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2021 Journal Article Community-wide experimental evaluation of the PROSS stability-design methodPeleg, Yoav, Vincentelli, Renaud, Collins, Brett M., Chen, Kai-En, Livingstone, Emma K., Weeratunga, Saroja, Leneva, Natalya, Guo, Qian, Remans, Kim, Perez, Kathryn, Bjerga, Gro E K, Larsen, Øivind, Vaněk, Ondřej, Skořepa, Ondřej, Jacquemin, Sophie, Poterszman, Arnaud, Kjær, Svend, Christodoulou, Evangelos, Albeck, Shira, Dym, Orly, Ainbinder, Elena, Unger, Tamar, Schuetz, Anja, Matthes, Susann, Bader, Michael, de Marco, Ario, Storici, Paola, Semrau, Marta S., Stolt-Bergner, Peggy ... Fleishman, Sarel J. (2021). Community-wide experimental evaluation of the PROSS stability-design method. Journal of Molecular Biology, 433 (13) 166964, 166964. doi: 10.1016/j.jmb.2021.166964 |
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2021 Journal Article A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter releaseLi, Lei, Liu, Haowen, Krout, Mia, Richmond, Janet E., Wang, Yu, Bai, Jihong, Weeratunga, Saroja, Collins, Brett M., Ventimiglia, Donovan, Yu, Yi, Xia, Jingyao, Tang, Jing, Liu, Jie and Hu, Zhitao (2021). A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release. Journal of Cell Biology, 220 (4) e202008121, 1-24. doi: 10.1083/jcb.202008121 |
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2021 Journal Article Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formationTillu, Vikas A., Rae, James, Gao, Ya, Ariotti, Nicholas, Floetenmeyer, Matthias, Kovtun, Oleksiy, McMahon, Kerrie-Ann, Chaudhary, Natasha, Parton, Robert G. and Collins, Brett M. (2021). Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation. Nature Communications, 12 (1) 931, 931. doi: 10.1038/s41467-021-21035-4 |
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2021 Journal Article Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolaeZhou, Yong, Ariotti, Nicholas, Rae, James, Liang, Hong, Tillu, Vikas, Tee, Shern, Bastiani, Michele, Bademosi, Adekunle T., Collins, Brett M., Meunier, Frederic A., Hancock, John F. and Parton, Robert G. (2021). Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae. Journal of Cell Biology, 220 (3) e202005138. doi: 10.1083/jcb.202005138 |
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2020 Journal Article Neuropilin-1 is a host factor for SARS-CoV-2 infectionDaly, James L., Simonetti, Boris, Klein, Katja, Chen, Kai-En, Williamson, Maia Kavanagh, Antón-Plágaro, Carlos, Shoemark, Deborah K., Simón-Gracia, Lorena, Bauer, Michael, Hollandi, Reka, Greber, Urs F., Horvath, Peter, Sessions, Richard B., Helenius, Ari, Hiscox, Julian A., Teesalu, Tambet, Matthews, David A., Davidson, Andrew D., Collins, Brett M., Cullen, Peter J. and Yamauchi, Yohei (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370 (6518), 861-865. doi: 10.1126/science.abd3072 |
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2020 Journal Article Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29Crawley-Snowdon, Harriet, Yang, Ji-Chun, Zaccai, Nathan R., Davis, Luther J., Wartosch, Lena, Herman, Emily K., Bright, Nicholas A., Swarbrick, James S., Collins, Brett M., Jackson, Lauren P., Seaman, Matthew N. J., Luzio, J. Paul, Dacks, Joel B., Neuhaus, David and Owen, David J. (2020). Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29. Nature Communications, 11 (1) 5031, 1-15. doi: 10.1038/s41467-020-18773-2 |
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2020 Journal Article An epilepsy-associated GRIN2A rare variant disrupts CaMKIIα phosphorylation of GluN2A and NMDA receptor traffickingMota Vieira, Marta, Nguyen, Thien A., Wu, Kunwei, Badger, John D., Collins, Brett M., Anggono, Victor, Lu, Wei and Roche, Katherine W. (2020). An epilepsy-associated GRIN2A rare variant disrupts CaMKIIα phosphorylation of GluN2A and NMDA receptor trafficking. Cell Reports, 32 (9) 108104, 108104. doi: 10.1016/j.celrep.2020.108104 |
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2020 Journal Article Recognising the signals for endosomal traffickingWeeratunga, Saroja, Paul, Blessy and Collins, Brett M. (2020). Recognising the signals for endosomal trafficking. Current Opinion in Cell Biology, 65, 17-27. doi: 10.1016/j.ceb.2020.02.005 |
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2020 Journal Article EhC2B, a C2 domain-containing protein, promotes erythrophagocytosis in Entamoeba histolytica via actin nucleationTripathi, Aashutosh, Jain, Megha, Chandra, Mintu, Parveen, Sameena, Yadav, Rupali, Collins, Brett M., Maiti, Sankar and Datta, Sunando (2020). EhC2B, a C2 domain-containing protein, promotes erythrophagocytosis in Entamoeba histolytica via actin nucleation. PLOS Pathogens, 16 (5) e1008489, e1008489. doi: 10.1371/journal.ppat.1008489 |
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2020 Journal Article Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007 |
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2020 Journal Article Caveolae control contractile tension for epithelia to eliminate tumor cellsTeo, Jessica L., Gomez, Guillermo A., Weeratunga, Saroja, Davies, Elizabeth M., Noordstra, Ivar, Budnar, Srikanth, Katsuno-Kambe, Hiroko, McGrath, Meagan J., Verma, Suzie, Tomatis, Vanesa, Acharya, Bipul R., Balasubramaniam, Lakshmi, Templin, Rachel M., McMahon, Kerrie-Ann, Lee, Yoke Seng, Ju, Robert J., Stebhens, Samantha J., Ladoux, Benoit, Mitchell, Christina A., Collins, Brett M., Parton, Robert G. and Yap, Alpha S. (2020). Caveolae control contractile tension for epithelia to eliminate tumor cells. Developmental Cell, 54 (1), 75-91.e7. doi: 10.1016/j.devcel.2020.05.002 |
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2019 Journal Article Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteinsSimonetti, Boris, Paul, Blessy, Chaudhari, Karina, Weeratunga, Saroja, Steinberg, Florian, Gorla, Madhavi, Heesom, Kate J., Bashaw, Greg J., Collins, Brett M. and Cullen, Peter J. (2019). Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. Nature Cell Biology, 21 (10), 1219-1233. doi: 10.1038/s41556-019-0393-3 |
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2019 Journal Article Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytesUgrankar, Rupali, Bowerman, Jade, Hariri, Hanaa, Chandra, Mintu, Chen, Kevin, Bossanyi, Marie-France, Datta, Sanchari, Rogers, Sean, Eckert, Kaitlyn M., Vale, Gonçalo, Victoria, Alexia, Fresquez, Joseph, McDonald, Jeffrey G., Jean, Steve, Collins, Brett M. and Henne, W. Mike (2019). Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes. Developmental Cell, 50 (5), 557-572.e5. doi: 10.1016/j.devcel.2019.07.021 |
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2019 Journal Article STXBP1 encephalopathy: connecting neurodevelopmental disorders with α-synucleinopathies?Lanoue, Vanessa, Chai, Ye Jin, Brouillet, Julie Z., Weckhuysen, Sarah, Palmer, Elizabeth E., Collins, Brett M. and Meunier, Frederic A. (2019). STXBP1 encephalopathy: connecting neurodevelopmental disorders with α-synucleinopathies?. Neurology, 93 (3), 114-123. doi: 10.1212/WNL.0000000000007786 |
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2019 Journal Article Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureusMonk, Ian R., Shaikh, Nausad, Begg, Stephanie L., Gajdiss, Mike, Sharkey, Liam K. R., Lee, Jean Y. H., Pidot, Sacha J., Seemann, Torsten, Kuiper, Michael, Winnen, Brit, Hvorup, Rikki, Collins, Brett M., Bierbaum, Gabriele, Udagedara, Saumya R., Morey, Jacqueline R., Pulyani, Neha, Howden, Benjamin P., Maher, Megan J., McDevitt, Christopher A., King, Glenn F. and Stinear, Timothy P. (2019). Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nature Communications, 10 (1) 3067, 3067. doi: 10.1038/s41467-019-10932-4 |
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Featured 2019 Journal Article Towards a molecular understanding of endosomal trafficking by Retromer and RetrieverChen, Kai‐En, Healy, Michael D. and Collins, Brett M. (2019). Towards a molecular understanding of endosomal trafficking by Retromer and Retriever. Traffic, 20 (7) tra.12649, 465-478. doi: 10.1111/tra.12649 |
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2019 Journal Article Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse modelMilne, Michael R., Qian, Lei, Turnbull, Marion T., Kinna, Genevieve, Collins, Brett M., Teasdale, Rohan D. and Coulson, Elizabeth J. (2019). Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model. Neurobiology of Aging, 77, 144-153. doi: 10.1016/j.neurobiolaging.2019.01.011 |
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2019 Journal Article Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscsZhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238 |
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2019 Journal Article Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificitiesChandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y |
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2018 Journal Article Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2αChen, Kai-En, Tillu, Vikas A., Chandra, Mintu and Collins, Brett M. (2018). Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α. Structure, 26 (12), 1612-1625.e4. doi: 10.1016/j.str.2018.08.010 |
