The Molecular Mechanism Of Retromer And Sorting Nexin Function In Endosomal Membrane Trafficking (2006-2008)
Abstract
Protein trafficking to and from endosomes is essential for controlling the interaction of a cell with its environment and regulating numerous signalling events. This project will provide a molecular understanding of how the multi-subunit retromer protein complex directs the process of protein sorting at endosomes. Building on studies of other membrane coat complexes this project will use a combination of X-ray crystallographic 3D-structure determination, biochemistry and cell biology to study how retromer is assembled and how it transports transmembrane receptors in the endosomal system.
