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Professor Peter Gray
Professor

Peter Gray

Email: 
Phone: 
+61 7 334 63888

Overview

Background

Professor Peter Gray is a pioneer of biotechnology research and development in Australia. In 2003 he was appointed AIBN’s inaugural Director and has since overseen the institute’s growth to 450 people and an annual turnover of $40million. Before joining AIBN, he was Professor and Head of Biotechnology at UNSW.

Professor Gray has held academic positions at University College London and the University of California, Berkeley. He has had commercial experience in the US, working for Eli Lilly and Co and the Cetus Corporation. His research collaborations include groups at Stanford University; the University of California, Berkeley; and the University of British Columbia, Vancouver.

He serves on several boards and government committees. He is on the board of Engineering Conferences International, New York, a group that runs global, multi-disciplinary engineering conferences, many of which have played key roles in developing emerging industry sectors. The conferences include cell culture engineering; vaccine technology; and scale-up and manufacturing of cell-based therapies. Professor Gray also serves on the board of Biopharmaceuticals Australia Pty Ltd, the company established to build a GMP grade biopharmaceuticals manufacturing facility in Brisbane, and has been heavily involved in negotiations that led to DSM Biologics becoming the facility’s operator.

Professor Gray is a Fellow and Vice-President of the Australian Academy of Technological Sciences and Engineering and a Fellow of the Australian Institute of Company Directors. He has chaired, served on organising committees for, and given plenary and keynote addresses at many key international conferences. In 2006 he attracted to Sydney and chaired the International Biotechnology Symposium – the first time a conference in the four-yearly series was held in the southern hemisphere. Professor Gray is a founder and past president of the Australian Biotechnology Association (Ausbiotech).

Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses. He has twice been listed by Engineers Australia among the top 100 most influential engineers in Australia, and in 2001 was awarded the Australian Government’s Centenary Medal.

Availability

Professor Peter Gray is:
Available for supervision
Media expert

Qualifications

  • Australian Academy of Technological Sciences and Engineering, Australian Academy of Technological Sciences and Engineering
  • Engineers Australia, Engineers Australia
  • International Institute of Biotechnology and Toxicology, International Institute of Biotechnology and Toxicology

Research impacts

Research

Mammalian Cell Lines and Stem Cell Bioprocesses

Professor Peter Gray leads a research group with a focus on bioengineering of mammalian cell protein expression and stem cell systems. The research group is growing a strategic link with DSM Biologics, a contract manufacturer that takes early-stage projects to the next stage of commercial development. AIBN is developing mammalian cell lines, which form the basis of biologics, medicines based on natural proteins, and DSM will produce and commercialise them at a $65 million scale-up facility at Brisbane’s Princess Alexandra Hospital in Brisbane.

Professor Gray's research group is collaborating with Sydney-based Biosceptre International Ltd in a partnership aiming to develop a bio-process for producing monoclonal antibodies to treat cancer. AIBN researchers will characterise candidate therapeutic monoclonal antibodies that bind to Biosceptre's novel cancer target, known as nf-P2X7. Research and development will include antibody and cell line development; bioprocess development; and recombinant protein production in pre-commercial quantities ahead of preclinical trials. The Biosceptre collaboration is a critical step towards preclinical and human clinical trials. The long-term goal is to develop a therapeutic monoclonal antibody capable of specifically detecting nf-P2X7 and inducing cancer cell death without affecting normal healthy cells.

Ongoing research in Professor Gray's research group and Australian Animal Health Laboratory in Victoria with a Hendra virus antibody aims to determine its shelf life, to see how long it can be stored. The AIBN research group has developed a process to produce large amounts of high-quality antibody. The research group has produce batches of the experimental antibody for Queensland Health and collaborators at the CSIRO Australian Animal Health Laboratory in Geelong for testing in animal trials.

Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses.

Works

Search Professor Peter Gray’s works on UQ eSpace

87 works between 1990 and 2024

21 - 40 of 87 works

2015

Journal Article

High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis

Orellana, Camila A., Marcellin, Esteban, Schulz, Benjamin L., Nouwens, Amanda S., Gray, Peter P. and Nielsen, Lars K. (2015). High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis. Journal of Proteome Research, 14 (2), 609-618. doi: 10.1021/pr501027c

High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis

2014

Journal Article

Intracellular trafficking pathways for nuclear delivery of plasmid DNA complexed with highly efficient endosome escape polymers

Gillard, Marianne, Jia, Zhongfan, Hou, Jeff Jia Cheng, Song, Michael, Gray, Peter P., Munro, Trent P. and Monteiro, Michael J. (2014). Intracellular trafficking pathways for nuclear delivery of plasmid DNA complexed with highly efficient endosome escape polymers. Biomacromolecules, 15 (10), 3569-3576. doi: 10.1021/bm5008376

Intracellular trafficking pathways for nuclear delivery of plasmid DNA complexed with highly efficient endosome escape polymers

2014

Journal Article

Polyethyleneimine-poly(ethylene glycol)-star-copolymers as efficient and biodegradable vectors for mammalian cell transfection

Ladewig, Katharina, Xu, Zhi Ping, Gray, Peter and Lu, G. Q. (Max) (2014). Polyethyleneimine-poly(ethylene glycol)-star-copolymers as efficient and biodegradable vectors for mammalian cell transfection. Journal of Biomedical Materials Research - Part A, 102 (7), 2137-2146. doi: 10.1002/jbm.a.34888

Polyethyleneimine-poly(ethylene glycol)-star-copolymers as efficient and biodegradable vectors for mammalian cell transfection

2014

Journal Article

Timed-release polymers as novel transfection reagents

Gillard, Marianne, Jia, Zhongfan, Gray, Peter P., Munro, Trent P. and Monteiro, Michael J. (2014). Timed-release polymers as novel transfection reagents. Polymer Chemistry, 5 (10), 3372-3378. doi: 10.1039/c4py00176a

Timed-release polymers as novel transfection reagents

2014

Journal Article

High-throughput ClonePix FL analysis of mAb-expressing clones using the UCOE expression system

Hou, Jeff Jia Cheng, Hughes, Ben S., Smede, Matthew, Leung, Kar Man, Levine, Kara, Rigby, Susan, Gray, Peter P. and Munro, Trent P. (2014). High-throughput ClonePix FL analysis of mAb-expressing clones using the UCOE expression system. New Biotechnology, 31 (3), 214-220. doi: 10.1016/j.nbt.2014.02.002

High-throughput ClonePix FL analysis of mAb-expressing clones using the UCOE expression system

2014

Journal Article

Thermoresponsive worms for expansion and release of human embryonic stem cells

Chen, Xiaoli, Prowse, Andrew B. J., Jia, Zhongfan, Tellier, Helena, Munro,Trent P., Gray, Peter P. and Monteiro, Michael J. (2014). Thermoresponsive worms for expansion and release of human embryonic stem cells. Biomacromolecules, 15 (3), 844-855. doi: 10.1021/bm401702h

Thermoresponsive worms for expansion and release of human embryonic stem cells

2013

Journal Article

Technoeconomic analysis of renewable aviation fuel from microalgae, Pongamia pinnata, and sugarcane

Klein-Marcuschamer, Daniel, Turner, Christopher, Allen, Mark, Gray, Peter, Dietzgen, Ralf G., Gresshoff, Peter M., Hankamer, Ben, Heimann, Kirsten, Scott, Paul T., Stephens, Evan, Speight, Robert and Nielsen, Lars K. (2013). Technoeconomic analysis of renewable aviation fuel from microalgae, Pongamia pinnata, and sugarcane. Biofuels, Bioproducts and Biorefining, 7 (4), 416-428. doi: 10.1002/bbb.1404

Technoeconomic analysis of renewable aviation fuel from microalgae, Pongamia pinnata, and sugarcane

2013

Journal Article

Selective inhibition of human group IIA-secreted phospholipase a 2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes

Lee, Lawrence K., Bryant, Katherine J., Bouveret, Romaric, Lei, Pei-Wen, Duff, Anthony P., Harrop, Stephen J., Huang, Edwin P., Harvey, Richard P., Gelb, Michael H., Gray, Peter P., Curmi, Paul M., Cunningham, Anne M., Church, W. Bret and Scott, Kieran F. (2013). Selective inhibition of human group IIA-secreted phospholipase a 2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes. Journal of Biological Chemistry, 288 (21), 15269-15279. doi: 10.1074/jbc.M112.397893

Selective inhibition of human group IIA-secreted phospholipase a 2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes

2013

Journal Article

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

Martínez, Verónica S., Dietmair, Stefanie, Quek, Lake-Ee, Hodson, Mark P., Gray, Peter and Nielsen, Lars K. (2013). Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption. Biotechnology and Bioengineering, 110 (2), 660-666. doi: 10.1002/bit.24728

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

2012

Journal Article

Analysis of Mitochondrial Function and Localisation during Human Embryonic Stem Cell Differentiation In Vitro

Prowse, Andrew B. J., Chong, Fenny, Elliott, David A., Elefanty, Andrew G., Stanley, Edouard G., Gray, Peter P., Munro, Trent P. and Osborne, Geoffrey W. (2012). Analysis of Mitochondrial Function and Localisation during Human Embryonic Stem Cell Differentiation In Vitro. PLoS One, 7 (12) e52214, e52214-1-e52214-10. doi: 10.1371/journal.pone.0052214

Analysis of Mitochondrial Function and Localisation during Human Embryonic Stem Cell Differentiation In Vitro

2012

Journal Article

A multi-omics analysis of recombinant protein production in Hek293 cells

Dietmair, Stefanie, Hodson, Mark P., Quek, Lake-Ee, Timmins, Nicholas E., Gray, Peter and Nielsen, Lars K. (2012). A multi-omics analysis of recombinant protein production in Hek293 cells. Plos One, 7 (8) e43394, e43394.1-e43394.15. doi: 10.1371/journal.pone.0043394

A multi-omics analysis of recombinant protein production in Hek293 cells

2012

Journal Article

Metabolite profiling of CHO cells with different growth characteristics

Dietmair, Stefanie, Hodson, Mark P., Quek, Lake-Ee, Timmins, Nicholas E., Chrysanthopoulos, Panagiotis, Jacob, Shana S., Gray, Peter and Nielsen, Lars K. (2012). Metabolite profiling of CHO cells with different growth characteristics. Biotechnology and Bioengineering, 109 (6), 1404-1414. doi: 10.1002/bit.24496

Metabolite profiling of CHO cells with different growth characteristics

2012

Journal Article

Recombinant human albumin supports single cell cloning of CHO cells in chemically defined media

Zhu, Jiang, Wooh, Jong Wei, Hou, Jeff Jia Cheng, Hughes, Benjamin S., Gray, Peter P. and Munro, Trent P. (2012). Recombinant human albumin supports single cell cloning of CHO cells in chemically defined media. Biotechnology Progress, 28 (3), 887-891. doi: 10.1002/btpr.1549

Recombinant human albumin supports single cell cloning of CHO cells in chemically defined media

2012

Book Chapter

Analysis of protein expression via alternate 3’ Untranslated Region (UTR) signals through the use of site specific recombination

Hou, Jeff Jia Cheng, Song, Michael, Munro, Trent P. and Gray, Peter P. (2012). Analysis of protein expression via alternate 3’ Untranslated Region (UTR) signals through the use of site specific recombination. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. (pp. 47-51) edited by Nigel Jenkins, Niall Barron and Paula Alves. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-0884-6_8

Analysis of protein expression via alternate 3’ Untranslated Region (UTR) signals through the use of site specific recombination

2012

Book Chapter

An optimised transfection platform for the Epi-CHO transient expression system in serum-free media

Codamo, Joe, Munro, Trent P., Hughes, Benjamin S., Song, Michael and Gray, Peter P. (2012). An optimised transfection platform for the Epi-CHO transient expression system in serum-free media. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. (pp. 19-23) edited by Nigel Jenkins, Niall Barron and Paula Alves. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-0884-6_3

An optimised transfection platform for the Epi-CHO transient expression system in serum-free media

2012

Book Chapter

Metabolomic analysis of CHO cultures with different growth characteristics – development of a metabolite extraction protocol for suspension adapted mammalian cells

Dietmair, Stefanie, Timmins, Nicholas E., Chrysanthopoulos, Panagiotis, Gray, Peter P., Krömer, Jens O. and Nielsen, Lars K. (2012). Metabolomic analysis of CHO cultures with different growth characteristics – development of a metabolite extraction protocol for suspension adapted mammalian cells. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. (pp. 37-41) edited by Nigel Jenkins, Niall Barron and Paula Alves. Dordrecht, Netherlands: Springer.

Metabolomic analysis of CHO cultures with different growth characteristics – development of a metabolite extraction protocol for suspension adapted mammalian cells

2011

Journal Article

Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates

Munro, Trent P., Mahler, Stephen M., Huang, Edwin P., Chin, David Y. and Gray, Peter P. (2011). Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates. mAbs, 3 (5), 440-452. doi: 10.4161/mabs.3.5.16968

Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates

2011

Journal Article

New frontiers in cell line development: Challenges for biosimilars

Hou, Jeff Jia Cheng, Codamo, Joe, Pilbrough, Warren, Hughes, Benjamin, Gray, Peter P. and Munro, Trent P. (2011). New frontiers in cell line development: Challenges for biosimilars. Journal of Chemical Technology and Biotechnology, 86 (7), 895-904. doi: 10.1002/jctb.2574

New frontiers in cell line development: Challenges for biosimilars

2011

Journal Article

Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening

Song, Michael, Raphaelli, Kristin, Jones, Martina L., Aliabadi-Zadeh, Khosrow, Leung, Kar Man, Crowley, David, Hughes, Benjamin, Mahler, Stephen, Gray, Peter P., Huang, Edwin P. and Chin, David Y. (2011). Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening. Journal of Chemical Technology and Biotechnology, 86 (7), 935-941. doi: 10.1002/jctb.2618

Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening

2011

Journal Article

Efficient mAb production in CHO cells incorporating PEI-mediated transfection, mild hypothermia and the co-expression of XBP-1

Codamo, Joe, Hou, Jeff Jia Cheng, Hughes, Benjamin S., Gray, Peter P. and Munro, Trent P. (2011). Efficient mAb production in CHO cells incorporating PEI-mediated transfection, mild hypothermia and the co-expression of XBP-1. Journal of Chemical Technology and Biotechnology, 86 (7), 923-934. doi: 10.1002/jctb.2572

Efficient mAb production in CHO cells incorporating PEI-mediated transfection, mild hypothermia and the co-expression of XBP-1

Funding

Current funding

  • 2021 - 2026
    Induced pluripotent stem cell derived cardiomyocytes: a new therapy for 'no-option' end stage heart failure (MRFF Stem Cell Therapies grant from University of Sydney).
    University of Sydney
    Open grant
  • 2014 - 2027
    Developing a scalable process for translating hEsc and iPS cell science to clinical applications
    Merchant Charitable Foundation
    Open grant

Past funding

  • 2020 - 2022
    Using human pluripotent stem cells to achieve scalable high purity production of cardiac cells for transplantation studies (National Stem Cell Foundation of Australia grant administered by WIMR)
    The Westmead Institute for Medical Research
    Open grant
  • 2019 - 2021
    Using human pluripotent stem cells to achieve scalable, high purity production of cardiac cells for transplantation studies (No. 2)
    The Westmead Institute for Medical Research
    Open grant
  • 2019 - 2021
    Using Pluripotent Stem Cells to Achieve Scalable, High Purity Production of Cardiac Cells for Transplantation Studies
    The Westmead Institute for Medical Research
    Open grant
  • 2017 - 2023
    ARC Training Centre for Biopharmaceutical Innovation
    ARC Industrial Transformation Training Centres
    Open grant
  • 2016 - 2019
    Development of a New Specific Immunosuppressive Monoclonal Antibody to Advance Transplantation (NHMRC Development Grant administered by The University of Sydney)
    University of Sydney
    Open grant
  • 2015
    Continuous manufacturing of biopharmaceuticals through mammalian expression technology
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2014 - 2023
    The National Biologics Facility - NCRIS 2013/2015/2016-17/2017-18/2018-19/2019-2023 (administered by Therapeutic Innovation Australia (TIA))
    Therapeutic Innovation Australia Limited
    Open grant
  • 2013 - 2016
    Highly productive and selective bio-organic hybrid membrane water filters
    Murdoch University
    Open grant
  • 2013 - 2015
    Safety assessment of anti-hendra virus antibody in humans
    Queensland Health
    Open grant
  • 2012 - 2013
    Safety of Hendra virus anti-G glycoprotein monoclonal antibody in humans
    NHMRC Targeted Research
    Open grant
  • 2012 - 2014
    Cell line development for the biologics plant of the future
    Queensland Government Smart Futures Research Partnerships Program
    Open grant
  • 2012
    An intergrated fluidic circuit system for digital PCR analysis, single-cell gene- expression, and high-throughput preparation of next-generation sequencing libraries.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    On-Demand 3-Dimensional Polymer Scaffolds for Directed Stem Cell Differentiation
    ARC Discovery Projects
    Open grant
  • 2011 - 2013
    EIF Project 4 - Biological Therapies, Part 2 - Biopharmaceuticals (Commonwealth-funded EIF grant administered by Therapeutic Innovation Australia (TIA) Ltd).
    Open grant
  • 2011 - 2019
    Stem Cells Australia (ARC Special Research Initiative administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2011 - 2015
    The National Biologics Facility
    Queensland Government Smart Futures Co-Investment Fund
    Open grant
  • 2011 - 2013
    Highly productive and selective bio-organic hybrid membrane water filters - National Centre of Excellence in Desalination
    Murdoch University
    Open grant
  • 2010 - 2014
    Queensland Sustainable Aviation Fuel Initiative
    Queensland Government Smart State National and International Research Alliances Program
    Open grant
  • 2009
    2009 University of Queensland Trans-Pacific Fellowship - Senior Academic Fellowship
    UQ Trans-Pacific Fellowship
    Open grant
  • 2009 - 2011
    AIBN BioReactor Program (ASCC Collaborative Stream 1 - Module 2)
    Australian Stem Cell Centre
    Open grant
  • 2009 - 2010
    Process Modelling Applicable to Biofuels
    Queensland Government Smart Futures Partnerships-Alliances Facilitation Program
    Open grant
  • 2009 - 2011
    Queensland Bio Jet Fuel Initiative
    Queensland Government Smart Futures Partnerships-Alliances Facilitation Program
    Open grant
  • 2007 - 2011
    National Collaborative Research Infrastructure Strategy (NCRIS) - Capability Area 5.5 Biotechnology Products
    National Collaborative Infrastructure Strategy - Queensland Government Contribution
    Open grant
  • 2005 - 2006
    Australia-United Kingdom Bionanotechnology Mission
    Department of Education, Science, and Training
    Open grant

Supervision

Availability

Professor Peter Gray is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

Contact Professor Peter Gray directly for media enquiries about:

  • Bioengineering
  • Biopharmaceutical production
  • Bioprocessing
  • Biotechnology
  • Biotechnology - economics
  • Cell cultures
  • Commercialisation and science research
  • Economics - biotechnology
  • Metabolism
  • Metabolites
  • Resarch and commercialisation
  • Science research innovation
  • Stem cells

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