Potency and activity of Meso-Endothelial bipotent progenitors in vivo (2019-2022)

Blood vessels comprise an inner endothelial layer and surrounding mesenchyme. These vessels are integral to many organs and constitute a unique system connecting different parts of the body. Despite their importance little is known about how they are maintained and how they contribute to the response to injury. Previous work from the team has described several populations of stem cell capable of self renewal and repletion of the endothelium or the mesenchyme. This project will examine the potency of these different progenitors to give rise to each of these fates in homeostasis but also during sounding and bone formation. This will help define a unique population of stem cells capable of both vascular and mesenchymal repair.