Endosomal Protein Transport: From Molecular Structures to Biological Function (2009-2011)
Abstract
Protein trafficking within the endosomal system is essential for controlling the interaction of a cell with its environment and for regulating numerous cell signalling events. Building on our studies of other membrane coat complexes this project will use a combination of X-ray crystallographic structure determination, biochemistry and cell biology to study how Retromer and related proteins interact with endosomal organelles, with trafficking biomolecules and with regulatory proteins to control endosomal trafficking. This multidisciplinary approach will provide a detailed understanding of how these protein coats are assembled, and how their structures lead to such exquisite selectivity during the dynamic process of intracellular transport.
