Dr David Simmons
Dr

David Simmons

Email: 
Phone: 
+61 7 336 51962

Availability

Dr David Simmons is:
Available for supervision

Fields of research

Animal physiology - cell Biological Sciences Biomedical and Clinical Sciences Cell development, proliferation and death Foetal development and medicine Reproduction Zoology

Qualifications

  • Doctor of Philosophy, W.Ont.

Search Professor David Simmons’s works on UQ eSpace

95 works between 1999 and 2024
All (95) Journal Article (67) Book Chapter (3) Conference Publication (25)

1 - 20 of 95 works

2024

Journal Article

Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice

Cheung, Sang Won, Willis, Emily F., Simmons, David G., Bellingham, Mark C. and Noakes, Peter G. (2024). Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice. Neurobiology of Disease, 200 106614, 1-13. doi: 10.1016/j.nbd.2024.106614

Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice

2024

Journal Article

Cover Image, Volume 50, Issue 3

Cheung, Sang Won, Bhavnani, Ekta, Simmons, David G., Bellingham, Mark C. and Noakes, Peter G. (2024). Cover Image, Volume 50, Issue 3. Neuropathology and Applied Neurobiology, 50 (3). doi: 10.1111/nan.12993

Cover Image, Volume 50, Issue 3

2024

Journal Article

Perineuronal nets are phagocytosed by MMP‐9 expressing microglia and astrocytes in the SOD1<sup>G93A</sup> ALS mouse model

Cheung, Sang Won, Bhavnani, Ekta, Simmons, David G., Bellingham, Mark C. and Noakes, Peter G. (2024). Perineuronal nets are phagocytosed by MMP‐9 expressing microglia and astrocytes in the SOD1G93A ALS mouse model. Neuropathology and Applied Neurobiology, 50 (3) e12982, e12982. doi: 10.1111/nan.12982

Perineuronal nets are phagocytosed by MMP‐9 expressing microglia and astrocytes in the SOD1<sup>G93A</sup> ALS mouse model

2024

Journal Article

Trophoblast Side-Population Markers are Dysregulated in Preeclampsia and Fetal Growth Restriction

Wong, Georgia P., Hartmann, Sunhild, Simmons, David G., Ellis, Sarah, Nonn, Olivia, Cannon, Ping, Nguyen, Tuong-Vi, Nguyen, Anna, Bartho, Lucy A., Tong, Stephen, Hannan, Natalie J. and Kaitu’u-Lino, Tu’uhevaha J. (2024). Trophoblast Side-Population Markers are Dysregulated in Preeclampsia and Fetal Growth Restriction. Stem Cell Reviews and Reports, 20 (7), 1954-1970. doi: 10.1007/s12015-024-10764-w

Trophoblast Side-Population Markers are Dysregulated in Preeclampsia and Fetal Growth Restriction

2023

Conference Publication

The effects of metformin treatment for diabetes during pregnancy on placental mitochondrial function and fetal outcomes

Zimmerman, Dayna, Ibe, Somtochukwu, Simmons, David, Holland, Olivia and Cuffe, James (2023). The effects of metformin treatment for diabetes during pregnancy on placental mitochondrial function and fetal outcomes. Annual Meeting of the International-Federation-of-Placenta-Associations (IFPA), Rotorua, New Zealand, 5-8 September 2023. London, United Kingdom: Elsevier.

The effects of metformin treatment for diabetes during pregnancy on placental mitochondrial function and fetal outcomes

2023

Conference Publication

Characterising side population genes in placentas from patients with preeclampsia and/or fetal growth restriction

Wong, Georgia, Hannan, Natalie, Cannon, Ping, Kandel, Manju, Nguyen, Tuong-Vi, Simmons, David and Kaitu'u-Lino, Tu'uhevaha (2023). Characterising side population genes in placentas from patients with preeclampsia and/or fetal growth restriction. Annual Meeting of the International-Federation-of-Placenta-Associations (IFPA), Rotorua, New Zealand, 5 - 8 September 2023. London, United Kingdom: Elsevier.

Characterising side population genes in placentas from patients with preeclampsia and/or fetal growth restriction

2023

Conference Publication

In vitro investigation into the regulation and function of SPINT1, a biomarker for fetal growth restriction

Murphy, Ciara, Hannan, Natalie, Simmons, David, Tuong-Vi Nguyen,, Cannon, Ping, Kandel, Manju, Nguyen, Anna, Tong, Stephen and Kaitu'u-Lino, Tu'uhevaha (2023). In vitro investigation into the regulation and function of SPINT1, a biomarker for fetal growth restriction. Annual Meeting of the International-Federation-of-Placenta-Associations (IFPA), Rotorua, New Zealand, 5-8 September 2023. London, United Kingdom: Elsevier.

In vitro investigation into the regulation and function of SPINT1, a biomarker for fetal growth restriction

2023

Conference Publication

Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4 and 5 (LGR4 and LGR5) in Placental Development and Preeclampsia

Wong, Georgia P., Simmons, David G., Hannan, Natalie J., Cannon, Ping, Kandel, Manju, Nguyen, Tuong-Vi, Masci, Joshua and Kaitu'u-Lino, Tu'uhevaha J. (2023). Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4 and 5 (LGR4 and LGR5) in Placental Development and Preeclampsia. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD Australia, 21-25 March 2023. Heidelberg, Germany: Springer.

Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4 and 5 (LGR4 and LGR5) in Placental Development and Preeclampsia

2021

Journal Article

Genome-wide transcriptomic analysis of the forebrain of postnatal Slc13a4+/− mice

Harvey, Tracey J., Davila, Raul Ayala, Vidovic, Diana, Sharmin, Sazia, Piper, Michael and Simmons, David G. (2021). Genome-wide transcriptomic analysis of the forebrain of postnatal Slc13a4+/− mice. BMC Research Notes, 14 (1) 269, 269. doi: 10.1186/s13104-021-05687-5

Genome-wide transcriptomic analysis of the forebrain of postnatal Slc13a4+/− mice

2021

Journal Article

The placental ferroxidase zyklopen is not essential for iron transport to the fetus in mice

Helman, Sheridan L., Wilkins, Sarah J., McKeating, Daniel R., Perkins, Anthony V., Whibley, Page E., Cuffe, James S. M., Simmons, David G., Fuqua, Brie K., Vulpe, Christopher D., Wallace, Daniel F., O'Callaghan, Jessica L., Pelzer, Elise S., Anderson, Gregory J. and Frazer, David M. (2021). The placental ferroxidase zyklopen is not essential for iron transport to the fetus in mice. The Journal of Nutrition, 151 (9), 1-10. doi: 10.1093/jn/nxab174

The placental ferroxidase zyklopen is not essential for iron transport to the fetus in mice

2021

Journal Article

Perineuronal net abnormalities in Slc13a4+/- mice are rescued by postnatal administration of N-acetylcysteine

Sharmin, Sazia, Pradhan, Jonu, Zhang, Zhe, Bellingham, Mark, Simmons, David and Piper, Michael (2021). Perineuronal net abnormalities in Slc13a4+/- mice are rescued by postnatal administration of N-acetylcysteine. Experimental Neurology, 342 113734, 1-16. doi: 10.1016/j.expneurol.2021.113734

Perineuronal net abnormalities in Slc13a4+/- mice are rescued by postnatal administration of N-acetylcysteine

2020

Journal Article

Cell-extrinsic requirement for sulfate in regulating hippocampal neurogenesis

Zhang, Zhe, Jhaveri, Dhanisha, Sharmin, Sazia, Harvey, Tracey J., Dawson, Paul A., Piper, Michael and Simmons, David G. (2020). Cell-extrinsic requirement for sulfate in regulating hippocampal neurogenesis. Biology Open, 9 (7) bio053132, 1-7. doi: 10.1242/bio.053132

Cell-extrinsic requirement for sulfate in regulating hippocampal neurogenesis

2020

Journal Article

Molecular analysis of the human placental cysteine dioxygenase type 1 gene

Dawson, Paul A., Weerasekera, Shalini J., Atcheson, Ranita J., Twomey, Sarah A. and Simmons, David G. (2020). Molecular analysis of the human placental cysteine dioxygenase type 1 gene. Molecular Genetics and Metabolism Reports, 22 100568, 100568. doi: 10.1016/j.ymgmr.2020.100568

Molecular analysis of the human placental cysteine dioxygenase type 1 gene

2020

Journal Article

Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction

Eaton, Malcolm, Davies, Alastair H., Devine, Jay, Zhao, Xiang, Simmons, David G., Maríusdóttir, Elín, Natale, David R. C., Matyas, John R., Bering, Elizabeth A., Workentine, Matthew L., Hallgrimsson, Benedikt and Cross, James C. (2020). Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction. PL o S One, 15 (1) e0226735, 1-27. doi: 10.1371/journal.pone.0226735

Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction

2019

Journal Article

Periconceptional alcohol exposure causes female-specific perturbations to trophoblast differentiation and placental formation in the rat

Kalisch-Smith, Jacinta I., Steane, Sarah E., Simmons, David G., Pantaleon, Marie, Anderson, Stephen T., Akison, Lisa K., Wlodek, Mary E. and Moritz, Karen M. (2019). Periconceptional alcohol exposure causes female-specific perturbations to trophoblast differentiation and placental formation in the rat. Development, 146 (11) dev172205, dev172205. doi: 10.1242/dev.172205

Periconceptional alcohol exposure causes female-specific perturbations to trophoblast differentiation and placental formation in the rat

2019

Journal Article

Secondary placental defects in Cxadr mutant mice

Outhwaite, Jennifer E., Patel, Jatin and Simmons, David G. (2019). Secondary placental defects in Cxadr mutant mice. Frontiers in Physiology, 10 (MAY) 622, 622. doi: 10.3389/fphys.2019.00622

Secondary placental defects in Cxadr mutant mice

2019

Journal Article

Postnatal N-acetylcysteine administration rescues impaired social behaviors and neurogenesis in Slc13a4 haploinsufficient mice

Zhang, Zhe, Dawson, Paul Anthony, Piper, Michael and Simmons, David Gordon (2019). Postnatal N-acetylcysteine administration rescues impaired social behaviors and neurogenesis in Slc13a4 haploinsufficient mice. EBioMedicine, 43, 435-446. doi: 10.1016/j.ebiom.2019.03.081

Postnatal N-acetylcysteine administration rescues impaired social behaviors and neurogenesis in Slc13a4 haploinsufficient mice

2019

Journal Article

TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival

Mittermeier, Lorenz, Demirkhanyan, Lusine, Stadlbauer, Benjamin, Breit, Andreas, Recordati, Camilla, Hilgendorff, Anne, Matsushita, Masayuki, Braun, Attila, Simmons, David G., Zakharian, Eleonora, Gudermann, Thomas and Chubanov, Vladimir (2019). TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival. Proceedings of the National Academy of Sciences, 116 (10), 201810633-4715. doi: 10.1073/pnas.1810633116

TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival

2018

Journal Article

Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice

Langford, Michael B., Outhwaite, Jennifer E., Hughes, Martha, Natale, David R C and Simmons, David G (2018). Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice. Scientific reports, 8 (1) 3961, 3961. doi: 10.1038/s41598-018-22040-2

Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice

2018

Journal Article

Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration

Tan, Kah Ni, Simmons, David, Carrasco-Pozo, Catalina and Borges, Karin (2018). Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. Journal of Neurochemistry, 144 (4), 431-442. doi: 10.1111/jnc.14275

Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration

Current funding

  • 2022 - 2025
    Is SPINT1 a key regulator of placental development? (ARC Discovery Project administered by the University of Melbourne)
    University of Melbourne
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2021
    Trophoblast cell-cell fusion in preeclampsia
    NHMRC Project Grant
    Open grant
  • 2012
    Placental clock gene expression in the Spiny Mouse
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2011
    UQ Travel Awards Category 1 - Dr David R C Natale
    UQ Travel Grants Scheme
    Open grant
  • 2010
    Dual channel electrophysiological recordings
    NHMRC Equipment Grant
    Open grant
  • 2010
    Establishment of a digital Scanscope system for virtual microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    In Situ Hybridization Suite for Biomedical Science Researchers
    NHMRC Equipment Grant
    Open grant
  • 2009
    "Real Time PCR Facility for Biomedical Researchers"
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Cell-cell fusion and syncytiotrophoblast formation in the murine placenta
    UQ Early Career Researcher
    Open grant
  • 2009 - 2012
    Interstitially Invasive Trophoblast of the Murine Placenta: Developmental Origins, Functions and Gene Expression.
    NHMRC Project Grant
    Open grant
  • 2008
    Molecular mechanisms and regulation of uterine fluid secretion
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Dr David Simmons is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The influence of RyR modifications on the downstream mitochondrial Ca2+ handling

    Associate Advisor

    Other advisors: Professor Bradley Launikonis, Dr Daniel Singh

  • Doctor Philosophy

    Understanding the impact of metformin on one carbon metabolism, placental function and fetal outcomes.

    Associate Advisor

    Other advisors: Dr James Cuffe

Completed supervision

Enquiries

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