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2021 Journal Article Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug deliveryRaza, Aun, Alavi, Seyed Ebrahim, Sime, Fekade Bruck, Han, Felicity Y., Roberts, Jason A., Popat, Amirali, Falconer, James R. and Kumeria, Tushar (2021). Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery. Acta Biomaterialia, 126, 277-290. doi: 10.1016/j.actbio.2021.03.042 |
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2021 Journal Article Semi-mechanistic PK/PD modelling of meropenem and sulbactam combination against carbapenem-resistant strains of Acinetobacter baumanniiMohd Sazlly Lim, Sazlyna, Heffernan, Aaron J., Zowawi, Hosam M., Roberts, Jason A. and Sime, Fekade B. (2021). Semi-mechanistic PK/PD modelling of meropenem and sulbactam combination against carbapenem-resistant strains of Acinetobacter baumannii. European Journal of Clinical Microbiology and Infectious Diseases, 40 (9), 1943-1952. doi: 10.1007/s10096-021-04252-z |
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2021 Journal Article Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumanniiMohd Sazlly Lim, S., Heffernan, A.J., Roberts, J.A. and Sime, F.B. (2021). Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 65 (5) e02472-20. doi: 10.1128/aac.02472-20 |
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2021 Journal Article Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosaHeffernan, Aaron J., Sime, Fekade B., Lim, Sazlyna Mohd Sazlly, Naicker, Saiyuri, Andrews, Katherine T., Ellwood, David, Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason A. (2021). Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosa. Drugs in R&D, 21 (2), 203-215. doi: 10.1007/s40268-021-00344-5 |
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2021 Journal Article PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral deliveryRaza, Aun, Miles, Jared A., Bruck Sime, Fekade, Ross, Benjamin P., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2021). PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery. International Journal of Pharmaceutics, 597 120280, 120280. doi: 10.1016/j.ijpharm.2021.120280 |
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2021 Journal Article Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosaHeffernan, Aaron James, Sime, Fekade Bruck, Naicker, Saiyuri, Andrews, Katherine, Ellwood, David, Guerra-Valero, Yarmarly, Wallis, Steven, Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason Alexander (2021). Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa. Diagnostic microbiology and infectious disease, 100 (2) 115329, 115329. doi: 10.1016/j.diagmicrobio.2021.115329 |
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2021 Journal Article Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearanceSime, Fekade Bruck, Roberts, Jason A., Jeffree, Rosalind L., Pandey, Saurabh, Adiraju, Santosh, Livermore, Amelia, Butler, Jenie, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Cotta, Menino Osbert (2021). Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearance. Clinical Pharmacokinetics, 60 (5), 655-664. doi: 10.1007/s40262-020-00979-8 |
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2021 Journal Article Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenemRaza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Falconer, James R., Kumeria, Tushar and Popat, Amirali (2021). Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem. ACS Biomaterials Science and Engineering, 7 (5) acsbiomaterials.0c01284, 1836-1853. doi: 10.1021/acsbiomaterials.0c01284 |
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2021 Book Chapter PK/PD and the drug delivery regimen for infusion in the critical care settingSime, Fekade B. and Roberts, Jason A. (2021). PK/PD and the drug delivery regimen for infusion in the critical care setting. Drug delivery approaches: perspectives from pharmacokinetics and pharmacodynamics. (pp. 355-374) edited by Bret Berner, Toufigh Gordi, Heather A. E. Benson and Michael S.Roberts. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9781119772767.ch10 |
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2020 Journal Article Cerebrospinal fluid penetration of ceftolozane/tazobactam in critically ill patients with an indwelling external ventricular drainSime, Fekade B, Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2020). Cerebrospinal fluid penetration of ceftolozane/tazobactam in critically ill patients with an indwelling external ventricular drain. Antimicrobial Agents and Chemotherapy, 65 (1) e01698-20, 1-11. doi: 10.1128/aac.01698-20 |
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2020 Journal Article A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane–tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studiesParker, Suzanne L., Pandey, Saurabh, Sime, Fekade B., Stuart, Janine, Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2020). A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane–tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies. Clinical Chemistry and Laboratory Medicine (CCLM), 59 (5), 921-933. doi: 10.1515/cclm-2020-1196 |
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2020 Journal Article Oral meropenem for superbugs: challenges and opportunitiesRaza, Aun, Ngieng, Shih Chen, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2020). Oral meropenem for superbugs: challenges and opportunities. Drug Discovery Today, 26 (2), 551-560. doi: 10.1016/j.drudis.2020.11.004 |
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2020 Journal Article Ceftriaxone dosing in patients admitted from the emergency department with sepsisHeffernan, Aaron J., Curran, Rebecca A., Denny, Kerina J., Sime, Fekade B., Stanford, Claire L., McWhinney, Brett, Ungerer, Jacobus, Roberts, Jason A. and Lipman, Jeffrey (2020). Ceftriaxone dosing in patients admitted from the emergency department with sepsis. European Journal of Clinical Pharmacology, 77 (2), 207-214. doi: 10.1007/s00228-020-03001-z |
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2020 Journal Article Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant in Patients with Normal Renal Clearance: Can It Be a Treatment Option?Mohd Sazlly Lim, Sazlyna, Heffernan, Aaron J., Roberts, Jason A. and Sime, Fekade B. (2020). Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant in Patients with Normal Renal Clearance: Can It Be a Treatment Option?. Microbial drug resistance (Larchmont, N.Y.), 27 (4) mdr.2020.0197, 546-552. doi: 10.1089/mdr.2020.0197 |
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2020 Journal Article Challenges in antifungal therapy in diabetes mellitusMohd Sazlly Lim, Sazlyna, Sinnollareddy, Mahipal and Sime, Fekade Bruck (2020). Challenges in antifungal therapy in diabetes mellitus. Journal of Clinical Medicine, 9 (9) 2878, 2878-9. doi: 10.3390/jcm9092878 |
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2020 Journal Article Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniaeSumi, Chandra Datta, Heffernan, Aaron J., Naicker, Saiyuri, Islam, Kamrul, Cottrell, Kyra, Wallis, Steven C., Lipman, Jeffrey, Harris, Patrick N. A., Sime, Fekade B. and Roberts, Jason A. (2020). Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy, 75 (9), 2633-2640. doi: 10.1093/jac/dkaa211 |
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2020 Journal Article What are the predictors for achieving therapeutic levetiracetam serum concentrations in adult neurological patients?Cotta, Menino Osbert, Abdul-Aziz, Mohd Hafiz, Frey, Otto R., Sime, Fekade Bruck, Roberts, Jason A. and Roehr, Anka C. (2020). What are the predictors for achieving therapeutic levetiracetam serum concentrations in adult neurological patients?. Therapeutic Drug Monitoring, 42 (4), 626-630. doi: 10.1097/ftd.0000000000000731 |
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2020 Journal Article Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection modelHeffernan, Aaron J., Sime, Fekade B., Sarovich, Derek S., Neely, Michael, Guerra-Valero, Yarmarly, Naicker, Saiyuri, Cottrell, Kyra, Harris, Patrick, Andrews, Katherine T., Ellwood, David, Wallis, Steven C., Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason A. (2020). Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model. Antimicrobial Agents and Chemotherapy, 64 (9) e00879-20. doi: 10.1128/aac.00879-20 |
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2020 Journal Article Non-polymyxin based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infectionsMohd Sazlly Lim, S., Naicker, S., Ayfan, A. K., Zowawi, H., Roberts, J. A. and Sime, F. B. (2020). Non-polymyxin based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections. International Journal of Antimicrobial Agents, 56 (4) 106115, 106115. doi: 10.1016/j.ijantimicag.2020.106115 |
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2020 Journal Article Development of Population and Bayesian Models for Applied Use in Patients Receiving CefepimeLiu, Jiajun, Neely, Michael, Lipman, Jeffrey, Sime, Fekade, Roberts, Jason A., Kiel, Patrick J., Avedissian, Sean N., Rhodes, Nathaniel J. and Scheetz, Marc H. (2020). Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime. Clinical Pharmacokinetics, 59 (8), 1027-1036. doi: 10.1007/s40262-020-00873-3 |
