Overview
Background
I am a neuroscientist interested in how cellular and molecular mechanisms regulate brain development, neural circuits and brain function across the lifespan, and how disruption of these processes contributes to neurodevelopmental, neuropsychiatric and neurodegenerative disorders. My research focuses particularly on neural progenitor cells, oligodendrocyte biology, myelination and neuron–glia interactions, with broader interests in neurocognition, brain health and disease.
I completed my PhD at the University of Tasmania investigating ion channel signalling in oligodendrocyte progenitor cells and its role in neural circuit function and myelination. I subsequently undertook postdoctoral research at The University of Queensland, including at the Queensland Brain Institute, where I investigated neural progenitor function, neuronal migration and cortical development in models of neurodevelopmental disorders, and at Mater Research–UQ, where I investigated oligodendrocyte dysfunction, myelination and cellular signalling in neurological and neuropsychiatric disease, including multiple sclerosis-like pathology.
Across these research programs, I have developed expertise in developmental neuroscience, cellular and molecular neuroscience, neural progenitor biology, neuron–glia interactions, myelination and neural circuit function, using experimental approaches spanning molecular and cellular biology, advanced microscopy, electrophysiology, animal models and behavioural neuroscience. My broader research interests are centred on understanding how changes in cellular signalling and interactions between neural cell types shape brain function in health and disease.
Alongside my research, I contribute to tertiary teaching and student supervision across neuroscience, psychology and biomedical sciences at The University of Queensland, with a particular interest in research-informed education and scientific communication.
Availability
- Dr Raphael Ricci is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Biological Sciences, Universidade Estadual de Campinas (Unicamp)
- Doctor of Philosophy of Neurosciences, University of Tasmania
- Member, "Science Without Boarders" Alumni, "Science Without Boarders" Alumni
- Member, Australian Neuroscience Society, Australian Neuroscience Society
- Member, International Brain Research Organisation, International Brain Research Organisation
- Member, Society for Neuroscience, Society for Neuroscience
Research interests
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Neural circuit development and function
Understanding how oligodendrocyte progenitor cells (OPCs) and oligodendrocytes contribute to the formation, maintenance and function of neural circuits across the lifespan. Particular interest centres on how progenitor cell biology, neuronal activity, cellular signalling and myelination interact to shape neural circuit development and function in health and disease.
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Oligodendrocyte progenitor cell biology and myelination
Understanding the cellular and molecular mechanisms that regulate oligodendrocyte progenitor cell proliferation, survival, differentiation and maturation. This includes how OPC and oligodendrocyte function contributes to myelination, neural circuit integrity and brain function, and how these processes become disrupted in neurological and neurodegenerative disease.
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Neuron–glia interactions and neural circuits
The reciprocal interactions between neurons and oligodendrocyte lineage cells in regulating neural circuit development and function. Particular emphasis is placed on how neuronal activity, ion channel signalling and communication between neurons and glia influence OPC behaviour, oligodendrocyte development and neural circuit function.
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Brain development and neurodevelopmental disorders
The cellular mechanisms underlying brain development, with particular interest in neural progenitor cells, oligodendrocyte lineage cells and the establishment of functional neural circuits. This work examines how disruption of developmental signalling, progenitor cell behaviour and neuronal–glial interactions may contribute to neurodevelopmental disorders, including autism spectrum disorder.
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Neurological and neurodegenerative disease
The mechanisms by which disruption of oligodendrocyte progenitor cell biology, oligodendrocyte function, myelination and neural circuit integrity contributes to neurological and neurodegenerative disease. Particular relevance includes demyelinating disorders such as multiple sclerosis, with a focus on cellular dysfunction, disease progression and mechanisms of repair.
Research impacts
My research aims to understand how changes in the cells and molecular pathways that build and maintain the brain can contribute to neurological disorders. In particular, I investigate how neural progenitor cells, oligodendrocytes and their interactions with neurons regulate brain development, neural circuits and myelination, and how disruption of these processes can affect brain function and behaviour. This work has relevance to conditions including autism spectrum disorder, multiple sclerosis and other neurological and neuropsychiatric disorders.
My research has contributed to understanding the cellular mechanisms that regulate the development and maintenance of the nervous system. During my PhD, I identified an important role for the voltage-gated calcium channel CaV1.2 in the survival of adult oligodendrocyte progenitor cells, providing new insight into how these cells are regulated in the mature brain. My subsequent research at the Queensland Brain Institute examined how disrupted cellular signalling affects neural progenitor proliferation, neurogenesis, neuronal migration and cortical development, including mechanisms relevant to neurodevelopmental disorders. More recent work has investigated how oligodendrocyte dysfunction, myelination and cellular signalling contribute to neurological disease.
The potential impact of this research is to improve our understanding of the biological mechanisms underlying brain health and disease, providing knowledge that can ultimately inform the development of better approaches to disease prevention, diagnosis and treatment. I also place strong emphasis on research translation and scientific communication, including communicating neuroscience to students, researchers and broader audiences and supporting meaningful engagement with health and biomedical research.
Works
Search Professor Raphael Ricci’s works on UQ eSpace
2026
Journal Article
Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration
Ricci, Raphael P., Foo, Cheng Xiang, Ronacher, Katharina and Cullen, Carlie L. (2026). Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration. Frontiers in Molecular Neuroscience, 19 1709065. doi: 10.3389/fnmol.2026.1709065
2025
Conference Publication
SARS-COV-2 infection affects oligodendrocyte lineage cells in the mouse motor cortex
Ricci, R. P., Foo, C. X., Ronacher, K. and Cullen, C. (2025). SARS-COV-2 infection affects oligodendrocyte lineage cells in the mouse motor cortex. XVII European Meeting on Glial Cells in Health and Disease, Marseille, France, 8-11 July 2025. Hoboken, NJ USA: John Wiley & Sons.
2025
Conference Publication
Delaying development myelination results in altered network processing in zebrafish larvae
Lepre, M., Lee, R., Lee, C., Ricci, R., Gasperini, R., Scott, E. K., Young, K. M., Favre-Bulle, I. and Cullen, C. L. (2025). Delaying development myelination results in altered network processing in zebrafish larvae. XVII European Meeting on Glial Cells in Health and Disease, Marseille, France, 8 - 11 July 2025. Hoboken, NJ, United States: John Wiley & Son.
2025
Journal Article
Demyelination produces a shift in the population of cortical neurons that synapse with callosal oligodendrocyte progenitor cells
Summers, Benjamin S., Blizzard, Catherine A., Ricci, Raphael R., Pitman, Kimberley A., Dempsey, Bowen, McMullan, Simon, Sutherland, Brad A., Young, Kaylene M. and Cullen, Carlie L. (2025). Demyelination produces a shift in the population of cortical neurons that synapse with callosal oligodendrocyte progenitor cells. eNeuro, 12 (6) ENEURO.0113-25.2025, 1-22. doi: 10.1523/eneuro.0113-25.2025
2022
Conference Publication
Short-term myelin loss is sufficient to alter neuronal synapses: insight into disease progression in MS
Makowiecki, K., Pepper, R. E., Cullen, C. L., Pitman, K. A., Ricci, R., Blizzard, C., Emery, B. and Young, K. M. (2022). Short-term myelin loss is sufficient to alter neuronal synapses: insight into disease progression in MS. MS Australia Progress in MS Research Scientific Conference, Hobart, TAS, Australia, 4 - 5 April 2022. London, United Kingdom: Sage Publications.
2022
Journal Article
Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways
Zhen, Yilan, Cullen, Carlie L., Ricci, Raphael, Summers, Benjamin S., Rehman, Sakina, Ahmed, Zubair M., Foster, Antoinette Y., Emery, Ben, Gasperini, Robert and Young, Kaylene M. (2022). Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways. Communications Biology, 5 (1) 511, 511. doi: 10.1038/s42003-022-03470-1
2021
Conference Publication
Myelin influences synaptic plasticity in the adult mouse cortex
Pepper, R. E., Cullen, C. L., Makowiecki, K., Pitman, K. A., Ricci, R., Blizzard, C., Emery, B. and Young, K. M. (2021). Myelin influences synaptic plasticity in the adult mouse cortex. XV European Meeting on Glial Cells in Health and Disease, Marseille, France, 5–9 July 2021. Hoboken, NJ, United States: John Wiley & Sons.
2019
Journal Article
The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex
Pitman, Kimberley A., Ricci, Raphael, Gasperini, Robert, Beasley, Shannon, Pavez, Macarena, Charlesworth, Jac, Foa, Lisa and Young, Kaylene M. (2019). The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex. Glia, 68 (2), 376-392. doi: 10.1002/glia.23723
2017
Conference Publication
Understanding how voltage-gated calcium signalling regulates oligodendrocyte progenitor cell function in the mature central nervous system
Pitman, Kimberley, Ricci, Raphael, Gasperini, Robert, Charlesworth, Jac, Foa, Lisa and Young, Kaylene M. (2017). Understanding how voltage-gated calcium signalling regulates oligodendrocyte progenitor cell function in the mature central nervous system. Progress in MS Research Conference, Sydney, NSW, Australia, 11-13 October 2017. London, United Kingdom: Sage Publications.
Funding
Current funding
Supervision
Availability
- Dr Raphael Ricci is:
- Available for supervision
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Media
Enquiries
Contact Dr Raphael Ricci directly for media enquiries about:
- Autism
- Behaviour
- Brain ageing
- Brain and behaviour
- Brain development
- Brain disorders
- Brain function
- Brain health
- Brain plasticity
- Brain research
- Cognition
- Health research
- Learning
- Medical research
- Memory
- Mental health
- Mental wellbeing
- Multiple sclerosis
- Nervous system
- Neurodegenerative disease
- Neurodevelopment
- Neurological disorders
- Neuroscience
- Science communication
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