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Professor Peter Gray
Professor

Peter Gray

Email: 
Phone: 
+61 7 334 63888

Overview

Background

Professor Peter Gray is a pioneer of biotechnology research and development in Australia. In 2003 he was appointed AIBN’s inaugural Director and has since overseen the institute’s growth to 450 people and an annual turnover of $40million. Before joining AIBN, he was Professor and Head of Biotechnology at UNSW.

Professor Gray has held academic positions at University College London and the University of California, Berkeley. He has had commercial experience in the US, working for Eli Lilly and Co and the Cetus Corporation. His research collaborations include groups at Stanford University; the University of California, Berkeley; and the University of British Columbia, Vancouver.

He serves on several boards and government committees. He is on the board of Engineering Conferences International, New York, a group that runs global, multi-disciplinary engineering conferences, many of which have played key roles in developing emerging industry sectors. The conferences include cell culture engineering; vaccine technology; and scale-up and manufacturing of cell-based therapies. Professor Gray also serves on the board of Biopharmaceuticals Australia Pty Ltd, the company established to build a GMP grade biopharmaceuticals manufacturing facility in Brisbane, and has been heavily involved in negotiations that led to DSM Biologics becoming the facility’s operator.

Professor Gray is a Fellow and Vice-President of the Australian Academy of Technological Sciences and Engineering and a Fellow of the Australian Institute of Company Directors. He has chaired, served on organising committees for, and given plenary and keynote addresses at many key international conferences. In 2006 he attracted to Sydney and chaired the International Biotechnology Symposium – the first time a conference in the four-yearly series was held in the southern hemisphere. Professor Gray is a founder and past president of the Australian Biotechnology Association (Ausbiotech).

Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses. He has twice been listed by Engineers Australia among the top 100 most influential engineers in Australia, and in 2001 was awarded the Australian Government’s Centenary Medal.

Availability

Professor Peter Gray is:
Available for supervision
Media expert

Qualifications

  • Australian Academy of Technological Sciences and Engineering, Australian Academy of Technological Sciences and Engineering
  • Engineers Australia, Engineers Australia
  • International Institute of Biotechnology and Toxicology, International Institute of Biotechnology and Toxicology

Research impacts

Research

Mammalian Cell Lines and Stem Cell Bioprocesses

Professor Peter Gray leads a research group with a focus on bioengineering of mammalian cell protein expression and stem cell systems. The research group is growing a strategic link with DSM Biologics, a contract manufacturer that takes early-stage projects to the next stage of commercial development. AIBN is developing mammalian cell lines, which form the basis of biologics, medicines based on natural proteins, and DSM will produce and commercialise them at a $65 million scale-up facility at Brisbane’s Princess Alexandra Hospital in Brisbane.

Professor Gray's research group is collaborating with Sydney-based Biosceptre International Ltd in a partnership aiming to develop a bio-process for producing monoclonal antibodies to treat cancer. AIBN researchers will characterise candidate therapeutic monoclonal antibodies that bind to Biosceptre's novel cancer target, known as nf-P2X7. Research and development will include antibody and cell line development; bioprocess development; and recombinant protein production in pre-commercial quantities ahead of preclinical trials. The Biosceptre collaboration is a critical step towards preclinical and human clinical trials. The long-term goal is to develop a therapeutic monoclonal antibody capable of specifically detecting nf-P2X7 and inducing cancer cell death without affecting normal healthy cells.

Ongoing research in Professor Gray's research group and Australian Animal Health Laboratory in Victoria with a Hendra virus antibody aims to determine its shelf life, to see how long it can be stored. The AIBN research group has developed a process to produce large amounts of high-quality antibody. The research group has produce batches of the experimental antibody for Queensland Health and collaborators at the CSIRO Australian Animal Health Laboratory in Geelong for testing in animal trials.

Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses.

Works

Search Professor Peter Gray’s works on UQ eSpace

87 works between 1990 and 2024

41 - 60 of 87 works

2011

Journal Article

Enhanced CHO cell-based transient gene expression with the Epi-CHO expression system

Codamo, Joe, Munro, Trent P., Hughes, Benjamin S., Song, Michael and Gray, Peter P. (2011). Enhanced CHO cell-based transient gene expression with the Epi-CHO expression system. Molecular Biotechnology, 48 (2), 109-115. doi: 10.1007/s12033-010-9351-9

Enhanced CHO cell-based transient gene expression with the Epi-CHO expression system

2011

Journal Article

Stem cell integrins: Implications for ex-vivo culture and cellular therapies

Prowse, Andrew B. J., Chong, Fenny, Gray, Peter P. and Munro, Trent P. (2011). Stem cell integrins: Implications for ex-vivo culture and cellular therapies. Stem Cell Research, 6 (1), 1-12. doi: 10.1016/j.scr.2010.09.005

Stem cell integrins: Implications for ex-vivo culture and cellular therapies

2011

Book Chapter

Cell line isolation and design

Munro, Trent P., Pilbrough, Warren, Hughes, Benjamin S. and Gray, Peter P. (2011). Cell line isolation and design. Scientific Fundamentals of Biotechnology. (pp. 169-178) edited by Murray Moo-Young, Michael Butler, Colin Webb, Antonio Moreira,, Bernard Grodzinski, Z. F. Cui and Spiros Agathos. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-08-088504-9.00024-6

Cell line isolation and design

2011

Journal Article

Biologics and biosimilars: emerging technologies driving global opportunity

Mahler, Stephen and Gray, Peter (2011). Biologics and biosimilars: emerging technologies driving global opportunity. Journal of Chemical Technology & Biotechnology, 86 (7), 893-894. doi: 10.1002/jctb.2684

Biologics and biosimilars: emerging technologies driving global opportunity

2010

Journal Article

Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media

Prowse, Andrew B. J., Doran, Michael R., Cooper-White, Justin J., Chong, Fenny, Munro, Trent P., Fitzpatrick, Jane, Chung, Tung-Liang, Haylock, David N., Gray, Peter P. and Wolvetang, Ernst J. (2010). Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media. Biomaterials, 31 (32), 8281-8288. doi: 10.1016/j.biomaterials.2010.07.037

Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media

2010

Journal Article

Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol

Dietmair, Stefanie, Timmins, Nicholas E., Gray, Peter P., Nielsen, Lars K. and Kromer, Jens O. (2010). Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol. Analytical Biochemistry, 404 (2), 155-164. doi: 10.1016/j.ab.2010.04.031

Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol

2010

Journal Article

Defined high protein content surfaces for stem cell culture

Doran, Michael R., Frith, Jessica E., Prowse, Andrew B. J., Fitzpatrick, Jane, Wolvetang, Ernst J., Munro, Trent P., Gray, Peter P. and Cooper-White, Justin J. (2010). Defined high protein content surfaces for stem cell culture. Biomaterials, 31 (19), 5137-5142. doi: 10.1016/j.biomaterials.2010.03.015

Defined high protein content surfaces for stem cell culture

2010

Journal Article

A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies

Jones, Martina L., Seldon, Therese, Smede, Matthew, Linville, Ashleigh, Chin, David Y., Barnard, Ross, Mahler, Stephen M., Munster, David, Hart, Derek, Gray, Peter P. and Munro, Trent P. (2010). A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies. Journal of Immunological Methods, 354 (1-2), 85-90. doi: 10.1016/j.jim.2010.02.001

A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies

2010

Journal Article

Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles

Ladewig, K., Niebert, M., Xu, Z.P., Gray, P.P. and Lu, G.Q. (2010). Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles. Applied Clay Science, 48 (1-2), 280-289. doi: 10.1016/j.clay.2009.11.032

Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles

2010

Journal Article

Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles

Ladewig, Katharina, Niebert, Marcus, Xu, Zhi P., Gray, Peter P. and Lu, Gao Q. M. (2010). Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles. Biomaterials, 31 (7), 1821-1829. doi: 10.1016/j.biomaterials.2009.10.058

Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles

2009

Journal Article

Intraclonal protein expression heterogeneity in recombinant CHO cells

Pilbrough, Warren, Munro, Trent P. and Gray, Peter (2009). Intraclonal protein expression heterogeneity in recombinant CHO cells. PLoS One, 4 (12) e8432, e8432.1-e8432.11. doi: 10.1371/journal.pone.0008432

Intraclonal protein expression heterogeneity in recombinant CHO cells

2009

Journal Article

Multiplexed Staining of Live Human Embryonic Stem Cells for Flow Cytometric Analysis of Pluripotency Markers

Prowse, ABJ, Wilson, J, Osborne, GW, Gray, PP and Wolvetang, EJ (2009). Multiplexed Staining of Live Human Embryonic Stem Cells for Flow Cytometric Analysis of Pluripotency Markers. Stem Cells and Development, 18 (8), 1135-1139. doi: 10.1089/scd.2009.0080

Multiplexed Staining of Live Human Embryonic Stem Cells for Flow Cytometric Analysis of Pluripotency Markers

2009

Journal Article

A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps

Prowse, ABJ, Wolvetang, EJ and Gray, PP (2009). A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps. Biotechniques, 47 (1), 599-606. doi: 10.2144/000113151

A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps

2009

Conference Publication

Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease

Hart, D, Seldon, T, Jones, M, Sheng, Y, Palkova, A, Cullup, H, Munro, T, Sinfield, L, Rice, AM, Wilson, J, Gray, P, Barnard, R, Mahler, S and Munster, D (2009). Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease. 51st Annual Meeting of the American Society of Hematology, New Orleans LA, 5-8 December 2009. Washington, D.C.: American Society of Hematology.

Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease

2008

Journal Article

Subcellular compartment targeting of layered double hydroxide nanoparticles

Xu, Zhi Ping, Niebert, Marcus, Porazik, Katharina, Walker, Tara L., Cooper, Helen M., Middelberg, Anton P.J., Gray, Peter P., Bartlett, Perry F. and Lu, Gao Qing (Max) (2008). Subcellular compartment targeting of layered double hydroxide nanoparticles. Journal of Controlled Release, 130 (1), 86-94. doi: 10.1016/j.jconrel.2008.05.021

Subcellular compartment targeting of layered double hydroxide nanoparticles

2008

Journal Article

Accelerated cell line development using two-color fluorescence activated cell sorting to select highly expressing antibody-producing clones

Sleiman, Robert J., Gray, Peter P., McCall, Martin N., Codamo, Joe and Sunstrom, Noelle-Ann S. (2008). Accelerated cell line development using two-color fluorescence activated cell sorting to select highly expressing antibody-producing clones. Biotechnology and Bioengineering, 99 (3), 578-586. doi: 10.1002/bit.21612

Accelerated cell line development using two-color fluorescence activated cell sorting to select highly expressing antibody-producing clones

2008

Journal Article

Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma

Vari F, Munster D.J., Hsu J.L., Rossetti T.R., Stephen Mahler, Gray, Peter P., Turtle C.J., Prue R.L. and Hart D.N. (2008). Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma. British Journal Of Haematology, 143 (3), 374-377. doi: 10.1111/j.1365-2141.2008.07346.x

Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma

2007

Journal Article

Development of Super-CHO protein-free medium based on statistical design

Huang, EP, Marquis, CP and Gray, PP (2007). Development of Super-CHO protein-free medium based on statistical design. Journal of Chemical Technology And Biotechnology, 82 (5), 431-441. doi: 10.1002/jctb.1670

Development of Super-CHO protein-free medium based on statistical design

2007

Journal Article

Identification of potential pluripotency determinants for human embryonic stem cells following proteomic analysis of human and mouse fibroblast conditioned media

Prowse, A. B. J., McQuade, L. R., Bryant, K. J., Marcal, H. and Gray, P. P. (2007). Identification of potential pluripotency determinants for human embryonic stem cells following proteomic analysis of human and mouse fibroblast conditioned media. Journal of Proteome Research, 6 (9), 3796-3807. doi: 10.1021/pr0702262

Identification of potential pluripotency determinants for human embryonic stem cells following proteomic analysis of human and mouse fibroblast conditioned media

2006

Journal Article

Purification of monoclonal antibodies from cell culture supernatants by Gradiflow (TM) electrophoresis technology

Mahler, Stephen M., Leong, Sharon, Gilbert, Andrew, Yang, Fan, Gray, Peter, Van Dyk, Derek and Roeth, Philip (2006). Purification of monoclonal antibodies from cell culture supernatants by Gradiflow (TM) electrophoresis technology. Journal of Chemical Technology And Biotechnology, 81 (3), 445-453. doi: 10.1002/jctb.1426

Purification of monoclonal antibodies from cell culture supernatants by Gradiflow (TM) electrophoresis technology

Funding

Current funding

  • 2021 - 2026
    Induced pluripotent stem cell derived cardiomyocytes: a new therapy for 'no-option' end stage heart failure (MRFF Stem Cell Therapies grant from University of Sydney).
    University of Sydney
    Open grant
  • 2014 - 2027
    Developing a scalable process for translating hEsc and iPS cell science to clinical applications
    Merchant Charitable Foundation
    Open grant

Past funding

  • 2020 - 2022
    Using human pluripotent stem cells to achieve scalable high purity production of cardiac cells for transplantation studies (National Stem Cell Foundation of Australia grant administered by WIMR)
    The Westmead Institute for Medical Research
    Open grant
  • 2019 - 2021
    Using human pluripotent stem cells to achieve scalable, high purity production of cardiac cells for transplantation studies (No. 2)
    The Westmead Institute for Medical Research
    Open grant
  • 2019 - 2021
    Using Pluripotent Stem Cells to Achieve Scalable, High Purity Production of Cardiac Cells for Transplantation Studies
    The Westmead Institute for Medical Research
    Open grant
  • 2017 - 2023
    ARC Training Centre for Biopharmaceutical Innovation
    ARC Industrial Transformation Training Centres
    Open grant
  • 2016 - 2019
    Development of a New Specific Immunosuppressive Monoclonal Antibody to Advance Transplantation (NHMRC Development Grant administered by The University of Sydney)
    University of Sydney
    Open grant
  • 2015
    Continuous manufacturing of biopharmaceuticals through mammalian expression technology
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2014 - 2023
    The National Biologics Facility - NCRIS 2013/2015/2016-17/2017-18/2018-19/2019-2023 (administered by Therapeutic Innovation Australia (TIA))
    Therapeutic Innovation Australia Limited
    Open grant
  • 2013 - 2016
    Highly productive and selective bio-organic hybrid membrane water filters
    Murdoch University
    Open grant
  • 2013 - 2015
    Safety assessment of anti-hendra virus antibody in humans
    Queensland Health
    Open grant
  • 2012 - 2013
    Safety of Hendra virus anti-G glycoprotein monoclonal antibody in humans
    NHMRC Targeted Research
    Open grant
  • 2012 - 2014
    Cell line development for the biologics plant of the future
    Queensland Government Smart Futures Research Partnerships Program
    Open grant
  • 2012
    An intergrated fluidic circuit system for digital PCR analysis, single-cell gene- expression, and high-throughput preparation of next-generation sequencing libraries.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    On-Demand 3-Dimensional Polymer Scaffolds for Directed Stem Cell Differentiation
    ARC Discovery Projects
    Open grant
  • 2011 - 2013
    EIF Project 4 - Biological Therapies, Part 2 - Biopharmaceuticals (Commonwealth-funded EIF grant administered by Therapeutic Innovation Australia (TIA) Ltd).
    Open grant
  • 2011 - 2019
    Stem Cells Australia (ARC Special Research Initiative administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2011 - 2015
    The National Biologics Facility
    Queensland Government Smart Futures Co-Investment Fund
    Open grant
  • 2011 - 2013
    Highly productive and selective bio-organic hybrid membrane water filters - National Centre of Excellence in Desalination
    Murdoch University
    Open grant
  • 2010 - 2014
    Queensland Sustainable Aviation Fuel Initiative
    Queensland Government Smart State National and International Research Alliances Program
    Open grant
  • 2009
    2009 University of Queensland Trans-Pacific Fellowship - Senior Academic Fellowship
    UQ Trans-Pacific Fellowship
    Open grant
  • 2009 - 2011
    AIBN BioReactor Program (ASCC Collaborative Stream 1 - Module 2)
    Australian Stem Cell Centre
    Open grant
  • 2009 - 2010
    Process Modelling Applicable to Biofuels
    Queensland Government Smart Futures Partnerships-Alliances Facilitation Program
    Open grant
  • 2009 - 2011
    Queensland Bio Jet Fuel Initiative
    Queensland Government Smart Futures Partnerships-Alliances Facilitation Program
    Open grant
  • 2007 - 2011
    National Collaborative Research Infrastructure Strategy (NCRIS) - Capability Area 5.5 Biotechnology Products
    National Collaborative Infrastructure Strategy - Queensland Government Contribution
    Open grant
  • 2005 - 2006
    Australia-United Kingdom Bionanotechnology Mission
    Department of Education, Science, and Training
    Open grant

Supervision

Availability

Professor Peter Gray is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

Contact Professor Peter Gray directly for media enquiries about:

  • Bioengineering
  • Biopharmaceutical production
  • Bioprocessing
  • Biotechnology
  • Biotechnology - economics
  • Cell cultures
  • Commercialisation and science research
  • Economics - biotechnology
  • Metabolism
  • Metabolites
  • Resarch and commercialisation
  • Science research innovation
  • Stem cells

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