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2019

Journal Article

A versatile and robust serine protease inhibitor scaffold from Actinia tenebrosa

Chen, Xingchen, Leahy, Darren, Van Haeften, Jessica, Hartfield, Perry, Prentis, Peter J., van der Burg, Chloé A., Surm, Joachim M., Pavasovic, Ana, Madio, Bruno, Hamilton, Brett R., King, Glenn F., Undheim, Eivind A. B., Brattsand, Maria and Harris, Jonathan M. (2019). A versatile and robust serine protease inhibitor scaffold from Actinia tenebrosa. Marine Drugs, 17 (12) 701, 701. doi: 10.3390/md17120701

A versatile and robust serine protease inhibitor scaffold from Actinia tenebrosa

2019

Journal Article

Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus

Walker, Andrew A., Robinson, Samuel D., Undheim, Eivind A. B., Jin, Jiayi, Han, Xiao, Fry, Bryan G., Vetter, Irina and King, Glenn F. (2019). Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus. Toxins, 11 (11) 673, 673. doi: 10.3390/toxins11110673

Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus

2019

Journal Article

Fluorescence imaging of peripheral nerves by a Nav1.7-targeted inhibitor cystine knot peptide

Gonzales, Junior, Demetrio de Souza Franca, Paula, Jiang, Yan, Pirovano, Giacomo, Kossatz, Susanne, Guru, Navjot, Yarilin, Dimitry, Agwa, Akello J., Schroeder, Christina I, Patel, Snehal, Ganly, Ian, King, Glenn F. and Reiner, Thomas (2019). Fluorescence imaging of peripheral nerves by a Nav1.7-targeted inhibitor cystine knot peptide. Bioconjugate Chemistry, 30 (11) acs.bioconjchem.9b00612, 2879-2888. doi: 10.1021/acs.bioconjchem.9b00612

Fluorescence imaging of peripheral nerves by a Nav1.7-targeted inhibitor cystine knot peptide

2019

Journal Article

The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides

Deplazes, Evelyne, Chin, Yanni K.‐Y., King, Glenn F. and Mancera, Ricardo L. (2019). The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides. Proteins, 88 (3) prot.25828, 485-502. doi: 10.1002/prot.25828

The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides

2019

Journal Article

Development of high-throughput fluorescent-based screens to accelerate discovery of P2X inhibitors from animal venoms

Bibic, Lucka, Herzig, Volker, King, Glenn F. and Stokes, Leanne (2019). Development of high-throughput fluorescent-based screens to accelerate discovery of P2X inhibitors from animal venoms. Journal of Natural Products, 82 (9) acs.jnatprod.9b00410, 2559-2567. doi: 10.1021/acs.jnatprod.9b00410

Development of high-throughput fluorescent-based screens to accelerate discovery of P2X inhibitors from animal venoms

2019

Journal Article

A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain

Lin King, John V., Emrick, Joshua J., Kelly, Mark J. S., Herzig, Volker, King, Glenn F., Medzihradszky, Katalin F. and Julius, David (2019). A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain. Cell, 178 (6), 1362-1374.e16. doi: 10.1016/j.cell.2019.07.014

A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain

2019

Journal Article

Tying pest insects in knots: the deployment of spider‐venom‐derived knottins as bioinsecticides

King, Glenn F. (2019). Tying pest insects in knots: the deployment of spider‐venom‐derived knottins as bioinsecticides. Pest Management Science, 75 (9) ps.5452, 2437-2445. doi: 10.1002/ps.5452

Tying pest insects in knots: the deployment of spider‐venom‐derived knottins as bioinsecticides

2019

Journal Article

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Monk, Ian R., Shaikh, Nausad, Begg, Stephanie L., Gajdiss, Mike, Sharkey, Liam K. R., Lee, Jean Y. H., Pidot, Sacha J., Seemann, Torsten, Kuiper, Michael, Winnen, Brit, Hvorup, Rikki, Collins, Brett M., Bierbaum, Gabriele, Udagedara, Saumya R., Morey, Jacqueline R., Pulyani, Neha, Howden, Benjamin P., Maher, Megan J., McDevitt, Christopher A., King, Glenn F. and Stinear, Timothy P. (2019). Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nature Communications, 10 (1) 3067, 3067. doi: 10.1038/s41467-019-10932-4

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

2019

Journal Article

Sea anemone toxins: a structural overview

Madio, Bruno, King, Glenn F. and Undheim, Eivind A. B. (2019). Sea anemone toxins: a structural overview. Marine Drugs, 17 (6) 325, 325. doi: 10.3390/md17060325

Sea anemone toxins: a structural overview

2019

Journal Article

The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro

Nixon, Samantha A., Saez, Natalie J., Herzig, Volker, King, Glenn F. and Kotze, Andrew C. (2019). The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Veterinary Parasitology, 270, 40-46. doi: 10.1016/j.vetpar.2019.05.008

The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro

2019

Journal Article

Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR

El Hamdaoui, Yamina, Wu, Xiaosa, Clark, Richard J., Giribaldi, Julien, Anangi, Raveendra, Craik, David J., King, Glenn F., Dutertre, Sebastien, Kaas, Quentin, Herzig, Volker and Nicke, Annette (2019). Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR. Frontiers in Pharmacology, 10 (MAY) 577, 577. doi: 10.3389/fphar.2019.00577

Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR

2019

Journal Article

The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues

Cristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F. and Rash, Lachlan D. (2019). The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochemical Pharmacology, 163, 381-390. doi: 10.1016/j.bcp.2019.03.004

The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues

2019

Journal Article

NMR structure and dynamics of inhibitory repeat domain variant 12, a plant protease inhibitor from Capsicum annuum, and its structural relationship to other plant protease inhibitors

Gartia, Janeka, Anangi, Raveendra, Joshi, Rakesh S., Giri, Ashok P., King, Glenn F., Barnwal, Ravi P. and Chary, Kandala V. R. (2019). NMR structure and dynamics of inhibitory repeat domain variant 12, a plant protease inhibitor from Capsicum annuum, and its structural relationship to other plant protease inhibitors. Journal of Biomolecular Structure and Dynamics, 38 (5), 1-10. doi: 10.1080/07391102.2019.1607559

NMR structure and dynamics of inhibitory repeat domain variant 12, a plant protease inhibitor from Capsicum annuum, and its structural relationship to other plant protease inhibitors

2019

Journal Article

A process of convergent amplification and tissue‐specific expression dominate the evolution of toxin and toxin‐like genes in sea anemones

Surm, Joachim M., Smith, Hayden L., Madio, Bruno, Undheim, Eivind A. B., King, Glenn F., Hamilton, Brett R., van der Burg, Chloé A., Pavasovic, Ana and Prentis, Peter J. (2019). A process of convergent amplification and tissue‐specific expression dominate the evolution of toxin and toxin‐like genes in sea anemones. Molecular Ecology, 28 (9) mec.15084, 2272-2289. doi: 10.1111/mec.15084

A process of convergent amplification and tissue‐specific expression dominate the evolution of toxin and toxin‐like genes in sea anemones

2019

Journal Article

Can we resolve the taxonomic bias in spider venom research?

Herzig, Volker, King, Glenn F. and Undheim, Eivind A.B. (2019). Can we resolve the taxonomic bias in spider venom research?. Toxicon: X, 1 100005, 100005. doi: 10.1016/j.toxcx.2018.100005

Can we resolve the taxonomic bias in spider venom research?

2018

Journal Article

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target

Ma, Linlin, Chin, Yanni K.Y., Dekan, Zoltan, Herzig, Volker, Chow, Chun Yuen, Heighway, Jacqueline, Lam, Sau Wing, Guillemin, Gilles J., Alewood, Paul F. and King, Glenn F. (2018). Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target. Biochemical Pharmacology, 158, 60-72. doi: 10.1016/j.bcp.2018.08.038

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target

2018

Journal Article

Buzz kill: Function and proteomic composition of venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae)

Walker, Andrew, Dobson, James, Jin, Jiayi, Robinson, Samuel, Herzig, Volker, Vetter, Irina, King, Glenn and Fry, Bryan (2018). Buzz kill: Function and proteomic composition of venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae). Toxins, 10 (11) 456, 456. doi: 10.3390/toxins10110456

Buzz kill: Function and proteomic composition of venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae)

2018

Journal Article

Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7

Agwa, Akello J., Blomster, Linda V., Craik, David J., King, Glenn F. and Schroeder, Christina I. (2018). Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry, 29 (10) acs.bioconjchem.8b00505, 3309-3319. doi: 10.1021/acs.bioconjchem.8b00505

Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7

2018

Journal Article

Entomo-venomics: the evolution, biology and biochemistry of insect venoms

Walker, Andrew A., Robinson, Samuel D., Yeates, David K., Jin, Jiayi, Baumann, Kate, Dobson, James, Fry, Bryan G. and King, Glenn F. (2018). Entomo-venomics: the evolution, biology and biochemistry of insect venoms. Toxicon: official journal of the International Society on Toxinology, 154, 15-27. doi: 10.1016/j.toxicon.2018.09.004

Entomo-venomics: the evolution, biology and biochemistry of insect venoms

2018

Journal Article

1H, 13C and 15N NMR assignments of two plant protease inhibitors (IRD7 and IRD12) from the plant Capsicum annuum

Gartia, Janeka, Barnwal, Ravi Pratap, Anangi, Raveendra, Giri, Ashok R., King, Glenn and Chary, Kandala V. R. (2018). 1H, 13C and 15N NMR assignments of two plant protease inhibitors (IRD7 and IRD12) from the plant Capsicum annuum. Biomolecular NMR Assignments, 13 (1), 31-35. doi: 10.1007/s12104-018-9846-z

1H, 13C and 15N NMR assignments of two plant protease inhibitors (IRD7 and IRD12) from the plant Capsicum annuum