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Dr Raphael Ricci
Dr

Raphael Ricci

Email: 

Overview

Background

I am a neuroscientist interested in how cellular and molecular mechanisms regulate brain development, neural circuits and brain function across the lifespan, and how disruption of these processes contributes to neurodevelopmental, neuropsychiatric and neurodegenerative disorders. My research focuses particularly on neural progenitor cells, oligodendrocyte biology, myelination and neuron–glia interactions, with broader interests in neurocognition, brain health and disease.

I completed my PhD at the University of Tasmania investigating ion channel signalling in oligodendrocyte progenitor cells and its role in neural circuit function and myelination. I subsequently undertook postdoctoral research at The University of Queensland, including at the Queensland Brain Institute, where I investigated neural progenitor function, neuronal migration and cortical development in models of neurodevelopmental disorders, and at Mater Research–UQ, where I investigated oligodendrocyte dysfunction, myelination and cellular signalling in neurological and neuropsychiatric disease, including multiple sclerosis-like pathology.

Across these research programs, I have developed expertise in developmental neuroscience, cellular and molecular neuroscience, neural progenitor biology, neuron–glia interactions, myelination and neural circuit function, using experimental approaches spanning molecular and cellular biology, advanced microscopy, electrophysiology, animal models and behavioural neuroscience. My broader research interests are centred on understanding how changes in cellular signalling and interactions between neural cell types shape brain function in health and disease.

Alongside my research, I contribute to tertiary teaching and student supervision across neuroscience, psychology and biomedical sciences at The University of Queensland, with a particular interest in research-informed education and scientific communication.

Availability

Dr Raphael Ricci is:
Available for supervision
Media expert

Qualifications

  • Bachelor (Honours) of Biological Sciences, Universidade Estadual de Campinas (Unicamp)
  • Doctor of Philosophy of Neurosciences, University of Tasmania
  • Member, "Science Without Boarders" Alumni, "Science Without Boarders" Alumni
  • Member, Australian Neuroscience Society, Australian Neuroscience Society
  • Member, International Brain Research Organisation, International Brain Research Organisation
  • Member, Society for Neuroscience, Society for Neuroscience

Research interests

  • Neural circuit development and function

    Understanding how oligodendrocyte progenitor cells (OPCs) and oligodendrocytes contribute to the formation, maintenance and function of neural circuits across the lifespan. Particular interest centres on how progenitor cell biology, neuronal activity, cellular signalling and myelination interact to shape neural circuit development and function in health and disease.

  • Oligodendrocyte progenitor cell biology and myelination

    Understanding the cellular and molecular mechanisms that regulate oligodendrocyte progenitor cell proliferation, survival, differentiation and maturation. This includes how OPC and oligodendrocyte function contributes to myelination, neural circuit integrity and brain function, and how these processes become disrupted in neurological and neurodegenerative disease.

  • Neuron–glia interactions and neural circuits

    The reciprocal interactions between neurons and oligodendrocyte lineage cells in regulating neural circuit development and function. Particular emphasis is placed on how neuronal activity, ion channel signalling and communication between neurons and glia influence OPC behaviour, oligodendrocyte development and neural circuit function.

  • Brain development and neurodevelopmental disorders

    The cellular mechanisms underlying brain development, with particular interest in neural progenitor cells, oligodendrocyte lineage cells and the establishment of functional neural circuits. This work examines how disruption of developmental signalling, progenitor cell behaviour and neuronal–glial interactions may contribute to neurodevelopmental disorders, including autism spectrum disorder.

  • Neurological and neurodegenerative disease

    The mechanisms by which disruption of oligodendrocyte progenitor cell biology, oligodendrocyte function, myelination and neural circuit integrity contributes to neurological and neurodegenerative disease. Particular relevance includes demyelinating disorders such as multiple sclerosis, with a focus on cellular dysfunction, disease progression and mechanisms of repair.

Research impacts

My research aims to understand how changes in the cells and molecular pathways that build and maintain the brain can contribute to neurological disorders. In particular, I investigate how neural progenitor cells, oligodendrocytes and their interactions with neurons regulate brain development, neural circuits and myelination, and how disruption of these processes can affect brain function and behaviour. This work has relevance to conditions including autism spectrum disorder, multiple sclerosis and other neurological and neuropsychiatric disorders.

My research has contributed to understanding the cellular mechanisms that regulate the development and maintenance of the nervous system. During my PhD, I identified an important role for the voltage-gated calcium channel CaV1.2 in the survival of adult oligodendrocyte progenitor cells, providing new insight into how these cells are regulated in the mature brain. My subsequent research at the Queensland Brain Institute examined how disrupted cellular signalling affects neural progenitor proliferation, neurogenesis, neuronal migration and cortical development, including mechanisms relevant to neurodevelopmental disorders. More recent work has investigated how oligodendrocyte dysfunction, myelination and cellular signalling contribute to neurological disease.

The potential impact of this research is to improve our understanding of the biological mechanisms underlying brain health and disease, providing knowledge that can ultimately inform the development of better approaches to disease prevention, diagnosis and treatment. I also place strong emphasis on research translation and scientific communication, including communicating neuroscience to students, researchers and broader audiences and supporting meaningful engagement with health and biomedical research.

Works

Search Professor Raphael Ricci’s works on UQ eSpace

9 works between 2017 and 2026

1 - 9 of 9 works

2026

Journal Article

Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration

Ricci, Raphael P., Foo, Cheng Xiang, Ronacher, Katharina and Cullen, Carlie L. (2026). Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration. Frontiers in Molecular Neuroscience, 19 1709065. doi: 10.3389/fnmol.2026.1709065

Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration

2025

Conference Publication

SARS-COV-2 infection affects oligodendrocyte lineage cells in the mouse motor cortex

Ricci, R. P., Foo, C. X., Ronacher, K. and Cullen, C. (2025). SARS-COV-2 infection affects oligodendrocyte lineage cells in the mouse motor cortex. XVII European Meeting on Glial Cells in Health and Disease, Marseille, France, 8-11 July 2025. Hoboken, NJ USA: John Wiley & Sons.

SARS-COV-2 infection affects oligodendrocyte lineage cells in the mouse motor cortex

2025

Conference Publication

Delaying development myelination results in altered network processing in zebrafish larvae

Lepre, M., Lee, R., Lee, C., Ricci, R., Gasperini, R., Scott, E. K., Young, K. M., Favre-Bulle, I. and Cullen, C. L. (2025). Delaying development myelination results in altered network processing in zebrafish larvae. XVII European Meeting on Glial Cells in Health and Disease, Marseille, France, 8 - 11 July 2025. Hoboken, NJ, United States: John Wiley & Son.

Delaying development myelination results in altered network processing in zebrafish larvae

2025

Journal Article

Demyelination produces a shift in the population of cortical neurons that synapse with callosal oligodendrocyte progenitor cells

Summers, Benjamin S., Blizzard, Catherine A., Ricci, Raphael R., Pitman, Kimberley A., Dempsey, Bowen, McMullan, Simon, Sutherland, Brad A., Young, Kaylene M. and Cullen, Carlie L. (2025). Demyelination produces a shift in the population of cortical neurons that synapse with callosal oligodendrocyte progenitor cells. eNeuro, 12 (6) ENEURO.0113-25.2025, 1-22. doi: 10.1523/eneuro.0113-25.2025

Demyelination produces a shift in the population of cortical neurons that synapse with callosal oligodendrocyte progenitor cells

2022

Conference Publication

Short-term myelin loss is sufficient to alter neuronal synapses: insight into disease progression in MS

Makowiecki, K., Pepper, R. E., Cullen, C. L., Pitman, K. A., Ricci, R., Blizzard, C., Emery, B. and Young, K. M. (2022). Short-term myelin loss is sufficient to alter neuronal synapses: insight into disease progression in MS. MS Australia Progress in MS Research Scientific Conference, Hobart, TAS, Australia, 4 - 5 April 2022. London, United Kingdom: Sage Publications.

Short-term myelin loss is sufficient to alter neuronal synapses: insight into disease progression in MS

2022

Journal Article

Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways

Zhen, Yilan, Cullen, Carlie L., Ricci, Raphael, Summers, Benjamin S., Rehman, Sakina, Ahmed, Zubair M., Foster, Antoinette Y., Emery, Ben, Gasperini, Robert and Young, Kaylene M. (2022). Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways. Communications Biology, 5 (1) 511, 511. doi: 10.1038/s42003-022-03470-1

Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways

2021

Conference Publication

Myelin influences synaptic plasticity in the adult mouse cortex

Pepper, R. E., Cullen, C. L., Makowiecki, K., Pitman, K. A., Ricci, R., Blizzard, C., Emery, B. and Young, K. M. (2021). Myelin influences synaptic plasticity in the adult mouse cortex. XV European Meeting on Glial Cells in Health and Disease, Marseille, France, 5–9 July 2021. Hoboken, NJ, United States: John Wiley & Sons.

Myelin influences synaptic plasticity in the adult mouse cortex

2019

Journal Article

The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex

Pitman, Kimberley A., Ricci, Raphael, Gasperini, Robert, Beasley, Shannon, Pavez, Macarena, Charlesworth, Jac, Foa, Lisa and Young, Kaylene M. (2019). The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex. Glia, 68 (2), 376-392. doi: 10.1002/glia.23723

The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex

2017

Conference Publication

Understanding how voltage-gated calcium signalling regulates oligodendrocyte progenitor cell function in the mature central nervous system

Pitman, Kimberley, Ricci, Raphael, Gasperini, Robert, Charlesworth, Jac, Foa, Lisa and Young, Kaylene M. (2017). Understanding how voltage-gated calcium signalling regulates oligodendrocyte progenitor cell function in the mature central nervous system. Progress in MS Research Conference, Sydney, NSW, Australia, 11-13 October 2017. London, United Kingdom: Sage Publications.

Understanding how voltage-gated calcium signalling regulates oligodendrocyte progenitor cell function in the mature central nervous system

Funding

Current funding

  • 2026 - 2030
    Timing is everything: unravelling the role of developmental myelination in neural network function
    NHMRC IDEAS Grants
    Open grant

Supervision

Availability

Dr Raphael Ricci is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Media

Enquiries

Contact Dr Raphael Ricci directly for media enquiries about:

  • Autism
  • Behaviour
  • Brain ageing
  • Brain and behaviour
  • Brain development
  • Brain disorders
  • Brain function
  • Brain health
  • Brain plasticity
  • Brain research
  • Cognition
  • Health research
  • Learning
  • Medical research
  • Memory
  • Mental health
  • Mental wellbeing
  • Multiple sclerosis
  • Nervous system
  • Neurodegenerative disease
  • Neurodevelopment
  • Neurological disorders
  • Neuroscience
  • Science communication

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au