth of IGF-I producing CHO cells. Cytotechnology, 24 (55), 55-64. doi: 10.1023/A:1007969502256

Chinese hamster ovary cells produce sufficient recombinant insulin-like growth factor I to support growth in serum-free medium - Serum-free growth of IGF-I producing CHO cells

1997

Journal Article

'Super-CHO' - A cell line capable of regulatable autocrine growth under fully defined, protein free conditions

Gray, P. P. (1997). 'Super-CHO' - A cell line capable of regulatable autocrine growth under fully defined, protein free conditions. Abstracts of Papers of The American Chemical Society, 213, 61-BIOT.

'Super-CHO' - A cell line capable of regulatable autocrine growth under fully defined, protein free conditions

1997

Journal Article

Expression of recombinant human follicle stimulating hormone mRNA in Chinese hamster ovary cells under different promoters

Watanapokasin, Y and Gray, PP (1997). Expression of recombinant human follicle stimulating hormone mRNA in Chinese hamster ovary cells under different promoters. Asia-pacific Journal of Molecular Biology And Biotechnology, 5 (2), 87-93.

Expression of recombinant human follicle stimulating hormone mRNA in Chinese hamster ovary cells under different promoters

Funding

Current funding

  • 2021 - 2026
    Induced pluripotent stem cell derived cardiomyocytes: a new therapy for 'no-option' end stage heart failure (MRFF Stem Cell Therapies grant from University of Sydney).
    University of Sydney
    Open grant
  • 2014 - 2027
    Developing a scalable process for translating hEsc and iPS cell science to clinical applications
    Merchant Charitable Foundation
    Open grant

Past funding

  • 2020 - 2022
    Using human pluripotent stem cells to achieve scalable high purity production of cardiac cells for transplantation studies (National Stem Cell Foundation of Australia grant administered by WIMR)
    The Westmead Institute for Medical Research
    Open grant
  • 2019 - 2021
    Using human pluripotent stem cells to achieve scalable, high purity production of cardiac cells for transplantation studies (No. 2)
    The Westmead Institute for Medical Research
    Open grant
  • 2019 - 2021
    Using Pluripotent Stem Cells to Achieve Scalable, High Purity Production of Cardiac Cells for Transplantation Studies
    The Westmead Institute for Medical Research
    Open grant
  • 2017 - 2023
    ARC Training Centre for Biopharmaceutical Innovation
    ARC Industrial Transformation Training Centres
    Open grant
  • 2016 - 2019
    Development of a New Specific Immunosuppressive Monoclonal Antibody to Advance Transplantation (NHMRC Development Grant administered by The University of Sydney)
    University of Sydney
    Open grant
  • 2015
    Continuous manufacturing of biopharmaceuticals through mammalian expression technology
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2014 - 2023
    The National Biologics Facility - NCRIS 2013/2015/2016-17/2017-18/2018-19/2019-2023 (administered by Therapeutic Innovation Australia (TIA))
    Therapeutic Innovation Australia Limited
    Open grant
  • 2013 - 2016
    Highly productive and selective bio-organic hybrid membrane water filters
    Murdoch University
    Open grant
  • 2013 - 2015
    Safety assessment of anti-hendra virus antibody in humans
    Queensland Health
    Open grant
  • 2012 - 2013
    Safety of Hendra virus anti-G glycoprotein monoclonal antibody in humans
    NHMRC Targeted Research
    Open grant
  • 2012 - 2014
    Cell line development for the biologics plant of the future
    Queensland Government Smart Futures Research Partnerships Program
    Open grant
  • 2012
    An intergrated fluidic circuit system for digital PCR analysis, single-cell gene- expression, and high-throughput preparation of next-generation sequencing libraries.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    On-Demand 3-Dimensional Polymer Scaffolds for Directed Stem Cell Differentiation
    ARC Discovery Projects
    Open grant
  • 2011 - 2013
    EIF Project 4 - Biological Therapies, Part 2 - Biopharmaceuticals (Commonwealth-funded EIF grant administered by Therapeutic Innovation Australia (TIA) Ltd).
    Open grant
  • 2011 - 2019
    Stem Cells Australia (ARC Special Research Initiative administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2011 - 2015
    The National Biologics Facility
    Queensland Government Smart Futures Co-Investment Fund
    Open grant
  • 2011 - 2013
    Highly productive and selective bio-organic hybrid membrane water filters - National Centre of Excellence in Desalination
    Murdoch University
    Open grant
  • 2010 - 2014
    Queensland Sustainable Aviation Fuel Initiative
    Queensland Government Smart State National and International Research Alliances Program
    Open grant
  • 2009
    2009 University of Queensland Trans-Pacific Fellowship - Senior Academic Fellowship
    UQ Trans-Pacific Fellowship
    Open grant
  • 2009 - 2011
    AIBN BioReactor Program (ASCC Collaborative Stream 1 - Module 2)
    Australian Stem Cell Centre
    Open grant
  • 2009 - 2010
    Process Modelling Applicable to Biofuels
    Queensland Government Smart Futures Partnerships-Alliances Facilitation Program
    Open grant
  • 2009 - 2011
    Queensland Bio Jet Fuel Initiative
    Queensland Government Smart Futures Partnerships-Alliances Facilitation Program
    Open grant
  • 2007 - 2011
    National Collaborative Research Infrastructure Strategy (NCRIS) - Capability Area 5.5 Biotechnology Products
    National Collaborative Infrastructure Strategy - Queensland Government Contribution
    Open grant
  • 2005 - 2006
    Australia-United Kingdom Bionanotechnology Mission
    Department of Education, Science, and Training
    Open grant

Supervision

Availability

Professor Peter Gray is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

Contact Professor Peter Gray directly for media enquiries about:

  • Bioengineering
  • Biopharmaceutical production
  • Bioprocessing
  • Biotechnology
  • Biotechnology - economics
  • Cell cultures
  • Commercialisation and science research
  • Economics - biotechnology
  • Metabolism
  • Metabolites
  • Resarch and commercialisation
  • Science research innovation
  • Stem cells

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