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2018

Book Chapter

Appropriate antimicrobial therapy in critically ill patients

Sime, Fekade B. and Roberts, Jason A. (2018). Appropriate antimicrobial therapy in critically ill patients. Abdominal Sepsis: a multidisciplinary approach. (pp. 319-342) edited by Massimo Sartelli, Matteo Bassetti and Ignacio Martin-Loeches. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-59704-1_21

Appropriate antimicrobial therapy in critically ill patients

2018

Book Chapter

Antibiotic pharmacodynamics

Sime, Fekade B. and Roberts, Jason A. (2018). Antibiotic pharmacodynamics. Antibiotic pharmacokinetic/pharmacodynamic considerations in the critically ill. (pp. 17-29) edited by Andrew Udy, Jason A. Roberts and Jeffrey Lipman. Singapore, Singapore: Springer Nature. doi: 10.1007/978-981-10-5336-8_2

Antibiotic pharmacodynamics

2017

Journal Article

Using population pharmacokinetic modeling and Monte Carlo simulations to determine whether standard doses of piperacillin in piperacillin-tazobactam regimens are adequate for the management of febrile neutropenia

Sime, Fekade Bruck, Hahn, Uwe, Warner, Morgyn S., Tiong, Ing Soo, Roberts, Michael S., Lipman, Jeffrey, Peake, Sandra L. and Roberts, Jason A. (2017). Using population pharmacokinetic modeling and Monte Carlo simulations to determine whether standard doses of piperacillin in piperacillin-tazobactam regimens are adequate for the management of febrile neutropenia. Antimicrobial Agents and Chemotherapy, 61 (11) e00311-17, e00311-17. doi: 10.1128/AAC.00311-17

Using population pharmacokinetic modeling and Monte Carlo simulations to determine whether standard doses of piperacillin in piperacillin-tazobactam regimens are adequate for the management of febrile neutropenia

2017

Journal Article

Dosing antibiotic prophylaxis during cardiopulmonary bypass—a higher level of complexity? A structured review

Paruk, Fathima, Sime, Fekade B., Lipman, Jeffrey and Roberts, Jason A. (2017). Dosing antibiotic prophylaxis during cardiopulmonary bypass—a higher level of complexity? A structured review. International Journal of Antimicrobial Agents, 49 (4), 395-402. doi: 10.1016/j.ijantimicag.2016.12.014

Dosing antibiotic prophylaxis during cardiopulmonary bypass—a higher level of complexity? A structured review

2017

Journal Article

Pharmacodynamics of aerosolized fosfomycin and amikacin against resistant clinical isolates of Pseudomonas aeruginosa and Klebsiella pneumoniae in a hollow-fiber infection model: experimental basis for combination therapy

Sime, Fekade Bruck, Johnson, Adam, Whalley, Sarah, Santoyo-Castelazo, Anahi, Montgomery, A. Bruce, Walters, Kathie Ann, Lipman, Jeffrey, Hope, William W. and Roberts, Jason A. (2017). Pharmacodynamics of aerosolized fosfomycin and amikacin against resistant clinical isolates of Pseudomonas aeruginosa and Klebsiella pneumoniae in a hollow-fiber infection model: experimental basis for combination therapy. Antimicrobial Agents and Chemotherapy, 61 (1) e01763-16, e01763-16. doi: 10.1128/AAC.01763-16

Pharmacodynamics of aerosolized fosfomycin and amikacin against resistant clinical isolates of Pseudomonas aeruginosa and Klebsiella pneumoniae in a hollow-fiber infection model: experimental basis for combination therapy

2016

Journal Article

Antibiotic dosing in critically ill patients receiving renal replacement therapy

Sime, Fekade Bruck and Roberts, Jason A. (2016). Antibiotic dosing in critically ill patients receiving renal replacement therapy. Expert Review of Clinical Pharmacology, 9 (4), 497-499. doi: 10.1586/17512433.2016.1133290

Antibiotic dosing in critically ill patients receiving renal replacement therapy

2015

Journal Article

Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization

Sime, Fekade B., Udy, Andrew A. and Roberts, Jason A. (2015). Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization. Current Opinion in Pharmacology, 24, 1-6. doi: 10.1016/j.coph.2015.06.002

Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization

2015

Journal Article

Optimization of dosing regimens and dosing in special populations

Sime, F. B., Roberts, M. S. and Roberts, J. A. (2015). Optimization of dosing regimens and dosing in special populations. Clinical Microbiology and Infection, 21 (10), 886-893. doi: 10.1016/j.cmi.2015.05.002

Optimization of dosing regimens and dosing in special populations

2015

Journal Article

Optimizing dosing of antibiotics in critically ill patients

Parker, Suzanne L., Sime, Fekade B. and Roberts, Jason A. (2015). Optimizing dosing of antibiotics in critically ill patients. Current Opinion in Infectious Diseases, 28 (6), 497-504. doi: 10.1097/QCO.0000000000000206

Optimizing dosing of antibiotics in critically ill patients

2015

Journal Article

Adequacy of high-dose cefepime regimen in febrile neutropenic patients with hematological malignancies

Sime, Fekade Bruck., Roberts, Michael S., Tiong, Ing Soo., Gardner, Julia H., Lehman, Sheila., Peake, Sandra L., Hahn, Uwe., Warner, Morgyn S. and Roberts, Jason A. (2015). Adequacy of high-dose cefepime regimen in febrile neutropenic patients with hematological malignancies. Antimicrobial Agents and Chemotherapy, 59 (9), 5463-5469. doi: 10.1128/AAC.00389-15

Adequacy of high-dose cefepime regimen in febrile neutropenic patients with hematological malignancies

2015

Journal Article

Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial

Sime, Fekade B., Roberts, Michael S., Tiong, Ing S., Gardner, Julia H., Lehman, Sheila, Peake, Sandra L., Hahn, Uwe, Warner, Morgyn S. and Roberts, Jason A. (2015). Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial. Journal of Antimicrobial Chemotherapy, 70 (8) dkv123, 2369-2375. doi: 10.1093/jac/dkv123

Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial

2015

Conference Publication

Can therapeutic drug monitoring optimise exposure of piperacillin in febrile neutropenic patients with haematological malignancies? A randomised controlled trial

Sime, F. B., Roberts, M., Tiong, I. S., Gardner, J., Lehman, S., Peake, S., Hahn, U., Warner, M. and Roberts, J. (2015). Can therapeutic drug monitoring optimise exposure of piperacillin in febrile neutropenic patients with haematological malignancies? A randomised controlled trial. 20th Congress of European Hematology Association, Vienna, Austria, 11-14 June 2015. Pavia, Italy: Fondazione Ferrata Storti.

Can therapeutic drug monitoring optimise exposure of piperacillin in febrile neutropenic patients with haematological malignancies? A randomised controlled trial

2014

Journal Article

How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?

Wong, Gloria, Sime, Fekade Bruck, Lipman, Jeffrey and Roberts, Jason A. (2014). How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?. BMC Infectious Diseases, 14 (288) 288, 1-11. doi: 10.1186/1471-2334-14-288

How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?

2014

Journal Article

Simultaneous determination of seven β-lactam antibiotics in human plasma for therapeutic drug monitoring and pharmacokinetic studies

Sime, Fekade Bruck, Roberts, Michael S., Roberts, Jason A. and Robertson, Thomas A. (2014). Simultaneous determination of seven β-lactam antibiotics in human plasma for therapeutic drug monitoring and pharmacokinetic studies. Journal of Chromatography B, 960, 134-144. doi: 10.1016/j.jchromb.2014.04.029

Simultaneous determination of seven β-lactam antibiotics in human plasma for therapeutic drug monitoring and pharmacokinetic studies

2014

Journal Article

An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units

Wong, Gloria, Brinkman, Alexander, Benefield, Russell J., Carlier, Mieke, De Waele, Jan J., Helali, Najoua, Frey, Otto, Harbarth, Stephan, Huttner, Angela, McWhinney, Brett, Misset, Benoit, Pea, Federico, Preisenberger, Judit, Roberts, Michael S., Robertson, Thomas A., Roehr, Anka, Sime, Fekade Bruck, Taccone, Fabio Silvio, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2014). An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units. Journal of Antimicrobial Chemotherapy, 69 (5) dkt523, 1416-1423. doi: 10.1093/jac/dkt523

An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units

2014

Journal Article

Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy

Sime, Fekade Bruck, Roberts, Michael S., Warner, Morgyn S., Hahn, Uwe, Robertson, Thomas A., Yeend, Sue, Phay, Andy, Lehman, Sheila, Lipman, Jeffrey, Peake, Sandra L. and Roberts, Jason A. (2014). Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy. Antimicrobial Agents and Chemotherapy, 58 (6), 3533-3537. doi: 10.1128/AAC.02340-14

Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy

2012

Journal Article

Does beta-lactam pharmacokinetic variability in critically ill patients justify therapeutic drug monitoring? A systematic review

Sime, Fekade Bruck, Roberts, Michael S., Peake, Sandra L., Lipman, Jeffrey and Roberts, Jason A. (2012). Does beta-lactam pharmacokinetic variability in critically ill patients justify therapeutic drug monitoring? A systematic review. Annals of Intensive Care, 2 (1) 35, 35.1-35.11. doi: 10.1186/2110-5820-2-35

Does beta-lactam pharmacokinetic variability in critically ill patients justify therapeutic drug monitoring? A systematic review