Professor

Bradley Launikonis

Email: 
Phone: 
+61 7 336 54301

Availability

Professor Bradley Launikonis is:
Available for supervision

Fields of research

Biological Sciences Zoology

Qualifications

  • Doctor of Philosophy, La Trobe University

Search Professor Bradley Launikonis’s works on UQ eSpace

92 works between 1997 and 2025
All (92) Journal Article (70) Conference Publication (22)

1 - 20 of 92 works

2025

Journal Article

From Muscle-Based Nonshivering Thermogenesis to Malignant Hyperthermia in Mammals

Launikonis, Bradley S. and Murphy, Robyn M. (2025). From Muscle-Based Nonshivering Thermogenesis to Malignant Hyperthermia in Mammals. Annual Review of Physiology. doi: 10.1146/annurev-physiol-022724-105205

From Muscle-Based Nonshivering Thermogenesis to Malignant Hyperthermia in Mammals

2024

Journal Article

Muscle fibre mitochondrial [Ca2+] dynamics during Ca2+ waves in RYR1 gain‐of‐function mouse

Gaglianone, Rhayanna B. and Launikonis, Bradley S. (2024). Muscle fibre mitochondrial [Ca2+] dynamics during Ca2+ waves in RYR1 gain‐of‐function mouse. Acta Physiologica, 240 (3) e14098, e14098. doi: 10.1111/apha.14098

Muscle fibre mitochondrial [Ca2+] dynamics during Ca2+ waves in RYR1 gain‐of‐function mouse

2023

Journal Article

Ryanodine receptor activity and store‐operated Ca <sup>2+</sup> entry: critical regulators of Ca <sup>2+</sup> content and function in skeletal muscle

Pearce, Luke, Meizoso‐Huesca, Aldo, Seng, Crystal, Lamboley, Cedric R., Singh, Daniel P. and Launikonis, Bradley S. (2023). Ryanodine receptor activity and store‐operated Ca 2+ entry: critical regulators of Ca 2+ content and function in skeletal muscle. The Journal of Physiology, 601 (19), 4183-4202. doi: 10.1113/jp279512

Ryanodine receptor activity and store‐operated Ca <sup>2+</sup> entry: critical regulators of Ca <sup>2+</sup> content and function in skeletal muscle

2023

Journal Article

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B. and Mobli, Mehdi (2023). A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications, 14 (1) 1036, 1-13. doi: 10.1038/s41467-023-36579-w

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

2023

Journal Article

Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals

Singh, Daniel P., Pearce, Luke, Choi, Rocky H., Meizoso-Huesca, Aldo, Wette, Stefan G., Scott, John W., Lamboley, Cedric R., Murphy, Robyn M. and Launikonis, Bradley S. (2023). Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals. Proceedings of the National Academy of Sciences, 120 (4) e2117503120, 1-12. doi: 10.1073/pnas.2117503120

Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals

2022

Journal Article

Tiny changes in cytoplasmic [Ca<sup>2+</sup>] cause large changes in mitochondrial Ca<sup>2+</sup>: what are the triggers and functional implications?

Seng, Crystal, Pearce, Luke, Meizoso-Huesca, Aldo, Singh, Daniel P., Murphy, Robyn M., Lamboley, Cedric and Launikonis, Bradley S. (2022). Tiny changes in cytoplasmic [Ca2+] cause large changes in mitochondrial Ca2+: what are the triggers and functional implications?. American Journal of Physiology-Cell Physiology, 323 (4), C1285-C1289. doi: 10.1152/ajpcell.00092.2022

Tiny changes in cytoplasmic [Ca<sup>2+</sup>] cause large changes in mitochondrial Ca<sup>2+</sup>: what are the triggers and functional implications?

2022

Journal Article

Erratum: Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers (The Journal of general physiology (2022) 154 9 PII: e20211299404062022c)

Barclay, Christopher J. and Launikonis, Bradley S. (2022). Erratum: Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers (The Journal of general physiology (2022) 154 9 PII: e20211299404062022c). The Journal of general physiology, 154 (9) e20211299404062022c. doi: 10.1085/jgp.20211299404062022c

Erratum: Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers (The Journal of general physiology (2022) 154 9 PII: e20211299404062022c)

2022

Journal Article

A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers

Barclay, Christopher J. and Launikonis, Bradley S. (2022). A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers. Journal of General Physiology, 154 (9) e202112994. doi: 10.1085/jgp.202112994

A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers

2022

Journal Article

Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle

Meizoso-Huesca, Aldo, Pearce, Luke, Barclay, Christopher J. and Launikonis, Bradley S. (2022). Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle. Proceedings of the National Academy of Sciences, 119 (4) e2119203119, 1-8. doi: 10.1073/pnas.2119203119

Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle

2022

Journal Article

Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

Zhang, Jingyan, Singh, Daniel P., Ko, Christopher Y., Nikolaienko, Roman, Wong King Yuen, Siobhan M., Schwarz, Jacob A., Treinen, Levy M., Tung, Ching-Chieh, Rožman, Kaja, Svensson, Bengt, Aldrich, Courtney C., Zima, Aleksey V., Thomas, David D., Bers, Donald M., Launikonis, Bradley S., Van Petegem, Filip and Cornea, Razvan L. (2022). Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. Journal of Biological Chemistry, 298 (1) 101412, 101412. doi: 10.1016/j.jbc.2021.101412

Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

2021

Journal Article

Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle

Lamboley, Cedric R., Pearce, Luke, Seng, Crystal, Meizoso-Huesca, Aldo, Singh, Daniel P., Frankish, Barnaby P., Kaura, Vikas, Lo, Harriet P., Ferguson, Charles, Allen, Paul D., Hopkins, Philip M., Parton, Robert G., Murphy, Robyn M., van der Poel, Chris, Barclay, Christopher J. and Launikonis, Bradley S. (2021). Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances, 7 (44) eabi7166, 1-15. doi: 10.1126/sciadv.abi7166

Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle

2021

Journal Article

The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle

Meizoso-Huesca, Aldo and Launikonis, Bradley S. (2021). The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle. Journal of General Physiology, 153 (1) e202012747, 1-12. doi: 10.1085/jgp.202012747

The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle

2020

Journal Article

Phasic store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle fibers from exercised mice

Lilliu, Elena, Hilber, Karlheinz, Launikonis, Bradley S. and Koenig, Xaver (2020). Phasic store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle fibers from exercised mice. Frontiers in Physiology, 11 597647, 1-11. doi: 10.3389/fphys.2020.597647

Phasic store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle fibers from exercised mice

2020

Journal Article

A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction

Ferreira, Juan J., Pequera, Germán, Launikonis, Bradley S., Ríos, Eduardo and Brum, Gustavo (2020). A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction. The Journal of Physiology, 599 (1) JP279917, 157-170. doi: 10.1113/jp279917

A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction

2020

Journal Article

Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling

Huerlimann, Roger, Maes, Gregory E., Maxwell, Michael J., Mobli, Mehdi, Launikonis, Bradley S., Jerry, Dean R. and Wade, Nicholas M. (2020). Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling. Gene, 752 144765, 144765. doi: 10.1016/j.gene.2020.144765

Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling

2020

Conference Publication

Effects of diet induced obesity on rat skeletal muscle Ca2+ handling and cellular adaptations

Singh, Daniel P., Watt, Matthew J. and Launikonis, Bradley S. (2020). Effects of diet induced obesity on rat skeletal muscle Ca2+ handling and cellular adaptations. 64th Annual Meeting of the Biophysical-Society, San Diego, CA, United States, 15-19 February 2020. St. Louis, MO, United States: Cell Press.

Effects of diet induced obesity on rat skeletal muscle Ca2+ handling and cellular adaptations

2020

Journal Article

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Rebbeck, Robyn T., Singh, Daniel P., Janicek, Kevyn A., Bers, Donald M., Thomas, David D., Launikonis, Bradley S. and Cornea, Razvan L. (2020). RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. Scientific Reports, 10 (1) 1791, 1791. doi: 10.1038/s41598-020-58461-1

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

2020

Journal Article

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions

Azimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed and Monteith, Gregory R. (2020). A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacology and Translational Science, 3 (1) acsptsci.9b00081, 135-147. doi: 10.1021/acsptsci.9b00081

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions

2020

Conference Publication

Total Calcium Content of Sarcoplasmic Reticulum and Mitochondria in Ryanodine Receptor Variant Muscle

Lamboley, Cedric R., Pearce, Luke and Launikonis, Bradley S. (2020). Total Calcium Content of Sarcoplasmic Reticulum and Mitochondria in Ryanodine Receptor Variant Muscle. In: 64th Annual Meeting of the Biophysical Society, San Diego, CA United States, (98A-99A). 15-19 February 2020.

Total Calcium Content of Sarcoplasmic Reticulum and Mitochondria in Ryanodine Receptor Variant Muscle

2019

Journal Article

Components of activation heat in skeletal muscle

Barclay, C. J. and Launikonis, B. S. (2019). Components of activation heat in skeletal muscle. Journal of Muscle Research and Cell Motility, 42 (1), 1-16. doi: 10.1007/s10974-019-09547-5

Components of activation heat in skeletal muscle

Current funding

  • 2024 - 2027
    Heat regulation by the fibre types in muscle
    ARC Discovery Projects
    Open grant
  • 2024 - 2025
    Membrane cholesterol in dysferlin-deficient muscle
    Jain Foundation
    Open grant
  • 2022 - 2025
    Regulated muscle-based thermogenesis for body temperature regulation
    ARC Discovery Projects
    Open grant

Past funding

  • 2022 - 2023
    Leaky ryanodine receptors in dysferlinopathy
    Jain Foundation
    Open grant
  • 2022 - 2024
    cAMP-dependent modulation of calcium handling in skeletal muscle
    Research Donation Generic
    Open grant
  • 2020 - 2024
    Assessment of the ability of small molecule RyR modulators to correct the Ca2+ fluxes in skeletal muscle fibers with RyR myopathy
    RyR-1 Foundation
    Open grant
  • 2020 - 2023
    Sarcoplasmic reticulum-mitochondrial functional interactions in muscle
    ARC Discovery Projects
    Open grant
  • 2020 - 2023
    Diagnosing Malignant Hyperthermia from Muscle Fibres obtained from Needle Biopsy
    The Sydney Children's Hospitals Network (Randwick and Westmead) (Incorporating The Royal Alexandra Hospital For Children)
    Open grant
  • 2019 - 2020
    Ca2+ handling and tubular (t-) system function in dysferlinopathy
    Jain Foundation
    Open grant
  • 2019 - 2021
    Junctional membrane calcium dynamics in skeletal muscle fibres with ryanodine receptor variants
    AFM-Telethon Research Grant
    Open grant
  • 2018 - 2021
    Calcium cycling and heat generation in skeletal muscle fibres
    ARC Discovery Projects
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Physiological activation and targets of calcium signaling in muscle
    ARC Future Fellowships
    Open grant
  • 2014
    Cellular metabolic respirometry and enzymatic assessment suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Assoc/Professor Tom Shannon
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2013
    Identifying the pathways of excessive calcium leak in to dystrophic muscle
    Brain Foundation
    Open grant
  • 2012 - 2016
    Manipulating store-operated Ca2+ entry to improve muscle function in dystrophy
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Gamma-Secretase inhibitors as novel pharmacological agents to target stroke-induced brain injury
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Muscle fibre excitability and Ca2+ regulation in skeletal muscle of amphibians and mammals.
    ARC Discovery Projects
    Open grant
  • 2010 - 2012
    Improving muscle function in dystrophy
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2010
    UQ Travel Awards Category 1, Thomas Shannon
    UQ Travel Grants Scheme
    Open grant
  • 2008 - 2009
    Maintaining calcium balance in healthy skeletal muscle and the deleterious changes with ageing and in dystrophy
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2008 - 2009
    Calcium regulation in the skeletal muscle triad and along the fibre.
    ARC Discovery Projects
    Open grant
  • 2008
    Membrane excitability and cellular calcium regulation in the peripheral nervous system under different (patho)-physiological conditions and in inflammatory disease
    ARC Linkage International
    Open grant
  • 2008
    Olympus disk-spinning confocal microscope system capable of simutaneously imaging a ratiometric (UV) non-ratiometric (visible range) dye
    Ramaciotti Foundation
    Open grant
  • 2008
    Understanding cell physiology by confocal laser scanning microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2008
    Can local increases in cytoplasmic {Ca2+} trigger action potentials in the tubular system of skeletal muscle fibres?
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2007 - 2008
    Control of Ca2+ release in excitation-contration coupling and its modulation by membrane cholesterol
    NHMRC Training (Postdoctoral) Fellowship
    Open grant
  • 2007 - 2010
    Store operated Ca2+ entry in skeletal fibres from normal and dystrophin-deficient muscle
    NHMRC Project Grant
    Open grant

Availability

Professor Bradley Launikonis is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The influence of RyR modifications on the downstream mitochondrial Ca2+ handling

    Principal Advisor

    Other advisors: Dr David Simmons, Dr Daniel Singh

  • Doctor Philosophy

    The influence of RyR modifications on the downstream mitochondrial Ca2+ handling

    Principal Advisor

    Other advisors: Dr David Simmons, Dr Daniel Singh

  • Doctor Philosophy

    Signalling between brown adipose tissue and skeletal muscle for body temperature maintenance.

    Principal Advisor

    Other advisors: Dr Daniel Singh

  • Doctor Philosophy

    The influence of RyR modifications on the downstream mitochondrial Ca2+ handling

    Principal Advisor

    Other advisors: Dr David Simmons, Dr Daniel Singh

Completed supervision

Enquiries

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