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2008 Journal Article West Nile Virus NS2B/NS3 protease as an antiviral targetChappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2008). West Nile Virus NS2B/NS3 protease as an antiviral target. Current Medicinal Chemistry, 15 (27), 2771-2784. doi: 10.2174/092986708786242804 |
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2008 Journal Article Potent cationic inhibitors of West Nile Virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activityStoermer, Martin J., Chappell, Keith J., Liebscher, Susann, Jensen, Christina M., Gan, Chun H., Gupta, Praveer K., Xu, Wei-Jun, Young, Paul R. and Fairlie, David P. (2008). Potent cationic inhibitors of West Nile Virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity. Journal of Medicinal Chemistry, 51 (18), 5714-5721. doi: 10.1021/jm800503y |
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2008 Journal Article Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activityChappell, Keith J., Stoermer, Martin J., Fairlie, David P. and Young, Paul R. (2008). Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity. Journal of General Virology, 89 (4), 1010-1014. doi: 10.1099/vir.0.83447-0 |
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2008 Journal Article A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteasesMarcon, L., Kozak, D., Battersby, B.J., Chappell, K., Fairlie, D., Young, P.R. and Trau, M. (2008). A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteases. Analytical Biochemistry, 2008 (376), 151-153. doi: 10.1016/j.ab.2008.01.034 |
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2007 Journal Article Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2007). Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3. Protein Expression and Purification, 53 (1), 87-96. doi: 10.1016/j.pep.2006.10.022 |
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2006 Journal Article Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studiesChappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2006). Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies. Journal of Biological Chemistry, 281 (50), 38448-38458. doi: 10.1074/jbc.M607641200 |
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2005 Journal Article Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactionsChappell, Keith J., Nall, Tessa A., Stoermer, Martin J., Fang, Ning-Xia, Tyndall, Joel D. A., Fairlie, David P. and Young, Paul R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280 (4), 2896-2903. doi: 10.1074/jbc.M409931200 |
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2004 Journal Article Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 proteaseNall, T. A., Chappell, K. J., Stoermer, M. J., Fang, N. X., Tyndall, J. D. A., Young, P. R. and Fairlie, D. P. (2004). Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease. Journal of Biological Chemistry, 279 (47), 48535-48542. doi: 10.1074/jbc.M406810200 |
