Towards Next Generation Anthelmintics (2009-2012)
Abstract
The agricultural industry is in urgent need of new treatments for parasite infections in commercial livestock (sheep, cattle, goats). The current antiparasitic agrochemical market, a multi billion dollar industry, is supported by only three classes of drug, all of which are >25 years old and are increasingly ineffective due to the widespread resistance. This project advances prior knowledge of new natural product nematocidal agents discovered from Australian marine biodiversity, by applying synthetic chemistry and specialist bioassays, to design and develop next generation anthelmintics effective against all known drug resistance nematodes.
