The inhibition of muscle disuse atrophy in burrowing frogs (2006-2011)
Abstract
The aim of this project is to investigate the underlying regulatory mechanisms which inhibit muscle wasting in the green striped burrowing frog, Cyclorana alboguttata. We will take a novel integrative approach, examining physiological, biochemical and molecular processes associated with the inhibition of muscle atrophy in aestivating C. alboguttata, focusing on the role of metabolic depression, antioxidants and endogenous opioids. The significance of this study stems from utilising a unique animal model to examine the regulatory mechanisms that are associated with a natural inhibition of muscle atrophy.
