Overview
Background
Dr Haotian Yang is a postdoctoral research fellow driving the study of tumour self-seeding as part of a joint liver cancer research project of UQ Frazer Institute and Gallipoli Medical Research. He graduated with a Bachelor of Biomedical Science (Honours Class I) from UQ, focusing on the role of reactive oxygen species during chemotherapy in liver cancer. Dr Yang later completed his PhD at UQ, where he developed the first spontaneous model demonstrating the process of tumour self-seeding and characterised the tumour self-seeded cells responsible for this phenomenon. His current research investigates the biological and clinical significance of tumour self-seeding and aims to identify novel therapeutics that inhibit this process for the treatment of liver cancer.
Availability
- Dr Haotian Yang is:
- Available for supervision
Qualifications
- Bachelor (Honours) of Biomedical Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research impacts
From his Honours study, Dr Yang published a highly influential review paper on reactive oxygen species (ROS), providing academics with critical insights into the role of ROS in cancer cells during carcinogenesis and chemotherapy (J. Exp. Clin. Cancer Res. 2018). This review has been cited by more than 700 papers according to Google Scholar and is ranked in the top 1% of citations in clinical medicine. His current research has reported the first animal model to recapitulate the spontaneous process of tumour self-seeding and identify emerging cell targets with diagnostic, prognostic, and therapeutic potential in cancers (Cell Rep. 2024). This study significantly reshapes the understanding of cancer progression, challenging the central tenet of cancer biology that circulating tumour cells metastasise to distant organs in a unidirectional process.
Works
Search Professor Haotian Yang’s works on UQ eSpace
2024
Journal Article
STING nanoagonist boosts antitumor immunity of therapeutic DNA vaccines
Jia, Wencong, Chandra, Janin, Teoh, Siok Min, Tolley, Lynn, Yang, Haotian, Tse, Brian W. C., Sokolowski, Kamil A., Liang, Xiaowen, Crawford, Darrell H. G., Steel, Jason C., Yu, Chengzhong, Roberts, Michael S., Frazer, Ian H., Chen, Yu, Wang, Haolu and Yu, Meihua (2024). STING nanoagonist boosts antitumor immunity of therapeutic DNA vaccines. Nano Letters, 24 (49), 1-10. doi: 10.1021/acs.nanolett.4c03846
2024
Conference Publication
Therapeutic targeting of a-specific PI3K improves chemotherapy efficacy by inhibiting hepatic stellate cell activation in liver cancer
Ruan, Qi, Cao, Lu, Yang, Haotian, Burke, Leslie, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2024). Therapeutic targeting of a-specific PI3K improves chemotherapy efficacy by inhibiting hepatic stellate cell activation in liver cancer. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.
2024
Journal Article
Identification and characterization of TM4SF1+ tumor self-seeded cells
Yang, Haotian, Wang, Haolu, He, Yaowu, Yang, Yang, Thompson, Erik W., Xia, Di, Burke, Leslie J., Cao, Lu, Hooper, John D., Roberts, Michael S., Crawford, Darrell H.G. and Liang, Xiaowen (2024). Identification and characterization of TM4SF1+ tumor self-seeded cells. Cell Reports, 43 (7) 114512, 1-24. doi: 10.1016/j.celrep.2024.114512
2023
Conference Publication
Reactive oxygen species-mediated hepatic stellate cell activation via PI3K in liver cancer
Ruan, Qi, Cao, Lu, Yang, Haotian, Burke, Leslie, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2023). Reactive oxygen species-mediated hepatic stellate cell activation via PI3K in liver cancer. EASL Congress 2023, Vienna, Austria, 21 - 24 June 2023. Amsterdam, Netherlands: Elsevier.
2022
Book Chapter
Theranostic nanoparticles for imaging and targeted drug delivery to the liver
Wang, Haolu, Yang, Haotian, Ruan, Qi, Roberts, Michael S. and Liang, Xiaowen (2022). Theranostic nanoparticles for imaging and targeted drug delivery to the liver. Fundamentals of drug delivery. (pp. 311-328) edited by Heather A. E. Benson, Michael S. Roberts, Adrian C. Williams and Xiaowen Liang. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9781119769644.ch12
2021
Journal Article
A monochromophoric approach to succinct ratiometric fluorescent probes without probe-product crosstalk
Xin, Kai, Li, Xinxing, Guo, Yinghua, Zhong, Youhuan, Wang, Jungang, Yang, Haotian, Zhao, Jie, Guo, Chunlei, Huang, Yunxia, Lei, Zuhai, Ying, Yi-Lun, Luo, Xiao, Wang, Haolu, Qian, Xuhong, Yang, Wen, Liang, Xiaowen and Yang, Youjun (2021). A monochromophoric approach to succinct ratiometric fluorescent probes without probe-product crosstalk. CCS Chemistry, 3 (8), 2307-2315. doi: 10.31635/ccschem.020.202000480
2020
Journal Article
Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury
Wang, Haolu, Burke, Leslie J., Patel, Jatin, Tse, Brian W.C., Bridle, Kim R., Cogger, Victoria C., Li, Xinxing, Liu, Xin, Yang, Haotian, Crawford, Darrell H. G., Roberts, Michael S., Gao, Wenchao and Liang, Xiaowen (2020). Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics, 10 (15), 6715-6727. doi: 10.7150/thno.44900
2019
Journal Article
Impact of age on risk of lymph node positivity in patients with colon cancer
Wang, Haolu, Lu, Hao, Yang, Haotian, Zhang, Xianwen, Thompson, Erik W., Roberts, Michael S., Hu, Zhigian, Liang, Xiaowen and Li, Xinxing (2019). Impact of age on risk of lymph node positivity in patients with colon cancer. Journal of Cancer, 10 (9), 2102-2108. doi: 10.7150/jca.28377
2018
Journal Article
Anionic long-circulating quantum dots for long-term intravital vascular imaging
Wang, Haolu, Yang, Haotian, Xu, Zhi Ping, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Anionic long-circulating quantum dots for long-term intravital vascular imaging. Pharmaceutics, 10 (4) 244, 244. doi: 10.3390/pharmaceutics10040244
2018
Journal Article
The role of cellular reactive oxygen species in cancer chemotherapy
Yang, Haotian, Villani, Rehan M., Wang, Haolu, Simpson, Matthew J., Roberts, Michael S., Tang, Min and Liang, Xiaowen (2018). The role of cellular reactive oxygen species in cancer chemotherapy. Journal of Experimental and Clinical Cancer Research, 37 (1) 266, 266. doi: 10.1186/s13046-018-0909-x
2018
Journal Article
Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells
Luo, Xiao, Yang, Haotian, Wang, Haolu, Ye, Zhiwei, Zhou, Zhongneng, Gu, Luyan, Chen, Jinquan, Xiao, Yi, Liang, Xiaowen, Qian, Xuhong and Yang, Youjun (2018). Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells. Analytical Chemistry, 90 (9), 5803-5809. doi: 10.1021/acs.analchem.8b00218
2018
Journal Article
Indocyanine green-incorporating nanoparticles for cancer theranostics
Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872
2017
Journal Article
The prognostic value of negative lymph node count for patients with cervical cancer after radical surgery
Lu, Hao, Guo, Rong, Yang, Haotian, Wang, Haolu, Liang, Xiaowen, Hu, Zhiqian and Li, Xinxing (2017). The prognostic value of negative lymph node count for patients with cervical cancer after radical surgery. Oncotarget, 9 (2), 2810-2818. doi: 10.18632/oncotarget.23596
Supervision
Availability
- Dr Haotian Yang is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Media
Enquiries
For media enquiries about Dr Haotian Yang's areas of expertise, story ideas and help finding experts, contact our Media team: