![Professor Peter Gray](/sites/default/files/profiles/1295.jpeg)
Overview
Background
Professor Peter Gray is a pioneer of biotechnology research and development in Australia. In 2003 he was appointed AIBN’s inaugural Director and has since overseen the institute’s growth to 450 people and an annual turnover of $40million. Before joining AIBN, he was Professor and Head of Biotechnology at UNSW.
Professor Gray has held academic positions at University College London and the University of California, Berkeley. He has had commercial experience in the US, working for Eli Lilly and Co and the Cetus Corporation. His research collaborations include groups at Stanford University; the University of California, Berkeley; and the University of British Columbia, Vancouver.
He serves on several boards and government committees. He is on the board of Engineering Conferences International, New York, a group that runs global, multi-disciplinary engineering conferences, many of which have played key roles in developing emerging industry sectors. The conferences include cell culture engineering; vaccine technology; and scale-up and manufacturing of cell-based therapies. Professor Gray also serves on the board of Biopharmaceuticals Australia Pty Ltd, the company established to build a GMP grade biopharmaceuticals manufacturing facility in Brisbane, and has been heavily involved in negotiations that led to DSM Biologics becoming the facility’s operator.
Professor Gray is a Fellow and Vice-President of the Australian Academy of Technological Sciences and Engineering and a Fellow of the Australian Institute of Company Directors. He has chaired, served on organising committees for, and given plenary and keynote addresses at many key international conferences. In 2006 he attracted to Sydney and chaired the International Biotechnology Symposium – the first time a conference in the four-yearly series was held in the southern hemisphere. Professor Gray is a founder and past president of the Australian Biotechnology Association (Ausbiotech).
Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses. He has twice been listed by Engineers Australia among the top 100 most influential engineers in Australia, and in 2001 was awarded the Australian Government’s Centenary Medal.
Availability
- Professor Peter Gray is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Australian Academy of Technological Sciences and Engineering, Australian Academy of Technological Sciences and Engineering
- Engineers Australia, Engineers Australia
- International Institute of Biotechnology and Toxicology, International Institute of Biotechnology and Toxicology
Research impacts
Research
Mammalian Cell Lines and Stem Cell Bioprocesses
Professor Peter Gray leads a research group with a focus on bioengineering of mammalian cell protein expression and stem cell systems. The research group is growing a strategic link with DSM Biologics, a contract manufacturer that takes early-stage projects to the next stage of commercial development. AIBN is developing mammalian cell lines, which form the basis of biologics, medicines based on natural proteins, and DSM will produce and commercialise them at a $65 million scale-up facility at Brisbane’s Princess Alexandra Hospital in Brisbane.
Professor Gray's research group is collaborating with Sydney-based Biosceptre International Ltd in a partnership aiming to develop a bio-process for producing monoclonal antibodies to treat cancer. AIBN researchers will characterise candidate therapeutic monoclonal antibodies that bind to Biosceptre's novel cancer target, known as nf-P2X7. Research and development will include antibody and cell line development; bioprocess development; and recombinant protein production in pre-commercial quantities ahead of preclinical trials. The Biosceptre collaboration is a critical step towards preclinical and human clinical trials. The long-term goal is to develop a therapeutic monoclonal antibody capable of specifically detecting nf-P2X7 and inducing cancer cell death without affecting normal healthy cells.
Ongoing research in Professor Gray's research group and Australian Animal Health Laboratory in Victoria with a Hendra virus antibody aims to determine its shelf life, to see how long it can be stored. The AIBN research group has developed a process to produce large amounts of high-quality antibody. The research group has produce batches of the experimental antibody for Queensland Health and collaborators at the CSIRO Australian Animal Health Laboratory in Geelong for testing in animal trials.
Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses.
Works
Search Professor Peter Gray’s works on UQ eSpace
2011
Journal Article
Enhanced CHO cell-based transient gene expression with the Epi-CHO expression system
Codamo, Joe, Munro, Trent P., Hughes, Benjamin S., Song, Michael and Gray, Peter P. (2011). Enhanced CHO cell-based transient gene expression with the Epi-CHO expression system. Molecular Biotechnology, 48 (2), 109-115. doi: 10.1007/s12033-010-9351-9
2011
Journal Article
Stem cell integrins: Implications for ex-vivo culture and cellular therapies
Prowse, Andrew B. J., Chong, Fenny, Gray, Peter P. and Munro, Trent P. (2011). Stem cell integrins: Implications for ex-vivo culture and cellular therapies. Stem Cell Research, 6 (1), 1-12. doi: 10.1016/j.scr.2010.09.005
2011
Book Chapter
Cell line isolation and design
Munro, Trent P., Pilbrough, Warren, Hughes, Benjamin S. and Gray, Peter P. (2011). Cell line isolation and design. Scientific Fundamentals of Biotechnology. (pp. 169-178) edited by Murray Moo-Young, Michael Butler, Colin Webb, Antonio Moreira,, Bernard Grodzinski, Z. F. Cui and Spiros Agathos. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-08-088504-9.00024-6
2011
Journal Article
Biologics and biosimilars: emerging technologies driving global opportunity
Mahler, Stephen and Gray, Peter (2011). Biologics and biosimilars: emerging technologies driving global opportunity. Journal of Chemical Technology & Biotechnology, 86 (7), 893-894. doi: 10.1002/jctb.2684
2010
Journal Article
Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media
Prowse, Andrew B. J., Doran, Michael R., Cooper-White, Justin J., Chong, Fenny, Munro, Trent P., Fitzpatrick, Jane, Chung, Tung-Liang, Haylock, David N., Gray, Peter P. and Wolvetang, Ernst J. (2010). Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media. Biomaterials, 31 (32), 8281-8288. doi: 10.1016/j.biomaterials.2010.07.037
2010
Journal Article
Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol
Dietmair, Stefanie, Timmins, Nicholas E., Gray, Peter P., Nielsen, Lars K. and Kromer, Jens O. (2010). Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol. Analytical Biochemistry, 404 (2), 155-164. doi: 10.1016/j.ab.2010.04.031
2010
Journal Article
Defined high protein content surfaces for stem cell culture
Doran, Michael R., Frith, Jessica E., Prowse, Andrew B. J., Fitzpatrick, Jane, Wolvetang, Ernst J., Munro, Trent P., Gray, Peter P. and Cooper-White, Justin J. (2010). Defined high protein content surfaces for stem cell culture. Biomaterials, 31 (19), 5137-5142. doi: 10.1016/j.biomaterials.2010.03.015
2010
Journal Article
A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies
Jones, Martina L., Seldon, Therese, Smede, Matthew, Linville, Ashleigh, Chin, David Y., Barnard, Ross, Mahler, Stephen M., Munster, David, Hart, Derek, Gray, Peter P. and Munro, Trent P. (2010). A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies. Journal of Immunological Methods, 354 (1-2), 85-90. doi: 10.1016/j.jim.2010.02.001
2010
Journal Article
Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles
Ladewig, K., Niebert, M., Xu, Z.P., Gray, P.P. and Lu, G.Q. (2010). Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles. Applied Clay Science, 48 (1-2), 280-289. doi: 10.1016/j.clay.2009.11.032
2010
Journal Article
Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles
Ladewig, Katharina, Niebert, Marcus, Xu, Zhi P., Gray, Peter P. and Lu, Gao Q. M. (2010). Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles. Biomaterials, 31 (7), 1821-1829. doi: 10.1016/j.biomaterials.2009.10.058
2009
Journal Article
Intraclonal protein expression heterogeneity in recombinant CHO cells
Pilbrough, Warren, Munro, Trent P. and Gray, Peter (2009). Intraclonal protein expression heterogeneity in recombinant CHO cells. PLoS One, 4 (12) e8432, e8432.1-e8432.11. doi: 10.1371/journal.pone.0008432
2009
Journal Article
Multiplexed Staining of Live Human Embryonic Stem Cells for Flow Cytometric Analysis of Pluripotency Markers
Prowse, ABJ, Wilson, J, Osborne, GW, Gray, PP and Wolvetang, EJ (2009). Multiplexed Staining of Live Human Embryonic Stem Cells for Flow Cytometric Analysis of Pluripotency Markers. Stem Cells and Development, 18 (8), 1135-1139. doi: 10.1089/scd.2009.0080
2009
Journal Article
A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps
Prowse, ABJ, Wolvetang, EJ and Gray, PP (2009). A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps. Biotechniques, 47 (1), 599-606. doi: 10.2144/000113151
2009
Conference Publication
Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease
Hart, D, Seldon, T, Jones, M, Sheng, Y, Palkova, A, Cullup, H, Munro, T, Sinfield, L, Rice, AM, Wilson, J, Gray, P, Barnard, R, Mahler, S and Munster, D (2009). Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease. 51st Annual Meeting of the American Society of Hematology, New Orleans LA, 5-8 December 2009. Washington, D.C.: American Society of Hematology.
2008
Journal Article
Subcellular compartment targeting of layered double hydroxide nanoparticles
Xu, Zhi Ping, Niebert, Marcus, Porazik, Katharina, Walker, Tara L., Cooper, Helen M., Middelberg, Anton P.J., Gray, Peter P., Bartlett, Perry F. and Lu, Gao Qing (Max) (2008). Subcellular compartment targeting of layered double hydroxide nanoparticles. Journal of Controlled Release, 130 (1), 86-94. doi: 10.1016/j.jconrel.2008.05.021
2008
Journal Article
Accelerated cell line development using two-color fluorescence activated cell sorting to select highly expressing antibody-producing clones
Sleiman, Robert J., Gray, Peter P., McCall, Martin N., Codamo, Joe and Sunstrom, Noelle-Ann S. (2008). Accelerated cell line development using two-color fluorescence activated cell sorting to select highly expressing antibody-producing clones. Biotechnology and Bioengineering, 99 (3), 578-586. doi: 10.1002/bit.21612
2008
Journal Article
Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma
Vari F, Munster D.J., Hsu J.L., Rossetti T.R., Stephen Mahler, Gray, Peter P., Turtle C.J., Prue R.L. and Hart D.N. (2008). Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma. British Journal Of Haematology, 143 (3), 374-377. doi: 10.1111/j.1365-2141.2008.07346.x
2007
Journal Article
Development of Super-CHO protein-free medium based on statistical design
Huang, EP, Marquis, CP and Gray, PP (2007). Development of Super-CHO protein-free medium based on statistical design. Journal of Chemical Technology And Biotechnology, 82 (5), 431-441. doi: 10.1002/jctb.1670
2007
Journal Article
Identification of potential pluripotency determinants for human embryonic stem cells following proteomic analysis of human and mouse fibroblast conditioned media
Prowse, A. B. J., McQuade, L. R., Bryant, K. J., Marcal, H. and Gray, P. P. (2007). Identification of potential pluripotency determinants for human embryonic stem cells following proteomic analysis of human and mouse fibroblast conditioned media. Journal of Proteome Research, 6 (9), 3796-3807. doi: 10.1021/pr0702262
2006
Journal Article
Purification of monoclonal antibodies from cell culture supernatants by Gradiflow (TM) electrophoresis technology
Mahler, Stephen M., Leong, Sharon, Gilbert, Andrew, Yang, Fan, Gray, Peter, Van Dyk, Derek and Roeth, Philip (2006). Purification of monoclonal antibodies from cell culture supernatants by Gradiflow (TM) electrophoresis technology. Journal of Chemical Technology And Biotechnology, 81 (3), 445-453. doi: 10.1002/jctb.1426
Funding
Current funding
Supervision
Availability
- Professor Peter Gray is:
- Available for supervision
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Supervision history
Completed supervision
-
2015
Doctor Philosophy
Development of a Culture Platform for the Expansion of Pluripotent Human Embryonic Stem Cells Cells with the use of Nanopolymers
Principal Advisor
Other advisors: Professor Michael Monteiro
-
2015
Doctor Philosophy
Novel Cell Engineering of the Unfolded Protein Response to Achieve Efficient Therapeutic Protein Production Cell Line
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2012
Doctor Philosophy
Modulating epigenetic and post-transcriptional regulation for increased recombinant protein production in mammalian cells.
Principal Advisor
-
2011
Doctor Philosophy
Process development and characterisation of transient expression technology in CHO cells
Principal Advisor
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Associate Advisor
Other advisors: Dr Verónica Martinez Salazar, Professor Esteban Marcellin
-
2020
Doctor Philosophy
Engineering Chinese Hamster Ovary Cells for Improved Monoclonal Antibody Productivity by Modulating Feedback Regulation of the Secretory Pathway
Associate Advisor
Other advisors: Dr Marianne Gillard, Emeritus Professor Stephen Mahler
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2016
Doctor Philosophy
Understanding CHO cells biology for enhanced biopharmaceutical production: a comparative transcriptomic and proteomic approach
Associate Advisor
Other advisors: Professor Esteban Marcellin, Professor Lars Nielsen
-
2014
Doctor Philosophy
Engineered Polymer Nanoparticles for Intracellular DNA Delivery
Associate Advisor
Other advisors: Professor Michael Monteiro
-
2014
Doctor Philosophy
Understanding and overcoming monoterpene toxicity in Saccharomyces cerevisia for the production of sustainable jet fuels
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Global metabolic effect of manipulating pyruvate dehydrogenase complex activity in mammalian cells
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Using network thermodynamics and metabolomics for the study of dynamic mammalian cell metabolism
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2012
Doctor Philosophy
Characterisation of mammalian cells during protein production - a systems biology approach
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2009
Doctor Philosophy
Nanoparticles with Application in the Delivery of Nucleic Acids to Mammalian Cells
Associate Advisor
Media
Enquiries
Contact Professor Peter Gray directly for media enquiries about:
- Bioengineering
- Biopharmaceutical production
- Bioprocessing
- Biotechnology
- Biotechnology - economics
- Cell cultures
- Commercialisation and science research
- Economics - biotechnology
- Metabolism
- Metabolites
- Resarch and commercialisation
- Science research innovation
- Stem cells
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