Overview
Background
Dr. Liu specialises in extracellular vesicles, osteosarcoma, breast cancer, tissue engineering, immunomodulation and biomaterial functionalisation.
Dr. Liu is a clinician (surgeon)-scientist with clinical and preclinical expertise in tissue repair and immunomodulation. Dr. Liu obtained Bachelor’s and Master’s degrees from Shanghai JiaoTong University (China); and a PhD degree from RWTH Aachen University (Germany).
Dr. Liu works with extracellular vesicles, including newly discovered matrix-bound nanovesicles. Dr. Liu’s current projects involve assessing the role of extracellular vesicle glycans on immunomodulation in metastatic breast cancer and metastatic pediatric cancers, such as osteosarcoma. Dr. Liu also has a background in biological scaffold functionalisation with the goal of developing innovative approaches that bring advanced benefits directly to clinical soft tissue repair.
Availability
- Dr Zhengni Liu is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, Shanghai Jiao Tong University
- Masters (Research), Shanghai Jiao Tong University
- Doctoral (Research), Rheinisch Westfalische Technische Hochschule Aachen
Research interests
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Biomaterials
Biomaterials for soft tissue repair
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Extracellular Vesicles
Applications of Extracellular Vesicles in Tissue Engineering and tumor treatment
Research impacts
Advancing immunomodulation in metastatic cancers with Extracellular Vesicles
Dr. Liu's groundbreaking research focuses on extracellular vesicles (EVs), including the newly discovered matrix-bound nanovesicles, which are emerging as pivotal players in cellular communication. Their current projects delve into the crucial role of extracellular vesicle glycans in immunomodulation, particularly in metastatic breast cancer and metastatic pediatric cancers like osteosarcoma. The implications of her research are substantial and multidimensional, reflecting a significant impact on both scientific understanding and clinical applications.
Dr. Liu’s work contributes to a deeper understanding of the biochemical mechanisms that underpin cancer metastasis and immune evasion. By exploring how glycans on extracellular vesicles influence immune responses, their research uncovers novel pathways through which cancer cells manipulate the immune system to spread and thrive in other body parts. This knowledge broadens the scientific community's understanding of cancer biology and highlights the intricate networks of cell communication mediated by EVs. Understanding the role of EV glycans in immunomodulation opens up new avenues for therapeutic intervention in Targeted Therapies and Biomarkers for Cancer.
Advancing Abdominal Hernia Repair with Innovative Biomaterials
As a researcher specialising in biomaterials for abdominal hernia repair, Dr. Liu’s work focuses on developing and refining materials that enhance the effectiveness and safety of surgical interventions for hernia patients. Hernias, which involve the protrusion of internal organs through the abdominal wall, are a prevalent issue impacting millions worldwide, necessitating durable and reliable treatments.Dr. Liu is now focusing on the newly developed EVs, namely matrix-bonded nanovesicles, and their potential application for tissue engineering, especially for abdominal wall repair, including Improved Surgical Outcomes and Enhanced Patient Recover.
Dr. Liu maintains active collaborations with hospital networks and surgical teams to ensure that the benefits of our research are directly conveyed to clinical practice. Dr. Liu’s team also engages with patient advocacy groups to educate hernia sufferers about the latest treatment options, empowering them with knowledge to make informed decisions about their healthcare.
Works
Search Professor Zhengni Liu’s works on UQ eSpace
2020
Journal Article
Electrospun scaffold with sustained antibacterial and tissue-matched mechanical properties for potential application as functional mesh
Liu, Zhengni, Zhu, Xiaoqiang and Tang, Rui (2020). Electrospun scaffold with sustained antibacterial and tissue-matched mechanical properties for potential application as functional mesh. International Journal of Nanomedicine, 15, 4991-5004. doi: 10.2147/ijn.s248970
2019
Journal Article
Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation
Liu, Zhen-ni, Jia, Wen-qian, Jiang, Tao, Dai, Jing-wen, Shuai, Chen and Lv, Xiong-wen (2019). Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation. International Immunopharmacology, 77 105915. doi: 10.1016/j.intimp.2019.105915
2019
Journal Article
Research progress on the anti-hepatic fibrosis action and mechanism of natural products
Shan, Liang, Liu, Zhenni, Ci, Leilei, Shuai, Chen, Lv, Xiongwen and Li, Jun (2019). Research progress on the anti-hepatic fibrosis action and mechanism of natural products. International Immunopharmacology, 75 105765. doi: 10.1016/j.intimp.2019.105765
2019
Journal Article
Tacrolimus exposure early after lung transplantation and exploratory associations with acute cellular rejection
Darley, D. R., Carlos, L., Hennig, S., Liu, Z., Day, R. and Glanville, A. R. (2019). Tacrolimus exposure early after lung transplantation and exploratory associations with acute cellular rejection. European Journal of Clinical Pharmacology, 75 (7), 879-888. doi: 10.1007/s00228-019-02658-5
2019
Journal Article
Triangle trocar configuration in laparoscopic totally extraperitoneal inguinal hernia repair: a prospective randomized controlled study
Zhu, Xiaoqiang, Liu, Zhengni, Shen, Jianfeng and Tang, Rui (2019). Triangle trocar configuration in laparoscopic totally extraperitoneal inguinal hernia repair: a prospective randomized controlled study. Journal of Surgical Research, 239, 149-155. doi: 10.1016/j.jss.2019.01.067
2019
Journal Article
Effects of dilution ratio on nutrient removal, sedimentation efficiency, and lipid production by <i>Scenedesmus obliquus</i> in diluted cattle wastewater
Xia, Ting, Liu, Zhenni, Pan, Xinxing, Huang, Enze, Chen, Dan and Xiao, Zhixing (2019). Effects of dilution ratio on nutrient removal, sedimentation efficiency, and lipid production by Scenedesmus obliquus in diluted cattle wastewater. Energy Sources Part A-Recovery Utilization and Environmental Effects, 42 (1), 121-130. doi: 10.1080/15567036.2019.1587060
2019
Journal Article
Purinergic P2X7 receptor blockade mitigates alcohol-induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity
Su, Qian-qian, Tian, Yang-yang, Liu, Zhen-ni, Ci, Lei-lei and Lv, Xiong-wen (2019). Purinergic P2X7 receptor blockade mitigates alcohol-induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity. International Immunopharmacology, 66, 52-61. doi: 10.1016/j.intimp.2018.11.012
2019
Conference Publication
A Study of FMCW Radar For The Detection of Water Level Inside a Wine Jar
Wang, Min, Yao, Jinjie, Han, Yan, Jiang, Rundong, Liu, Zhenni and Fan, Yahong (2019). A Study of FMCW Radar For The Detection of Water Level Inside a Wine Jar. Cross Strait Quad-Regional Radio Science and Wireless Technology Conference (CSQRWC), Taiyuan Peoples R China, Jul 18-21, 2019. NEW YORK: IEEE. doi: 10.1109/csqrwc.2019.8799309
2018
Journal Article
Promoting early neovascularization of SIS-repaired abdominal wall by controlled release of bioactive VEGF
Tang, Rui, Wang, Xin, Zhang, Hanying, Liang, Xi, Feng, Xueyi, Zhu, Xiaoqiang, Lu, Xinwu, Wu, Fei and Liu, Zhengni (2018). Promoting early neovascularization of SIS-repaired abdominal wall by controlled release of bioactive VEGF. RSC Advances, 8 (9), 4548-4560. doi: 10.1039/c7ra11954b
2016
Journal Article
Hepatectomy for patients with alveolar echinococcosis: Long-term follow-up observations of 144 cases
Du, Chengsong, Liu, Zhengni, Yang, Xianwei, Yan, Lunan, Li, Bo, Wen, Tianfu, Yang, Jiangyin, Xu, Mingqing, Chen, Zheyu and Wang, Wentao (2016). Hepatectomy for patients with alveolar echinococcosis: Long-term follow-up observations of 144 cases. International Journal of Surgery, 35, 147-152. doi: 10.1016/j.ijsu.2016.09.094
2016
Journal Article
Risk Factors Associated with Peer Victimization and Bystander Behaviors among Adolescent Students
Huang, Zepeng, Liu, Zhenni, Liu, Xiangxiang, Lv, Laiwen, Zhang, Yan, Ou, Limin and Li, Liping (2016). Risk Factors Associated with Peer Victimization and Bystander Behaviors among Adolescent Students. International Journal of Environmental Research and Public Health, 13 (8) 759. doi: 10.3390/ijerph13080759
2016
Journal Article
Hepatocellular carcinoma cases with high levels of c-Raf-1 expression may benefit from postoperative adjuvant sorafenib after hepatic resection even with high risk of recurrence
Lei, Jianyong, Zhong, Jinjing, Hao, Jingcheng, Liu, Zhengni, Zhang, Peng, Wu, Lixue, Yan, Lunan, Zhu, Jinqiang, Zeng, Yong, Li, Bo, Wen, Tianfu and Wang, Wentao (2016). Hepatocellular carcinoma cases with high levels of c-Raf-1 expression may benefit from postoperative adjuvant sorafenib after hepatic resection even with high risk of recurrence. OncoTarget, 7 (27), 42598-42607. doi: 10.18632/oncotarget.3799
2015
Journal Article
De Novo Malignancies After Liver Transplantation With 14 Cases at a Single Center
Liu, Z. -N., Wang, W. -T. and Yan, L. -N. (2015). De Novo Malignancies After Liver Transplantation With 14 Cases at a Single Center. Transplantation Proceedings, 47 (8), 2483-2487. doi: 10.1016/j.transproceed.2015.08.008
2015
Journal Article
A Facile Top-Down Protocol for Postsynthesis Modification of Hierarchical Aluminum-Rich MFI Zeolites
Yu, Lili, Huang, Shengjun, Miao, Shu, Chen, Fucun, Zhang, Shuang, Liu, Zhenni, Xie, Sujuan and Xu, Longya (2015). A Facile Top-Down Protocol for Postsynthesis Modification of Hierarchical Aluminum-Rich MFI Zeolites. Chemistry-A European Journal, 21 (3), 1048-1054. doi: 10.1002/chem.201404817
2014
Journal Article
Differences between Zn/HZSM-5 and Zn/HZSM-11 zeolite catalysts in alkylation of benzene with dimethyl ether
Liu, Hui, Wei, Huijuan, Xin, Wenjie, Song, Chao, Xie, Sujuan, Liu, Zhenni, Liu, Shenglin and Xu, Longya (2014). Differences between Zn/HZSM-5 and Zn/HZSM-11 zeolite catalysts in alkylation of benzene with dimethyl ether. Journal of Energy Chemistry, 23 (5), 617-624. doi: 10.1016/S2095-4956(14)60192-3
2014
Journal Article
Host tissue integration process in abdominal wall defect repair: a comparison of two porcine-derived grafts in a long-term study
Liu, Zhengni, Yang, Zhi, Zhou, Zhiyuan, Song, Zhicheng, Wang, Huichun, Yang, JianJun, Tang, Rui, Tan, Qiang and Gu, Yan (2014). Host tissue integration process in abdominal wall defect repair: a comparison of two porcine-derived grafts in a long-term study. Expert Opinion on Biological Therapy, 14 (7), 883-892. doi: 10.1517/14712598.2014.907783
2014
Journal Article
Preparation of hierarchical mordenite zeolites by sequential steaming-acid leaching-alkaline treatment
Huang, Shengjun, Liu, Xiaohan, Yu, Lili, Miao, Shu, Liu, Zhenni, Zhang, Shuang, Xie, Sujuan and Xu, Longya (2014). Preparation of hierarchical mordenite zeolites by sequential steaming-acid leaching-alkaline treatment. Microporous and Mesoporous Materials, 191, 18-26. doi: 10.1016/j.micromeso.2014.02.039
2014
Journal Article
Influences of Si/Al Ratios on the Mesopore Distributions of Hierarchical MFI Zeolites Synthesized by Organosilane Surfactant
Yu, Lili, Huang, Shengjun, Miao, Shu, Zhu, Gangue, Zhang, Shuang, Liu, Zhenni, Xin, Wenjie, Xie, Sujuan and Xu, Longya (2014). Influences of Si/Al Ratios on the Mesopore Distributions of Hierarchical MFI Zeolites Synthesized by Organosilane Surfactant. Industrial & Engineering Chemistry Research, 53 (2), 693-700. doi: 10.1021/ie4032633
2014
Journal Article
Carbon nanotubes as VEGF carriers to improve the early vascularization of porcine small intestinal submucosa in abdominal wall defect repair
Liu, Zhengni, Feng, Xueyi, Wang, Huichun, Ma, Jun, Liu, Wei, Cui, Daxiang, Gu, Yan and Tang, Rui (2014). Carbon nanotubes as VEGF carriers to improve the early vascularization of porcine small intestinal submucosa in abdominal wall defect repair. International Journal of Nanomedicine, 9, 1275-1286. doi: 10.2147/ijn.s58626
2013
Journal Article
Transalkylation of Phenol with Cumene on Zeolite Catalysts
Huang, Shengjun, Zhang, Shuang, Yu, Lili, Liu, Zhenni, Xin, Wenjie, Xie, Sujuan and Xu, Longya (2013). Transalkylation of Phenol with Cumene on Zeolite Catalysts. Industrial & Engineering Chemistry Research, 52 (32), 10996-11000. doi: 10.1021/ie401527f
Funding
Current funding
Supervision
Availability
- Dr Zhengni Liu is:
- Available for supervision
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Available projects
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Treating breast cancer metastasis by targeting immunosuppressive extracellular vesicles
This proposal aims to develop effective treatments for the deadliest subtype of breast cancer: triple-negative breast cancer (TNBC). To accomplish this, we will focus on targeting immunosuppressive extracellular vesicles (EVs) that promote TNBC cell survival and metastatic spread. Our approach involves identifying and implementing strategies to reactivate the immune system in patients with TNBC metastases. By enhancing the body’s ability to recognize and eliminate TNBC cells, the goal is to reduce the need for conventional therapeutics with harmful side effects.
Supervision history
Current supervision
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Doctor Philosophy
Extracellular vesicle-based senotherapeutics for aging diabetic kidney disease
Associate Advisor
Other advisors: Associate Professor Joy Wolfram
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Doctor Philosophy
Maximising the success of cancer immunotherapy by preventing extracellular vesicle hijacking of the immune system
Associate Advisor
Other advisors: Dr Allie Lam, Associate Professor Joy Wolfram
Media
Enquiries
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