Raphael Ricci

I am an early career neuroscientist investigating the capacity for neural progenitor cell behaviour to shape neural circuit formation, maintenance and function during development and throughout adulthood. More specifically, the role of oligodendrocyte progenitors and myelin in brain circuit formation and maintenance. My research examines the brain under health and pathological conditions by performing manipulations relevant to autism spectrum disorder, multiple sclerosis and schizophrenia. While under the supervision of Prof Helen Cooper at the Queensland Brain Institute – University of Queensland - I studied how the WRC-Cyfip1-FMRP protein network impaired apical radial glial progenitor function and neural migration, leading to cortical malformation and Autism-like traits in mice. During my PhD at University of Tasmania and under the supervision of Prof Kaylene Young, I studied the effect of neuronal activity on cells of the oligodendrocyte lineage. I found that voltage-gated calcium channels are critical for oligodendrocyte progenitor cell survival and characterised the impact of kainite receptor dysfunction on neuropathology and behaviour in mice. Currently under the supervision of Dr Carlie Cullen I am using transgenic mice strategies to determine how aberrant myelination can contribute to onset of neuropsychiatric and neurodegenerative disorders. I am also using mouse models of demyelination to investigate the effect of infectious diseases such as COVID19 and influenza on oligodendrocyte lineage cell function and the impact for myelin repair and multiple sclerosis disease progression. I have a long-standing interest in neuroscience research, that extends from understanding how brain function is regulated during development and in healthy ageing, and the dysregulated signalling pathways that enable neurodevelopmental and neurodegenerative disorders.