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2017 Journal Article An expanded genome-wide association study of type 2 diabetes in EuropeansScott, Robert A., Scott, Laura J., Mägi, Reedik, Marullo, Letizia, Gaulton, Kyle J., Kaakinen, Marika, Pervjakova, Natalia, Pers, Tune H., Johnson, Andrew D., Eicher, John D., Jackson, Anne U., Ferreira, Teresa, Lee, Yeji, Ma, Clement, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Van Zuydam, Natalie R., Mahajan, Anubha, Chen, Han, Almgren, Peter, Voight, Ben F., Grallert, Harald, Müller-Nurasyid, Martina, Ried, Janina S., Rayner, Nigel W., Robertson, Neil, Karssen, Lennart C., van Leeuwen, Elisabeth M. ... Prokopenko, Inga (2017). An expanded genome-wide association study of type 2 diabetes in Europeans. Diabetes, 66 (11), 2888-2902. doi: 10.2337/db16-1253 |
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2017 Journal Article Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: a transethnic genome-wide meta-analysisWheeler, Eleanor, Leong, Aaron, Liu, Ching-Ti, Hivert, Marie-France, Strawbridge, Rona J., Podmore, Clara, Li, Man, Yao, Jie, Sim, Xueling, Hong, Jaeyoung, Chu, Audrey Y., Zhang, Weihua, Wang, Xu, Chen, Peng, Maruthur, Nisa M., Porneala, Bianca C., Sharp, Stephen J., Jia, Yucheng, Kabagambe, Edmond K., Chang, Li-Ching, Chen, Wei-Min, Elks, Cathy E., Evans, Daniel S., Fan, Qiao, Giulianini, Franco, Go, Min Jin, Hottenga, Jouke-Jan, Hu, Yao, Jackson, Anne U. ... Meigs, James B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: a transethnic genome-wide meta-analysis. PLoS Medicine, 14 (9) e1002383, e1002383. doi: 10.1371/journal.pmed.1002383 |
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2017 Journal Article Detection and quantification of inbreeding depression for complex traits from SNP dataYengo, Loic, Zhu, Zhihong, Wray, Naomi R., Weir, Bruce S., Yang, Jian, Robinson, Matthew R. and Visscher, Peter M. (2017). Detection and quantification of inbreeding depression for complex traits from SNP data. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 114 (32), 8602-8607. doi: 10.1073/pnas.1621096114 |
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2017 Journal Article Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profilesVerbanck, Marie, Canouil, Mickael, Leloire, Audrey, Dhennin, Veronique, Coumoul, Xavier, Yengo, Loïc, Froguel, Philippe and Poulain-Godefroy, Odile (2017). Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles. PLoS One, 12 (6) e0179583, e0179583. doi: 10.1371/journal.pone.0179583 |
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2017 Journal Article Early metabolic markers identify potential targets for the prevention of type 2 diabetesPeddinti, Gopal, Cobb, Jeff, Yengo, Loic, Froguel, Philippe, Kravic, Jasmina, Balkau, Beverley, Tuomi, Tiinamaija, Aittokallio, Tero and Groop, Leif (2017). Early metabolic markers identify potential targets for the prevention of type 2 diabetes. Diabetologia, 60 (9), 1740-1750. doi: 10.1007/s00125-017-4325-0 |
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2017 Journal Article Genome-wide physical activity interactions in adiposity ― a meta-analysis of 200,452 adultsGraff, Mariaelisa, Scott, Robert A., Justice, Anne E., Young, Kristin L., Feitosa, Mary F., Barata, Llilda, Winkler, Thomas W., Chu, Audrey Y., Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, Qibin, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, Eicher, John D., Hayes, James E., Cornelis, Marilyn, Kutalik, Zoltan, Lim, Elise, Luan, Jian’an, Huffman, Jennifer E., Zhang, Weihua, Zhao, Wei, Griffin, Paula J. ... Kilpeläinen, Tuomas O. (2017). Genome-wide physical activity interactions in adiposity ― a meta-analysis of 200,452 adults. PLoS Genetics, 13 (4) e1006528, e1006528. doi: 10.1371/journal.pgen.1006528 |
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2017 Journal Article Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traitsJustice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin, Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y., Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zolta'n, Xue, Luting, Mahajan, Anubha, Renström, Frida, Wu, Joseph, Qi, Qibin, Ahmad, Shafqat, Alfred, Tamuno, Amin, Najaf, Bielak, Lawrence F., Bonnefond, Amelie, Bragg, Jennifer ... Cupples, L. Adrienne (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 8 (1) 14977, 14977. doi: 10.1038/ncomms14977 |
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2017 Journal Article Relationship between salivary/pancreatic amylase and body mass index: a systems biology approachBonnefond, Amélie, Yengo, Loïc, Dechaume, Aurélie, Canouil, Mickaël, Castelain, Maxime, Roger, Estelle, Allegaert, Frédéric, Caiazzo, Robert, Raverdy, Violeta, Pigeyre, Marie, Arredouani, Abdelilah, Borys, Jean-Michel, Levy-Marchal, Claire, Weill, Jacques, Roussel, Ronan, Balkau, Beverley, Marre, Michel, Pattou, François, Brousseau, Thierry and Froguel, Philippe (2017). Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach. BMC Medicine, 15 (1) 37, 37. doi: 10.1186/s12916-017-0784-x |
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2016 Journal Article KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preferenceSchumann, Gunter, Liu, Chunyu, O'Reilly, Paul, Gao, He, Song, Parkyong, Xu, Bing, Ruggeri, Barbara, Amin, Najaf, Jia, Tianye, Preis, Sarah, Lepe, Marcelo Segura, Akira, Shizuo, Barbieri, Caterina, Baumeister, Sebastian, Cauchi, Stephane, Clarke, Toni-Kim, Enroth, Stefan, Fischer, Krista, Hallfors, Jenni, Harris, Sarah E., Hieber, Saskia, Hofer, Edith, Hottenga, Jouke-Jan, Johansson, Asa, Joshi, PeterK., Kaartinen, Niina, Laitinen, Jaana, Lemaitre, Rozenn, Loukola, Anu ... Elliott, Paul (2016). KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Proceedings of the National Academy of Sciences, 113 (50), 14372-14377. doi: 10.1073/pnas.1611243113 |
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2016 Journal Article Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youthsMorandi, Anita, Bonnefond, Amelie, Lobbens, Stephane, Yengo, Loic, del Giudice, Emanuele Miraglia, Grandone, Anna, Levy-Marchal, Claire, Weill, Jacques, Maffeis, Claudio and Froguel, Philippe (2016). Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youths. Journal of Clinical Endocrinology and Metabolism, 101 (11), 4244-4250. doi: 10.1210/jc.2016-2432 |
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2016 Journal Article Genome-wide analysis identifies 12 loci influencing human reproductive behaviorBarban, Nicola, Jansen, Rick, de Vlaming, Ronald, Vaez, Ahmad, Mandemakers, Jornt J., Tropf, Felix C., Shen, Xia, Wilson, James F., Chasman, Daniel I., Nolte, Illa M., Tragante, Vinicius, van der Laan, Sander W., Perry, John R. B., Kong, Augustine, Ahluwalia, Tarunveer S., Albrecht, Eva, Yerges-Armstrong, Laura, Atzmon, Gil, Auro, Kirsi, Ayers, Kristin, Bakshi, Andrew, Ben-Avraham, Danny, Berger, Klaus, Bergman, Aviv, Bertram, Lars, Bielak, Lawrence F., Bjornsdottir, Gyda, Bonder, Marc Jan, Broer, Linda ... Mills, Melinda C. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48 (12), 1462-1472. doi: 10.1038/ng.3698 |
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2016 Journal Article Detection of human adaptation during the past 2000 yearsField, Yair, Boyle, Evan A., Telis, Natalie, Gao, Ziyue, Gaulton, Kyle J., Golan, David, Yengo, Loic, Rocheleau, Ghislain, Froguel, Philippe, McCarthy, Mark I. and Pritchard, Jonathan K. (2016). Detection of human adaptation during the past 2000 years. Science, 354 (6313), 1-10. doi: 10.1126/science.aag0776 |
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2016 Journal Article The genetics of blood pressure regulation and its target organs from association studies in 342,415 individualsEhret, G.B., Ferreira, T., Chasman, D.I., Jackson, A.U., Schmidt, E.M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L.A., Kanoni, S., Petersen, A.-K., Pihur, V., Strawbridge, R.J., Shungin, D., Hughes, M.F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S., Kleber, M.E., Guo, X., Lyytikainen, L.-P., Fava, C., Eriksson, N., Nolte, I.M., Magnusson, P.K., Salfati, E.L., Rallidis, L.S. ... Munroe, P.B. (2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48 (10), 1171-1184. doi: 10.1038/ng.3667 |
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2016 Journal Article Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profilingYengo, Loic, Arredouani, Abdelilah, Marre, Michel, Roussel, Ronan, Vaxillaire, Martine, Falchi, Mario, Haoudi, Abdelali, Tichet, Jean, Balkau, Beverley, Bonnefond, Amelie and Froguel, Philippe (2016). Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. Molecular Metabolism, 5 (10), 918-925. doi: 10.1016/j.molmet.2016.08.011 |
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2016 Journal Article Genomic insights into the origin of farming in the ancient Near EastLazaridis, Iosif, Nadel, Dani, Rollefson, Gary, Merrett, Deborah C., Rohland, Nadin, Mallick, Swapan, Fernandes, Daniel, Novak, Mario, Gamarra, Beatriz, Sirak, Kendra, Connell, Sarah, Stewardson, Kristin, Harney, Eadaoin, Fu, Qiaomei, Gonzalez-Fortes, Gloria, Jones, Eppie R., Roodenberg, Songul Alpaslan, Lengyel, Gyorgy, Bocquentin, Fanny, Gasparian, Boris, Monge, Janet M., Gregg, Michael, Eshed, Vered, Mizrahi, Ahuva-Sivan, Meiklejohn, Christopher, Gerritsen, Fokke, Bejenaru, Luminita, Blueher, Matthias, Campbell, Archie ... Reich, David (2016). Genomic insights into the origin of farming in the ancient Near East. Nature, 536 (7617), 419-424. doi: 10.1038/nature19310 |
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2016 Journal Article Variable clustering in high-dimensional linear regression: The R package clereYengo, Loic, Jacques, Julien, Biernacki, Christophe and Canouil, Mickael (2016). Variable clustering in high-dimensional linear regression: The R package clere. The R Journal, 8 (1), 92-106. doi: 10.32614/rj-2016-006 |
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2016 Journal Article The genetic architecture of type 2 diabetesFuchsberger, Christian, Flannick, Jason, Teslovich, Tanya M., Mahajan, Anubha, Agarwala, Vineeta, Gaulton, Kyle J., Ma, Clement, Fontanillas, Pierre, Moutsianas, Loukas, McCarthy, Davis J., Rivas, Manuel A., Perry, John R. B., Sim, Xueling, Blackwell, Thomas W., Robertson, Neil R., Rayner, N. William, Cingolani, Pablo, Locke, Adam E., Tajes, Juan Fernandez, Highland, Heather M., Dupuis, Josee, Chines, Peter S., Lindgren, Cecilia M., Hartl, Christopher, Jackson, Anne U., Chen, Han, Huyghe, Jeroen R., van de Bunt, Martijn, Pearson, Richard D. ... McCarthy, Mark I. (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41-47. doi: 10.1038/nature18642 |
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2016 Journal Article Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasisFavennec, Marie, Hennart, Benjamin, Verbanck, Marie, Pigeyre, Marie, Caiazzo, Robert, Raverdy, Violeta, Verkindt, Helene, Leloire, Audrey, Guillemin, Gilles J., Yengo, Loic, Allorge, Delphine, Froguel, Philippe, Pattou, Francois and Poulain-Godefroy, Odile (2016). Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasis. Plos One, 11 (6) e0158051, e0158051. doi: 10.1371/journal.pone.0158051 |
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2016 Journal Article Erratum: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (PLoS Genet (2015) 11:10 (e1005378) DOI: 10.1371/journal.pgen.1005378)Winkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tõnu, Fall, Tove, Kilpeläinen, Tuomas O., Lu, Yingchang, Mägi, Reedik, Mihailov, Evelin, Pers, Tune H., Rüeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C. ... Loos, Ruth J.F. (2016). Erratum: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (PLoS Genet (2015) 11:10 (e1005378) DOI: 10.1371/journal.pgen.1005378). PLoS Genetics, 12 (6) e1006166. doi: 10.1371/JOURNAL.PGEN.1006166 |
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2016 Journal Article KAT2B is required for pancreatic beta cell adaptation to metabolic stress by controlling the unfolded protein responseRabhi, Nabil, Denechaud, Pierre-Damien, Gromada, Xavier, Hannou, Sarah Anissa, Zhang, Hongbo, Rashid, Talha, Salas, Elisabet, Durand, Emmanuelle, Sand, Olivier, Bonnefond, Amelie, Yengo, Loic, Chavey, Carine, Bonner, Caroline, Kerr-Conte, Julie, Abderrahmani, Amar, Auwerx, Johan, Fajas, Lluis, Froguel, Philippe and Annicotte, Jean-Sebastien (2016). KAT2B is required for pancreatic beta cell adaptation to metabolic stress by controlling the unfolded protein response. Cell Reports, 15 (5), 1051-1061. doi: 10.1016/j.celrep.2016.03.079 |
