
Overview
Background
Professor Peter Gray is a pioneer of biotechnology research and development in Australia. In 2003 he was appointed AIBN’s inaugural Director and has since overseen the institute’s growth to 450 people and an annual turnover of $40million. Before joining AIBN, he was Professor and Head of Biotechnology at UNSW.
Professor Gray has held academic positions at University College London and the University of California, Berkeley. He has had commercial experience in the US, working for Eli Lilly and Co and the Cetus Corporation. His research collaborations include groups at Stanford University; the University of California, Berkeley; and the University of British Columbia, Vancouver.
He serves on several boards and government committees. He is on the board of Engineering Conferences International, New York, a group that runs global, multi-disciplinary engineering conferences, many of which have played key roles in developing emerging industry sectors. The conferences include cell culture engineering; vaccine technology; and scale-up and manufacturing of cell-based therapies. Professor Gray also serves on the board of Biopharmaceuticals Australia Pty Ltd, the company established to build a GMP grade biopharmaceuticals manufacturing facility in Brisbane, and has been heavily involved in negotiations that led to DSM Biologics becoming the facility’s operator.
Professor Gray is a Fellow and Vice-President of the Australian Academy of Technological Sciences and Engineering and a Fellow of the Australian Institute of Company Directors. He has chaired, served on organising committees for, and given plenary and keynote addresses at many key international conferences. In 2006 he attracted to Sydney and chaired the International Biotechnology Symposium – the first time a conference in the four-yearly series was held in the southern hemisphere. Professor Gray is a founder and past president of the Australian Biotechnology Association (Ausbiotech).
Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses. He has twice been listed by Engineers Australia among the top 100 most influential engineers in Australia, and in 2001 was awarded the Australian Government’s Centenary Medal.
Availability
- Professor Peter Gray is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Australian Academy of Technological Sciences and Engineering, Australian Academy of Technological Sciences and Engineering
- Engineers Australia, Engineers Australia
- International Institute of Biotechnology and Toxicology, International Institute of Biotechnology and Toxicology
Research impacts
Research
Mammalian Cell Lines and Stem Cell Bioprocesses
Professor Peter Gray leads a research group with a focus on bioengineering of mammalian cell protein expression and stem cell systems. The research group is growing a strategic link with DSM Biologics, a contract manufacturer that takes early-stage projects to the next stage of commercial development. AIBN is developing mammalian cell lines, which form the basis of biologics, medicines based on natural proteins, and DSM will produce and commercialise them at a $65 million scale-up facility at Brisbane’s Princess Alexandra Hospital in Brisbane.
Professor Gray's research group is collaborating with Sydney-based Biosceptre International Ltd in a partnership aiming to develop a bio-process for producing monoclonal antibodies to treat cancer. AIBN researchers will characterise candidate therapeutic monoclonal antibodies that bind to Biosceptre's novel cancer target, known as nf-P2X7. Research and development will include antibody and cell line development; bioprocess development; and recombinant protein production in pre-commercial quantities ahead of preclinical trials. The Biosceptre collaboration is a critical step towards preclinical and human clinical trials. The long-term goal is to develop a therapeutic monoclonal antibody capable of specifically detecting nf-P2X7 and inducing cancer cell death without affecting normal healthy cells.
Ongoing research in Professor Gray's research group and Australian Animal Health Laboratory in Victoria with a Hendra virus antibody aims to determine its shelf life, to see how long it can be stored. The AIBN research group has developed a process to produce large amounts of high-quality antibody. The research group has produce batches of the experimental antibody for Queensland Health and collaborators at the CSIRO Australian Animal Health Laboratory in Geelong for testing in animal trials.
Professor Gray has graduated more than 60 PhD students from his research group, in fields including secondary metabolite bioprocesses; bioconversion of cellulosic substrates; mammalian cell expression of complex proteins; nanoparticles for drug delivery; and the development of stem-cell based bioprocesses.
Works
Search Professor Peter Gray’s works on UQ eSpace
2015
Journal Article
High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis
Orellana, Camila A., Marcellin, Esteban, Schulz, Benjamin L., Nouwens, Amanda S., Gray, Peter P. and Nielsen, Lars K. (2015). High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis. Journal of Proteome Research, 14 (2), 609-618. doi: 10.1021/pr501027c
2014
Journal Article
Intracellular trafficking pathways for nuclear delivery of plasmid DNA complexed with highly efficient endosome escape polymers
Gillard, Marianne, Jia, Zhongfan, Hou, Jeff Jia Cheng, Song, Michael, Gray, Peter P., Munro, Trent P. and Monteiro, Michael J. (2014). Intracellular trafficking pathways for nuclear delivery of plasmid DNA complexed with highly efficient endosome escape polymers. Biomacromolecules, 15 (10), 3569-3576. doi: 10.1021/bm5008376
2014
Journal Article
Polyethyleneimine-poly(ethylene glycol)-star-copolymers as efficient and biodegradable vectors for mammalian cell transfection
Ladewig, Katharina, Xu, Zhi Ping, Gray, Peter and Lu, G. Q. (Max) (2014). Polyethyleneimine-poly(ethylene glycol)-star-copolymers as efficient and biodegradable vectors for mammalian cell transfection. Journal of Biomedical Materials Research - Part A, 102 (7), 2137-2146. doi: 10.1002/jbm.a.34888
2014
Journal Article
Timed-release polymers as novel transfection reagents
Gillard, Marianne, Jia, Zhongfan, Gray, Peter P., Munro, Trent P. and Monteiro, Michael J. (2014). Timed-release polymers as novel transfection reagents. Polymer Chemistry, 5 (10), 3372-3378. doi: 10.1039/c4py00176a
2014
Journal Article
High-throughput ClonePix FL analysis of mAb-expressing clones using the UCOE expression system
Hou, Jeff Jia Cheng, Hughes, Ben S., Smede, Matthew, Leung, Kar Man, Levine, Kara, Rigby, Susan, Gray, Peter P. and Munro, Trent P. (2014). High-throughput ClonePix FL analysis of mAb-expressing clones using the UCOE expression system. New Biotechnology, 31 (3), 214-220. doi: 10.1016/j.nbt.2014.02.002
2014
Journal Article
Thermoresponsive worms for expansion and release of human embryonic stem cells
Chen, Xiaoli, Prowse, Andrew B. J., Jia, Zhongfan, Tellier, Helena, Munro,Trent P., Gray, Peter P. and Monteiro, Michael J. (2014). Thermoresponsive worms for expansion and release of human embryonic stem cells. Biomacromolecules, 15 (3), 844-855. doi: 10.1021/bm401702h
2013
Journal Article
Technoeconomic analysis of renewable aviation fuel from microalgae, Pongamia pinnata, and sugarcane
Klein-Marcuschamer, Daniel, Turner, Christopher, Allen, Mark, Gray, Peter, Dietzgen, Ralf G., Gresshoff, Peter M., Hankamer, Ben, Heimann, Kirsten, Scott, Paul T., Stephens, Evan, Speight, Robert and Nielsen, Lars K. (2013). Technoeconomic analysis of renewable aviation fuel from microalgae, Pongamia pinnata, and sugarcane. Biofuels, Bioproducts and Biorefining, 7 (4), 416-428. doi: 10.1002/bbb.1404
2013
Journal Article
Selective inhibition of human group IIA-secreted phospholipase a 2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes
Lee, Lawrence K., Bryant, Katherine J., Bouveret, Romaric, Lei, Pei-Wen, Duff, Anthony P., Harrop, Stephen J., Huang, Edwin P., Harvey, Richard P., Gelb, Michael H., Gray, Peter P., Curmi, Paul M., Cunningham, Anne M., Church, W. Bret and Scott, Kieran F. (2013). Selective inhibition of human group IIA-secreted phospholipase a 2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes. Journal of Biological Chemistry, 288 (21), 15269-15279. doi: 10.1074/jbc.M112.397893
2013
Journal Article
Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption
Martínez, Verónica S., Dietmair, Stefanie, Quek, Lake-Ee, Hodson, Mark P., Gray, Peter and Nielsen, Lars K. (2013). Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption. Biotechnology and Bioengineering, 110 (2), 660-666. doi: 10.1002/bit.24728
2012
Journal Article
Analysis of Mitochondrial Function and Localisation during Human Embryonic Stem Cell Differentiation In Vitro
Prowse, Andrew B. J., Chong, Fenny, Elliott, David A., Elefanty, Andrew G., Stanley, Edouard G., Gray, Peter P., Munro, Trent P. and Osborne, Geoffrey W. (2012). Analysis of Mitochondrial Function and Localisation during Human Embryonic Stem Cell Differentiation In Vitro. PLoS One, 7 (12) e52214, e52214-1-e52214-10. doi: 10.1371/journal.pone.0052214
2012
Journal Article
A multi-omics analysis of recombinant protein production in Hek293 cells
Dietmair, Stefanie, Hodson, Mark P., Quek, Lake-Ee, Timmins, Nicholas E., Gray, Peter and Nielsen, Lars K. (2012). A multi-omics analysis of recombinant protein production in Hek293 cells. Plos One, 7 (8) e43394, e43394.1-e43394.15. doi: 10.1371/journal.pone.0043394
2012
Journal Article
Metabolite profiling of CHO cells with different growth characteristics
Dietmair, Stefanie, Hodson, Mark P., Quek, Lake-Ee, Timmins, Nicholas E., Chrysanthopoulos, Panagiotis, Jacob, Shana S., Gray, Peter and Nielsen, Lars K. (2012). Metabolite profiling of CHO cells with different growth characteristics. Biotechnology and Bioengineering, 109 (6), 1404-1414. doi: 10.1002/bit.24496
2012
Journal Article
Recombinant human albumin supports single cell cloning of CHO cells in chemically defined media
Zhu, Jiang, Wooh, Jong Wei, Hou, Jeff Jia Cheng, Hughes, Benjamin S., Gray, Peter P. and Munro, Trent P. (2012). Recombinant human albumin supports single cell cloning of CHO cells in chemically defined media. Biotechnology Progress, 28 (3), 887-891. doi: 10.1002/btpr.1549
2012
Book Chapter
Metabolomic analysis of CHO cultures with different growth characteristics – development of a metabolite extraction protocol for suspension adapted mammalian cells
Dietmair, Stefanie, Timmins, Nicholas E., Chrysanthopoulos, Panagiotis, Gray, Peter P., Krömer, Jens O. and Nielsen, Lars K. (2012). Metabolomic analysis of CHO cultures with different growth characteristics – development of a metabolite extraction protocol for suspension adapted mammalian cells. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. (pp. 37-41) edited by Nigel Jenkins, Niall Barron and Paula Alves. Dordrecht, Netherlands: Springer.
2012
Book Chapter
Analysis of protein expression via alternate 3’ Untranslated Region (UTR) signals through the use of site specific recombination
Hou, Jeff Jia Cheng, Song, Michael, Munro, Trent P. and Gray, Peter P. (2012). Analysis of protein expression via alternate 3’ Untranslated Region (UTR) signals through the use of site specific recombination. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. (pp. 47-51) edited by Nigel Jenkins, Niall Barron and Paula Alves. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-0884-6_8
2012
Book Chapter
An optimised transfection platform for the Epi-CHO transient expression system in serum-free media
Codamo, Joe, Munro, Trent P., Hughes, Benjamin S., Song, Michael and Gray, Peter P. (2012). An optimised transfection platform for the Epi-CHO transient expression system in serum-free media. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. (pp. 19-23) edited by Nigel Jenkins, Niall Barron and Paula Alves. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-0884-6_3
2011
Journal Article
Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates
Munro, Trent P., Mahler, Stephen M., Huang, Edwin P., Chin, David Y. and Gray, Peter P. (2011). Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates. mAbs, 3 (5), 440-452. doi: 10.4161/mabs.3.5.16968
2011
Journal Article
Efficient mAb production in CHO cells incorporating PEI-mediated transfection, mild hypothermia and the co-expression of XBP-1
Codamo, Joe, Hou, Jeff Jia Cheng, Hughes, Benjamin S., Gray, Peter P. and Munro, Trent P. (2011). Efficient mAb production in CHO cells incorporating PEI-mediated transfection, mild hypothermia and the co-expression of XBP-1. Journal of Chemical Technology and Biotechnology, 86 (7), 923-934. doi: 10.1002/jctb.2572
2011
Journal Article
New frontiers in cell line development: Challenges for biosimilars
Hou, Jeff Jia Cheng, Codamo, Joe, Pilbrough, Warren, Hughes, Benjamin, Gray, Peter P. and Munro, Trent P. (2011). New frontiers in cell line development: Challenges for biosimilars. Journal of Chemical Technology and Biotechnology, 86 (7), 895-904. doi: 10.1002/jctb.2574
2011
Journal Article
Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening
Song, Michael, Raphaelli, Kristin, Jones, Martina L., Aliabadi-Zadeh, Khosrow, Leung, Kar Man, Crowley, David, Hughes, Benjamin, Mahler, Stephen, Gray, Peter P., Huang, Edwin P. and Chin, David Y. (2011). Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening. Journal of Chemical Technology and Biotechnology, 86 (7), 935-941. doi: 10.1002/jctb.2618
Funding
Current funding
Supervision
Availability
- Professor Peter Gray is:
- Available for supervision
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Supervision history
Completed supervision
-
2015
Doctor Philosophy
Novel Cell Engineering of the Unfolded Protein Response to Achieve Efficient Therapeutic Protein Production Cell Line
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2015
Doctor Philosophy
Development of a Culture Platform for the Expansion of Pluripotent Human Embryonic Stem Cells Cells with the use of Nanopolymers
Principal Advisor
Other advisors: Professor Michael Monteiro
-
2012
Doctor Philosophy
Modulating epigenetic and post-transcriptional regulation for increased recombinant protein production in mammalian cells.
Principal Advisor
-
2011
Doctor Philosophy
Process development and characterisation of transient expression technology in CHO cells
Principal Advisor
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Associate Advisor
Other advisors: Dr Veronica Martinez Salazar, Professor Esteban Marcellin
-
2020
Doctor Philosophy
Engineering Chinese Hamster Ovary Cells for Improved Monoclonal Antibody Productivity by Modulating Feedback Regulation of the Secretory Pathway
Associate Advisor
Other advisors: Dr Marianne Gillard, Emeritus Professor Stephen Mahler
-
2016
Doctor Philosophy
Understanding CHO cells biology for enhanced biopharmaceutical production: a comparative transcriptomic and proteomic approach
Associate Advisor
Other advisors: Professor Esteban Marcellin, Professor Lars Nielsen
-
2014
Doctor Philosophy
Engineered Polymer Nanoparticles for Intracellular DNA Delivery
Associate Advisor
Other advisors: Professor Michael Monteiro
-
2014
Doctor Philosophy
Understanding and overcoming monoterpene toxicity in Saccharomyces cerevisia for the production of sustainable jet fuels
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Global metabolic effect of manipulating pyruvate dehydrogenase complex activity in mammalian cells
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Using network thermodynamics and metabolomics for the study of dynamic mammalian cell metabolism
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2012
Doctor Philosophy
Characterisation of mammalian cells during protein production - a systems biology approach
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2009
Doctor Philosophy
Nanoparticles with Application in the Delivery of Nucleic Acids to Mammalian Cells
Associate Advisor
Media
Enquiries
Contact Professor Peter Gray directly for media enquiries about:
- Bioengineering
- Biopharmaceutical production
- Bioprocessing
- Biotechnology
- Biotechnology - economics
- Cell cultures
- Commercialisation and science research
- Economics - biotechnology
- Metabolism
- Metabolites
- Resarch and commercialisation
- Science research innovation
- Stem cells
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