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2024 Journal Article Analysis of three characterization assays reveals ddPCR of LIN28A as the most sensitive for the detection of residual pluripotent stem cells in cellular therapy productsSun, Jinda, Yates, Clarissa, Dingwall, Steve, Ongtengco, Cherica, Power, Dominique, Gray, Peter and Prowse, Andrew (2024). Analysis of three characterization assays reveals ddPCR of LIN28A as the most sensitive for the detection of residual pluripotent stem cells in cellular therapy products. Cytotherapy, 26 (11), 1374-1381. doi: 10.1016/j.jcyt.2024.05.019 |
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2024 Journal Article Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmiasSelvakumar, Dinesh, Clayton, Zoe E., Prowse, Andrew, Dingwall, Steve, Kim, Sul Ki, Reyes, Leila, George, Jacob, Shah, Haisam, Chen, Siqi, Leung, Halina H. L., Hume, Robert D., Tjahjadi, Laurentius, Igoor, Sindhu, Skelton, Rhys J. P., Hing, Alfred, Paterson, Hugh, Foster, Sheryl L., Pearson, Lachlan, Wilkie, Emma, Marcus, Alan D., Jeyaprakash, Prajith, Wu, Zhixuan, Chiu, Han Shen, Ongtengco, Cherica Felize J., Mulay, Onkar, McArthur, Jeffrey R., Barry, Tony, Lu, Juntang, Tran, Vu ... Chong, James J. H. (2024). Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias. Nature Cardiovascular Research, 3 (2), 145-165. doi: 10.1038/s44161-023-00419-3 |
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2022 Journal Article Engineering death resistance in CHO cells for improved perfusion cultureMacDonald, Michael A., Nöbel, Matthias, Martínez, Verónica S., Baker, Kym, Shave, Evan, Gray, Peter P., Mahler, Stephen, Munro, Trent, Nielsen, Lars K. and Marcellin, Esteban (2022). Engineering death resistance in CHO cells for improved perfusion culture. mAbs, 14 (1) e2083465, 1-13. doi: 10.1080/19420862.2022.2083465 |
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2022 Journal Article Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and BokMacDonald, Michael A., Barry, Craig, Groves, Teddy, Martínez, Verónica S., Gray, Peter P., Baker, Kym, Shave, Evan, Mahler, Stephen, Munro, Trent, Marcellin, Esteban and Nielsen, Lars K. (2022). Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and Bok. Biotechnology and Bioengineering, 119 (6), 1380-1391. doi: 10.1002/bit.28062 |
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2020 Journal Article ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cellsOrellana, Camila A., Martínez, Verónica S., MacDonald, Michael A., Henry, Matthew N., Gillard, Marianne, Gray, Peter P., Nielsen, Lars K., Mahler, Stephen and Marcellin, Esteban (2020). ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells. Biotechnology and Bioengineering, 118 (1) bit.27548, 481-490. doi: 10.1002/bit.27548 |
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2020 Journal Article Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in-human, randomised, controlled, phase 1 studyPlayford, Elliott Geoffrey, Munro, Trent, Mahler, Stephen M., Elliott, Suzanne, Gerometta, Michael, Hoger, Kym L., Jones, Martina L., Griffin, Paul, Lynch, Kathleen D., Carroll, Heidi, El Saadi, Debra, Gilmour, Margaret E., Hughes, Benjamin, Hughes, Karen, Huang, Edwin, de Bakker, Christopher, Klein, Reuben, Scher, Mark G., Smith, Ina L., Wang, Lin-Fa, Lambert, Stephen B., Dimitrov, Dimiter S., Gray, Peter P. and Broder, Christopher C. (2020). Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in-human, randomised, controlled, phase 1 study. The Lancet Infectious Diseases, 20 (4), 445-454. doi: 10.1016/S1473-3099(19)30634-6 |
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2020 Journal Article Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical productionHenry, Matthew N., MacDonald, Michael A., Orellana, Camila A., Gray, Peter P., Gillard, Marianne, Baker, Kym, Nielsen, Lars K., Marcellin, Esteban, Mahler, Stephen and Martinez, Veronica S. (2020). Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production. Biotechnology and Bioengineering, 117 (4) bit.27269, 1187-1203. doi: 10.1002/bit.27269 |
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2019 Journal Article Fibronectin-conjugated thermoresponsive nanobridges generate three dimensional human pluripotent stem cell cultures for differentiation towards the neural lineagesHarkness, Linda, Chen, Xiaoli, Jia, Zhongfan, Davies, Anthony M., Monteiro, Michael, Gray, Peter and Pera, Martin (2019). Fibronectin-conjugated thermoresponsive nanobridges generate three dimensional human pluripotent stem cell cultures for differentiation towards the neural lineages. Stem Cell Research, 38 101441, 101441. doi: 10.1016/j.scr.2019.101441 |
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2019 Journal Article Media composition modulates human embryonic stem cell morphology and may influence preferential lineage differentiation potentialHarkness, Linda, Chen, Xiaoli, Gillard, Marianne, Gray, Peter Paul and Davies, Anthony Mitchell (2019). Media composition modulates human embryonic stem cell morphology and may influence preferential lineage differentiation potential. PLoS ONE, 14 (3) e0213678, e0213678. doi: 10.1371/journal.pone.0213678 |
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2019 Book Chapter Cell line isolation and designMunro, Trent P., Pilbrough, Warren, Hughes, Benjamin S. and Gray, Peter P. (2019). Cell line isolation and design. Comprehensive biotechnology. (pp. 144-153) edited by Murray Moo-Young. Oxford, United Kingdom: Pergamon. doi: 10.1016/B978-0-444-64046-8.00013-6 |
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2018 Journal Article Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effectBuchsteiner, Maria, Quek, Lake-Ee, Gray, Peter and Nielsen, Lars K. (2018). Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect. Biotechnology and Bioengineering, 115 (9), 2315-2327. doi: 10.1002/bit.26724 |
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2018 Journal Article RNA-seq highlights high clonal variation in monoclonal antibody producing CHO cellsOrellana, Camila A., Marcellin, Esteban, Palfreyman, Robin W., Munro, Trent P., Gray, Peter P. and Nielsen, Lars K. (2018). RNA-seq highlights high clonal variation in monoclonal antibody producing CHO cells. Biotechnology Journal, 13 (3) 1700231, e1700231. doi: 10.1002/biot.201700231 |
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2018 Journal Article Methods for expansion of 3D cultures of human embryonic stem cells using a thermoresponsive polymerChen, Xiaoli, Harkness, Linda, Jia, Zhongfan, Prowse, Andrew, Monteiro, Michael J. and Gray, Peter P. (2018). Methods for expansion of 3D cultures of human embryonic stem cells using a thermoresponsive polymer. Tissue Engineering. Part C. Methods, 24 (3), 146-157. doi: 10.1089/ten.TEC.2017.0331 |
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2017 Journal Article Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cellsOrellana, Camila A., Marcellin, Esteban, Gray, Peter P. and Nielsen, Lars K. (2017). Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells. Biotechnology and Bioengineering, 114 (8), 1825-1836. doi: 10.1002/bit.26316 |
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2016 Conference Publication 3D neuronal differentiation: using a thermo-responsive polymer for expansion and release of differentiated hESCHarkness, Linda, Chen, Xiaoli, Davies, Anthony M., Jia, Zhongfan, Monteiro, Michael J., Pera, Martin and Gray, Peter P. (2016). 3D neuronal differentiation: using a thermo-responsive polymer for expansion and release of differentiated hESC. Conference on Changing the Face of Modern Medicine - Stem Cells and Gene Therapy, Florence, Italy, 18-21 October 2016. New Rochelle, NY, United States: Mary Ann Liebert. |
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2016 Conference Publication Methods and analysis of pluripotency markers and cell viability in hESC cultured as 3D aggregatesHarkness, Linda, Chen, Xiaoli, Gray, Peter P. and Davies, Anthony M. (2016). Methods and analysis of pluripotency markers and cell viability in hESC cultured as 3D aggregates. 14th Annual Meeting of the International Society for Stem Cell Research, San Francisco, CA, United States, 22-25 June 2016. |
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2016 Conference Publication 3D neuronal differentiation: using a thermo-responsive polymer for expansion and release of differentiated hESCHarkness, Linda, Chen, Xiaoli, Davies, Anthony M., Jia, Zhongfan, Monteiro, Michael J., Pera, Martin and Gray, Peter P. (2016). 3D neuronal differentiation: using a thermo-responsive polymer for expansion and release of differentiated hESC. EMBO/EMBL Symposium: Organoids: Modelling organ development and disease in 3D culture, Heidelberg, Germany, 12-15 October 2016. |
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2015 Journal Article Dynamic metabolic flux analysis using B-splines to study the effects of temperature shift on CHO cell metabolismMartinez, Verónica S., Buchsteiner, Maria, Gray, Peter, Nielsen, Lars K. and Quek, Lake-Ee (2015). Dynamic metabolic flux analysis using B-splines to study the effects of temperature shift on CHO cell metabolism. Metabolic Engineering Communications, 2, 46-57. doi: 10.1016/j.meteno.2015.06.001 |
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2015 Journal Article Synthesis of silica nanoparticles with controllable surface roughness for therapeutic protein deliveryNiu, Yuting, Yu, Meihua, Zhang, Jun, Yang, Yannan, Xu, Chun, Yeh, Michael, Taran, Elena, Hou, Jeff Jia Cheng, Gray, Peter P. and Yu, Chengzhong (2015). Synthesis of silica nanoparticles with controllable surface roughness for therapeutic protein delivery. Journal of Materials Chemistry B, 3 (43), 8477-8485. doi: 10.1039/c5tb01405k |
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2015 Conference Publication Intracellular trafficking pathways for plasmid DNA complexed with highly efficient endosome escape polymersGillard, M., Jia, Z., Jia, J., Song, M., Gray, P. P., Munro, T. P. and Monteriro, M. J. (2015). Intracellular trafficking pathways for plasmid DNA complexed with highly efficient endosome escape polymers. European Society for Animal Cell Technology (ESACT), Barcelona, Spain, 31 May- 3 June 2015. |
