Defining the molecular mechanisms of intracellular protein trafficking (2011-2014)
Abstract
Intracellular transport of biomolecules is critical for normal cellular processes such as signaling, neurosecretion and development. Defects in these fundamental processes or subversion by pathogens also lead to many debilitating human diseases. This project will build on Australia's strong program of structural and cellular biology research to develop fundamental insights into how protein machineries control dynamic intracellular trafficking with such exquisite selectivity, with important implications for future design of pharmaceuticals aimed at inhibiting or enhancing these systems.
