Overview
Availability
- Dr Daniel Singh is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Daniel Singh’s works on UQ eSpace
2023
Journal Article
Ryanodine receptor activity and store‐operated Ca <sup>2+</sup> entry: critical regulators of Ca <sup>2+</sup> content and function in skeletal muscle
Pearce, Luke, Meizoso‐Huesca, Aldo, Seng, Crystal, Lamboley, Cedric R., Singh, Daniel P. and Launikonis, Bradley S. (2023). Ryanodine receptor activity and store‐operated Ca 2+ entry: critical regulators of Ca 2+ content and function in skeletal muscle. The Journal of Physiology, 601 (19), 4183-4202. doi: 10.1113/jp279512
2023
Journal Article
Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals
Singh, Daniel P., Pearce, Luke, Choi, Rocky H., Meizoso-Huesca, Aldo, Wette, Stefan G., Scott, John W., Lamboley, Cedric R., Murphy, Robyn M. and Launikonis, Bradley S. (2023). Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals. Proceedings of the National Academy of Sciences, 120 (4) e2117503120, 1-12. doi: 10.1073/pnas.2117503120
2022
Journal Article
Tiny changes in cytoplasmic [Ca<sup>2+</sup>] cause large changes in mitochondrial Ca<sup>2+</sup>: what are the triggers and functional implications?
Seng, Crystal, Pearce, Luke, Meizoso-Huesca, Aldo, Singh, Daniel P., Murphy, Robyn M., Lamboley, Cedric and Launikonis, Bradley S. (2022). Tiny changes in cytoplasmic [Ca2+] cause large changes in mitochondrial Ca2+: what are the triggers and functional implications?. American Journal of Physiology-Cell Physiology, 323 (4), C1285-C1289. doi: 10.1152/ajpcell.00092.2022
2022
Journal Article
Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening
Zhang, Jingyan, Singh, Daniel P., Ko, Christopher Y., Nikolaienko, Roman, Wong King Yuen, Siobhan M., Schwarz, Jacob A., Treinen, Levy M., Tung, Ching-Chieh, Rožman, Kaja, Svensson, Bengt, Aldrich, Courtney C., Zima, Aleksey V., Thomas, David D., Bers, Donald M., Launikonis, Bradley S., Van Petegem, Filip and Cornea, Razvan L. (2022). Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. Journal of Biological Chemistry, 298 (1) 101412, 101412. doi: 10.1016/j.jbc.2021.101412
2021
Journal Article
Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle
Lamboley, Cedric R., Pearce, Luke, Seng, Crystal, Meizoso-Huesca, Aldo, Singh, Daniel P., Frankish, Barnaby P., Kaura, Vikas, Lo, Harriet P., Ferguson, Charles, Allen, Paul D., Hopkins, Philip M., Parton, Robert G., Murphy, Robyn M., van der Poel, Chris, Barclay, Christopher J. and Launikonis, Bradley S. (2021). Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances, 7 (44) eabi7166, 1-15. doi: 10.1126/sciadv.abi7166
2021
Other Outputs
Ryanodine receptor calcium regulation in healthy and compromised skeletal muscle
Singh, Daniel (2021). Ryanodine receptor calcium regulation in healthy and compromised skeletal muscle. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/ba6ef1f
2020
Journal Article
Comparative label-free mass spectrometric analysis of temporal changes in the skeletal muscle proteome after impact trauma in rats
Liu, Lian, Broszczak, Daniel A., Broadbent, James A., Singh, Daniel P., Steck, Roland, Parker, Tony J. and Peake, Jonathan M. (2020). Comparative label-free mass spectrometric analysis of temporal changes in the skeletal muscle proteome after impact trauma in rats. AJP: Endocrinology and Metabolism, 318 (6), E1022-E1037. doi: 10.1152/ajpendo.00433.2019
2020
Journal Article
RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays
Rebbeck, Robyn T., Singh, Daniel P., Janicek, Kevyn A., Bers, Donald M., Thomas, David D., Launikonis, Bradley S. and Cornea, Razvan L. (2020). RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. Scientific Reports, 10 (1) 1791, 1791. doi: 10.1038/s41598-020-58461-1
2019
Journal Article
Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle
Koenig, Xaver, Choi, Rocky H., Schicker, Klaus, Singh, Daniel P., Hilber, Karlheinz and Launikonis, Bradley S. (2019). Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle. Biochimica et Biophysica Acta, 1866 (7), 1239-1248. doi: 10.1016/j.bbamcr.2019.02.014
2019
Conference Publication
High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development
Rebbeck, Robyn T., Singh, Daniel P., Ginsburg, Kenneth S., Dong, Xiaoqiong, Thomas, David D., Bers, Donald M., Launikonis, Bradley S. and Cornea, Razvan L. (2019). High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD, United States, 2-6 March, 2019. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2018.11.2062
2018
Conference Publication
High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications
Rebbeck, Robyn T., Dong, Xiaoqiong, Ginsburg, Kenneth S., Singh, Daniel P., Gillispie, Gregory D., Thomas, David D., Launikonis, Bradley S., Bers, Donald M. and Cornea, Razvan L. (2018). High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications. 62nd Annual Meeting of the Biophysical Society, San Francisco, California, 17-21 February 2018. St. Louis, MO, United States: Cell Press.
2017
Journal Article
Effects of topical icing on inflammation, angiogenesis, revascularization, and myofiber regeneration in skeletal muscle following contusion injury
Singh, Daniel P., Lonbani, Zohreh Barani, Woodruff, Maria A., Parker, Tony J., Steck, Roland and Peake, Jonathan M. (2017). Effects of topical icing on inflammation, angiogenesis, revascularization, and myofiber regeneration in skeletal muscle following contusion injury. Frontiers in Physiology, 8, 93. doi: 10.3389/fphys.2017.00093
Funding
Past funding
Supervision
Availability
- Dr Daniel Singh is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Signalling between brown adipose tissue and skeletal muscle for body temperature maintenance.
Associate Advisor
Other advisors: Professor Bradley Launikonis
-
Doctor Philosophy
The influence of RyR modifications on the downstream mitochondrial Ca2+ handling
Associate Advisor
Other advisors: Dr David Simmons, Professor Bradley Launikonis
Media
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