DNA exhibits new self-assembled structures due to clustered DNA methylation (2018-2021)
Abstract
Epigenetics controls whether genes and genetic programs are turned on or off in living systems. Our investigators have recently discovered that key physical properties of native DNA polymers are strongly influenced by epigenetic patterns created by living organisms. This project aims to build on this discovery to develop a highly innovative and simple technology to investigate detailed epigenetic patterns in DNA by directly interrogating the physical properties of DNA polymers in their native state. By performing research to fully understand this phenomenon, this project aims to provide entirely new tools for the study of epigenetics with broad potential applications in the life sciences, biotechnology and nanotechnology.
