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2024

Journal Article

Single-molecule imaging of stochastic interactions that drive dynein activation and cargo movement in cells

Tirumala, Nireekshit Addanki, Redpath, Gregory Michael Ian, Skerhut, Sarah Viktoria, Dolai, Pritha, Kapoor-Kaushik, Natasha, Ariotti, Nicholas, Vijay Kumar, K. and Ananthanarayanan, Vaishnavi (2024). Single-molecule imaging of stochastic interactions that drive dynein activation and cargo movement in cells. Journal of Cell Biology, 223 (3) ARTN e202210026. doi: 10.1083/jcb.202210026

Single-molecule imaging of stochastic interactions that drive dynein activation and cargo movement in cells

2024

Journal Article

Single molecule visualization of tropomyosin isoform organization in the mammalian actin cytoskeleton

Cagigas, Maria L., Ariotti, Nicholas, Hook, Jeff, Rae, James, Parton, Robert G., Bryce, Nicole S., Gunning, Peter W. and Hardeman, Edna C. (2024). Single molecule visualization of tropomyosin isoform organization in the mammalian actin cytoskeleton. Cytoskeleton. doi: 10.1002/cm.21883

Single molecule visualization of tropomyosin isoform organization in the mammalian actin cytoskeleton

2024

Journal Article

The HIV capsid mimics karyopherin engagement of FG-nucleoporins

Dickson, C. F., Hertel, S., Tuckwell, A. J., Li, N., Ruan, J., Al-Izzi, S. C., Ariotti, N., Sierecki, E., Gambin, Y., Morris, R. G., Towers, G. J., Böcking, T. and Jacques, D. A. (2024). The HIV capsid mimics karyopherin engagement of FG-nucleoporins. Nature, 626 (8000), 836-842. doi: 10.1038/s41586-023-06969-7

The HIV capsid mimics karyopherin engagement of FG-nucleoporins

2024

Journal Article

Investigating Epidermal Growth Factor Receptor Trafficking with High-Resolution Enzymatic Protein-Tagging and Transmission Electron Microscopy

Ariotti, Nicholas (2024). Investigating Epidermal Growth Factor Receptor Trafficking with High-Resolution Enzymatic Protein-Tagging and Transmission Electron Microscopy. Methods in molecular biology (Clifton, N.J.), 2800, 75-87. doi: 10.1007/978-1-0716-3834-7_7

Investigating Epidermal Growth Factor Receptor Trafficking with High-Resolution Enzymatic Protein-Tagging and Transmission Electron Microscopy

2023

Journal Article

Cell surface plasticity in response to shape change in the whole organism

Hall, Thomas E., Ariotti, Nicholas, Lo, Harriet P., Rae, James, Ferguson, Charles, Martel, Nick, Lim, Ye-Wheen, Giacomotto, Jean and Parton, Robert G. (2023). Cell surface plasticity in response to shape change in the whole organism. Current Biology, 33 (19), 4276-4284. doi: 10.1016/j.cub.2023.08.068

Cell surface plasticity in response to shape change in the whole organism

2023

Journal Article

The role of membrane lipids in the formation and function of caveolae

Kenworthy, Anne K., Han, Bing, Ariotti, Nicholas and Parton, Robert G. (2023). The role of membrane lipids in the formation and function of caveolae. Cold Spring Harbor Perspectives in Biology, 15 (9) a041413, 1-19. doi: 10.1101/cshperspect.a041413

The role of membrane lipids in the formation and function of caveolae

2023

Journal Article

Physico-chemical properties of functionally adhesive spider silk nanofibres

Joel, Anna-Christin, Rawal, Aditya, Yao, Yin, Jenner, Andrew, Ariotti, Nicholas, Weissbach, Margret, Adler, Lewis, Stafstrom, Jay and Blamires, Sean J. (2023). Physico-chemical properties of functionally adhesive spider silk nanofibres. Biomaterials Science, 11 (6), 2139-2150. doi: 10.1039/d2bm01599d

Physico-chemical properties of functionally adhesive spider silk nanofibres

2023

Journal Article

Microtubule–mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast

Chacko, Leeba Ann, Mikus, Felix, Ariotti, Nicholas, Dey, Gautam and Ananthanarayanan, Vaishnavi (2023). Microtubule–mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast. Journal of Cell Science, 136 (1) jcs260705, 1-8. doi: 10.1242/jcs.260705

Microtubule–mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast

2022

Journal Article

Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers

Longatte, Guillaume, Lisi, Fabio, Chen, Xueqian, Walsh, James, Wang, Wenqian, Ariotti, Nicholas, Boecking, Till, Gaus, Katharina and Gooding, J. Justin (2022). Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers. Physical Chemistry Chemical Physics, 24 (45), 28029-28039. doi: 10.1039/d2cp03627d

Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers

2022

Journal Article

Macrophage-targeting and complete lysosomal degradation of self-assembled two-dimensional poly(ε-caprolactone) platelet particles

Ganda, Sylvia, Wong, Chin Ken, Biazik, Joanna, Raveendran, Radhika, Zhang, Lin, Chen, Fan, Ariotti, Nicholas and Stenzel, Martina H. (2022). Macrophage-targeting and complete lysosomal degradation of self-assembled two-dimensional poly(ε-caprolactone) platelet particles. ACS Applied Materials and Interfaces, 14 (31), 35333-35343. doi: 10.1021/acsami.2c06555

Macrophage-targeting and complete lysosomal degradation of self-assembled two-dimensional poly(ε-caprolactone) platelet particles

2022

Journal Article

Controlling the Biological Behaviors of Polymer-Coated Upconverting Nanoparticles by Adjusting the Linker Length of Estrone Ligands

Zhang, Lin, Cao, Cheng, Kaushik, Natasha, Lai, Rebecca Y., Liao, Jiayan, Wang, Guannan, Ariotti, Nicholas, Jin, Dayong and Stenzel, Martina H. (2022). Controlling the Biological Behaviors of Polymer-Coated Upconverting Nanoparticles by Adjusting the Linker Length of Estrone Ligands. Biomacromolecules, 23 (6), 2572-2585. doi: 10.1021/acs.biomac.2c00265

Controlling the Biological Behaviors of Polymer-Coated Upconverting Nanoparticles by Adjusting the Linker Length of Estrone Ligands

2022

Journal Article

Nanovoid formation induces property variation within and across individual silkworm silk threads

Craig, Hamish C., Yao, Yin, Ariotti, Nicholas, Setty, Mohan, Remadevi, Rechana, Kasumovic, Michael M., Rajkhowa, Rangam, Rawal, Aditya and Blamires, Sean J. (2022). Nanovoid formation induces property variation within and across individual silkworm silk threads. Journal of Materials Chemistry B, 10 (29), 5561-5570. doi: 10.1039/d2tb00357k

Nanovoid formation induces property variation within and across individual silkworm silk threads

2022

Journal Article

Trehalose coated nanocellulose to inhibit the infections by S. aureus

Li, Yimeng, Milewska, Malgorzata, Khine, Yee Yee, Ariotti, Nicholas and Stenzel, Martina H. (2022). Trehalose coated nanocellulose to inhibit the infections by S. aureus. Polymer Chemistry, 13 (11), 1502-1509. doi: 10.1039/d1py01422f

Trehalose coated nanocellulose to inhibit the infections by S. aureus

2022

Journal Article

Green Stealth Engineering of Lifetime-Biocatalytic Nanocatalyst for Neuroblastoma Therapy

Mehmood, Rashid, Amaldoss, Maria J. N., Mofarah, Sajjad S., Zheng, Qinxiang, Kaushik, Natasha K., Ariotti, Nicholas, Rawal, Aditya, Yang, Jia-Lin, Koshy, Pramod and Sorrell, Charles C. (2022). Green Stealth Engineering of Lifetime-Biocatalytic Nanocatalyst for Neuroblastoma Therapy. Applied Surface Science, 572 151464, 151464. doi: 10.1016/j.apsusc.2021.151464

Green Stealth Engineering of Lifetime-Biocatalytic Nanocatalyst for Neuroblastoma Therapy

2022

Journal Article

SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

Ecker, Manuela, Schregle, Richard, Kapoor-Kaushik, Natasha, Rossatti, Pascal, Betzler, Verena M., Kempe, Daryan, Biro, Maté, Ariotti, Nicholas, Redpath, Gregory M. I. and Rossy, Jeremie (2022). SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling. eLife, 11 e67550. doi: 10.7554/eLife.67550

SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

2021

Journal Article

Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Lo, Harriet P., Lim, Ye-Wheen, Xiong, Zherui, Martel, Nick, Ferguson, Charles, Ariotti, Nicholas, Giacomotto, Jean, Rae, James, Floetenmeyer, Matthias, Moradi, Shayli Varasteh, Gao, Ya, Tillu, Vikas A., Xia, Di, Wang, Huang, Rahnama, Samira, Nixon, Susan J., Bastiani, Michele, Day, Ryan D., Smith, Kelly A., Palpant, Nathan J., Johnston, Wayne A., Alexandrov, Kirill, Collins, Brett M., Hall, Thomas E. and Parton, Robert G. (2021). Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle. Journal of Cell Biology, 220 (12) e201905065. doi: 10.1083/jcb.201905065

Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

2021

Journal Article

Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell-substrate adhesion in cancer cells and mechanosensitivity of cell proliferation

Cagigas, Maria Lastra, Bryce, Nicole S., Ariotti, Nicholas, Brayford, Simon, Gunning, Peter W. and Hardeman, Edna C. (2021). Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell-substrate adhesion in cancer cells and mechanosensitivity of cell proliferation. Nature Materials, 21 (1), 120-128. doi: 10.1038/s41563-021-01087-z

Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell-substrate adhesion in cancer cells and mechanosensitivity of cell proliferation

2021

Journal Article

Inhibition of S. aureus infection of human umbilical vein endothelial cells (HUVECs) by trehalose- and glucose-functionalized gold nanoparticles

Li, Yimeng, Ariotti, Nicholas, Aghaei, Behnaz, Pandzic, Elvis, Ganda, Sylvia, Willcox, Mark, Sanchez-Felix, Manuel and Stenzel, Martina (2021). Inhibition of S. aureus infection of human umbilical vein endothelial cells (HUVECs) by trehalose- and glucose-functionalized gold nanoparticles. Angewandte Chemie - International Edition, 60 (42), 22652-22658. doi: 10.1002/anie.202106544

Inhibition of S. aureus infection of human umbilical vein endothelial cells (HUVECs) by trehalose- and glucose-functionalized gold nanoparticles

2021

Journal Article

A robust method for particulate detection of a genetic tag for 3D electron microscopy

Rae, James, Ferguson, Charles, Ariotti, Nicholas, Webb, Richard I., Cheng, Han-Hao, Mead, James L., Riches, James D., Hunter, Dominic J.B., Martel, Nick, Baltos, Joanne, Christopoulos, Arthur, Bryce, Nicole S., Cagigas, Maria Lastra, Fonseka, Sachini, Sayre, Marcel E., Hardeman, Edna C., Gunning, Peter W., Gambin, Yann, Hall, Thomas E. and Parton, Robert G. (2021). A robust method for particulate detection of a genetic tag for 3D electron microscopy. eLife, 10 e64630, 1-17. doi: 10.7554/eLife.64630

A robust method for particulate detection of a genetic tag for 3D electron microscopy

2021

Journal Article

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

Tillu, Vikas A., Rae, James, Gao, Ya, Ariotti, Nicholas, Floetenmeyer, Matthias, Kovtun, Oleksiy, McMahon, Kerrie-Ann, Chaudhary, Natasha, Parton, Robert G. and Collins, Brett M. (2021). Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation. Nature Communications, 12 (1) 931, 931. doi: 10.1038/s41467-021-21035-4

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation