Professor

Bradley Launikonis

Email: 
Phone: 
+61 7 336 54301

Availability

Professor Bradley Launikonis is:
Available for supervision

Fields of research

Biological Sciences Zoology

Qualifications

  • Doctor of Philosophy, La Trobe University

Search Professor Bradley Launikonis’s works on UQ eSpace

95 works between 1997 and 2025
All (95) Journal Article (71) Book Chapter (1) Conference Publication (23)

21 - 40 of 95 works

2020

Journal Article

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions

Azimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed and Monteith, Gregory R. (2020). A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacology and Translational Science, 3 (1) acsptsci.9b00081, 135-147. doi: 10.1021/acsptsci.9b00081

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions

2020

Conference Publication

Total Calcium Content of Sarcoplasmic Reticulum and Mitochondria in Ryanodine Receptor Variant Muscle

Lamboley, Cedric R., Pearce, Luke and Launikonis, Bradley S. (2020). Total Calcium Content of Sarcoplasmic Reticulum and Mitochondria in Ryanodine Receptor Variant Muscle. In: 64th Annual Meeting of the Biophysical Society, San Diego, CA United States, (98A-99A). 15-19 February 2020.

Total Calcium Content of Sarcoplasmic Reticulum and Mitochondria in Ryanodine Receptor Variant Muscle

2019

Journal Article

Components of activation heat in skeletal muscle

Barclay, C. J. and Launikonis, B. S. (2019). Components of activation heat in skeletal muscle. Journal of Muscle Research and Cell Motility, 42 (1), 1-16. doi: 10.1007/s10974-019-09547-5

Components of activation heat in skeletal muscle

2019

Journal Article

Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle

Koenig, Xaver, Choi, Rocky H., Schicker, Klaus, Singh, Daniel P., Hilber, Karlheinz and Launikonis, Bradley S. (2019). Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle. Biochimica et Biophysica Acta, 1866 (7), 1239-1248. doi: 10.1016/j.bbamcr.2019.02.014

Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle

2019

Conference Publication

High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development

Rebbeck, Robyn T., Singh, Daniel P., Ginsburg, Kenneth S., Dong, Xiaoqiong, Thomas, David D., Bers, Donald M., Launikonis, Bradley S. and Cornea, Razvan L. (2019). High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD, United States, 2-6 March, 2019. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2018.11.2062

High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development

2019

Conference Publication

Determination of heat production in human skeletal muscle from measurements of basal Ca2+ movements

Barclay, Christopher J. and Launikonis, Bradley S. (2019). Determination of heat production in human skeletal muscle from measurements of basal Ca2+ movements. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD, United States, 2-6 March 2019. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2018.11.2805

Determination of heat production in human skeletal muscle from measurements of basal Ca2+ movements

2018

Journal Article

Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation

Cully, Tanya R., Choi, Rocky H., Bjorksten, Andrew R., Stephenson, D. George, Murphy, Robyn M. and Launikonis, Bradley S. (2018). Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation. Proceedings of the National Academy of Sciences of the United States of America, 115 (32), 201800490-8220. doi: 10.1073/pnas.1800490115

Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation

2018

Journal Article

Store-operated Ca2+ entry is activated by every action potential in skeletal muscle

Koenig, Xaver, Choi, Rocky H. and Launikonis, Bradley S. (2018). Store-operated Ca2+ entry is activated by every action potential in skeletal muscle. Communications Biology, 1 (1) 31, 31. doi: 10.1038/s42003-018-0033-7

Store-operated Ca2+ entry is activated by every action potential in skeletal muscle

2018

Journal Article

NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat

Launikonis, Bradley S., Cully, Tanya R., Csernoch, Laszlo and Stephenson, D. George (2018). NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat. The Journal of General Physiology, 150 (1), 95-110. doi: 10.1085/jgp.201711891

NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat

2018

Conference Publication

High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications

Rebbeck, Robyn T., Dong, Xiaoqiong, Ginsburg, Kenneth S., Singh, Daniel P., Gillispie, Gregory D., Thomas, David D., Launikonis, Bradley S., Bers, Donald M. and Cornea, Razvan L. (2018). High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications. 62nd Annual Meeting of the Biophysical Society, San Francisco, California, 17-21 February 2018. St. Louis, MO, United States: Cell Press.

High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications

2018

Conference Publication

Every Action Potential Activates Store-Operated Ca2+ Entry in Skeletal Muscle

Koenig, Xaver and Launikonis, Bradley S. (2018). Every Action Potential Activates Store-Operated Ca2+ Entry in Skeletal Muscle. 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 17-21, 2018. Cambridge, MA United States: Cell Press.

Every Action Potential Activates Store-Operated Ca2+ Entry in Skeletal Muscle

2017

Journal Article

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R. and Hudson, James E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proceedings of the National Academy of Sciences of the United States of America, 114 (40), E8372-E8381. doi: 10.1073/pnas.1707316114

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

2017

Journal Article

Dantrolene requires Mg2+ to arrest malignant hyperthermia

Choi, Rocky H., Koenig, Xaver and Launikonis, Bradley S. (2017). Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proceedings of the National Academy of Sciences of the United States of America, 114 (18), 4811-4815. doi: 10.1073/pnas.1619835114

Dantrolene requires Mg2+ to arrest malignant hyperthermia

2017

Journal Article

Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle

Bakker, Anthony J., Cully, Tanya R., Wingate, Catherine D., Barclay, Christopher J. and Launikonis, Bradley S. (2017). Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. Journal of General Physiology, 149 (3), 323-334. doi: 10.1085/jgp.201611727

Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle

2017

Journal Article

Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise

Cully, Tanya R., Murphy, Robyn M., Roberts, Llion, Raastad, Truls, Fassett, Robert G., Coombes, Jeff S., Jayasinghe, Isuru D. and Launikonis, Bradley S. (2017). Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise. Nature Communications, 8 (1) 14266, 14266.1-14266.10. doi: 10.1038/ncomms14266

Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise

2017

Conference Publication

Towards the role of store-operated Ca2+ entry in skeletal muscle physiology

Koenig, X. and Launikonis, B. S. (2017). Towards the role of store-operated Ca2+ entry in skeletal muscle physiology. Joint Meeting of the Federation of European Physiological Societies and the Austrian Physiological Society with Participation of the Czech, French, Italian, Slovak, Slovenian, Swiss and Turkish Physiological Societies, Vienna, Austria, 13–15 September 2017. Chichester, West Sussex United Kingdom: Wiley.

Towards the role of store-operated Ca2+ entry in skeletal muscle physiology

2017

Conference Publication

Genetic and histological characterisation of excitation-contraction coupling related structural myopathy cohort

Beecroft, S., Choi, R., McLean, C., Olive, M., Ryan, M., Davis, M., Laing, N., Launikonis, B. and Ravenscroft, G. (2017). Genetic and histological characterisation of excitation-contraction coupling related structural myopathy cohort. 22nd International Annual Congress of the World-Muscle-Society (WMS), Saint Malo France, 3-7 October 2017. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.nmd.2017.06.023

Genetic and histological characterisation of excitation-contraction coupling related structural myopathy cohort

2017

Conference Publication

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Hudson, J., Mills, R., Titmarsh, D., Koenig, X., Parker, B., Ryall, J., Quaife-Ryan, G., Voges, H., Hodson, M., Ferguson, C., Drowley, L., Plowright, A., Wang, Q., Gregorevic, P., Xin, M., Thomas, W., Parton, R., Nielsen, L., Launikonis, B., James, D., Elliott, D. and Porrello, E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Perth, Australia, 10 - 13 August 2017. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2017.06.375

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

2017

Conference Publication

Dantrolene Shifts the Affinity of the Ryanodine Receptor for MG(2+)

Choi, Rocky H., Konig, F. Xaver, Cully, Tanya R. and Launikonis, Bradley S. (2017). Dantrolene Shifts the Affinity of the Ryanodine Receptor for MG(2+). 61st Annual Meeting of the Biophysical-Society, New Orleans, LA United States, Feb 11-15, 2017. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2016.11.584

Dantrolene Shifts the Affinity of the Ryanodine Receptor for MG(2+)

2016

Journal Article

A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres

Cully, Tanya R., Edwards, Joshua N., Murphy, Robyn M. and Launikonis, Bradley S. (2016). A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres. Journal of Physiology, 594 (11), 2795-2810. doi: 10.1113/JP271658

A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres

Current funding

  • 2025 - 2026
    Membrane cholesterol in dysferlin-deficient muscle
    Jain Foundation
    Open grant
  • 2024 - 2027
    Heat regulation by the fibre types in muscle
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    Regulated muscle-based thermogenesis for body temperature regulation
    ARC Discovery Projects
    Open grant

Past funding

  • 2024 - 2025
    Membrane cholesterol in dysferlin-deficient muscle
    Jain Foundation
    Open grant
  • 2022 - 2023
    Leaky ryanodine receptors in dysferlinopathy
    Jain Foundation
    Open grant
  • 2022 - 2024
    cAMP-dependent modulation of calcium handling in skeletal muscle
    Research Donation Generic
    Open grant
  • 2020 - 2024
    Assessment of the ability of small molecule RyR modulators to correct the Ca2+ fluxes in skeletal muscle fibers with RyR myopathy
    RyR-1 Foundation
    Open grant
  • 2020 - 2023
    Sarcoplasmic reticulum-mitochondrial functional interactions in muscle
    ARC Discovery Projects
    Open grant
  • 2020 - 2023
    Diagnosing Malignant Hyperthermia from Muscle Fibres obtained from Needle Biopsy
    The Sydney Children's Hospitals Network (Randwick and Westmead) (Incorporating The Royal Alexandra Hospital For Children)
    Open grant
  • 2019 - 2020
    Ca2+ handling and tubular (t-) system function in dysferlinopathy
    Jain Foundation
    Open grant
  • 2019 - 2021
    Junctional membrane calcium dynamics in skeletal muscle fibres with ryanodine receptor variants
    AFM-Telethon Research Grant
    Open grant
  • 2018 - 2021
    Calcium cycling and heat generation in skeletal muscle fibres
    ARC Discovery Projects
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Physiological activation and targets of calcium signaling in muscle
    ARC Future Fellowships
    Open grant
  • 2014
    Cellular metabolic respirometry and enzymatic assessment suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Assoc/Professor Tom Shannon
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2013
    Identifying the pathways of excessive calcium leak in to dystrophic muscle
    Brain Foundation
    Open grant
  • 2012 - 2016
    Manipulating store-operated Ca2+ entry to improve muscle function in dystrophy
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Gamma-Secretase inhibitors as novel pharmacological agents to target stroke-induced brain injury
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Muscle fibre excitability and Ca2+ regulation in skeletal muscle of amphibians and mammals.
    ARC Discovery Projects
    Open grant
  • 2010 - 2012
    Improving muscle function in dystrophy
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2010
    UQ Travel Awards Category 1, Thomas Shannon
    UQ Travel Grants Scheme
    Open grant
  • 2008 - 2009
    Maintaining calcium balance in healthy skeletal muscle and the deleterious changes with ageing and in dystrophy
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2008 - 2009
    Calcium regulation in the skeletal muscle triad and along the fibre.
    ARC Discovery Projects
    Open grant
  • 2008
    Membrane excitability and cellular calcium regulation in the peripheral nervous system under different (patho)-physiological conditions and in inflammatory disease
    ARC Linkage International
    Open grant
  • 2008
    Olympus disk-spinning confocal microscope system capable of simutaneously imaging a ratiometric (UV) non-ratiometric (visible range) dye
    Ramaciotti Foundation
    Open grant
  • 2008
    Understanding cell physiology by confocal laser scanning microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2008
    Can local increases in cytoplasmic {Ca2+} trigger action potentials in the tubular system of skeletal muscle fibres?
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2007 - 2008
    Control of Ca2+ release in excitation-contration coupling and its modulation by membrane cholesterol
    NHMRC Training (Postdoctoral) Fellowship
    Open grant
  • 2007 - 2010
    Store operated Ca2+ entry in skeletal fibres from normal and dystrophin-deficient muscle
    NHMRC Project Grant
    Open grant

Availability

Professor Bradley Launikonis is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    The influence of RyR modifications on the downstream mitochondrial Ca2+ handling

    Principal Advisor

    Other advisors: Dr David Simmons, Dr Daniel Singh

  • Doctor Philosophy

    The influence of RyR modifications on the downstream mitochondrial Ca2+ handling

    Principal Advisor

    Other advisors: Dr David Simmons, Dr Daniel Singh

  • Doctor Philosophy

    Signalling between brown adipose tissue and skeletal muscle for body temperature maintenance.

    Principal Advisor

    Other advisors: Dr Daniel Singh

  • Doctor Philosophy

    The influence of RyR modifications on the downstream mitochondrial Ca2+ handling

    Principal Advisor

    Other advisors: Dr David Simmons, Dr Daniel Singh

Completed supervision

Enquiries

For media enquiries about Professor Bradley Launikonis's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au